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Semi-supervised Counting of Grape Berries in the Field Based on Density Mutual Exclusion

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Plant Phenomics 2023年第4期5卷 825-835页

作者： Yanan Li Yuling Tang Yifei liu Dingrun Zheng School of Computer Science and Engineering School of Artificial IntelligenceWuhan Institute of TechnologyWuhan 430205China Hubei Key Laboratory of Intelligent Robot Wuhan Institute of TechnologyWuhan 430073China

Automated counting of grape berries has become one of the most important tasks in grape yield prediction.However,dense distribution of berries and the severe occlusion between berries bring great challenges to counting algorithm based on deep learning.The collection of data required for model training is also a tedious and expensive work.To address these issues and cost-effectively count grape berries,a semi-supervised counting of grape berries in the field based on density mutual exclusion(CDMENet)is proposed.The algorithm uses VGG16 as the backbone to extract image features.Auxiliary tasks based on density mutual exclusion are introduced.The tasks exploit the spatial distribution pattern of grape berries in density levels to make full use of unlabeled data.In addition,a density difference loss is designed.The feature representation is enhanced by amplifying the difference of features between different density levels.The experimental results on the field grape berry dataset show that CDMENet achieves less counting errors.Compared with the state of the arts,coefficient of determination(R^(2))is improved by 6.10%,and mean absolute error and root mean square error are reduced by 49.36%and 54.08%,respectively.The code is available at.

关键词： Grape mutual backbone

Residual stress with asymmetric spray quenching for thick aluminum alloy plates

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International Journal of Minerals,Metallurgy and Materials 2023年第11期30卷 2200-2211页

作者： Ning Fan Zhihui li Yanan Li Xiwu li Yongan Zhang Baiqing Xiong State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China

Solution and quenching heat treatments are generally carried out in a roller hearth furnace for large-scale thick aluminum alloy plates.However,the asymmetric or uneven spray water flow rate is inevitable under industrial production conditions,which leads to an asymmetric residual stress distribution.The spray quenching treatment was conducted on self-designed spray equipment,and the residual stress along the thickness direction was measured by a layer removal method based on deflections.Under the asymmetric spray quenching condition,the subsurface stress of the high-flow rate surface was lower than that of the low-flow rate surface,and the difference between the two subsurface stresses increased with the increase in the difference in water flow rates.The subsurface stress underneath the surface with a water flow rate of 0.60 m^(3)/h was 15.38 MPa less than that of 0.15 m^(3)/h.The simulated residual stress by finite element(FE)method of the high heat transfer coefficient(HTC)surface was less than that of the low HTC surface,which is consistent with the experimental results.The FE model can be used to analyze the strain and stress evolution and predict the quenched stress magnitude and distribution.

关键词： aluminum alloy spray quenching residual stress layer removal method finite element method

Sediment settlement rate and consolidation time of flling reclamation in coal mining subsidence land

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International Journal of Coal Science & Technology 2022年第3期9卷 232-246页

作者： linghua Duo Zhenqi Hu Kun Yang Yanan Li Faculty of Geomatics East China University of TechnologyNanchang 30013China School of Environment and Spatial Informatics China University of Mining and TechnologyXuzhou 221116China Institute of Land Reclamation and Ecological Restoration China University of Mining and Technology(Beijing)D11 Xueyuan RoadHaidian DistrictBeijing 100083China

With the continuous growth of the population and the continuous reduction of cultivated land,China’s food security is greatly threatened.In addition,China’s coal mining has been mainly underground mining,causing land subsidence and damaging existing cultivated land.This efect intensifes the contradiction between the growth of the risk population and the reduction of cultivated land.The reclamation of mining subsidence land with Yellow River sediment is often used as an efective way to improve the recovery rate of cultivated land.Shortening the reclamation time and realizing continuous flling are signifcant issues.The work presented in this paper studied the sediment settlement rate and consolidation time by combining theory,feld flling and reclamation tests and numerical simulations.A feld flling test study was carried out in the lowlands of Jibeiwang Village,Qihe County,Shandong Province,China.By calculating the drainage consolidation time,the consolidation factor of 0.015656 m^(2)/d,and the time factor for sediment consolidation of 0.575 were determined.The sediment consolidation time for this test was 9.18 days.The calculation of sediment deposition rate and consolidation time is of great practical signifcance to guide the Yellow River sediment flling,realize continuous flling,and save reclamation time and cost.

关键词： Yellow River sediment Mining subsidence land Filling reclamation Consolidation time

Joint Doppler Shift and Channel Estimation for UAV mmWave System with Massive ULA

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China Communications 2022年第4期19卷 67-82页

作者： Yanan Li Yue Zhu Tiankui Zhang Dian Fan The China Academy of Information and Communications Technology Beijing 100191China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing key engineering laboratory of testing and validation for smart terminal and hardware

A joint Doppler shift and channel estimation method for the millimeter-wave communication system of an unmanned aerial vehicle(UAV) equipped with a large-scale uniform linear antenna(ULA) array has been proposed. Since Doppler shift induces intercarrier interference, the parameters of the channel paths have been decomposed into the Doppler shift and the channel information. In order to obtain the Doppler shift, a new estimation algorithm based on a combination of discrete Fourier transform and phase rotation has been proposed, which can determine the appropriate number of antennas. In addition to estimating the channel information, a low-complexity joint Doppler shift and channel estimation method has been designed that can quickly obtain accurate estimates. Furthermore, the achievable sum rate, the theoretical bounds of the mean squared errors, and the Cram?er-Rao lower bounds of the estimation method have been derived. The analysis and simulation results prove that the performance of the proposed approach is close to the theoretical inference.

关键词： ULA Doppler shift estimation channel estimation achievable sum rate

Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy

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Cancer Biology & Medicine 2019年第3期16卷 415-434页

作者： Yanan Li Qingrong Dong Yukun Cui Department of Radiology First Clinical Medical CollegeShanxi Medical UniversityTaiyuan030001China GuangdongProvincial Key Laboratory of Breast Cancer Diagnosis and Treatment Shantou University Medical College Cancer HospitalShantou515041China

The RAS-RAF-MEK-ERK signaling pathway(MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers.As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosis, which makes their inhibition an attractive antitumor strategy.Dozens of potent non-ATP-competitive allosteric MEK1/2 inhibitors have been developed that have produced substantial improvement in clinical outcomes over the past decade.However, the efficacy of these agents is limited, and response rates are variable in a wide range of tumors that harbor RAS and RAF mutations due to the development of resistance, which is derived mainly from the persistence of MAPK signaling and increased activation of the mutual feedback networks.Both intrinsic and acquired resistance to MEK inhibitors necessitates the synergistic targeting of both pathways to restore the therapeutic effects of a single agent.In this review, the significant role of the MAPK pathway in carcinogenesis and its therapeutic potential are comprehensively examined with a focus on MEK inhibitors.Then, the activation of feedback networks accompanying MEK inhibition is briefly reviewed.Combination strategies that involve the simultaneous inhibition of the original and resistance pathways are highlighted and elaborately described on the basis of the latest research progress.Finally, the obstacles to the development of MEK-related combination systems are discussed in order to lay the groundwork for their clinical application as frontline treatments for individual patients with MAPK-hyperactivated malignancies.

关键词： MAPK signaling pathway MEK inhibitor reciprocal feedback networks combination therapy malignancy

Algorithm for simulating ocean circulation on a quantum computer

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中国科学:地球科学英文版 2023年第10期66卷 2254-2264页

作者： Ruimin SHANG Zhimin WANG Shangshang SHI Jiaxin li Yanan Li Yongjian GU College of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao266100China

The accurate and efficient simulation of ocean circulation is a fundamental topic in marine science;however,it is also a well-known and dauntingly difficult problem that requires solving nonlinear partial differential equations with multiple variables.In this paper,we present for the first time an algorithm for simulating ocean circulation on a quantum computer to achieve a computational speedup.Our approach begins with using primitive equations describing the ocean dynamics and then discretizing these equations in time and space.It results in several linear system of equations(LSE)with sparse coefficient matrices.We solve these sparse LSE using the variational quantum linear solver that enables the present algorithm to run easily on near-term quantum computers.Additionally,we develop a scheme for manipulating the data flow in the algorithm based on the quantum random access memory and l∞norm tomography technique.The efficiency of our algorithm is verified using multiple platforms,including MATLAB,a quantum virtual simulator,and a real quantum computer.The impact of the number of shots and the noise of quantum gates on the solution accuracy is also discussed.Our findings demonstrate that error mitigation techniques can efficiently improve the solution accuracy.With the rapid advancements in quantum computing,this work represents an important first step toward solving the challenging problem of simulating ocean circulation using quantum computers.

关键词： Ocean circulation Primitive equations linear system of equations Variational quantum linear solver Error mitigation technique

Habitat quality assessment of mining cities based on InVEST model—a case study of Yanshan County,Jiangxi Province

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International Journal of Coal Science & Technology 2022年第2期9卷 245-254页

作者： Yanan Li linghua Duo Ming Zhang Jingyuan Yang Xiaofei Guo Research Center of Geological Resource Economics and Management East China University of TechnologyNanchang 30013China Faculty of Geomatics East China University of TechnologyNanchang 30013China

The assessment of the spatiotemporal evolution of habitat quality caused by land use changes can provide a scientifc basis for the ecological protection and green development of mining cities.Taking Yanshan County as an example of a typical mining city,this article discussed the spatial pattern and evolution characteristics of habitat quality in 2000 and 2018 based on the ArcGIS platform and the InVEST model.The conclusions are as below:from 2000 to 2018,the area of farmland and construction land changed the most in the study area.Among them,the area of farmland decreased by 3.48%,and the area of industrial and mining land and construction land increased by 53.25%.Areas of low,relatively low and high habitat quality expanded,and areas of medium and relatively high habitat quality shrank,which is closely related to the distribution of land use.The areas with high habitat degradation degrees appear around cities,mining areas and watersheds,while the areas with low habitat degradation degrees are mainly distributed in the southern woodland.The distribution of cold and hot spots in the habitat quality distribution of Yanshan County presents a pattern of“hot in the south and cold in the north”.The results are of great signifcance to the precise implementation of ecosystem management decisions in mining cities and the creation of a landscape pattern of“beautiful countrysides,green cities,and green mines”.

关键词： InVEST model Habitat quality Land use change Temporal and spatial pattern Mining city

Analysis of environmental selection pressure of superoxide dismutase in deep-sea sea cucumber

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Journal of Oceanology and limnology 2024年第3期42卷 893-904页

作者： Yanan Li Zongfu CHEN Haibin ZHANG Ruoyu liU Shuichun CHEN li liN Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhou 510222China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China College of Marine Science Fujian Agriculture and Forestry UniversityFuzhou 350002China Zhanjiang Tianli Sea Cucumber New Technology Development Co. Ltd.Zhanjiang 524000China

Manganese superoxide dismutase(MnSOD)is an antioxidant that exists in mitochondria and can effectively remove superoxide anions in mitochondria.In a dark,high-pressure,and low-temperature deep-sea environment,MnSOD is essential for the survival of sea cucumbers.Six MnSODs were identified from the transcriptomes of deep and shallow-sea sea cucumbers.To explore their environmental adaptation mechanism,we conducted environmental selection pressure analysis through the branching site model of PAML software.We obtained night positive selection sites,and two of them were significant(97F→H,134K→V):97F→H located in a highly conservative characteristic sequence,and its polarity c hange might have a great impact on the function of MnSOD;134K→V had a change in piezophilic a bility,which might help MnSOD adapt to the environment of high hydrostatic pressure in the deepsea.To further study the effect of these two positive selection sites on MnSOD,we predicted the point mutations of F97H and K134V on shallow-sea sea cucumber by using MAESTROweb and PyMOL.Results show that 97F→H,134K→V might improve MnSOD’s efficiency of scavenging superoxide a nion and its ability to resist high hydrostatic pressure by moderately reducing its stability.The above results indicated that MnSODs of deep-sea sea cucumber adapted to deep-sea environments through their amino acid changes in polarity,piezophilic behavior,and local stability.This study revealed the correlation between MnSOD and extreme environment,and will help improve our understanding of the organism’s adaptation mechanisms in deep sea.

关键词： Holothuroidea environmental adaptation positive selection point mutation

CHD4-induced up-regulation of ERα activity contributes to breast cancer progression

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Genes & Diseases 2024年第3期11卷 132-135页

作者： Aman Sattout Xiaomin Yu Zhuo Sun Yanan Li Yulin li Shujing li Wei Huo Huijian Wu School of Bioengineering&Key Laboratory of Protein Modification and Disease Liaoning ProvinceDalian University of TechnologyDalianLiaoning 116024China Department of Oncology Central Hospital Affiliated with Dalian University of TechnologyDalianLiaoning 116089China

The estrogen signaling system is a crucial regulator of metabolicandphysiologicalprocesses.However,abnormal activation of estrogen signaling may play a role in breast cancer initiation and progression.Crucial to this pathway is the interaction between estrogen receptor alpha(ERa)and various co-transcription activators.1 Although numerous studies have investigated ER coregulators,the protein-protein interaction networks of ERa are not fully understood.Recent research has shown that high chromodomain helicase DNA-binding 4(CHD4)expression is linked to poor prognosis in various cancers.2,?In this study,we demonstrated that both CHD4 and ERαcontribute to breast cancer progression while providing evidence of the regulatory processes and functional interplay between these two proteins.

关键词： breast cancer ERα