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艺术创新视角下造型设计的未来发展研究

玩具世界 2024年第5期 20-22页

作者：霍亚楠河北广播电视台

文章从艺术创新的角度出发，探讨了造型设计与艺术创新的内在联系，分析了艺术创新对造型设计的推动作用，并预测了艺术创新视角下造型设计的未来发展趋势。文章强调，注重原创性和独特性、融合多元文化元素、关注生态环保理念，以及加... 详细信息

文章从艺术创新的角度出发，探讨了造型设计与艺术创新的内在联系，分析了艺术创新对造型设计的推动作用，并预测了艺术创新视角下造型设计的未来发展趋势。文章强调，注重原创性和独特性、融合多元文化元素、关注生态环保理念，以及加强科技与艺术的融合，是未来造型设计的主要发展方向。此外，文章还提出了培养艺术创新意识、加强跨学科交流合作、整合创新设计资源和促进产业链上下游协同等路径，以推动造型设计的创新发展。

关键词：造型设计艺术创新发展趋势跨学科合作

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu yanan huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

LRP5基因突变导致骨质疏松症-假性胶质瘤综合征一例报告

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中华骨质疏松和骨矿盐疾病杂志 2024年第2期17卷 150-154页

作者：余安琪王晨秀邓颖黄水金何文静霍亚南林安华南昌大学江西医学院南昌330000 江西省人民医院(南昌医学院第一附属医院)内分泌骨质疏松科南昌330000

报告一例常染色体隐性遗传发病的骨质疏松症-假性胶质瘤综合征。先证者女性,23岁,父母非近亲结婚,出生后发现双目失明,婴儿期因发现右眼视网膜母细胞瘤行右眼球摘除术,9岁开始反复发生轻微外力骨折,诊断为成骨不全。查体发现脊柱侧凸畸... 详细信息

报告一例常染色体隐性遗传发病的骨质疏松症-假性胶质瘤综合征。先证者女性,23岁,父母非近亲结婚,出生后发现双目失明,婴儿期因发现右眼视网膜母细胞瘤行右眼球摘除术,9岁开始反复发生轻微外力骨折,诊断为成骨不全。查体发现脊柱侧凸畸形、胸廓畸形、双上肢肘外翻、四肢关节韧带松弛。双能X线吸收检测仪(dual energy X-ray absorptiometry,DXA)骨密度明显低于同龄人,腰椎1-4骨密度Z值-5,左髋骨密度Z值-1.8。X线摄片示全身骨小梁稀疏。Sanger测序显示低密度脂蛋白受体相关蛋白-5(lowdensity lipoprotein receptor-related protein 5,LRP5)基因的6号外显子和23号外显子发生复合杂合突变,导致***382Leu+***1611LeufsX33。本文通过文献复习对该病的临床表现和诊疗特点进行讨论及总结,以期帮助临床医生提高对这一疾病的认识。

关键词：低密度脂蛋白受体相关蛋白-5 骨质疏松症-假性神经胶质瘤综合征复合杂合突变

CHD4-induced up-regulation of ERα activity contributes to breast cancer progression

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Genes & Diseases 2024年第3期11卷 132-135页

作者： Aman Sattout Xiaomin Yu Zhuo Sun yanan Li Yulin Li Shujing Li Wei huo Huijian Wu School of Bioengineering&Key Laboratory of Protein Modification and Disease Liaoning ProvinceDalian University of TechnologyDalianLiaoning 116024China Department of Oncology Central Hospital Affiliated with Dalian University of TechnologyDalianLiaoning 116089China

The estrogen signaling system is a crucial regulator of ***,abnormal activation of estrogen signaling may play a role in breast cancer initiation and *** to this pathway is the interaction between estrogen receptor alpha(ERa)and various co-transcription activators.1 Although numerous studies have investigated ER coregulators,the protein-protein interaction networks of ERa are not fully *** research has shown that high chromodomain helicase DNA-binding 4(CHD4)expression is linked to poor prognosis in various cancers.2,?In this study,we demonstrated that both CHD4 and ERαcontribute to breast cancer progression while providing evidence of the regulatory processes and functional interplay between these two proteins.

关键词： breast cancer ERα

An Initial Perturbation Method for the Multiscale Singular Vector in Global Ensemble Prediction

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Advances in Atmospheric Sciences 2024年第3期41卷 545-563页

作者： Xin LIU Jing CHEN Yongzhu LIU Zhenhua huo Zhizhen XU Fajing CHEN Jing WANG yanan MA Yumeng HAN School of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing 210044China Chinese Academy of Meteorological Sciences Beijing 100081China CMA Earth System Modeling and Prediction Centre(CEMC) Beijing 100081China Key Laboratory of Earth System Modeling and Prediction of China Meteorological Administration Beijing 100081China Tianjin Meteorological Observatory Tianjin 300074China China Meteorological Administration Xiong’an Atmospheric Boundary Layer Key Laboratory Hebei 071799China

Ensemble prediction is widely used to represent the uncertainty of single deterministic Numerical Weather Prediction(NWP) caused by errors in initial conditions(ICs). The traditional Singular Vector(SV) initial perturbation method tends only to capture synoptic scale initial uncertainty rather than mesoscale uncertainty in global ensemble prediction. To address this issue, a multiscale SV initial perturbation method based on the China Meteorological Administration Global Ensemble Prediction System(CMA-GEPS) is proposed to quantify multiscale initial uncertainty. The multiscale SV initial perturbation approach entails calculating multiscale SVs at different resolutions with multiple linearized physical processes to capture fast-growing perturbations from mesoscale to synoptic scale in target areas and combining these SVs by using a Gaussian sampling method with amplitude coefficients to generate initial perturbations. Following that, the energy norm,energy spectrum, and structure of multiscale SVs and their impact on GEPS are analyzed based on a batch experiment in different seasons. The results show that the multiscale SV initial perturbations can possess more energy and capture more mesoscale uncertainties than the traditional single-SV method. Meanwhile, multiscale SV initial perturbations can reflect the strongest dynamical instability in target areas. Their performances in global ensemble prediction when compared to single-scale SVs are shown to(i) improve the relationship between the ensemble spread and the root-mean-square error and(ii) provide a better probability forecast skill for atmospheric circulation during the late forecast period and for short-to medium-range precipitation. This study provides scientific evidence and application foundations for the design and development of a multiscale SV initial perturbation method for the GEPS.

关键词： multiscale uncertainty singular vector initial perturbation global ensemble prediction system

NLRP3炎症小体与代谢性疾病关系研究进展

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中国当代医药 2023年第17期30卷 24-27页

作者：邓波霍亚南南昌市第一医院南昌大学第三附属医院内分泌科江西南昌330008 江西省人民医院内分泌科江西南昌330008

代谢性疾病是以慢性炎症反应为重要特征的一类疾病。NOD样受体家族含pyrin结构域蛋白3(NLRP3)作为炎症小体的关键调控蛋白之一,参与机体炎症反应调控。NLRP3不仅是先天性免疫系统的模式识别受体(PRRs),也是代谢紊乱的感应器。研究表明NL... 详细信息

代谢性疾病是以慢性炎症反应为重要特征的一类疾病。NOD样受体家族含pyrin结构域蛋白3(NLRP3)作为炎症小体的关键调控蛋白之一,参与机体炎症反应调控。NLRP3不仅是先天性免疫系统的模式识别受体(PRRs),也是代谢紊乱的感应器。研究表明NLRP3参与多种代谢性疾病的发生、发展,包括糖尿病、痛风、非酒精性脂肪性肝炎、动脉粥样硬化、肥胖等。本文就NLRP3炎症小体结构、激活、调控及与2型糖尿病、1型糖尿病、动脉粥样硬化、痛风等代谢性疾病关系的研究进展分别进行讨论,旨在为进一步探讨代谢性疾病的发病机制提供理论依据,从而为代谢性疾病的防治开辟新的途径。

关键词：炎症小体 NOD样受体家族含pyrin结构域蛋白3 代谢性疾病发病机制

中生代华北克拉通岩石圈减薄的证据——以河北武安固镇杂岩体为例

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岩石学报 2019年第4期35卷 989-1014页

作者：霍延安苏尚国杨誉博顾大鹏中国地质大学(北京)地球科学与资源学院北京100083

本文对位于华北克拉通中部的固镇侵入杂岩体(闪长岩、二长岩、石英二长岩和正长岩)进行了野外地质调查、岩相学、矿物学、地球化学、锆石U-Pb定年、Sr-Nd同位素和Lu-Hf同位素研究,进而探讨其形成时代、源区和成因,以期得到关于华北克拉... 详细信息

本文对位于华北克拉通中部的固镇侵入杂岩体(闪长岩、二长岩、石英二长岩和正长岩)进行了野外地质调查、岩相学、矿物学、地球化学、锆石U-Pb定年、Sr-Nd同位素和Lu-Hf同位素研究,进而探讨其形成时代、源区和成因,以期得到关于华北克拉通中部中生代岩石圈减薄研究的新启示。研究区岩体形成时代和岩石结构有一定关联性,总体来看,等粒结构的岩体形成时代早于似斑状结构岩体,研究区岩浆活动可分为两个期次:第一期次岩浆活动形成等粒结构的深成岩体,包括中细粒闪长岩、二长岩、石英二长岩和正长岩,形成时代约为130～135Ma;第二期次岩浆活动形成浅部的似斑状岩体,包括似斑状闪长岩和石英二长岩,形成时代约为127Ma。结合野外观察、岩相学、矿物学、地球化学等特征,讨论分析了固镇杂岩体的成因:固镇闪长岩富镁,高Mg~#值,Cr、Ni含量较高,富集LILE和LREE,亏损HFSE,铕异常不明显,具有高镁安山岩(HMA)性质,是与其相对应的侵入岩。固镇高镁闪长岩是被俯冲板片熔体和流体交代后的地幔橄榄岩部分熔融的产物,岩浆在上升途中与地壳发生了较弱的同化混染。固镇正长岩形成于加厚陆壳的部分熔融,地壳厚度约为40～67km。固镇二长岩是由区内正长岩和高镁闪长岩混合形成。研究区石英二长岩是区内高镁闪长岩与另一种更富硅的岩浆混合形成。俯冲板片物质(流体+熔体)对固镇高镁闪长岩的形成有重要贡献,显示出古太平洋板块俯冲作用的影响也涉及到了NCC中部,但受影响的程度小于NCC东部;正长岩形成于加厚陆壳部分熔融,显示出拆沉作用在中生代NCC中部岩石圈减薄过程中发挥了重要作用。结合角闪石温压计的计算结果和前人研究成果可以推测,NCC中部大规模拆沉作用发生的时间节点为127Ma。

关键词：固镇侵入杂岩体岩石成因华北克拉通岩石圈减薄古太平洋板块俯冲拆沉作用

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城市轨道交通视频监视系统建设方案

都市快轨交通 2016年第4期29卷 102-106页

作者：霍亚楠北京城建设计发展集团股份有限公司北京100037

介绍国内城市轨道交通线路视频监视系统建设模式演变过程,从最初的标清方案演变为高标清混合方案再到最新的全高清方案,并对高清视频系统的两大技术流派(由广播行业标准演进而来的HDTV非压缩监视技术和基于帧内及帧间压缩的HDTV监视系统... 详细信息

介绍国内城市轨道交通线路视频监视系统建设模式演变过程,从最初的标清方案演变为高标清混合方案再到最新的全高清方案,并对高清视频系统的两大技术流派(由广播行业标准演进而来的HDTV非压缩监视技术和基于帧内及帧间压缩的HDTV监视系统)进行优缺点分析,经分析非压缩方案的建设投资是最多的,但系统图像质量优异,压缩方案会导致图像延迟和解码后视频不清晰,但造价便宜。进一步结合南京地铁11号线北段和昆明地铁6号线实际工程中视频监视系统的建设情况,分析并研究最新轨道交通视频监视系统所采用的运营和公安共享一套平台的高清视频解决方案,以期达到优化视频资源配置,节省投资的目的。

关键词：城市轨道交通视频监视系统运营公安南京昆明

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中国硼矿资源供需形势分析

中国矿业 2023年第12期32卷 8-17页

作者：霍延安刘秋颖王莹中化地质矿山总局化工地质调查总院北京100013

中国硼矿资源储量丰富,居世界第四位,但存在分布集中、高储低产、开采难度大等问题。同时,随着硼的应用场景不断拓宽,需求量增长,进口量快速攀升,导致硼矿资源对外依存度持续上涨。本文将定量分析与定性分析相结合,同时采用灰色系统理论... 详细信息

中国硼矿资源储量丰富,居世界第四位,但存在分布集中、高储低产、开采难度大等问题。同时,随着硼的应用场景不断拓宽,需求量增长,进口量快速攀升,导致硼矿资源对外依存度持续上涨。本文将定量分析与定性分析相结合,同时采用灰色系统理论GM(1,1)模型和部门预测法对中国2022—2026年硼消费量进行预测。灰色系统理论GM(1,1)模型所得数值贴近部门预测法中性预测值,预测2022—2026年中国硼表观消费量(以B2O3计)分别为:115.64万t、122.66万t、130.18万t、138.24万t、146.86万t。此外,中国面临硼矿资源供需不平衡的情况,为改变这一现状,本文从供应端、市场端、需求端三方面出发,分析中国硼矿行业存在的问题,并提出建议:对已圈定的传统硼矿产地加大勘查开发力度,坚持不懈探索新的成矿潜力区,同时,“走出去”开发利用国外资源;推动硼矿行业全产业链优化升级,做到上中下游资源合理配置,解决各环节之间的供需矛盾;提高产业集中度,整合已经关闭或面临倒闭的小硼化工企业,加强针对硼矿资源的产学研合作的科学成果转化,并吸收消化国外先进技术,发展高端硼产品。

关键词：硼矿资源供需形势需求预测战略建议