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The Coupled Effects of Dryness and Non-condensable Gas Content of Geothermal Fluid on the Power Generation Potential of an Enhanced Geothermal System

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Acta Geologica Sinica(English Edition) 2021年第6期95卷 1948-1957页

作者： LI Tailu LI Xuelong jia yanan GAO Xiang School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Tian Architectural Design Company Limited Tianjin 300384China

The Enhanced Geothermal System(EGS) is a recognized geothermal exploitation system for hot dry rock(HDR), which is a rich resource in China. In this study, a numerical simulation method is used to study the effects of geothermal fluid dryness and non-condensable gas content on the specific enthalpy of geothermal fluid. Combined with the organic Rankine cycle(ORC), a numerical model is established to ascertain the difference in power generation caused by geothermal fluid dryness and non-condensable gas content. The results show that the specific enthalpy of geothermal fluid increases with the increase of geothermal fluid temperature and geothermal fluid dryness. If the dryness of geothermal fluid is ignored, the estimation error will be large for geothermal fluid enthalpy. Ignoring non condensable gas will increase the estimation of geothermal fluid enthalpy, so the existence of the non-condensable gas tends to reduce the installed capacity of a geothermal power plant. Additionally, both mass flow of the working medium and net power output of the ORC power generation system are increased with increasing dryness of geothermal fluid, however there is some impact of geothermal fluid dryness on thermal efficiency.

关键词： hot dry rock geothermal fluid dryness non-condensable gas organic Rankine cycle

Anlotinib suppresses lymphangiogenesis and lymphatic metastasis in lung adenocarcinoma through a process potentially involving VEGFR-3 signaling

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Cancer Biology & Medicine 2020年第3期17卷 753-767页

作者： Tingting Qin Zhujun Liu Jing Wang Junling Xia Shaochuan Liu yanan jia Hailin Liu Kai Li Department of Thoracic Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Biomedical Engineering Tianjin Medical UniversityTianjin 300070China

Objective:Lymphatic metastasis is one of the leading causes of malignancy dispersion in various types of ***,few anti-lymphangiogenic drugs have been approved for clinical use to ***,new therapies to block lymphangiogenesis are urgently ***:Immunohistochemistry,immunofluorescence,Western blot,migration assays,and lymphangiogenesis and lymphatic metastasis assays were ***:Anlotinib,a receptor tyrosine kinase inhibitor,suppressed the rate of new metastatic lesions(31.82%in the placebo arm and 18.18%in the anlotinib arm)in patients with advanced lung adenocarcinoma who were enrolled in our ALTER-0303 study.D2-40+-lymphatic vessel density was strongly correlated with disease stage,metastasis,and poor prognosis in 144 Chinese patients with lung *** mice bearing A549EGFP tumors,tumor lymphatic vessel density,tumor cell migration to lymph nodes,and the number of distant metastatic lesions were lower in the anlotinib group than in the *** inhibited the growth and migration of human lymphatic endothelial cells(hLECs)and lymphangiogenesisin vitro andin *** of hLECs with anlotinib downregulated phosphorylated vascular endothelial growth factor receptor 3(VEGFR-3).Conclusions:Anlotinib inhibits lymphangiogenesis and lymphatic metastasis,probably through inactivating VEGFR-3 *** results indicate that anlotinib may be beneficial for treatment in avoiding lymphangiogenesis and distant lymphatic metastasis in lung adenocarcinoma.(Trial registration:ALTER0303;NCT02388919;March 17,2015.)

关键词： Anlotinib VEGFR-3 dephosphorylation lymphangiogenesis lymph node metastasis lung adenocarcinoma

Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TG Fpi pathways via off-VEGF signaling

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Cancer Biology & Medicine 2020年第2期17卷 418-432页

作者： Xiaoling Zhang Yan Zhang yanan jia Tingting Qin Cuicui Zhang Yueya Li Chengmou Huang Zhujun Liu Jing Wang Kai Li Department of Thoracic Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Radiotherapy Lanzhou University Second HospitalLanzhou 100040China Department of Oncology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China

Objective:Bevacizumab is a recombinant humanized monoclonal antibody that blocks vascular endothelial growth factor(VEGF)with clear clinical ***,overall survival of some cancer types remains low owing to resistance to bevacizumab *** resistance is commonly ascribed to tumor cell invasion induced by hypoxia-inducible factor(HIF),less attention has been paid to the potential involvement of endothelial cells(ECs)in vasculature activated by anti-angiogenic ***:Human umbilical vein ECs(HUVECs),bEnd.3 cells,and mouse retinal microvascular ECs(MRMECs)were treated with bevacizumab under conditions of hypoxia and effects on biological behaviors,such as migration and tube formation,*** effects on TGFpi and CD 105(endoglin)were established via determination o f protein and mRNA *** further investigated whether the effects of bevacizumab could be reversed using the receptor tyrosine kinase inhibitor ***:Bevacizumab upregulated TGFpi as well as CD 105,a component o f the TGFP receptor complex and an angiogenesis *** CD 105 induced activation of Sm adl/5,the inflammatory pathway and endothelial-mesenchymal *** migration ability of HUVECs was enhanced by bevacizumab under *** o f CD 105 was abrogated by anlotinib,which targets multiple receptor tyrosine kinases including VEGFR2/3,FGFR1-4,PD G FRα/β,C-Kit,and ***:Bevacizumab promotes migration and tube formation of HUVECs via activation of the TGFβi pathway and upregulation of CD105 *** reverses the effects of bevacizumab by inhibiting the above signals.

关键词： HUVEC CD 105 bevacizumab anlotinib TGFβ

Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling

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Acta Pharmaceutica Sinica B 2018年第5期8卷 795-804页

作者： Keke Wang Ranran Ding Yanping Ha yanan jia Xiaomin Liao Sisi Wang Rujia Li Zhihua Shen Hui Xiong Junli Guo Wei Jie Department of Pathology Guangdong Medical University Department of Pathology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cardiovascular Institute of First Affiliated Hospital Hainan Medical University

Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury,but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes(CMs) for driving the differentiation of cardiac stem cells(CSCs).Forced hypoxia-inducible factor 1α(HIF-1α) expression and physical hypoxia(5% O_2) treatment could induce Jagged1 expression in neonatal rat CMs. Pharmacological inhibition of HIF-1α by YC-1 attenuated hypoxia-promoted Jagged1 expression in CMs. An ERK inhibitor(PD98059), but not inhibitors of JNK(SP600125), Notch(DAPT), NF-κB(PTDC), JAK(AG490), or STAT3(Stattic) suppressed hypoxiainduced Jagged1 protein expression in CMs. c-Kit^+ CSCs isolated from neonatal rat hearts using a magnetic-activated cell sorting method expressed GATA4, SM22α or vWF, but not Nkx2.5 and ***, 87.3% of freshly isolated CSCs displayed Notch1 receptor expression. Direct co-culture of CMs with BrdU-labeled CSCs enhanced CSCs differentiation, as evidenced by an increased number of BrdU^+/Nkx2.5^+ cells, while intermittent hypoxia for 21 days promoted co-culture-triggered differentiation of CSCs into CM-like cells. Notably, YC-1 and DAPT attenuated hypoxia-induced *** results suggest that hypoxia induces Jagged1 expression in CMs primarily through ERK signaling,and facilitates early cardiac lineage differentiation of CSCs in CM/CSC co-cultures via HIF-1α/Jagged1/Notch signaling.

关键词： Cardiac stem cell Cardiomyocyte,Co-culture Hypoxia Notch1 signaling Cell differentiation

中国和欧美国家养殖业抗生素使用负面问题及管理政策比较

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农业环境科学学报 2024年第6期43卷 1205-1219页

作者：贾亚楠唐忠中国人民大学农业与农村发展学院北京100872

畜禽养殖中抗生素的使用无疑推动了该产业的快速发展,但也引起了其耐药性威胁公共健康和养殖业可持续发展的担忧。本文系统梳理了兽用抗生素的使用,抗生素负面问题的显现、认知和管理政策的变化,分析了中国、美国、欧盟管理政策的差异... 详细信息

畜禽养殖中抗生素的使用无疑推动了该产业的快速发展,但也引起了其耐药性威胁公共健康和养殖业可持续发展的担忧。本文系统梳理了兽用抗生素的使用,抗生素负面问题的显现、认知和管理政策的变化,分析了中国、美国、欧盟管理政策的差异及其背后的原因。本文认为,我国在推进农业现代化进程中:应长期关注养殖业中抗生素使用可能带来的负面问题,加快生产方式的绿色转型;应提升公众对抗生素耐药性的认识,引导公众参与遏制耐药性发展的行动;应考虑我国的发展目标,吸取美国因利益集团阻挠而反应缓慢的教训,综合考虑成本和收益,发挥我国的体制优势,找到政策上的最优解;支持、推动全球抗生素管理的国际协同行动。

关键词：兽用抗生素使用抗生素耐药性政策演变国际比较

Forskolin Modulates the Inhibitory Effect of C-Type Natriuretic Peptide on Hypoxia-Induced Atrial Dynamics and Hypoxia Inducible Factor 1 Alpha Activity

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Journal of Biosciences and Medicines 2017年第1期5卷 1-10页

作者： Chengming Guan yanan jia Chaochao Bian Bo Zhang Dazhi Ding Xun Cui Institue of Clinical Medicine Yanbian University Yanji China Department of Physiology School of Medicine Yanbian University Yanji China Key Laboratory of Organism Functional Factors of the Changbai Mountain Ministry of Education Yanbian University Yanji China Cellular Function Research Center Yanbian University Yanji China

Our study investigated effects of C-type natriuretic peptide (CNP) on atrial dynamics and hypoxia inducible factor 1 alpha (HIF-1α) activity in perfused beating rat atria, under hypoxic conditions. Hypoxia significantly increased the levels of HIF-1α, concomitant with decreased trial dynamics. CNP (0.1 μmol/L) further decreased atrial dynamics under hypoxia and suppressed hypoxia-induced stimulation of HIF-1α expression. An adenylylcyclase (AC) activator, forskolin (0.1 μmol/L), significantly up-regulated atrial phosphodiesterase subtype 3A (PDE 3A) protein without affecting hypoxia-induced dynamics. In the presence of forskolin, the inhibitory effects of CNP on hypoxia-induced atrial dynamics and HIF-1α levels were significantly attenuated. Forskolin also prevented hypoxia-induced downregulation of PDE3A protein. These findings suggested that CNP inhibited atrial dynamics and HIF-1α activity in the isolated perfused beating rat atria under hypoxic conditions. Furthermore, both effects were modulated by the AC activator forskolin, through activation of CNP-PDE 3A signaling.

关键词： C-Type Natriuretic Peptide Hypoxia Inducible Factor-1α Phosphodiesterase Adenylyl Cyclase Forskolin

气象要素及土壤理化性质对不同土地利用方式下冬夏岩溶作用的影响

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生态学报 2014年第6期34卷 1418-1428页

作者：刘文张强贾亚男西南大学地理科学学院三峡库区生态环境教育部重点实验室重庆400715 国土资源部岩溶生态环境-重庆南川野外基地重庆408435 中国地质科学院岩溶地质研究所联合国教科文组织国际岩溶研究中心国土资源部/广西岩溶动力学重点实验室桂林541004

为揭示岩溶作用对不同人类活动强度土地利用方式、季节变化的响应,在重庆青木关岩溶槽谷区选取地质背景相同的6种典型土地利用方式(旱地,水田,退耕林,荒草地,杉竹混交林,竹林),利用标准溶蚀试片法得到各样点冬、夏两季单位面积溶蚀数据... 详细信息

为揭示岩溶作用对不同人类活动强度土地利用方式、季节变化的响应,在重庆青木关岩溶槽谷区选取地质背景相同的6种典型土地利用方式(旱地,水田,退耕林,荒草地,杉竹混交林,竹林),利用标准溶蚀试片法得到各样点冬、夏两季单位面积溶蚀数据。并用自动气象站降水、气温,各样点土壤水、土壤CO2、土壤有机质、土壤pH、土壤容重、土壤孔隙度等数据对溶蚀结果进行分析。结果是:(1),夏季各样点壤中平均溶蚀量为冬季的3.87倍,且最大溶蚀量从夏季-80cm处上升为冬季-20—-50cm处;(2),受人类活动影响强度大的旱地、水田溶蚀量大于人类活动强度逐渐削弱的退耕林、旱地,而受人类活动影响最小的山竹混交林、竹林溶蚀量最小。且在人类活动强度较大的夏季三者之间差值较大。分析认为:水分、热量与溶蚀的季节变动存较好正相关关系,是影响溶蚀的最基础因素;土壤CO2在降水量大的夏季才能更好地促进溶蚀;土壤有机质与土壤pH反相关,二者协同影响溶蚀,在有机质含量高、pH偏低的表层对溶蚀影响大,其它层位影响较小;土壤容重、土壤孔隙度反映的土壤质地对溶蚀的影响是双向的,偏黏土持水性好而渗透性差,可促进降水少的冬季的溶蚀,如荒草地;砂土则渗透性好而持水性差,对降水多的夏季溶蚀有利,如旱地。另外,农业活动中用到的农家肥、化肥含NO-3、SO2-4,也会促进溶蚀。研究成果可为更科学准确地评估岩溶碳汇效应提供参考。

关键词：人类活动土地利用降水气温土壤岩溶作用

Determination of Nine Phenolic Components in Leaves of Crataegus pinnatifida Bge.

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Medicinal Plant 2018年第2期9卷 22-26页

作者： Lei SHI Xiaobo YANG Zhe GAO yanan jia Zhenliang BI Fengqin LU Tong CUI College of Food Science and Technology Hebei Agricultural University Forestry Bureau of Xinglong County

[Objectives] To determine the nine phenolic components in the leaves of Crataegus pinnatifida Bge. [Methods] The reversedphase high-performance liquid chromatography( RP-HPLC) was applied. [Results] Nine phenolic components showed a good linear relationship in the range of 2-500 μg/m L with r in the range of 0. 999 5-0. 999 9. The recovery rate of spiked samples ranged from 93. 7% to110. 2%,and the relative standard deviation was in the range of 0. 69%-4. 58%. The leaves of 29 cultivars of C. pinnatifida Bge. were measured,and the average content of the nine phenolic components was as follows: isoquercitrin,hyperoside,procyanidin C1,procyanidin D1,epicatechin,procyanidin B2,chlorogenic acid,eucomic acid,and vitexin 2 "-O-rhamnoside. The contents of flavonoids and phenolic acids were high,up to 15 mg/g D. W,and the content of procyanidins was up to 6 mg/g D. W. [Conclusions]This method is easy and accurate in determination of phenolic components in the leaves of C. pinnatifida Bge.

关键词： High-performance liquid chromatography(HPLC) Leaves of Crataegus pinnatifida Bge Procyanidins Eucomic acid Flavonoids

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通道融合的渐进增强遥感图像全色锐化算法

中国图象图形学报 2023年第1期28卷 305-316页

作者：贾雅男郭晓杰天津大学智能与计算学部天津300350

目的遥感图像融合的目的是将低空间分辨率的多光谱图像和对应的高空间分辨率全色图像融合为高空间分辨率的多光谱图像。为了解决上采样多光谱图像带来的图像质量下降和空间细节不连续问题,本文提出了渐进式增强策略,同时为了更好地融合... 详细信息

目的遥感图像融合的目的是将低空间分辨率的多光谱图像和对应的高空间分辨率全色图像融合为高空间分辨率的多光谱图像。为了解决上采样多光谱图像带来的图像质量下降和空间细节不连续问题,本文提出了渐进式增强策略,同时为了更好地融合两种图像互补的信息,提出在通道维度上进行融合的策略。方法构建了一种端到端的网络,网络分为两个阶段:渐进尺度细节增强阶段和通道融合阶段。考虑到上采样低空间分辨率多光谱图像导致的细节模糊问题,在第1阶段将不同尺度的全色图像作为额外的信息,通过两个细节增强模块逐步增强多光谱图像;在第2阶段,全色图像在多光谱图像的每个通道上都通过结构保持模块进行融合,更好地利用两种图像的互补信息,获得高空间分辨率的多光谱图像。结果实验在GaoFen-2和QuickBird数据集上与表现优异的8种方法进行了比较,本文算法在有参考指标峰值信噪比(peak signal-to-noise ratio,PSNR)、结构相似度(structural similarity,SSIM)、相关系数(correlation coefficient,CC)和总体相对误差(erreur relative globale adimensionnelle de synthese,ERGAS)等评价指标上均取得最优值。在GaoFen-2数据集上PSNR、CC和ERGAS分别平均提高了0.872 dB、0.01和0.109,在QuickBird数据集上分别平均提高了0.755 dB、0.011和0.099。结论本文算法在空间分辨率和光谱保持方面都取得了良好的效果,生成了质量更高的融合结果。

关键词：全色锐化渐进增强通道融合深度学习多光谱图像