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medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011

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Chinese Journal of Cancer Research 2019年第5期31卷 825-837页

作者： Jufang Shi Guoxiang Liu Hong Wang Ayan mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen min Dai Jie He office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Health Economics School of Health Management/Public HealthHarbin Medical UniversityHarbin 150081China office of Public Health Strategic Information Institute of Medical InformationChinese Academy of Medical SciencesBeijing 100020China Department of Cancer Epidemiology Henan Office for Cancer Control and ResearchThe Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450008China Hunan office for Cancer Control and Research Hunan Provincial Cancer HospitalChangsha 410006China Institute of Epidemiology and Health Statistics Lanzhou UniversityLanzhou 730000China Center for Health management and Policy Key Lab of Health Economics and PolicyShandong UniversityJinan 250012China Department of Public Health Shandong Cancer Hospital Affiliated to Shandong UniversityJinan 250117China Heilongjiang office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150081China Institute of Chronic Non-communicable Diseases Prevention and Control Jiangsu Provincial Center for Disease Control and PreventionNanjing 210009China Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqi 830011China Department of Cancer Research and Control office Chongqing University Cancer HospitalChongqing 400030China Cancer Epidemiology Research Center Gansu Provincial Cancer HospitalLanzhou 730050China Cancer Prevention and Control office of Liaoning Province Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China Department of Cancer Prevention Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Cancer Institute The Fourth Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Thoracic Surg

objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in ***: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 ***: of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend mulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(Pous subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China.

关键词： Colorectal neoplasms health expenditures diagnosis therapeutics China

跨国公司与东道国当地企业的合作方式及其经济内涵

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当代经济管理 2011年第8期33卷 27-31页

作者：孙雅娜辽宁大学新华国际商学院辽宁沈阳110136

跨国公司与东道国当地企业的合作存在五种形式:一是与供给商的合作;二是与客户的合作;三是与竞争者的合作;四是与技术伙伴的合作;五是具有外溢效应的合作。采用何种形式的合作,取决于TNC要实现的目标以及SmE的合作能力;为建立与TNC更加... 详细信息

跨国公司与东道国当地企业的合作存在五种形式:一是与供给商的合作;二是与客户的合作;三是与竞争者的合作;四是与技术伙伴的合作;五是具有外溢效应的合作。采用何种形式的合作,取决于TNC要实现的目标以及SmE的合作能力;为建立与TNC更加紧密的合作关系,在东道国政府制定相关鼓励政策的同时,SmE还应努力提高人员素质和技术水平,以增强自身的合作能力。

关键词： TNC SmE 合作并购 oEm

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我“理解” 我快乐

科学之友 2010年第13期 145-146页

作者：赵亚娜青岛市崂山二中

理解可以给人友善、给心以安慰、给人以鼓舞。充分理解学生,既可以密切师生感情,又可焕发学生的创造热情、激发奋发向上、锐意进取的心理。

关键词：理解快乐

Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

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Cellular & molecular Immunology 2021年第7期18卷 1832-1834页

作者： Hao Wang Yu Yuan mingzhong Xiao Li Chen Youyun Zhao Haiwei Zhang Pinpin Long yana Zhou Xi Xu Yanshou Lei Bihao Wu Tingyue Diao Hao Cai Li Liu Zuoyu Shao Jingzhi Wang Yansen Bai Kai Wang miao Peng Linlin Liu Shi Han Fanghua mei Kun Cai Yake Lei An Pan Chaolong Wang Rui Gong Xiaodong Li Tangchun Wu ministry of Education and State Key Laboratory of Environmental Health(Incubating) School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hepatic Disease Institute Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhanChina Affiliated Hospital of Hubei University of Chinese medicine WuhanChina Hubei Province Academy of Traditional Chinese medicine WuhanChina CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences BeijingChina Hubei Provincial Center for Disease Control and Prevention WuhanChina

CoVID-19 caused by SARS-CoV-2 infection has caused substantial morbidity and mortality worldwide and paralyzed the international *** the magnitude and duration of the antibody response to SARS-CoV-2 is important to achieve a balance between curbing the pandemic and minimizing adverse effects on society.1 Although the antibody response to SARS-CoV-2 within 9 months has been extensively studied,2,3,4,5,6 little is known about the magnitude and kinetics of antibody responses for over 9 ***,with limited observations over 9 months(noduced inconsistent conclusions about antibody dynamics,suggesting different rates of antiviral antibody positivity at the last follow-up.2,7,8 These studies have been limited by a lack of measurement of neutralizing antibodies(NAbs),7 of inclusion of mild or asymptomatic cases,2,8 and of further exploration of potential predisposing factors for antibody dynamics.2,7 Considering the individual heterogeneity(such as disease severity)8 and time-dependent nature1 of the immune response,in-depth characterization of SARS-CoV-2 antibody kinetics across disease severity groups over a long period is urgently ***,we repeatedly tested Igm,IgG,viral spike protein receptor-binding dom(anti-RBD)IgG,and NAb titers in CoVID-19 patients during a follow-up period of up to 10 months and explored potential predisposing factors of antibody titers during follow-up.

关键词： infection severity mortality

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Natalka Gold Deposit

Journal of Geoscience and Environment Protection 2014年第3期2卷 66-71页

作者： E. m. Nikitenko T. I. mikhalitsyna m. I. Fomina o. T. Sotskaya North-East Interdisciplinary Scientific Research Institute N. A. N. A. Shilo Far East Branch Russian Academy of Sciences (NEISRI FEB RAS) Magadan Russia

Studies were taken of ore-bearing rocks, ores and gravity concentrates from Natalka gold deposit by a set of complex methods including mineralogical, petrographic and geochemical research, gravity concentration, and electronic microscopy. The major form of Au found is native: free gold is larger and dispersed, in the form of microinclusions. The obtained results are the basis for an effective technology to extract gold and sequence of profitable mining of Natalka deposit.

关键词： yana-Kolyma Fold System Natalka Gold Deposit mineralogical and Petrographic Characteristics Chemical Composition Gravitational Concentrates

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多孔TiC陶瓷的制备、性能及机理研究

人工晶体学报 2020年第2期49卷 299-304,330页

作者：赵小刚鲍崇高马娅娜马海强西安交通大学金属材料强度国家重点实验室西安710049

以Tio2和炭黑为反应物,TiC为添加物,通过反应烧结法制备出多孔TiC陶瓷。研究了TiC的添加量对晶粒大小、孔径尺寸、开气孔率及抗弯强度的影响。研究结果表明:随着TiC的添加量从0%增大到100%,反应生成TiC的粒径从0.17μm增大到0.71μm,孔... 详细信息

以Tio2和炭黑为反应物,TiC为添加物,通过反应烧结法制备出多孔TiC陶瓷。研究了TiC的添加量对晶粒大小、孔径尺寸、开气孔率及抗弯强度的影响。研究结果表明:随着TiC的添加量从0%增大到100%,反应生成TiC的粒径从0.17μm增大到0.71μm,孔径尺寸从0.15μm增大到1.51μm,开气孔率从78%持续降到38%,抗弯强度先增加后减小,添加量为80%时最高(86 mPa)。TiC生长机理主要是由于添加的TiC使Tio2周围的碳含量减少,从而导致反应生成TiC的熔点降低,扩散能力提高,晶粒粒径增大。

关键词：多孔陶瓷 TiC 反应烧结孔径尺寸晶格常数

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限幅激励式压电发电机性能分析与试验

机械工程学报 2020年第20期56卷 206-213页

作者：王淑云朱雅娜阚君武张忠华黄乐帅杨泽盟浙江师范大学精密机械与智能结构研究所金华321004 浙江省城市轨道交通智能运维技术与装备重点实验室金华321004

为提高旋转式压电发电机的可靠性及有效带宽,提出一种限幅激励式压电发电机,利用凸轮激励压电振子使其发生幅值可控的单向变形。从理论和试验两方面研究凸轮升程与升角、激振力及弹簧刚度等对发电机输出性能的影响规律。研究结果表明,... 详细信息

为提高旋转式压电发电机的可靠性及有效带宽,提出一种限幅激励式压电发电机,利用凸轮激励压电振子使其发生幅值可控的单向变形。从理论和试验两方面研究凸轮升程与升角、激振力及弹簧刚度等对发电机输出性能的影响规律。研究结果表明,利用移动凸轮限幅激励压电振子可获得无明显峰值、较平坦的电压幅频特性曲线;其他条件相同时,降低凸轮升程有助于降低最大输出电压、拓宽有效转速带宽,凸轮升角(30°~45°)增加对最大输出电压无影响、但可拓宽有效转速带宽,增加激振力可拓宽某一输出电压所对应的有效带宽,复位和缓冲弹簧刚度对有效转速带宽及转速值都有一定的影响,当复位弹簧刚度50 N/m、缓冲弹簧刚度20 N/m、激励距离8 mm、凸轮升程2 mm、升角为40°时,输出电压大于30 V所对应的有效转速范围为0~537.6 r/min,故通过合理匹配系统参数可有效提高发电机的可靠性及有效带宽;存在最佳电阻使发电机输出功率达到最大值,最佳电阻70 kΩ、转速392 r/min时的输出功率为10.88 mW。

关键词：压电发电机旋磁激励凸轮限幅刚度

姜黄素抑制食管癌KYSE70细胞上皮-间质转化

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肿瘤 2016年第11期36卷 1203-1211页

作者：张亚娜马望王峰吴少璇池艳艳樊青霞郑州大学第一附属医院肿瘤科河南郑州450052

目的 :探讨姜黄素对转化生长因子β1(transforming growth factor-beta 1,TGF-β1)诱导的食管癌KYSE70细胞上皮-间质转化(epithelialmesenchymal transformation,EmT)的影响。方法:不同浓度姜黄素处理KYSE70细胞12、24、48和72 h后,应用CCK-8法检测细胞的增殖情况。应用姜黄素(20μmol/L)、TGF-β1(10ng/m L)和姜黄素(20μmol/L)联合TGF-β1(10 ng/m L)处理KYSE70细胞后,在光学显微镜下观察细胞的形态,Transwell小室法检测各组细胞的侵袭能力,FCm法检测各组细胞的细胞周期分布,实时荧光定量PCR法和蛋白质印迹法分别检测各组细胞中EmT相关标志物E-钙黏蛋白(E-cadherin)、N-钙黏蛋白(N-cadherin)和波形蛋白(vimentin)m RNA及蛋白的表达。结果 :不同浓度姜黄素作用不同时间均能抑制食管癌KYSE70细胞的增殖(P值均m期细胞所占百分比低于TGF-β1处理组(Pm RNA(P=0.045)和蛋白(P=0.008)的表达水平均低于对照组,而N-cadherin和vimentin m RNA(P=0.003和Pm RNA(P=0.005)和蛋白(P=0.006)的表达水平均高于TGF-β1处理组,而N-cadherin和vimentin m RNA(P=0.010和PmT的发生。

关键词：食管肿瘤上皮-间质转化转化生长因子β1 姜黄素

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半正弦波相关型三维激光雷达

光子学报 2009年第2期38卷 255-258页

作者：张秀达严惠民羊华军李燕浙江大学现代光学仪器国家重点实验室浙江大学国家光学仪器工程技术研究中心杭州310027

提出了基于半正弦波-方波相关法的凝视成像三维激光雷达.用傅里叶级数展开对新方法进行了分析.理论分析表明,半正弦-方波相关可以在抑制高频噪音的同时加大调制的交流分量.基于新相关方法的探测系统可以在不损失测距准确度的条件下可以... 详细信息

提出了基于半正弦波-方波相关法的凝视成像三维激光雷达.用傅里叶级数展开对新方法进行了分析.理论分析表明,半正弦-方波相关可以在抑制高频噪音的同时加大调制的交流分量.基于新相关方法的探测系统可以在不损失测距准确度的条件下可以获得更大的输出光功率从而获得更大的探测距离.采用基于新方法的探测装置对～70m外约100m2的目标进行了探测实验.实验结果表明,基于新方法的激光雷达在60m处的分辨率约为0.3m,从而验证了理论分析的结论.

关键词：半正弦波凝视激光雷达调制深度三维成像