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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-Yi Yan Ke-Hui Zhang Di Zhang Xi-Mao Cui Xiao-Hua Jiang shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao Yin-Long Xu Jia-Wei Chai Kai Zheng Jun-Jie Kong Jun Liu shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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基于UG的拖拉机齿轮传动系统仿真研究

农机化研究 2025年第1期47卷 258-261,268页

作者：杨玉霞李艳钰济源职业技术学院河南济源454650

设计了一款拖拉机复合行星齿轮的动力系统,并基于UG仿真软件,建立了齿轮参数化模型,得到了齿轮的渐开线和齿廓线,最后建立了齿轮传动系统仿真模型。齿轮传动系统可靠性实验表明:系统齿轮运动符合预期,满足设计要求,证实了系统的可靠性。

关键词：拖拉机复合行星齿轮 UG 齿轮传动

FIR Systems Identification Under Quantized Output Observations and a Large Class of Persistently Exciting Quantized Inputs

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Journal of Systems Science & Complexity 2017年第5期30卷 1061-1071页

作者： HE yanyu GUO Jin Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of Sciences School of Automation and Electrical Engineering University of Science and Technology Beijing

This paper investigates the FIR systems identification with quantized output observations and a large class of quantized inputs. The limit inferior of the regressors' frequencies of occurrences is employed to characterize the input's persistent excitation, under which the strong convergence and the convergence rate of the two-step estimation algorithm are given. As for the asymptotical efficiency,with a suitable selection of the weighting matrix in the algorithm, even though the limit of the product of the Cram′er-Rao(CR) lower bound and the data length does not exist as the data length goes to infinity, the estimates still can be asymptotically efficient in the sense of CR lower bound. A numerical example is given to demonstrate the effectiveness and the asymptotic efficiency of the algorithm.

关键词： Asymptotic efficiency FIR system identification quantized input quantized output observations

Energy-Dissipative and Soften Resistant Hydrogels Based on Chitosan Physical Network: From Construction to Application

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Chinese Journal of Chemistry 2022年第17期40卷 2118-2134页

作者： yanyu Yang Decheng Wu College of Materials Science and Engineering Zhengzhou UniversityZhengzhouHenan450001 China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong518055 China

In spite of biological tissue-like peculiarity,multifarious functionalities and great application prospect,the low mechanics and soften behavior of hydrogels still retain a problem to be addressed for repetitive weight-bearing fields of flexible electronics,actuators,substitutions of soft tissues,wound dressing,wearable or implantable *** to the distinct combination of diversity,reversibility and impressive disruption-reconstruction capacity,the chitosan physical cross-links can server as recoverable“sacrificial bonds”to construct multifarious energy-dissipative and anti-soften hydrogels and further broaden their diversified *** this review,we summarized the gelation mechanisms of chitosan physical networks and highlighted the chitosan physical network based hydrogels in rational design,construction principle,and structure and performance *** recent progress in functional hydrogels for flexible electronics and biomaterials was systematically ***,the review will provide comprehensive guidelines on the design principle,performance modulation and functionality construction of energy-dissipative and soften resistant hydrogels.

关键词： Gels Physicalcross-Links Mechanical properties Functionality Sensors

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Ming-Ke Wang Ji-shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

A New Reaction-controlled Phase-transfer Catalyst System

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Chinese Chemical Letters 2004年第3期15卷 350-352页

作者： MingQiangLI XiGaoJIAN GuiMeiWANG yanyu DepartmentofPolymerScienceandMaterials DalianUniversityofTechnologyDalian116012

A new reaction-controlled phase-transfer catalyst system was designed and synthesized. In this system, heteropolytungstate [C7H7N(CH3)3]9PW9O34 was used for catalytic epoxidation of cyclohexene with H2O2 as the oxidant. The conversion of H2O2 was 100% and the yield of cyclohexene oxide was 87.1% based on cyclohexene. Infrared spectra showed that both fresh catalyst and the recovered catalyst do have completely same absorption peak, indicating the structure of catalyst is very stability and can be recycled.

关键词： Reaction-controlled phase-transfer catalyst cyclohexene epoxidation.

Mathematical simulation of hot metal desulfurization during KR process coupled with an unreacted core model

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 758-766页

作者： yanyu Zhao Wei Chen Shusen Cheng Lifeng Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

A three-dimensional mathematical model was established to predict the multiphase flow,motion and dispersion of desulfurizer particles,and desulfurization of hot metal during the Kanbara reactor(KR)*** turbulent kinetic energy-turbulent dissipation rate(k-ε)turbulence model,volume-of-fluid multiphase model,discrete-phase model,and unreacted core model for the reaction between the hot metal and particles were *** measured sulfur content of the hot metal with time during the actual KR process was employed to validate the current mathematical *** distance from the lowest point of the liquid level to the bottom of the ladle decreased from 3170 to2191 mm when the rotation speed increased from 30 to 110 r/min,which had a great effect on the dispersion of desulfurizer *** critical rotation speed for the vortex to reach the upper edge of the stirring impeller was 70 r/min when the immersion depth was 1500 *** desulfurization rate increased with the increase in the impeller rotation speed,whereas the influence of the immersion depth was relatively *** for different rotation parameters on the desulfurization rate constant and turbulent energy dissipation rate were proposed to evaluate the variation in sulfur content over time.

关键词： desulfurization unreacted core model desulfurizer dispersion KR process fluid flow