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Journal of Rare Earths 2014年第9期32卷 837-841页

作者：薛刚赵颖梁金生苑砚坤王赛飞陈丹 Institute of Power Source and Ecomaterials Science School of Materials Science and Engineering Hebei University of Technology

A novel catalytic material Lao.9Sr0.1MnO3 and tourmaline compound catalytic material was synthesized in the base of traditional catalytic material La0.9Sr0.1MnO3 which exhibited excellent catalytic activity for methane combustion. Different contents of toumaaline were added to give a series ofLa0.9Sr0.1MnO3 and tourmaline catalytic material through a sol-gel method. Samples above were characterized and analyzed by means of X-ray diffraction （XRD）, scanning electron microscopy （SEM）, Brunauer-Emmett-Teller method （BET）, temperaalre programmed reduction （TPR）, catalytic activity test and contact angle test. The as-prepared sample with 2% （m/m） tourmaline showed good homogeneity surface morphology and displayed the optimal catalytic activity. The light-off temperature reduced by 10 ℃ and the T90 decreased by 15 ℃. In addition, the mechanism of the reinforcement of catalytic activity was explored.

关键词： methane combustion perovskite tourmaline sol-gel method catalytic rare earths

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超声技术应用于气道管理的研究进展

国际麻醉学与复苏杂志 2017年第10期38卷 919-924页

作者：冯艳坤袁军武汉市第一医院麻醉科 430022

背景目前气道评估及管理仍然是一门不断更新的临床科学。近些年超声可视化技术的应用为围手术期、急诊及重症医学科患者的气道管理提供了一个动态的监测工具。目的针对超声技术在气道管理中的应用情况进行综述。内容描述呼吸道超声解剖... 详细信息

背景目前气道评估及管理仍然是一门不断更新的临床科学。近些年超声可视化技术的应用为围手术期、急诊及重症医学科患者的气道管理提供了一个动态的监测工具。目的针对超声技术在气道管理中的应用情况进行综述。内容描述呼吸道超声解剖结构，并概括超声在围手术期气道管理中的应用。趋向超声的应用使围手术期气道管理发生里程碑式的发展，未来将有更广阔的应用前景。

关键词：超声气道管理气管插管喉罩

人工智能教育大模型:体系架构与关键技术策略

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开放教育研究 2024年第5期30卷 76-86页

作者：刘邦奇喻彦琨王涛袁婷婷韩萌西北师范大学教育技术学院甘肃兰州730071 讯飞教育技术研究院安徽合肥230088

以大模型为代表的生成式人工智能技术为破解教学难题、革新教学样态带来了机遇。虽然大模型以其强大的泛化性能和跨领域的适应性,能够在多类场景中展现出强大能力,但若仅依靠海量数据训练带来的优势,往往很难满足教育场景下更高的知识... 详细信息

以大模型为代表的生成式人工智能技术为破解教学难题、革新教学样态带来了机遇。虽然大模型以其强大的泛化性能和跨领域的适应性,能够在多类场景中展现出强大能力,但若仅依靠海量数据训练带来的优势,往往很难满足教育场景下更高的知识准确度、价值观与安全性要求。为此,能够满足教育特定场景任务需要的人工智能教育大模型应运而生,能有效提升教育质量和推进个性化、智能化教学。本文综合分析了人工智能教育大模型的发展现状、概念内涵、技术特征和体系框架,旨在为人工智能教育大模型的未来发展提供理论与技术参考。当前,教育大模型的竞争力主要取决于技术和算力、教育数据和理解、教育场景和应用等,本文进而提出建设与应用框架及关键技术策略,以期推动中国版人工智能教育大模型在大规模因材施教、创新性与个性化教学中的应用,加快教育数字转型和智能升级。

关键词：人工智能教育大模型数据体系框架关键技术

智能技术赋能学校数字化治理:内涵、框架与典型场景

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现代远距离教育 2024年第4期 3-11页

作者：刘邦奇朱洪军喻彦琨袁立方西北师范大学甘肃兰州730070 讯飞教育技术研究院安徽合肥230088

随着生成式人工智能、数据智能等技术的快速发展与应用,教育数字化战略行动向纵深推进,技术赋能学校治理成为破解诸多现实问题的有效途径,然而学界仍缺少对其内涵本质、体系构成及技术应用的深刻认识。文章首先梳理分析了学校数字化治... 详细信息

随着生成式人工智能、数据智能等技术的快速发展与应用,教育数字化战略行动向纵深推进,技术赋能学校治理成为破解诸多现实问题的有效途径,然而学界仍缺少对其内涵本质、体系构成及技术应用的深刻认识。文章首先梳理分析了学校数字化治理的内涵和特征;其次,采用内容分析法从治理目标、治理主体、治理内容、治理方式和技术支撑五个维度提炼学校数字化治理构成要素及要素关系,基于协同治理理论构建以一体化管理与服务平台为支撑的学校数字化治理体系逻辑框架;最后,探讨了生成式人工智能、教育数据挖掘、教育知识图谱等智能技术赋能学校治理的作用机理,并探析智能升级学校管理信息化、智能化推动课程/专业建设、人工智能助力教师专业发展、数据智能赋能学生管理与服务、智能平台支撑协同共育等典型场景应用与案例。

关键词：智能技术学校数字化治理治理体系典型场景

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基于文献计量学的我国精神卫生政策分析

中华精神科杂志 2024年第9期57卷 605-614页

作者：孙艳坤冯羿凯鲍彦平施正丽师乐袁凯吴水琳陆林北京大学第六医院、北京大学精神卫生研究所、国家卫生健康委员会精神卫生学重点实验室(北京大学)、国家精神心理疾病临床医学研究中心(北京大学第六医院) 北京100191 北京大学公共卫生学院全球卫生学系北京100191 北京大学中国药物依赖性研究所北京100191 北京大学公共卫生学院北京100191

目的探讨我国改革开放以来精神卫生相关政策的特点与演变规律,为未来精神卫生政策的制定和发展规划提供参考。方法检索我国国家层面于1979年1月以来制定的精神卫生相关的政策文件,将我国精神卫生政策的制定工作分为2005年之前、2006—2... 详细信息

目的探讨我国改革开放以来精神卫生相关政策的特点与演变规律,为未来精神卫生政策的制定和发展规划提供参考。方法检索我国国家层面于1979年1月以来制定的精神卫生相关的政策文件,将我国精神卫生政策的制定工作分为2005年之前、2006—2010年、2011—2015年、2016—2023年4个阶段,利用共词分析、府际关系分析等文献计量的方法对各阶段政策文件数量、政府部门行文参与情况和政策热点主题进行分析。结果共检索到1987年1月1日至2023年10月31日精神卫生相关政策文件121篇,自2006年起历年发文数量呈波动趋势,2020年达到最高年发文量17篇;参与行文的部门数量随时间推移不断增加,由1987—2005年的4个部门增加到2016—2023年的37个部门。各部门精神卫生政策制定愈发深入;各阶段政策涉及热点主题愈发多元,各类政策更加细化且更具操作性。结论我国精神卫生政策领域表现出积极态势,多部门合作更加深入,政策内容更贴近全民精神健康需求,一定程度上促进了精神卫生事业的持续发展。

关键词：精神卫生卫生政策文献计量学

犬猫弓形虫病real-time荧光定量PCR检测方法的建立与应用

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中国兽医科学 2024年第5期54卷 602-608页

作者：施远国胡潇予柯艳坤李颖鑫文青元杨子鹏杨留禄袁子国深圳市动物疫病预防控制中心广东深圳518000 华南农业大学兽医学院广东广州510642

为建立一种灵敏性高、特异性强、可自动化检测犬猫弓形虫的分子学诊断方法,本研究提取弓形虫RH虫株DNA,以致密颗粒蛋白7(GRA7)基因保守区为靶标,设计特异性引物并构建标准质粒pMD18-GRA7,以标准质粒pMD18-GRA7作为模板,建立SYBR-Green... 详细信息

为建立一种灵敏性高、特异性强、可自动化检测犬猫弓形虫的分子学诊断方法,本研究提取弓形虫RH虫株DNA,以致密颗粒蛋白7(GRA7)基因保守区为靶标,设计特异性引物并构建标准质粒pMD18-GRA7,以标准质粒pMD18-GRA7作为模板,建立SYBR-GreenⅠ荧光定量PCR(real-time PCRor qPCR)检测方法。结果显示,该方法特异性引物只能扩增出弓形虫DNA样品,对阴性样品及其他犬猫寄生虫阳性样品DNA则未见扩增曲线。所建qPCR方法的检测下限为3 copies,当标准品浓度为3 copies/μL时,检测Ct值为29.4。对犬猫临床样品进行检测,并与商品化试剂盒结果相比校,阴阳性符合率达100%。上述结果表明,本研究建立的SYBR-GreenⅠ荧光定量PCR方法特异性好,敏感性强,结果稳定,可用于犬猫弓形虫病的临床检测。

关键词：弓形虫犬猫 GRA7 实时荧光定量PCR

D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2280-2291页

作者： Bowen Wang Li Wang Sijie Gu yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin yuan Hong Ouyang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510623China Program of Stem Cells and Regenerative Medicine Fifth Affiliated HospitalZhongshan School of MedicineSun Yat-Sen UniversityGuangdong 510080China

Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the ***,an effective therapy for this disease is ***,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE ***,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of *** injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse *** findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD.

关键词： D609 degeneration protective

Online Survey on Accessing Psychological Knowledge and Interventions During the COVID-19 Pandemic-China, 2020

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China CDC weekly 2020年第41期2卷 797-803页

作者： Qingdong Lu Lin Liu Yunhe Wang Le Shi Yingying Xu Zhengan Lu Jianyu Que Jingli Yue Kai yuan Wei Yan yankun Sun Jie Shi Yanping Bao Lin Lu National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijingChina School of Public Health Peking UniversityBeijingChina Institute of Mental Health National Clinical Research Center for Mental DisordersKey Laboratory of Mental Health and Peking University Sixth HospitalPeking UniversityBeijingChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijingChina

Summary What is already known on this topic?The public was at elevated risk of mental health illnesses during the coronavirus disease 2019(COVID-19)pandemic,so accessibility to psychological knowledge and interventions is vital to promptly respond to mental health *** is added by this report?During the pandemic period,40,724(71.9%)participants reportedly had access to psychological knowledge,and 36,546(64.5%)participants had accessed information on psychological *** who were male,unmarried,living alone,divorced or widowed,or infected with COVID-19 were less likely to access psychological knowledge and intervention.

关键词： COV prompt Access

Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China

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General Psychiatry 2020年第3期33卷 156-167页

作者： Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai yuan Wei Yan yankun Sun Maosheng Ran Yanping Bao Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina National Institute on Drug Dependence and Beijing Key Laboratory on Drug Dependence Research Peking UniversityBeijingChina Mental Health Institute of Inner Mongolia Autonomous Region HohhotInner MongoliaChina Xiamen City Xianyue Hospital XiamenFujianChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research BejjingChina Department of Social Work and Social Administration University of Hong KongHong KongChina

Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological *** This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health *** A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 *** problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity *** regression analyses were used to explore the factors that were associated with psychological *** The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,*** prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,*** with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological *** addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological *** Psychological problems are pervasive among healthcare workers during the COVID-19 *** negative information and participating in front-line work appear to *** ris

关键词： nurse workers sectional