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Clinical treatment considerationsin the intensity-modulated radiotherapy era for patients with NO-category nasopharyngeal carcinoma and enlarged neck lymph nodes

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Chinese Journal of Cancer 2017年第7期36卷 306-314页

作者： Hao Peng Lei Chen Rui Guo Yuan Zhang Wen.Fei Li yan.ping mao Ying Sun Fan Zhang Li.Zhi Liu Li Tian Jun Ma State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China State Key Laboratory of Oncology in South China Department of Radiation OncologySun Yat-sen University Cancer Center 651 Dongfeng Road East Guangzhou 510060 P. R. China

Background:Nasopharyngeal carcinoma(NPC) shows a high proportion of lymph node metastasis,and treatment guidelines have been developed for positive ***,no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes(ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph *** study aimed to determine the prognostic value and radiation dose for ENLNs in NO-category NPC patients treated with intensity-modulated radiotherapy(IMRT).Methods:We reviewed the medical data of 251 patients with non-metastatic,NO-category NPC treated with *** operating characteristic curves were used to calculate the cut-off value of the ENLN diameter for the prediction of disease *** biological equivalent dose(BED) for ENLNs was *** survival was compared between the small and large ENLN *** prognostic factors were identified using the Cox proportional hazards ***:The estimated 4-year regional relapse-free survival rate was higher in patients with ENLNs ≥5.5 mm than in those with ENLNs 0.05 for all survival rates).In the subgroup analysis,patients receiving BED ≥72 Gy had a similar prognosis as patients receiving BED <72 Gy in both the small and large ENLN *** multivariate analysis also confirmed that BED≥72 Gy was not associated with significantly improved prognosis in patients with NO-category ***:A BED of 72 Gy to ENLNs is considerably sufficient to provide a clinical benefit to patients with NO-category *** studies are warranted to validate the findings in the present study.

关键词： Nasopharyngeal carcinoma N0-category Enlarged neck lymph node Biological equivalent dose Intensity-modulated radiotherapy Prognosis

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Neuromodulation with chemicals: Opportunities and challenges

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Fundamental Research 2025年第1期5卷 55-62页

作者： Pan, Yifei Pan, Cong mao, Lanqun Yu, ping Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China College of Chemistry Beijing Normal University Beijing 100875 China

Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, in situ electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future. © 2024

关键词： Brain chemistry Chemical delivery In vivo Neurochemistry Neuromodulation

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Artificial intelligence advances drug delivery system and its clinical transition

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Science Bulletin 2025年第3期70卷 305-308页

作者： Hui Wang Xiao-yan You Guo-ping Zhao Master Lab for Innovative Application of Nature Products National Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of Sciences(CAS)Tianjin 300308China Henan Engineering Research Center of Food Microbiology College of Food and BioengineeringHenan University of Science and TechnologyLuoyang 471023China Haihe Laboratory of Synthetic Biology Tianjin 300308China CAS-Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Since November 2022,ChatGPT,an artificial intelligence(AI)chatbot,has rapidly captured global attention for its detailed responses and articulated answers across a broad spectrum of knowledge domains[1],[2].All industries will reorient around it,prompting a reevaluation of how this technology could further promote scientifical research and its clinical applications.

关键词： system transition spectrum

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Effects of biomass co-pyrolysis and herbaceous plant colonization on the transformation of tailings into soil like substrate

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Journal of Environmental Sciences 2025年第1期147卷 230-243页

作者： Bin Zhu Meiyan Si Xin Xie Ximin yan Jianhong Huang Senlin Tian ping Ning Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China Guizhou Research Institute of Coal Mine Design Co. Ltd.Guiyang 550025China

Enhancing soil organic matter characteristics,ameliorating physical structure,mitigating heavy metal toxicity,and hastening mineral weathering processes are crucial approaches to accomplish the transition of tailings substrate to a soil-like *** incorporation of biomass co-pyrolysis and plant colonization has been established to be a significant factor in soil substrate formation and soil pollutant *** this,there is presently an absence of research efforts aimed at synergistically utilizing these two technologies to expedite the process of mining tailings soil substrate *** current study aimed to investigate the underlying mechanism of geochemical changes and rapid mineral weathering during the process of transforming tailings substrate into a soil-like substrate,under the combined effects of biomass co-smoldering pyrolysis and plant *** findings of this study suggest that the incorporation of smoldering pyrolysis and plant colonization induces a high-temperature effect and biological effects,which enhance the physical and chemical properties of tailings,while simultaneously accelerating the rate of mineral *** improvements include the amelioration of extreme pH levels,nutrient enrichment,the formation of aggregates,and an increase in enzyme activity,all of which collectively demonstrate the successful attainment of tailings substrate *** of the acceleratedweathering was verified by phase and surfacemorphology analysis using X-ray diffraction and scanning electron *** corrosion and fragmentation on the surface *** weathering resulted in corrosion and fragmentation of the surface of the treated *** study confirms that co-smoldering pyrolysis of biomass,combined with plant colonization,can effectively promote the transformation of tailings into soil-like *** method has can effectively address the key challenges that have previously hind

关键词： Smoldering Biomass co-pyrolysis Phytoremediation Soil-like substrate Tailing restoration

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Electrospun nanofibers for electrochemical reduction of CO_(2): From spinning fabrication techniques to electrocatalyst design

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Nano Research 2025年第2期18卷 80-100页

作者： yanbiao Liu ping Feng Zhenzhen Wang yan yan Yong Zheng Yu Zhang Mingkai Liu Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110004China Institute for Technical Chemistry and Environmental Chemistry Friedrich-Schiller-Universitat JenaJena 07743Germany School of Chemistry&Chemical Engineering Anhui University of TechnologyMa’anshan 243002China College of Materials and Chemical Engineering Key Laboratory of inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

Electrochemical reduction of CO_(2)(ECO_(2)RR)into value-added fuels and chemicals presents a promising avenue for mitigating CO_(2) emissions while simultaneously contributing to economic growth,thereby addressing critical environmental and energy ***,the large-scale implementation of ECO_(2)RR is significantly impeded by the necessity to design efficient catalysts that exhibit both high activity and *** catalysts must overcome the sluggish kinetics associated with ECO_(2)RR as well as the competing hydrogen evolution *** recent decades,electrospun nanofibers have garnered considerable attention as potential catalysts for ECO_(2)RR,attributable to their high surface area with abundant active sites,tunable functionalities,and enhanced *** review comprehensively examines the rational design of ECO_(2)RR catalysts utilizing electrospinning *** commence with an in-depth exploration of the principles underlying the electrospinning process and subsequently summarize key factors influencing this process,including solution parameters,environmental conditions,and electrospinning operational ***,we discuss recent advancements in ECO_(2)RR catalysts synthesized through electrospinning,encompassing carbon nanofibers,composite nanofibers,and metal ***,we delineate future perspectives and the challenges that electrospun materials face in the context of ECO_(2)RR *** review aims to inspire high-quality research directed toward the advancement of electrospun materials for improved performance in ECO_(2)RR.

关键词： CO_(2)reduction reaction catalyst design electrospinning single-atom catalysts

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Super-high bed sintering for iron ores:variation and optimization of bed resistance

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Journal of Iron and Steel Research International 2025年第1期32卷 40-51页

作者： Liang-ping Xu Lin Xiong Hui-bo Liu Xi-duan yang Ai-xiang mao Pei-dun Chen Guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Central Research Institute Baosteel Group Co.Ltd.Shanghai201900China Manufacturing Management Department Guangdong Zhongnan Iron and Steel Co.Ltd.Shaoguan512123GuangdongChina Technology and Development Center Shandong Taishan Iron and Steel Group Co.Ltd.Jinan271100ShandongChina

As the bed depth increases,sintering yield increases,but the productivity *** reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the *** results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 *** improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 *** using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 *** bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 *** optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.

关键词： Super-high bed sintering Bed resistance Permeability Productivity Wet zone Combustion zone

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Comparisons of{100}texture improvement and formability in hot-rolled non-oriented electrical steel by austenite-ferrite phase transformation and shear deformation

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Journal of Iron and Steel Research International 2025年第1期32卷 171-185页

作者： Chi-hao Yu Hong-jiang Pan yan.ping Zhao De-ting Tang Hai-jun Wang Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093YunnanChina School of Electronics and Information Engineering Anshun UniversityAnshun561000GuizhouChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina

Over the years,the high magnetic induction of industrial Mn-added electrical steel is assumed to be the enhancement of{100}texture derived from its austenite-ferrite phase transformation during hot rolling(phase transformation(PT)method).However,it is still undetermined without straightforward experimental *** reason for{100}texture improvement of Mn-added electrical steel is experimentally confirmed due to the recrystallization induced by the austenite-ferrite phase transformation during hot ***,a more promising methodology to further improve{100}texture and formability of hot-rolled electrical steel is promoted by the control of hot rolling deformation condition(shear deformation(SD)method).The results show that the nucleation mechanisms of{100}oriented recrystallized grains are different in the samples by SD and PT methods,which are in-depth shear deformation and austenite-ferrite phase transformation,*** this case,coarse{100}oriented recrystallized grains and low residual stress are obtained in the sample by SD method,which is responsible for its superior{100}texture and *** contrast,the sample by PT method forms fine recrystallized grains with random orientations and accumulates severe residual stress.

关键词： Non-oriented electrical steel {100}texture Formability Austenite-ferrite phase transformation Shear deformation

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Cu/TiO_(2)adsorbents modified by air plasma for adsorption-oxidation of H_(2)S

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Journal of Environmental Sciences 2025年第2期148卷 476-488页

作者： Yongqi yan Xinyu yang ping Ning Chi Wang Xin Sun Fei Wang Peng Gao Kai Li Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500China Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China City College Kunming University of Science and TechnologyKunming 650500China

In this study,non-thermal plasma(NTP)was employed to modify the Cu/TiO_(2)adsorbent to efficiently purify H_(2)S in low-temperature and micro-oxygen *** effects of Cu loading amounts and atmospheres of NTP treatment on the adsorption-oxidation performance of the adsorbents were *** NTP modification successfully boosted the H_(2)S removal capacity to varying degrees,and the optimized adsorbent treated by air plasma(Cu/TiO_(2)-Air)attained the best H_(2)S breakthrough capacity of 113.29 mg H_(2)S/gadsorbent,which was almost 5 times higher than that of the adsorbent without NTP *** studies demonstrated that the superior performance of Cu/TiO_(2)-Air was attributed to increased mesoporous volume,more exposure of active sites(CuO)and functional groups(amino groups and hydroxyl groups),enhanced Ti-O-Cu interaction,and the favorable ratio of active oxygen ***,the X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results indicated the main reason for the deactivationwas the consumption of the active components(CuO)and the agglomeration of reaction products(CuS and SO_(4)^(2−))occupying the active sites on the surface and the inner pores of the adsorbents.

关键词： Non-thermal plasma(NTP) Surface modification Simultaneous adsorption-oxidation Cu/TiO_(2)(TiO_(2)loaded with copper) H_(2)S

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Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-Hui Li Qing Zhao Dong-Ao mao Kun Zhou Bao-Kuan Chen yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

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Bioaccessibility and health risk assessment of hydrophobic organic pollutants in soils from four typical industrial contaminated sites in China

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Journal of Environmental Sciences 2025年第1期147卷 282-293页

作者： Shi-ping Ou Xiao-Liang Liao Zi-Tao Huang yan-Cong Hu Zongwei Cai Zhi-Feng Chen Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China

There have been reports of potential health risks for people from hydrophobic organic pollutants,such as polycyclic aromatic hydrocarbons(PAHs),polychlorinated hydrocarbons(PCHs),and organophosphate flame retardants(OPFRs).When a contaminated site is used for residential housing or public utility and recreation areas,the soil-bound organic pollutantsmight pose a threat to human *** this study,we investigated the contamination profiles and potential risks to human health of 15 PAHs,6 PCHs,and 12 OPFRs in soils from four contaminated sites in *** used an in vitro method to determine the oral bioaccessibility of soil *** PAHswere found at concentrations ranging from26.4 ng/g to 987 ng/***(0.27-14.3 ng/g)and OPFRs(6.30-310 ng/g)were detected,but at low levels compared to earlier *** levels of PAHs,PCHs,and OPFRs released from contaminated soils into simulated gastrointestinal fluids ranged from 1.74%to 91.0%,2.51%to 39.6%,and 1.37%to 96.9%,*** on both spiked and unspiked samples,we found that the oral bioaccessibility of pollutantswas correlated with their logKow andmolecularweight,and the total organic carbon content and pH of *** in 13 out of 38 contaminated soil samples posed potential high risks to *** considering oral bioaccessibility,nine soils still posed potential risks,while the risks in the remaining soils became *** contribution of this paper is that it corrects the health risk of soil-bound organic pollutants by detecting bioaccessibility in actual soils from different contaminated sites.

关键词： Contaminated soil Hydrophobic organic pollutant Polycyclic aromatic hydrocarbon Oral bioaccessibility Risk assessment

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