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Psychological Status and Warfarin Therapy in Patients after Valve Replacement during the COVID-19 Pandemic:A Cross-sectional Study

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Current Medical Science 2024年第4期44卷 686-691页

作者： Xiao-yan CheN Sheng he Zhen TAN Feng GAO Hui JIANG Lu CheN Li yanG Yu-shan LIU Si-yi he Department of Cardiovascular Surgery The General Hospital of Western Theater CommandChengdu610083China Department of Digestive Medicine The General Hospital of Western Theater CommandChengdu610083China Department of General Surgery The General Hospital of Western Theater CommandChengdu610083China

Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve *** present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication *** Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient *** was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky *** A total of 309 patients(aged 52.2±11.4 years)were included in the present *** SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having *** SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having *** patients(2.3%)had both anxiety and *** regression analysis revealed that only monthly income was an independent influencing factor for *** anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater *** bleeding events and coagulation disorders could be observed in patients with anxiety,depression or *** anxiety occurred,patients showed worse medication ***,depression had no significant effect on medication *** During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of *** of its influencing factors will provide a reference for further standardized regulation of warfarin anticoagulant therapy after valve replacement.

关键词： Warfarin COVID-19 valve replacement depression anxiety

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Unraveling the Fundamental Mechanism of Interface Conductive Network Influence on the Fast‑Charging Performance of SiO‑Based Anode for Lithium‑Ion Batteries

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Nano-Micro Letters 2024年第3期16卷 53-68页

作者： Ruirui Zhang Zhexi Xiao Zhenkang Lin Xinghao yan Ziying he Hairong Jiang Zhou yang Xilai Jia Fei Wei Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Institute of Polymer Science and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China

Progress in the fast charging of high-capacity silicon monoxide(SiO)-based anode is currently hindered by insufficient conductivity and notable volume *** construction of an interface conductive network effectively addresses the aforementioned problems;however,the impact of its quality on lithium-ion transfer and structure durability is yet to be ***,the influence of an interface conductive network on ionic transport and mechanical stability under fast charging is explored for the first time.2D modeling simulation and Cryo-transmission electron microscopy precisely reveal the mitigation of interface polarization owing to a higher fraction of conductive inorganic species formation in bilayer solid electrolyte interphase is mainly responsible for a linear decrease in ionic diffusion energy ***,atomic force microscopy and Raman shift exhibit substantial stress dissipation generated by a complete conductive network,which is critical to the linear reduction of electrode residual *** study provides insights into the rational design of optimized interface SiO-based anodes with reinforced fast-charging performance.

关键词： Fast charging SiO anode Interface conductive network Ionic transport Mechanical stability

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Wild Gibbon Optimization Algorithm

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Computers, Materials & Continua 2024年第7期80卷 1203-1233页

作者： Jia Guo JinWang Ke yan Qiankun Zuo Ruiheng Li Zhou he Dong Wang Yuji Sato Hubei Key Laboratory of Digital Finance Innovation Hubei University of EconomicsWuhan430205China School of Information Engineering Hubei University of EconomicsWuhan430205China China Construction Third Engineering Bureau Installation Engineering Co. Ltd.Wuhan430074China Hubei Internet Finance Information Engineering Technology Research Center Hubei University of EconomicsWuhan430205China College of Informatics Huazhong Agricultural UniversityWuhan430070China Faculty of Computer and Information Sciences Hosei UniversityTokyo184-8584Japan

Complex optimization problems hold broad significance across numerous fields and ***,as the dimensionality of such problems increases,issues like the curse of dimensionality and local optima trapping also *** address these challenges,this paper proposes a novel Wild Gibbon Optimization Algorithm(WGOA)based on an analysis of wild gibbon population *** two strategies:community search and community *** community search strategy facilitates information exchange between two gibbon families,generating multiple candidate solutions to enhance algorithm ***,the community competition strategy reselects leaders for the population after each iteration,thus enhancing algorithm *** assess the algorithm’s performance,CEC2017 and CEC2022 are chosen as test *** the CEC2017 test suite,WGOA secures first place in 10 *** the CEC2022 benchmark functions,WGOA obtained the first rank in 5 *** ultimate experimental findings demonstrate that theWildGibbonOptimization Algorithm outperforms others in tested *** underscores the strong robustness and stability of the gibbonalgorithm in tackling complex single-objective optimization problems.

关键词： Complex optimization wild gibbon optimization algorithm community search community competition

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Access to Enantioenriched Allylic Alcohols via Peptide-Mimic Phosphonium Salt-Catalyzed Asymmetric Aerobic Hydroxylation

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Chinese Journal of Chemistry 2024年第17期42卷 2017-2022页

作者： Jixing Che Siqiang Fang Zanjiao Liu Jiaja he Jia-yan Zheng Fan Wang Tianli Wang Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan University29 Wangjiang RoadChengduSichuan610064China Department of Chemistry National University of SingaporeScience Drive 3Singapore 117543Singapore

The development of catalytic asymmetric methods that enable access to value-added functionalities or structures,exemplified by allylic alcohols,is a highly interesting yet challenging topic from both academic and industrial ***,before recent advances in chemical catalysis,there were scarce protocols toward constructing enantioenriched tertiary allylic alcohol *** this context,peptide-mimic phosphonium salts were found to be highly efficient in catalytic asymmetricα-hydroxylation ofα,β-unsaturated and/orβ,Y-unsaturated compounds with satisfactory regio-and stereochemical outcomes(up to 97%yield and 95%ee).This methodology tolerates a broad array of substrates and thus provides an expeditious and unified platform for the assembly of enantioenriched tertiary allylic alcohols by avoiding the use of additional reductants and expensive metal ***,the power of this protocol is enlarged by simple conditions and the use of air as a source of hydroxyl functionality.

关键词： Asymmetric catalysis Peptide-mimic phosphonium salts Aerobic hydroxylation Enantioenrichedα-allylic alcohols lon pairs Oxygen Ketones

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Success of susceptibility-guided eradication of helicobacter pylori in a region with high secondary clarithromycin and levofloxacin resistance rates

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World Journal of Gastroenterology 2024年第2期30卷 184-195页

作者： yan-Meng Wang Mo-Ye Chen Jing Chen Xin-he Zhang yan Feng Yu-Xi Han Yi-Ling Li Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department The First Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of helicobacter pylori(***)is increasing in severity,and successful eradication is ***,the eradication success rate has greatly declined,leaving a large number of patients with previous treatment *** To investigate secondary resistance rates,explore risk factors for antibiotic resistance,and assess the efficacy of susceptibility-guided *** We recruited 154 subjects positive for Urea Breath Test who attended The First Affiliated Hospital of China Medical University between July 2022 and April *** underwent a string test after an overnight *** gastric juice was obtained and transferred to vials containing storage ***,DNA extraction and the specific DNA amplification were performed using quantitative polymerase chain reaction(qPCR).Demographic information was also analyzed as part of the *** on these results,the participants were administered susceptibility-guided *** was compared with that of the empiric treatment *** A total of 132 individuals tested positive for the *** ureA gene by qPCR *** resistance rate reached a high level of 82.6%(n=109),LFX resistance rate was 69.7%(n=92)and dual resistance was 62.1%(n=82).Gastric symptoms[odds ratio(OR)=2.782;95%confidence interval(95%CI):1.076-7.194;P=0.035]and rural residence(OR=5.152;95%CI:1.407-18.861;P=0.013)were independent risk factors for secondary resistance to CLA and LFX,respectively.A total of 102 and 100 individuals received susceptibility-guided therapies and empiric treatment,*** antibiotic susceptibility-guided treatment and empiric treatment groups achieved successful eradication rates of 75.5%(77/102)and 59.0%(59/411)by the intention-to-treat(ITT)analysis and 90.6%(77/85)and 70.2%(59/84)by the per-protocol(PP)analysis,*** eradication rates of these two treatment strategies were significantly

关键词： helicobacter pylori Antibiotic resistance Clarithromycin Levofloxacin String-test Susceptibility-guided therapy Eradication rate

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New recessive compound heterozygous variants of RP1L1 in RP1L1 maculopathy

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 107-112页

作者： Wen-Chao Cao Qing-Shan Chen Run Gan Tao Huang Xiao-he yan The Second Clinical Medical College Jinan UniversityShenzhen 518040Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChin

AIM:To identify a maculopathy patient caused by new recessive compound heterozygous variants in ***:Comprehensive retinal morphological and functional examinations were evaluated for the patient with RP1L1 *** sequence capture array technique was used to screen potential pathologic *** chain reaction and Sanger sequencing were used to confirm the screening ***:Fundus examination showed round macular lesions appeared in both *** coherence tomography showed that the inner segment/outer segment continuity was disorganized and disruptive in the left eye,but it was uneven and slightly elevated in the right *** autofluorescence showed patchy hyper-autofluorescence in the *** field examination indicates central defects in both ***(ERG)and multifocal ERG showed no obvious *** fluorescein angiography in the macula showed obviously irregular hyper-fluorescence in the right eye and slightly hyper-fluorescence in the left *** found that the proband carried a missense variant(c.1972C>T)and a deletion variant(c.4717_4718del)of RP1L1,which were originated from the parents and formed compound heterozygous *** variants are likely pathogenic according to the ACMG *** imaging,ERG and detailed medical history are important diagnostic tools for differentiating between acquired and inherited retinal ***:A maculopathy case with detailed retinal phenotype and new recessive compound heterozygous variants of RP1L1 is identified in a Chinese family,which expands the understanding of phenotype and genotype in RP1L1 maculopathy.

关键词： maculopathy recessive compound heterozygous variants RP1L1

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Comprehensive understanding of the thriving electrocatalytic nitrate/nitrite reduction to ammonia under ambient conditions

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Journal of Energy Chemistry 2024年第5期92卷 459-483页

作者： Xinying Zhao Yuzhuo Jiang Mengfan Wang Yunfei Huan Qiyang Cheng yan.heng he Tao Qian Chenglin yan Collaborative Innovation Center of Suzhou Nano Science and Technology College of EnergySoochow UniversitySuzhou 215006JiangsuChina School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019JiangsuChina School of Petrochemical Engineering Changzhou UniversityChangzhou 213164JiangsuChina

Ammonia(NH_(3))is a multifunctional compound that is an important feedstock for the agricultural and pharmaceutical industries and attractive energy storage *** present,NH_(3)synthesis is highly dependent on the conventional Haber–Bosch process that operates under harsh conditions,which consumes large quantities of fossil fuels and releases a large amount of carbon *** an alternative,electrosynthesis is a prospective method for producing NH_(3)under normal temperature and pressure *** electrocatalytic nitrogen reduction to ammonia has attracted considerable attentions,the low solubility of N_(2)and high N≡N cracking energy render the achievements of high NH_(3) yield rate and Faradaic efficiency *** and nitrite(NO_(x)^(-))are common N-containing *** to their high solubilities and low dissociation energy of N=O,NO_(x)^(-)−are ideal raw materials for NH_(3) ***,electrocatalytic NO_(x)^(-)−reduction to NH_(3)(eNO_(x)RR)is a prospective strategy to simultaneously realise environmental protection and NH_(3) *** review offers a comprehensive understanding of the thriving eNO_(x)RR under ambient *** first,the popular theory and mechanism of eNO_(x)RR and a summary of the measurement system and evaluation criteria are ***,various strategies for developing NO_(x)−reduction catalysts are systematically presented and ***,the challenges and possible prospects of electrocatalytic NO_(x)^(-1) reduction are outlined to facilitate energy-saving and environmentally friendly large-scale synthesis of NH_(3) in the future.

关键词： Electrocatalytic nitrate reduction Electrocatalytic nitrite reduction Ammonia synthesis Pollutant removal Electrosynthesis

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Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of Diabetes 2024年第2期15卷 260-274页

作者： Yin-Xi he Ting Wang Wen-Xian Li yan-Xia Chen Department of Orthopaedic Trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

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Construction of a multifunctional Ti3C2Tx MXene/g-C3N4 artificial protective layer for dendrite-free aqueous Zn-ion batteries

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Rare Metals 2024年第10期43卷 4992-5004页

作者： Wei-Wei Wang Rui Huang Yu Tao Peng he Su-Xing Tuo Yu-Jian Bian Rui-Ting Hu Jun yan yan-Jie Liang Wen-Chao Zhang The Key Laboratory of Digital Flavour Research of Hunan China Tobacco Industry Co. Ltd College of Metallurgy and Environment Central South University College of Chemistry and Chemical Engineering Central South University

The electrochemical utilization of Zn anodes in aqueous batteries is hampered by the intricate and interconnected issues of Zn dendrite growth,H2evolution and Zn corrosion *** this study,a multifunctional protective layer comprising MXene and graphitic carbon nitride （g-C3N4） was constructed using a self-assembly *** MXene/g-C3N4protective layer exhibited robust zincophilic characteristics,which facilitated a uniform distribution of the electric field and ensured a sufficient influx of Zn2+.This reduces the Zn2+nucleation barrier and prevents dendrite *** addition,the hydrophobic nature of the protective layer,coupled with its negative charge,can repel SO42-and select water molecules from the electrolyte,which aids in mitigating corrosion and *** symmetric Zn cell coated with the MXene/g-C3N4protective layer showed remarkable stability,achieving over 2000 h of reversible cycling at1 mA·***,the MXene/g-C3N4-coated Zn anode paired with a sodium-doped V2O5cathode （NVO）exhibited enhanced cycling capability over 1500 cycles.

关键词： Artificial protective layers Dendrite-free Zn anodes g-C3N4 Interface stability Ti3C2Tx MXene

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Contrasting response of rice rhizosphere microbiomes to in situ cadmium-contaminated soil remediation

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Soil Ecology Letters 2024年第2期6卷 149-162页

作者： Zhongyi Cheng Qinyu Han yan.he Jiachun Shi Laosheng Wu Jianming Xu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Environment Remediation and Ecological health Ministry of EducationHangzhou310058China Department of Environmental Sciences University of CaliforniaRiversideCA92521USA

Changes in soil properties and microbial communities regulated rhizosphere protistan assemblages. • Bacterial community was more sensitive to soil amendments than protists and fungi. • Soil amendments trigger the role of specific protistan taxa Cercozoa on microbial interactions. Understanding the responses of different rhizosphere microbial lineages to soil amendments during in situ remediation of Cd-contaminated soil is of great importance in the assessment of the restoration and crop health. here, we evaluated the effects of lime (LM), biochar (BC), pig manure (PM), and a commercial Mg-Ca-Si conditioner (CMC) on the rice rhizosphere soil physicochemical properties and community assembly of bacteria, fungi, and protists in a six-year consecutive application of soil amendments field trial. Our results indicated that among the four amendments, the BC and CMC had the best efficiency in increasing soil pH, which were 5.2% and 16.2%, respectively. Despite the differences in soil Cd concentrations is not noticeable, all the soil amendment treatments significantly decreased the proportion of available Cd in total Cd compared to the control. Soil amendments significantly altered the diversity of bacterial community, while they had no effect on fungal and protistan communities. Linear discriminant analysis effect size (LEfSe) showed that the bacteria was more sensitive to soil amendment-induced changes. For protists, treatments with LM and BC changed the groups of protistan consumers, while treatments with PM and CMC significantly increased the relative abundances of protistan phototrophs. Co-occurrence network analysis revealed that soil amendments increased microbial network complexity and triggered the role of protists, especially for the predatory protists Cercozoa, on microbial trophic interactions. Further variation partitioning analysis revealed that edaphic properties, bacterial and fungal communities compositions together explained the 77% of the total variation i

关键词： cadmium soil amendments soil protist community microbial interactions

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