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Microstructure and texture evolution of cold drawing <110> single crystal copper

Science china(Technological Sciences) 2011年第6期54卷 1551-1559页

作者： cHEN Jian yan Wen LI Bing MA XiaoGuang DU XinZhi FAN XinHui Department of Applied Physics Northwestern Polytechical University Xi'an 710072 China School of Materials Science and chemical Engineering Xi'an Technological University Xi'an 710032 China

By means of electron backscattering diffraction and transmission electron microscopy the microstructure and texture of drawn single crystal copper with initial orientation （110） parallel to axial direction have been investigated in the present work. In or- der to analyze the effect of initial orientation on microstructure and texture of drawn copper, the results of the drawn （110） sin- gle crystal copper wires have been compared with （100） and （111） single crystal copper wires. It is found that the grain subdi- vision of （110） single crystal is more evident than that of （100） and （111）, and the textures consisting of （111） and （100） abruptly form in the drawn （110） single crystal. At high strains, due to shear strain, the distribution of fiber textures is imho- mogenous along the radial direction of drawn （110） single crystal copper wires. （100） is near the surface and （111） is at the center. The microstructure results of drawn （110） single crystal show that at low strains, it can be characterized as two kinds of geometrically necessary boundaries with noncrystalline character. At medium strains, S bands can be observed. At high strains, lamellar boundaries form. Mean misofientation and average spacing of dislocation boundary are larger in drawn （110） single crystal, as compared with （111） and （100）. In drawn （110） single crystal with high strains, the bimodal distribution forms at lower strains than in drawn （100） single crystal, which is because the dislocation boundaries with high angle are contributed by not only the boundary between （111） and （100） fiber textures but also the boundary in （111） or （100） texture.

关键词： single crystal copper cold drawing texture microstructure

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Study on Air-Purifying Performance of Semi-Flexible Asphalt Samples coated with Titanium Dioxide Using Different Methods

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Journal of Renewable Materials 2022年第5期10卷 1321-1335页

作者： Shoujing yan yangyang Wang Fengxia chi Xue Luo Tianjie Zhang chenchen Xi Institute of Road Engineering Zhejiang Scientific Research Institute of TransportHangzhou310023China Department of Architecture and civil Engineering Zhejiang UniversityHangzhou310027China Department of computer Science Boise State UniversityBoise83725-1145USA

Titanium dioxide(TiO_(2))was recently employed to apply onto road surfaces to degrade the harmful compounds from vehicle ***,it remains a challenging task to find a highly compatible pavement type for TiO_(2)application to achieve durable and efficient air-purifying *** study proposed to coat TiO_(2)particles onto semi-flexible pavement surface and tried to investigate an optimum coating *** coating methods,including direct mixing TiO_(2)(MT)with asphalt mixture,spraying dry TiO_(2)(ST)coating and watersolution-based TiO_(2)(WT)coating on semi-flexible pavement *** achieve this objective,semi-flexible samples were prepared to evaluate and compare the performances of three coating methods by employing resistance to wearing,NO removal efficiency tests and residual texture depth *** was found that the ST method not only provided better NO degrading efficiency but also improved the resistance to wearing than the other two methods.

关键词： Titanium dioxide air-purifying performance semi-flexible pavement coating methods

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Ripening behavior of M_(23)c_6 carbides in P92 steel during aging at 800°c

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Journal of Iron and Steel Research International 2017年第8期24卷 858-864页

作者： Xu yang Bo Liao Fu-ren Xiao Wei yan Yi-yin Shan Ke yang college of Materials Science and Engineering Yanshan University Institute of Metal Research Chinese Academy of Sciences

The rapid coarsening of the M_（23）c_6 carbides has been held responsible for the creep fracture in 9-12cr martensitic heat resistant steels.A commercial P92 steel was subjected to thermal aging at a high temperature of 800°c to investigate the ripening behavior of the M_（23）c_6 *** electron microscopy（SEM）and transmission electron microscopy（TEM）were employed to characterize the microstructure evolution,especially the ripening process of the M_（23）c_6 *** new concept of the effective mean size,dependent on the critical radius,was introduced to correct the measured mean size and then the Ostwald theory was applied to describe the ripening behavior of the M_（23）c_6 *** ripening of the M_（23）c_6 carbides was revealed to be grain boundary diffusion controlled.

关键词： P92steel M23c6 carbide Aging Ripening

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Metal/nanocarbon layer current collectors enhanced energy efficiency in lithium-sulfur batteries

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Science Bulletin 2017年第18期62卷 1267-1274页

作者： Jia-Qi Huang Pei-yan Zhai Hong-Jie Peng Wan-cheng Zhu Qiang Zhang Beijing Key Laboratory of Green chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Department of chemical Engineering Qufu Normal University

Lithium-sulfur （Li-S） batteries with intrinsic merits in high theoretical energy density are the most promising candidate as the next-generation power sources. The strategy to achieve a high utilization of active materials with high energy efficiency is strongly requested for practical applications with less energy loss during repeated cycling. In this contribution, a metal/nanocarbon layer current collector is proposed to enhance the redox reactions of polysulfides in a working Li-S cell. Such a concept is demon- strated by coating graphene-carbon nanotube hybrids （GNHs） on routine aluminum （AI） foil current collectors. The interracial conductivity and adhesion between the current collector and active material are significantly enhanced. Such novel cell configuration with metal/nanocarbon layer current collectors affords abundant Li ions for rapid redox reactions with small overpotential. consequently, the Li-S cells with nanostructured current collectors exhibit an initial discharge capacity of 1,113 mAh g-1 at 0.5 c, which is -300 mAh g-1 higher than those without a GNH coating layer. The capacity retention is 73% for cells with GNH after 300 cycles. A reduced voltage hysteresis and a high energy efficiency of ca. 90% are therefore achieved. Moreover, the AI/GNH layer current collectors are easily implanted into current cell assembly process for energy storage devices based on complex multi-electron redox reactions （e.g., Li-S batteries, Li-O2 batteries, fuel cells, and flow batteries）.

关键词： Lithium-sulfur battery Nanostructured current collectors Polysulfides Energy efficiency Pouch cell

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calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase c pathway

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Neural Regeneration Research 2017年第11期12卷 1870-1876页

作者： Lei Song Xiaoping Li Xiao-xue Bai Jian Gao chun-yan Wang Department of Respiratory Medicine First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Pediatrics First Hospital of Jilin UniversityChangchunJilin ProvinceChina cadre's Ward First Hospital of Jilin UniversityChangchunJilin provinceChina Department of Neurosurgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

The major pathological changes in Alzheimer＇s disease are beta amyloid deposits and cognitive impairment. calycosin is a typical phy- toestrogen derived from radix astragali that binds to estrogen receptors to produce estrogen-like effects. Radix astragali calycosin has been shown to relieve cognitive impairment induced by diabetes mellitus, suggesting calycosin may improve the cognitive function of Alzhei- mer＇s disease patients. The protein kinase c pathway is upstream of the mitogen-activated protein kinase pathway and exerts a neuropro- tective effect by regulating Alzheimer＇s disease-related beta amyloid degradation. We hypothesized that calycosin improves the cognitive function of a transgenic mouse model of Alzheimer＇s disease by activating the protein kinase c pathway. Various doses of calycosin （10, 20 and 40 mg/kg） were intraperitoneally injected into APP/PS1 transgenic mice that model Alzheimer＇s disease. calycosin diminished hippocampal beta amyloid, Tau protein, interleukin-lbeta, tumor necrosis factor-alpha, acetylcholinesterase and malondialdehyde levels in a dose-dependent manner, and increased acetylcholine and glutathione activities. The administration of a protein kinase c inhibitor, cal- phostin c, abolished the neuroprotective effects of calycosin including improving cognitive ability, and anti-oxidative and anti-inflammato- ry effects. Our data demonstrated that calycosin mitigated oxidative stress and inflammatory responses in the hippocampus of Alzheimer＇s disease model mice by activating the protein kinase c pathway, and thereby improving cognitive function.

关键词： nerve regeneration neurodegeneration Alzheimer's disease calycosin hippocampus oxidative stress inflammation mice protein kinase c calphostin c glutathione malondialdehyde neural regeneration

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Atypical skeletal manifestations of rickets in a familial hypocalciuric hypercalcemia patient

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Bone Research 2017年第3期5卷 242-249页

作者： Bo Wu Ou Wang yan Jiang Mei Li Xiaoping Xing Weibo Xia Department of Endocrinology Key Laboratory of Endocrinology Ministry of Health Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences

Familial hypocalciuric hypercalcemia （FHH） is caused by inactivating mutations in the calcium-sensing receptor （caSR） gene. The loss of function of caSR presents with rickets as the predominant skeletal abnormality in mice, but is rarely reported in humans. Here we report a case of a 16-year-old boy with FHH who presented with skeletal manifestations of rickets. To identify the possible pathogenic mutation, the patient was evaluated clinically, biochemically, and radiographicaUy. The patient and his family members were screened for genetic mutations. Physical examination revealed a pigeon breast deformity and X-ray examinations showed epiphyseal broadening, both of which indicate rickets. Biochemical tests also showed increased parathyroid hormone （PTH）, 1,25-dihydroxyvitamin D, and elevated ionized calcium. Based on these results, a diagnosis of FHH was suspected. Sequence analysis of the patient＇s caSR gene revealed a new missense mutation （c.2279T 〉 A） in exon 7, leading to the damaging amino change （p.I760N） in the mature caSR protein, confirming the diagnosis of ~H. Moreover, the skeletal abnormities may be related to but not limited to vitamin D abnormity. Elevated ~H levels and a rapid skeletal growth period in adolescence may have also contributed. Our study revealed that rickets-like features have a tendency to present atypically in FHH patients who have a mild vitamin D deficiency, and that caSR mutations may have a partial role in the pathogenesis of skeletal deformities.

关键词： ca Atypical skeletal manifestations of rickets in a familial hypocalciuric hypercalcemia patient PTH BMD

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Fast and accurate kernel density approximation using a divide-and-conquer approach

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Journal of Zhejiang University-Science c(computers and Electronics) 2010年第9期11卷 677-689页

作者： yan-xia JIN Kai ZHANG James T. KWOK Han-chang ZHOU School of Electronics and computer Science and Technology North University of China Taiyuan 030051 China Department of computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong China Key Laboratory of Instrumentation Science and Dynamic Measurement North University of China Taiyuan 030051 China

Density-based nonparametric clustering techniques,such as the mean shift algorithm,are well known for their flexibility and effectiveness in real-world vision-based *** underlying kernel density estimation process can be very expensive on large *** this paper,the divide-and-conquer method is proposed to reduce these computational *** dataset is first partitioned into a number of small,compact *** of the kernel estimator in each local cluster are then fit to a single,representative density *** key novelty presented here is the efficient derivation of the representative density function using concepts from function approximation,such that the expensive kernel density estimator can be easily summarized by a highly compact model with very few basis *** proposed method has a time complexity that is only linear in the sample size and data ***,the bandwidth of the resultant density model is adaptive to local data *** on color image filtering/segmentation show that,the proposed method is dramatically faster than both the standard mean shift and fast mean shift implementations based on kd-trees while

关键词： Nonparametric clustering Kernel density estimation Mean shift Image filtering

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Modulatory Effects and Action Mechanisms of Tryptanthrin on Murine Myeloid Leukemia cells

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cellular & Molecular Immunology 2009年第5期6卷 335-342页

作者： Hoi-Ling chan Hon-yan Yip Nai-Ki Mak Kwok-Nam Leung Department of Biochemistry The Chinese University of Hong Kong Shatin HKSAR China Department of Food and Nutritional SciencesProgramme The Chinese University of Hong Kong Shatin HKSAR China Department of Biology Hong Kong Baptist University Kowloon TongHKSAR China Department of Biochemistry and Food and Nutritional Sciences Programme The Chinese University of Hong Kong Shatin HKSAR China

Leukemia is the disorder of hematopoietic cell development and is characterized by an uncoupling of cell proliferation and differentiation. There is a pressing need for the development of novel tactics for leukemia therapy as conventional treatments often have severe adverse side effects. Tryptanthrin （6,12-dihydro-6,12-dioxoindolo- （2,1-b）-quinazoline） is a naturally-occurring, weakly basic alkaloid isolated from the dried roots of medicinal indigo plants （Ban-Lan-Gen）. It has been reported to have various biological and pharmacological activities, including anti-microbial, anti-inflammatory, immunomodulatory and anti-tumor effects. However, its modulatory effects and action mechanisms on myeloid cells remain poorly understood. In this study, tryptanthrin was shown to suppress the proliferation of the murine myeloid leukemia WEHI-3B JcS cells in a dose- and time-dependent manner. It also significantly reduced the growth of WEHI-3B JcS cells in vivo in syngeneic BALB/c mice. However, it exhibited no significant direct cytotoxicity on normal murine peritoneal macrophages. Flow cytometric analysis showed an obvious cell cycle arrest of the tryptanthrin-treated WEHI-3B JcS cells at the G0/G1 phase. The expression of cyclin D2, D3, cdk 2, 4 and 6 genes in WEHI-3B JcS cells was found to be down-regulated at 24 h as measured by RT-PcR. Morphological and functional studies revealed that tryptanthrin could induce differentiation in WEHI-3B JcS cells, as shown by the increases in vacuolation, cellular granularity and NBT-reducing activity in tryptanthrin-treated cells. collectively, our findings suggest that tryptanthrin might exert its anti-tumor effect on the murine myelomonocytic leukemia WEHI-3B JcS cells by causing cell cycle arrest and by triggering cell differentiation.

关键词： Ban-Lan-Gen tryptanthrin myeloid leukemia cell differentiation

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Effects of cold narcosis on memory acquisition, consolidation and retrieval in honeybees （Apis mellifera）

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Zoological Research 2014年第2期35卷 118-123页

作者： yan-Mei cHEN Yu FU Jing HE Jian-Hong WANG Medical Faculty Kunming University of Science and Technology Kunming 650550 China Biomedical Engineering Laboratory Information School Yunnan University Kunming 650091 China Key Laboratory of Animal Models and Human Disease Mechanisms of the chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

In learning and memory studies on honeybees （Apis mellifera）, cold-induced narcosis has been widely used to temporarily immobilize honeybees. In this study, we investigated the effects of cold narcosis on the associative memories in honeybees by using the proboscis extension response （PER） paradigm. Severe impairments in memory acquisition was found when cold narcosis was performed 30 rain, instead of 1 h before training. Locomotor activities were reduced when honeybees were tested 15 min, instead of 30 rain after cold narcosis. These results indicate that cold narcosis impairs locomotor activities, as well as memory acquisition in a time-dependent manner, but by comparison no such effects on memory retrieval have yet been observed.[0]

关键词： Honeybee cold narcosis Associative learning Memory

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增大冷速和退火对Al_(50)Ni_(50)合金耐蚀性能的改善

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Transactions of Nonferrous Metals Society of china 2024年第3期34卷 769-785页

作者：刘瀚泽闫芝成陈其张昊冯玉齐志港王兆萱潘少鹏贾义勇王伟民山东大学材料科学与工程学院材料液固结构演变与加工教育部重点实验室济南250061 太原理工大学材料科学与工程学院太原030002 华美新材料(菏泽)有限公司菏泽274000

通过周向速度(S_(c))分别为21和42 m/s的熔带甩带法制备单相Al_(50)Ni_(50)条带,然后采用多种实验方法研究在不同温度下退火Al_(50)Ni_(50)条带的显微组织和腐蚀行为。随着S_(c)从21 m/s提高到42 m/s,相应的铸态和退火条带的(100)晶体... 详细信息

通过周向速度(S_(c))分别为21和42 m/s的熔带甩带法制备单相Al_(50)Ni_(50)条带,然后采用多种实验方法研究在不同温度下退火Al_(50)Ni_(50)条带的显微组织和腐蚀行为。随着S_(c)从21 m/s提高到42 m/s,相应的铸态和退火条带的(100)晶体取向因子F(100)增大,再结晶的障碍减少以及钝化膜的总电阻增大。S_(c)=42m/s的铸态条带比21 m/s的铸态和退火的条带具有更稳定、更致密的Al_(2)O_(3)钝化膜,并可以通过在700℃退火进一步提升。因此,提高冷却速率和选择适当温度进一步退火可以提高AlNi条带的耐腐蚀性能。

关键词： AlNi合金快速凝固取向因子再结晶腐蚀性为

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