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Research Progress of Structure Based Antitumor Drug Design

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Chinese Journal of Structural Chemistry 2020年第12期39卷 2085-2090,2053页

作者： zhang Lei CHEN zhuo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

At present,the development of antineoplastic drugs has been highly *** strategies have been developed to explore the safety and effectiveness of antitumor *** recent years,the progress of structural analysis of tumor-associated proteins provides a solid foundation for the design of new targeted drugs through efficient prediction and screening *** this review,we briefly summarize the research and development of new antitumor drugs based on structure to enhance tumor targeting property and reduce side effects.

关键词： structure drug design antitumor

Embracing the age of artificial intelligence:paradigm shifts,opportunities,and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Science China(Life Sciences) 2024年第6期67卷 1302-1304页

作者： zhuo-Yu An Xiao-Hui zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China

Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an important medical development in treating hematological ***,the risk of acute graft-versus-host disease(a GVHD)severely limits its use.a GVHD is a sev... 详细信息

关键词： hematopoietic graft artificial

The Structures for the Loop-Witt Algebra

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2329-2344页

作者： Xiao Min TANG zhuo zhang Department of Mathematics Heilongjiang University Department of Mathematics Heihe College

The loop-Witt algebra is the Lie algebra of the tensor product of the Witt algebra and the Laurent polynomial algebra. In this paper we study the universal central extension, derivations and automorphism group for the... 详细信息

关键词： Loop-Witt algebra universal central extension derivation automorphism group

Natural killer/T-cell lymphoma with intracranial infiltration and Epstein-Barr virus infection: A case report

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World Journal of Clinical Cases 2020年第15期8卷 3284-3290页

作者： Nan Li Yi-zhuo Wang Yi zhang Wei-Ling zhang yan Zhou Dong-Sheng Huang Pediatric Department Beijing Tongren Hospital Affiliated to Capital Medical UniversityBeijing 100176China

BACKGROUND Because of atypical clinical symptoms,lymphoma is easily confused with infectious *** nasal-type natural killer/T-cell lymphoma(NKTL)is more common,and there are few cases of eyelid site onset and intracranial infiltration,which increases the difficulty of *** disease usually has a very poor prognosis and there are few reports of *** SUMMARY A 3-year-old boy was admitted to our hospital due to an initial misdiagnosis of"eyelid cellulitis"and failed antibiotic *** was characterized by fever,right eyeball bulging,convulsions,and abnormal liver *** blood Epstein-Barr virus(EBV)DNA was positive(8.798×10^4 copies/mL),and remained positive for about half a *** cranial imaging examination suggested a space-occupying lesion in the right eyelid,with the right temporal lobe and meninges *** boy underwent ocular mass *** pathological diagnosis was *** was diagnosed as having NKTL with intracranial infiltration,combined with chronic active EBV infection(CAEBV).Then he underwent systemic chemotherapy and intrathecal *** boy suffered from abnormal blood coagulation,oral mucositis,diarrhea,liver damage,and severe bone marrow suppression but ***,the tumor was completely relieved and his blood EBV-DNA level turned *** current follow-up has been more than 2 years and his condition is *** This case suggests that chemotherapy combined with intrathecal injection may have a good effect on intracranial infiltrating lymphoma and CAEBV,which deserves further study and discussion.

关键词： Natural killer/T-cell lymphoma Intracranial infiltration Chronic active Epstein-Barr virus infection Eyelid cellulitis Chemotherapy Case report

BIFER： a biphasic trace filter approach to scalable prediction of concurrency errors

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Frontiers of Computer Science 2015年第6期9卷 944-955页

作者： XiCHANG zhuo zhang Peng zhang Jianxin XUE Jianjun ZHAO Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Software Engineering National University of Defense Technology Changsha 410073 China Department of Software Engineering Shanghai Second Polytechnic University Shanghai 201209 China

Predictive trace analysis （PTA）, a static trace analysis technique for concurrent programs, can offer power- ful capability support for finding concurrency errors unseen in a previous program execution. Existing PTA techniques always face considerable challenges in scaling to large traces which contain numerous critical events. One main reason is that an analyzed trace includes not only redundant memory accessing events and threads that cannot contribute to dis- covering any additional errors different from the found can- didate ones, but also many residual synchronization events which still affect PTA to check whether these candidate ones are feasible or not even after removing the redundant events. Removing them from the trace can significantly improve the scalability of PTA without affecting the quality of the PTA results. In this paper, we propose a biphasic trace filter ap- proach, BIFER in short, to filter these redundant events and residual events for improving the scalability of PTA to expose general concurrency errors. In addition, we design a model which indicates the lock history and the happens-before his- tory of each thread with two kinds of ways to achieve the efficient filtering. We implement a prototypical tool BIFER for Java programs on the basis of a predictive trace analysis framework. Experiments show that BIFER can improve the scalability of PTA during the process of analyzing all of the traces.

关键词： predictive trace analysis concurrency errors scalability

An AND-type 1T-FeFET array with robust write and read operations

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Science China(Information Sciences) 2025年

作者： Jiacheng XU Jiayi ZHAO Hongrui zhang Haoji QIAN Jiani GU Bowen CHEN Gaobo LIN Rongzong SHEN Xinda SONG Huan LIU Yian DING Minglei MA Miaomiao zhang Xiao YU Bing CHEN Ran CHENG Gaobo XU Huaxiang YIN yan LIU Jiajia CHEN Chengji JIN Genquan HAN Hangzhou Institute of Technology and School of Microelectronics Xidian University Zhejiang Lab College of Integrated Circuits Zhejiang University Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences

HfO2-based ferroelectric field-effect transistor （FeF ET） has become a promising solution for next-generation embedded non-volatile memory （NVM） owing to its complementary metal-oxide-semiconductor （CMOS） compatibility,small footprint, high performance, and non-destructive readout [1]. Recent research of HfO2-based FeF ET has focused on the device operation mechanisms as well as reliability issues such as the interplay between polarization switching and charge trapping/detrapping [2], read-after-write latency [3] and endurance degradation [4]. It has been demonstrated that endurance higher than 1010cycles with negligible read-after-write latency is possible if the gate stack of FeF ET is well engineered [5].

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Super-biderivations of not-finitely graded Lie superalgebras related to generalized super-Virasoro algebras

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Frontiers of Mathematics in China 2020年第6期15卷 1295-1306页

作者： zhuo zhang Jixia YUAN Xiaomin TANG School of Mathematical Sciences Heilongjiang UniversityHarbin 150080China

We mainly study the super-biderivations of not-finitely graded Lie superalgebras related to generalized super-Virasoro *** particular,we prove that all super-biderivations of not-finitely graded Lie superalgebras rela... 详细信息

关键词： Lie superalgebra super-Virasoro algebras super-biderivation inner super-biderivations

Catalytic reductive dechlorination of p-chlorophenol in water using Ni/Fe nanoscale particles

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Journal of Environmental Sciences 2007年第3期19卷 362-366页

作者： zhang Wei-hua QUAN Xie zhang zhuo-yong College of Urban and Environmental Sciences Northeast Normal University Changchun 130024 China School of Environmental and Biological Science and Technology Dalian University of Technology Dalian 116023 China College of Chemistry Inner Mongolia University for the Nationalities Tongliao 028043 China

Nanoscale bimetallic Ni/Fe particles were synthesized from the reaction of sodium borohydride （NaBH4） with reduction of Ni^2＋ and Fe^2＋ in aqueous solution. The obtained Ni/Fe particles were characterized by TEM （transmission electron microscope）, XRD （X-ray diffractometer）, and N2-BET. The dechlorination activity of the Ni/Fe was investigated using p-chlorophenol （p-CP） as a probe agent. Results demonstrated that the nanoscale Ni/Fe could effectively dechlorinate p-CP at relatively low metal to solution ratio of 0.4 g/L （Ni 5 wt%）. The target with initial concentration ofp-CP 0.625 mmol/L was dechlorinted completely in 60 rain under ambient temperature and pressure. Factors affecting dechlorination efficiency, including reaction temperature, pH, Ni loading percentage over Fe, and metal to solution ratio, were investigated. The possible mechanism of dechlorination ofp-CP was proposed and discussed. The pseudo-first- order reaction took place on the surface of the Ni/Fe bimetallic particles, and the activation energy of the dechlorination reaction was determined to be 21.2 kJ/mol at the temperature rang of 287-313 K.

关键词： Ni/Fe bimetal nanoscale particles catalytic reduction p-CP dechlorination

Edge induced band bending in van der Waals heterojunctions:A first principle study

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Nano Research 2020年第3期13卷 701-708页

作者： yang Ou zhuo Kang Qingliang Liao Zheng zhang Yue zhang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Advanced Energy Materials and TechnologiesUniversity of Science and Technology BeijingBeijing 100083China State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity cf Science and Technology BeijingBeijing 100083China

The dangling bond free nature of two-dimensional(2D)material surface/interface makes van der Waals(vdW)heterostructure attractive for novel electronic and optoelectronic *** in practice,edge is unavoidable and could cause band bending at 2D material edge analog to surface/interface band bending in conventional three-dimensional(3D)***,we report a first principle simulation on edge band bending of free standing MoS2/WS2 vdW *** to the imbalance charges at edge,S terminated edge causes upward band bending while Mo/W terminated induces downward bending in undoped *** edge band bending is comparable to band gap and could obviously harm electronic and optoelectronic *** also investigate the edge band bending of electrostatic doped heterojunction.N doping raises the edge band whereas p doping causes a decline of edge *** n doping even reverses the downward edge band bending at Mo/W terminated *** contrast,heavy p doping doesn’t invert the upward bending to *** with former experiments,the expected band gap narrowing introduced by interlayer potential gradient at edge is not observed in our free-standing structures and suggests substrate’s important role in this imbalance charge induced phenomenon.

关键词： edge band bending imbalance charge electrostatic doping transition metal dichalcogenides(TMDCs)van der Waals(vdW)heterojunction first principle