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Tungsten 2022年第2期4卷 121-129页

作者： Meng Zhao Xi-Yu Zhu yan-zhen li Jiang-Nan Chang Ming-Xue li li-Hua Ma Xiao-Yuan Guo Henan Key Laboratory of Polyoxometalate Chemistry Institute of Molecular and Crystal EngineeringSchool of Chemistry and Chemical EngineeringHenan UniversityKaifeng475004China Agricultural Products’Quality and Safety Testing Center of Kaifeng Kaifeng Agriculture and Rural BureauHenan475004China

In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and *** compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(***,0.06μg·mL^(−1))and Escherichia coli(***,0.24μg·mL^(−1)),***,the potential mechanism of compound 1 was studied in *** potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).

关键词： Isopolytungstate Thiosemicarbazone Bioactivity Mechanism of action

Effects of dynamic cooling pre-aging treatment on mechanical properties and paint-bake hardening behavior of Al-Mg-Si alloy automotive sheets

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Journal of Central South University 2022年第3期29卷 950-959页

作者： GAO Guan-jun li Xi-wu yan li-zhen XIONG Bai-qing li Zhi-hui ZHANG Yong-an WEN Kai li Ya-nan State Key Laboratory of Non-ferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China

In the industrial production, the dynamic cooling pre-aging treatment was employed to replace the isothermal pre-aging during the continuous heat treatment production of Al-Mg-Si alloy automotive sheets. The effects of dynamic cooling pre-aging treatment on mechanical properties and paint-bake hardening behavior of an Al-Mg-Si alloy sheet are proposed in this study. The scanning electron microscopy, transmission electron microscopy, tensile test, Vickers hardness test, and differential scanning calorimetry were conducted for the purpose. It was found that the dynamic cooling pre-aging treatment at low temperature region led to the decreasing of cluster II, resulting in the deterioration of the ability of the paint-bake hardening. With the increase of the cooling pre-aging temperature, the increasing of cluster II effectively improved the stability against natural aging and the paint-bake hardening ability. The optimized dynamic cooling pre-aging temperature was ~150 ℃. In this condition, the hardness increase of the alloy sheet with pre-aging treatment is low during storage at room temperature. The high yield strength increment is obtained after paint-bake hardening.

关键词： Al-Mg-Si alloy mechanical properties paint-bake hardening behavior dynamic cooling pre-aging precipitates

A data-driven approach to RUL prediction of tools

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Advances in Manufacturing 2024年第1期12卷 6-18页

作者： Wei li liang-Chi Zhang Chu-Han Wu yan Wang zhen-Xiang Cui Chao Niu Department of Mechanical Engineering University College LondonLondonWC1E 7JEUK Shenzhen Key Laboratory of Cross-Scale Manufacturing Mechanics Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China SUSTech Institute for Manufacturing Innovation Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China School of Mechanical and Manufacturing Engineering The University of New South WalesKensingtonNSW2052Australia Baoshan Iron&Steel Co. Ltd.Shanghai200941People’s Republic of China

An effective and reliable prediction of the remaining useful life(RUL)of a tool is important to a metal forming process because it can significantly reduce unexpected maintenance,avoid machine shutdowns and increase system *** study proposes a new data-driven approach to the RUL prediction for metal forming processes under multiple contact sliding *** data-driven approach took advantage of bidirectional long short-term memory(BLSTM)and convolutional neural networks(CNN).A pre-trained lightweight CNN-based network,WearNet,was re-trained to classify the wear states of workpiece surfaces with a high accuracy,then the classification results were passed into a BLSTM-based regression model as inputs for RUL *** experimental results demonstrated that this approach was able to predict the RUL values with a small error(below 5%)and a low root mean square error(RMSE)(around 1.5),which was more superior and robust than the other state-of-the-art methods.

关键词： Remaining useful life(RUL) Bidirectional long short-term memory(BLSTM) Data-driven approach Metal forming

Influence of Nd^(3+) concentration on mid-infrared emission in PbF_(2) crystal co-doped with Ho^(3+) and Nd^(3+) ions

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Journal of Rare Earths 2024年第3期42卷 479-487,I0002页

作者： yan Chen Juncheng Tan Peixiong Zhang Weibi zheng lin li lianhan Zhang zhen li Yin Hang zhenqiang Chen Department of Optoelectronic Engineering Jinan UniversityGuangzhou510632China Guangdong Provincial Engineering Research Centerof Crystal and Laser Technology.Guangzhou 510632China Research Center of Laser Crystal Key Laboratory of High Power Laser MaterialsShanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai201800China

A promising series of Ho_(y)Nd_(x)Pb_((1-x-y))F_2(x = 0, 0.01, 0.02, 0.03, 0.04;y = 0.02) crystals was grown by the Bridgman method. The influence of the Nd^(3+)ions concentration on mid-infrared(~2.0, ~2.9 and ~3.9 μm)fluorescence emissions of Ho^(3+)ions in the PbF_(2) crystal excited by 808 nm laser diode was investigated in this work. The energy transfer mechanism between Nd^(3+)ions and Ho~(3+)ions under different concentrations of the Nd^(3+)ions was systematically analyzed. The results show that the Nd^(3+)ions have good sensitization and deactivation effect on the Ho^(3+)ions to stimulate the mid-infrared fluorescence emissions. The experimental analysis proves that the sensitization efficiency of the Nd^(3+)ions is relatively stable at around 93.45% with varying Nd^(3+)-doping concentrations. Concentration dependence studies indicate that the concentration of the Nd^(3+)ions has significant influence on mid-infrared *** the doping concentration of the Nd^(3+)ions is up to 2.0 at%, the intensity of ~2.0, ~2.9 and ~3.9 μm emissions all reach the maximum. The output characteristics of a 3.9 μm laser are simulated, and it is found that with the increase of the Nd^(3+)-doping concentration, the peak power, pulse width, and peak energy all meet the trend of first increasing and then decreasing, and Ho_(0.02)Nd_(0.02)Pb_(0.96)F_(2) crystal displays the best performance. All the results show that the Nd^(3+)/Ho^(3+)co-doped PbF_(2) crystals might act as a useful optical medium for mid-infrared laser applications.

关键词： Crystal growth Mid-infrared PbF_(2) Rare earth ions

TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 195-209页

作者： yan Zhang zhen-zhen Wang An-Qi Han Ming-Ya yang li-Xin Zhu Fa-Ming Pan Yong Wang Department of General Surgery The Second Hospital of Anhui Medical UniversityHefei 230601China Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China The Key Laboratory of Major Autoimmune Diseases Anhui Medical UniversityHefei 230032China

Background:As reported,γ-tubulin(TuBG1)is related to the occurrence and development of various types of malignant ***,its role in hepatocellular cancer(HCC)is not *** present study was to investigate the relationship between TuBG1 and clinical parameters and survival in HCC ***:The correlation between TuBG1 and clinical parameters and survival in HCC patients was ex-plored by bioinformatics *** was used for the *** molecular function of TuBG1 was measured using colony formation,scratch assay,trans-well assay and flow *** set enrichment analysis(GSEA)was used to pick up the enriched pathways,followed by investigating the target pathways using Western *** tumor-immune system interactions and drug bank database(TISIDB)was used to evaluate TuBG1 and *** on the TuBG1-related immune genes,a prognostic model was constructed and was further validated internally and ***:The bioinformatic analysis found high expressed TuBG1 in HCC tissue,which was confirmed us-ing immunohistochemistry and Western *** silencing the TuBG1 in HCC cell lines,more G1 arrested cells were found,cell proliferation and invasion were inhibited,and apoptosis was ***,the silence of TuBG1 increased the expressions of Ataxia-Telangiectasia and Rad-3(ATR),phospho-P38 mitogen-activated protein kinase(P-P38MAPK),phospho-P53(P-P53),B-cell lymphoma-2 associated X protein(Bax),cleaved caspase 3 and P21;decreased the expressions of B-cell lymphoma-2(Bcl-2),cyclin D1,cyclin E2,cyclin-dependent kinase 2(CDK2)and *** correlation analysis of immunohistochemistry and clinical parameters and survival data revealed that TuBG1 was negatively corre-lated with the overall *** constructed immune prognosis model could effectively evaluate the ***:The increased expression of TuBG1 in HCC is associated with poor prognosis,which might be involved in the oc

关键词： TuBG1 Hepatocellular carcinoma Apoptosis Cell cycling Immunomodulators

Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

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Bone Research 2023年第4期11卷 819-833页

作者： Ri-Xu liu Rong-He Gu Zhi-Peng li Zhi-Quan Hao Qin-Xiao Hu zhen-yan li Xiao-Gang Wang Wang Tang Xiao-He Wang Yu-Kai Zeng zhen-Wei li Qiu Dong Xiao-Feng Zhu Di Chen Ke-Wei Zhao Rong-Hua Zhang zhen-Gang Zha Huan-Tian Zhang Department of Bone and Joint Surgery the First Affiliated Hospital of Jinan UniversityKey Laboratory of Regenerative Medicine of Ministry of EducationJinan UniversityGuangzhou 510630 GuangdongChina Department of Orthopedic and Spine Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120 GuangdongChina School of Basic Medical Sciences of Guangxi Medical University the Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530022 GuangxiChina Key Laboratory of Big Data-Based Precision Medicine School of Engineering MedicineBeihang University100191 BeijingChina Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization College of PharmacyJinan UniversityGuangzhou 510630 GuangdongChina Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences518005 ShenzhenChina Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese Medicine510375 GuangzhouChina

Despite the diverse roles of tripartite motif(Trim)-containing proteins in the regulation of autophagy,the innate immune response,and cell differentiation,their roles in skeletal diseases are largely *** recently demonstrated that Trim21 plays a crucial role in regulating osteoblast(OB)differentiation in ***,how Trim21 contributes to skeletal degenerative disorders,including osteoporosis,remains ***,human and mouse bone specimens were evaluated,and the results showed that Trim21 expression was significantly elevated in bone tissues obtained from osteoporosis ***,we found that global knockout of the Trim21 gene(KO,Trim2^(1-/-))resulted in higher bone mass compared to that of the control *** further demonstrated that loss of Trim21 promoted bone formation by enhancing the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)and elevating the activity of OBs;moreover,Trim21 depletion suppressed osteoclast(OC)formation of RAW264.7 *** addition,the differentiation of OCs from bone marrow-derived macrophages(BMMs)isolated from Trim21^(-/-)and Ctsk-cre;Trim21^(f/f)mice was largely compromised compared to that of the littermate control ***,YAP1/β-catenin signaling was identified and demonstrated to be required for the Trim21-mediated osteogenic differentiation of *** importantly,the loss of Trim21 prevented ovariectomy(OVX)-and lipopolysaccharide(LPS)-induced bone loss in vivo by orchestrating the coupling of OBs and OCs through YAP1 *** current study demonstrated that Trim21 is crucial for regulating OB-mediated bone formation and OC-mediated bone resorption,thereby providing a basis for exploring Trim21 as a novel dual-targeting approach for treating osteoporosis and pathological bone loss.

关键词： YAP1 osteoporosis depletion

Sobolev Mapping of the Bergman Projections on Generalized Hartogs Triangles

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Acta Mathematica Sinica,English Series 2024年第2期40卷 451-466页

作者： Hong yan liU zhen Han TU School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we investigate Sobolev mapping properties of the Bergman *** domain we focus on is defined byΩm/n:={(z,w)∈C^(1+N):|w1|<|z|m1/n1<1,…|wN|<|z|/m_(N)/n_(N)<1},where m=(m1,…mN)∈(Z^(+))^(N),n=(n1,…nN)∈(Z^(+))N,N∈Z^(+).Sobolev irregularity of the Bergman projections on 2 is *** also prove some Sobolev regularity results of the Bergman projections onΩm/n for m=(1,…1).

关键词： Bergman projections generalized Hartogs triangles Sobolev spaces

New therapy for oral ulcer:Evodia rutaecarpa patch combined with acupoint application

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Traditional Medicine Research 2023年第9期8卷 23-33页

作者： yan-li zhen Jian-Peng Qin Yu-Fen li Jian Zhang Xiao-Hui Yu Ji li Dong-Kai Wang Department of Pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

Background:Oral ulcer is the most common and easily recurrent disease in stomatology,which influence the patients’communication,normal dietary,and *** rutaecarpa(ER)is a traditional Chinese herbal medicine recorded in ancient Chinese medical books,which has a medicinal history of more than 2,000 ***,the application of ER at plantar Yongquan point(KI1)is effective in the treatment of oral *** purpose of this study was to combine the modern transdermal drug delivery system with traditional Chinese medicine to develop the transdermal absorption patch of ER and apply it to the treatment of oral ulcer at Yongquan point of ***:Firstly,the medicinal materials of ER were extracted and the extracted materials were prepared into dispersed ER *** formulation and preparation process were screened by orthogonal design method and single factor investigation *** adhesive and transdermal properties of the patch were used as the evaluation index of the ***,Wistar rats were used as experimental animals to establish a rat model of mouth *** rats were randomly divided into normal group,model group(A),model group(B),low dose group,medium dose group and high dose *** efficacy of ER on rat’s oral ulcer model was evaluated through three aspect such as apparent index,pathological index and biochemical ***:The patch had suitable adhesion and good skin penetration,which was an effective treatment for oral *** vivo pharmacodynamic studies,compared with the normal group,the body mass and food intake of rats in each group after modeling decreased,the amount of drinking water increased,the tissue structure of oral mucosa was damaged,and the levels of inflammatory factors(TNF-α,IL-6)and malondialdehyde increased,the levels of anti-inflammatory factors(IL-10),cell growth factor(epidermal growth factor,TGF-β_(1))and superoxide dismutase *** with the model group,the body weight and food

关键词： oral ulcer Evodia rutaecarpa patch traditional Chinese medicine acupoint application pharmacodynamic

An Overview on the Composition and Age of Upper Crust of Proto-Tethyan Lajishan Intra-oceanic Arc,NE Tibet Plateau

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 285-302页

作者： FU Changlei HE Xiaohu yan zhen Jonathan CAITCHISON XIAO Wenjiao WANG Bingzhang li Wufu li Yusen SinoProbe Laboratory Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China Key Laboratory of the Northern Qinghai–Tibet Plateau Geological Processes and Mineral Resources Qinghai Geological Survey InstituteXining 810012China Department of Geology School of Earth SciencesYunnan UniversityKunming 650091China School of Earth and Environmental Sciences University of QueenslandBrisbane 4072Australia Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth Science and Resources China University of GeosciencesBeijing 100083China

Identification and anatomy of oceanic arcs within ancient orogenic belt are significant for better understanding the tectonic framework and closure process of paleo-ocean *** article summarizes the geological,geochemical,and geochronological characteristics of upper crust of Proto-Tethyan Lajishan intra-oceanic arc and provides new data to constrain the subduction evolution of the South Qilian *** intra-oceanic arc volcanic rocks,including intermediate-mafic lava,breccia,tuff,and minor felsic rocks,are distributed along southern part of the Lajishan ophiolite *** and isotopic compositions indicate that the intermediate-mafic lava were originated from depleted mantle contaminated by sediment melts or hydrous fluids,whereas the felsic rocks were likely generated by partial melting of juvenile mafic crust in intra-oceanic arc *** from felsic rocks yield consistent and concordant ages ranging from 506 to 523 Ma,suggesting these volcanic rocks represent the relicts of upper crust of the Cambrian intra-oceanic *** with the Cambrian forearc ophiolite and accretionary complex,we suggest that the Cambrian intra-oceanic arc in the Lajishan ophiolite belt is belonging to the intra-oceanic arc system which was generated by south-directed subduction in the South Qilian Ocean at a relatively short interval between approximately 530 and 480 Ma.

关键词： volcanic rocks intra-oceanic arc U-Pb age Lajishan ophiolite belt South Qilian Ocean Proto-Tethyan realm

Effects of conductive agent type on lithium extraction from salt lake brine with liFePO_(4) electrodes

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 678-687页

作者： zhen Zhang Pan Luo yan Zhang Yuhan Wang li liao Bo Yu Mingshan Wang Junchen Chen Bingshu Guo Xing li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Energy Storage Research Institute Southwest Petroleum UniversityChengdu 610500China

Electrochemical lithium extraction from salt lakes is an effective strategy for obtaining lithium at a low ***,the elevated Mg:li ratio and the presence of numerous coexisting ions in salt lake brines give rise to challenges,such as prolonged lithium extraction periods,diminished lithium extraction efficiency,and considerable environmental *** this work,li FePO4(LFP)served as the electrode material for electrochemical lithium *** conductive network in the LFP electrode was optimized by adjusting the type of conductive *** approach resulted in high lithium extraction efficiency and extended cycle *** the single conductive agent of acetylene black(AB)or multiwalled carbon nanotubes(MWCNTs)was replaced with the mixed conductive agent of AB/MWCNTs,the average diffusion coefficient of li+in the electrode increased from 2.35×10^(-9)or 1.77×10^(-9)to 4.21×10^(-9)cm^(2)·s^(-1).At the current density of 20 mA·g^(-1),the average lithium extraction capacity per gram of LFP electrode increased from 30.36 mg with the single conductive agent(AB)to 35.62 mg with the mixed conductive agent(AB/MWCNTs).When the mixed conductive agent was used,the capacity retention of the electrode after 30 cycles reached 82.9%,which was considerably higher than the capacity retention of 65.8%obtained when the single AB was ***,the electrode with mixed conductive agent of AB/MWCNTs provided good cycling *** the conductive agent content decreased or the loading capacity increased,the electrode containing the mixed conductive agent continued to show excellent electrochemical ***,a self-designed,highly efficient,continuous lithium extraction device was *** electrode utilizing the AB/MWCNT mixed conductive agent maintained excellent adsorption capacity and cycling performance in this *** work provides a new perspective for the electrochemical extraction of lithium using LFP electrodes.

关键词： salt lake brine lithium extraction electrochemical lithium extraction conductive agent extraction efficiency adsorption capacity