检索结果-南通市图书馆

马来酰胺酸-醋酸乙烯酯交替共聚物的光致发光性能及荧光水凝胶的制备

在线全文

学校读者我要写书评

暂无评论

高分子学报 2024年第9期55卷 1155-1164页

作者：郭照琰高易茹越刘振杰张晓红乔金樑中石化(北京)化工研究院有限公司北京100013

马来酸酐-醋酸乙烯酯交替共聚物及其衍生物是一类非共轭光致发光聚合物,在防伪、转光等领域具有很好的应用前景.本研究对自稳定沉淀聚合法制备的马来酸酐-醋酸乙烯酯交替共聚物(PMV)微球进行了酰胺化和酰亚胺化改性,制备出了光致发光的... 详细信息

马来酸酐-醋酸乙烯酯交替共聚物及其衍生物是一类非共轭光致发光聚合物,在防伪、转光等领域具有很好的应用前景.本研究对自稳定沉淀聚合法制备的马来酸酐-醋酸乙烯酯交替共聚物(PMV)微球进行了酰胺化和酰亚胺化改性,制备出了光致发光的水溶性马来酰胺酸-醋酸乙烯酯交替共聚物PMVN.通过对其光致发光性能的研究,发现其在室温和85℃下溶解的溶液及固体呈现出不同颜色及荧光特征,85℃下溶解的溶液及固体还呈现出蓝、红双发射的特性.在此研究结果基础上,成功制备出荧光水凝胶,所制备的光致发光聚合物和荧光水凝胶在疾病诊断、防伪和环境监测等方面具有很好的应用前景.

关键词：马来酸酐-醋酸乙烯酯交替共聚物荧光水凝胶自稳定沉淀聚合发光团簇蓝/红双发射聚集诱导发光

14种剑蕨属植物的孢子形态特征及其系统分类学意义

在线全文

学校读者我要写书评

暂无评论

植物科学学报 2016年第5期34卷 669-679页

作者：周喜乐严岳鸿赵国华刘红梅上海辰山植物园中国科学院上海辰山植物科学研究中心上海201602 深圳市热带亚热带植物多样性重点实验室深圳市中国科学院仙湖植物园广东深圳518004

利用扫描电子显微镜对水龙骨科(Polypodiaceae)剑蕨属(Loxogramme)14种植物的孢子形态和表面纹饰进行了观察。结果显示:剑蕨属的孢子具有单裂缝和三裂缝两种类型,个别物种具有中间过渡类型。剑蕨属的孢子纹饰为蠕虫状或浅波纹状。经比... 详细信息

利用扫描电子显微镜对水龙骨科(Polypodiaceae)剑蕨属(Loxogramme)14种植物的孢子形态和表面纹饰进行了观察。结果显示:剑蕨属的孢子具有单裂缝和三裂缝两种类型,个别物种具有中间过渡类型。剑蕨属的孢子纹饰为蠕虫状或浅波纹状。经比较发现,具三裂缝孢子的物种通常植株较小,而具单裂缝的种类则通常植株较大。从进化的角度来看,三裂缝孢子为原始类型,单裂缝孢子为进化类型,因而从孢子形态特征的角度支持剑蕨属为水龙骨科基部类群。

关键词：水龙骨科孢子形态扫描电镜分类学

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： yan Li Peng Hao Hongmei Duan Fei Hao Wen zhao Yudan Gao zhaoyang yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Multifunctional Nacre-Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template-Assisted In-Situ Polypyrrole Assembly

在线全文

学校读者我要写书评

暂无评论

NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Xiong, Jinhua zhao, Xu Liu, Zonglin Chen, He yan, Qian Lian, Huanxin Chen, Yunxiang Peng, Qingyu He, Xiaodong Harbin Inst Technol Ctr Composite Mat & Struct Natl Key Lab Sci & Technol Adv Composites Special Harbin 150080 Peoples R China

The large-scale, high-strength, super-tough, and multifunctional nacre-like heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite papers were fabricated using the in-situ assembly of PPy onto the HA/MXene hydrogel *** "brick-and-mortar" layered structure and abundant hydrogen-bonding interactions among MXene, PPy, and HA respond cooperatively to external stress and effectively increase the mechanical properties of HMP nanocomposite *** templating effect from HA/MXene was utilized to guide the assembly of conducting polymers, leading to high electrical conductivity and outstanding electromagnetic interference shielding performance. Robust, ultra-flexible, and multifunctional MXene-based electromagnetic interference (EMI) shielding nanocomposite films exhibit enormous potential for applications in artificial intelligence, wireless telecommunication, and portable/wearable electronic equipment. In this work, a nacre-inspired multifunctional heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper with large-scale, high strength, super toughness, and excellent tolerance to complex conditions is fabricated through the strategy of HA/MXene hydrogel template-assisted in-situ assembly of PPy. Benefiting from the "brick-and-mortar" layered structure and the strong hydrogen-bonding interactions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa), outstanding toughness (57.6 MJ m-3), exceptional foldability, and structural stability against ultrasonication. By using the template effect of HA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly, the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dB at an ultra-thin thickness (25.4 mu m) and a high specific EMI SE of 17,204.7 dB cm2 g-1. In addit

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole Multifunctionality

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

参数曲面五轴加工轨迹优化方法

组合机床与自动化加工技术 2014年第12期 1-4,9页

作者：赵延国赵吉宾邹强金海洋刘广保中国科学院沈阳自动化研究所沈阳110016 中国科学院大学北京100049

非线性误差是五轴加工中加工误差的重要来源,不可避免。针对五轴加工中的非线性误差问题,分析了非线性误差产生的原因,提出了一种减小机床非线性误差的轨迹优化算法。该方法直接计算各实际刀轨与工件参数曲面之间的误差,找出非线性误差... 详细信息

非线性误差是五轴加工中加工误差的重要来源,不可避免。针对五轴加工中的非线性误差问题,分析了非线性误差产生的原因,提出了一种减小机床非线性误差的轨迹优化算法。该方法直接计算各实际刀轨与工件参数曲面之间的误差,找出非线性误差过大的刀位,通过递归插入新刀位来减小非线性误差,直到满足精度。插入刀位点时,结合曲面凹凸性及刀具路径的弦弧逼近误差,同时将过切、欠切情况考虑在内。仿真分析结果显示该方法能避免插入不必要的刀位点,可显著减小非线性误差。

关键词：五轴加工非线性误差插补参数曲面

低强度超声联合载HSV_1-TK/GCV自杀基因阳离子微泡对高强度聚焦超声不完全消融后残余肝癌细胞的抑制作用

在线全文

学校读者我要写书评

暂无评论

中国介入影像与治疗学 2017年第1期14卷 45-49页

作者：修阳阳曾燕赵建农郭大静王志刚李发琪重庆医科大学附属第二医院放射科重庆400010 重庆医科大学超声分子影像学研究所重庆400010 超声医学工程重庆市市级重点实验室重庆400010

目的探讨载单纯疱疹病毒Ⅰ型胸苷激酶/更昔洛韦(HSV1-TK/GCV)自杀基因的阳离子微泡联合低强度超声对高强度聚焦超声(HIFU)辐照后残留肝癌SMCC-7721细胞的抑制作用。方法以低功率HIFU辐照肝癌SMCC-7721细胞,选取最佳残存细胞亚系并稳定... 详细信息

目的探讨载单纯疱疹病毒Ⅰ型胸苷激酶/更昔洛韦(HSV1-TK/GCV)自杀基因的阳离子微泡联合低强度超声对高强度聚焦超声(HIFU)辐照后残留肝癌SMCC-7721细胞的抑制作用。方法以低功率HIFU辐照肝癌SMCC-7721细胞,选取最佳残存细胞亚系并稳定培养。通过低强度超声辐照载TK基因的阳离子微泡转染细胞。分为对照组(残余癌)、残余癌+超声+TK/GCV组、残余癌+微泡+TK/GCV组及残余癌+微泡+超声+TK/GCV组。以Western Blot法检测TK基因是否成功转入并稳定表达。采用流式细胞仪观察并检测基因转染效率。筛选适宜前药GCV浓度,并检测各组别相同条件下细胞存活率。以流式细胞仪检测细胞周期及凋亡率。结果HIFU功率为5 W,频率为10.20 MHz,持续辐照40s,可获得残癌稳定模型。前药GCV的最适浓度为100μg/ml。相同条件下残余癌+微泡+超声+TK/GCV组癌细胞存活率最低(P<0.05),仅为(43.16±3.18)%,且TK蛋白的表达明显高于其他各组(P均<0.05)。结论低强度超声联合载HSV1-TK/GCV自杀基因阳离子微泡对高强度聚焦超声不完全消融肝癌细胞有明显抑制作用。

关键词：超声学微泡基因治疗癌肝细胞

五子衍宗丸提高大鼠睾丸支持细胞抵抗热应激能力的基因表达谱分析

在线全文

学校读者我要写书评

暂无评论

北京中医药大学学报 2017年第6期40卷 471-476页

作者：曹 赵俊云郭健李悦胡素芹简郭血骄北京中医药大学北京100029

目的采用全基因组表达谱芯片数据分析五子衍宗丸提高大鼠睾丸支持细胞抵抗热应激能力的作用机制。方法将原代培养的睾丸支持细胞分为五子衍宗丸组、正常组和模型组,分别给予五子衍宗丸溶液和等体积的PBS,培养24 h后,五子衍宗丸组和模型... 详细信息

目的采用全基因组表达谱芯片数据分析五子衍宗丸提高大鼠睾丸支持细胞抵抗热应激能力的作用机制。方法将原代培养的睾丸支持细胞分为五子衍宗丸组、正常组和模型组,分别给予五子衍宗丸溶液和等体积的PBS,培养24 h后,五子衍宗丸组和模型组给予43℃水浴15 min,正常组给予37℃水浴15 min处理。分别提取3组细胞总RNA,通过基因芯片技术进行数据分析。结果在支持细胞全基因组表达谱中,五子衍宗丸组与模型组比较共有1 203个差异表达基因,其中下调基因有697个,上调基因506个;正常组与模型组比较共有473个差异表达基因,其中上调基因168个,下调基因305个;与模型组相比,五子衍宗丸组和正常组共同下调的基因中RGD1305298、Trpt1、Dll3、Abi3和Ppp1r12b共5个基因表达差异明显,共同上调的基因中Dusp7表达差异明显,这些差异表达基因涉及到细胞周期、细胞凋亡、细胞代谢、细胞黏附等分子功能及Notch信号通路、细胞骨架调节、MAPK信号通路和紧密连接等通路。结论五子衍宗丸可能是通过维持支持细胞间紧密连接,抑制支持细胞凋亡,促进支持细胞分化成熟来提高睾丸支持细胞热应激的能力。

关键词：五子衍宗丸基因表达谱支持细胞热应激大鼠

磷石膏转化法制硫酸钾第一阶段反应条件的研究

在线全文

学校读者我要写书评

暂无评论

沈阳化工学院学报 2001年第2期15卷 85-88页

作者：赵长伟赵妍郭瓦力沈阳化工学院辽宁沈阳110021

通过正交试验对磷石膏转化法生产硫酸钾第一阶段反应过程中的影响因素进行研究 ,通过极差分析 ,确定过程的适宜工艺条件 :反应温度 5 0℃ ,反应时间 2 0min ,固液比 0 .7,配料比(SO4 2 - ∶2NH4 + ) =1∶1 .

关键词：磷石膏转化法正交法硫酸钾反应条件

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species