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Effectiveness of Tenofovir Alafenamide in Chronic Hepatitis B Patients with Normal Alanine Aminotransferase and Positive Hepatitis B Virus DNA

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 112-119页

作者： Wen-Kang Gao yan-yun shu Yue Chen yan Ai Xiao-Qian yang Fan Du Jin Ye Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background and Aims:With an increasing understanding of hepatitis B,the antiviral indications have been broadening *** evaluate the effectiveness of tenofovir alafena-mide(TAF)in chronic hepatitis B(CHB)patients with normal alanine aminotransferase(ALT)and detectable hepatitis B virus(HBV)DNA,those who are ineligible for broader anti-viral criteria from the Chinese CHB prevention guide(2019).Methods:A total of 117 patients were recruited and their data were collected from paper or electronic medical *** DNA and liver function were measured at baseline and throughout the 24-week *** effectiveness end-point was complete virological *** safety endpoint was the first occurrence of any clinical adverse event during the ***:Among the 117 patients,45 had normal ALT as well as detectable HBV DNA and they were not recommended for antiviral therapy according to Chinese Guidelines(2019).After TAF antiviral therapy,the rates of patients who achieved HBV DNA<20 IU/mL at 4,12 and 24 weeks were 77.1%,96.7%and 96.8%*** them,the undetectable rates of HBV DNA in patients with low baseline viral load at 4,12 and 24 weeks were 92.3%,100%and 100%,while the rates of those with high baseline viral load were 68.2%,94.1%and 94.4%.Compared with 71.4%,94.4%and 94.7%in the high baseline group,the undetectable rates of HBV DNA at 4,12 and 24 weeks in the low baseline liver stiffness group were 85.7%,100%and 100%.There was no statistical significance among the above ***:CHB patients who had normal ALT and detectable HBV DNA and did not meet“CHB prevention guide(2019)”,could achieve complete virological response in 24 weeks after antiviral treatment by TAF.

关键词： Chronic hepatitis B virus Tenofovir alafenamide Effectiveness Observational study

Rifaximin Prevents Intestinal Barrier Dysfunction and Alleviates Liver Injury in MCT-induced HSOS Mice

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Current Medical Science 2023年第6期43卷 1183-1194页

作者： yan-yun shu Li-lin HU Ling yanG Hui-kuan CHU Jin YE Yu JIN Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Ultrasound The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China

Objective Rifaximin is an effective component of treatment strategies for liver and intestinal ***,the efficacy of rifaximin in hepatic sinusoidal obstruction syndrome(HSOS)has not been *** present study aimed to investigate the efficacy and mechanism of rifaximin in *** An HSOS model was established in mice through the administration of monocrotaline(MCT,800 mg/kg),and part of the HSOS mice were intragastrically administered with ***,the efficacy of rifaximin in HSOS was evaluated based on the liver pathological findings,liver proinflammatory cytokines,and alanine aminotransferase and aspartate aminotransferase *** Ussing chamber was used to evaluate the intestinal permeability,and tight junction(TJ)proteins were measured by Western blotting and real-time polymerase chain reaction to evaluate the intestinal barrier ***,the serum proinflammatory cytokine levels were evaluated by enzyme-linked immunosorbent ***,an in vitro experiment was performed to determine the relationship between rifaximin and TJ *** Rifaximin effectively alleviated the MCT-induced HSOS liver injury,suppressed the expression of liver proinflammatory cytokines,and reduced the serum levels of tumor necrosis factor-alpha and ***,rifaximin reduced the intestinal permeability,improved the intestinal barrier integrity,and promoted the expression of TJ *** The results revealed that the intestinal barrier integrity was destroyed in MCT-induced *** significant alleviation of MCT-induced HSOS induced by rifaximin might be correlated to the repairment of intestinal barrier integrity via the regulation of the TJ protein expression.

关键词： rifaximin hepatic sinusoidal obstruction syndrome intestinal barrier tight junction proteins inflammation

Pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes in mice

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Acta Pharmacologica Sinica 2005年第2期26卷 250-256页

作者： Yong JIN,Jun LI~2,Long-fu RONG,Xiong-wen L(?),yan HUANG,shu-yun XUInstitute of Clinical Pharmacology,School of Pharmacy,Anhui Medical University,Hefei 230032,China Institute of Clinical Pharmacology School of Pharmacy Anhui Medical University Hefei China

Aim:To study the pharmacokinetics and tissue distribution of 5-fluorouracil en-capsulated by galactosylceramide liposomes(5-Fu-GCL)in ***:Theconcentration of 5-fluorouracil(5-Fu)in serum was detected by high performanceliquid chromatography after 5-Fu-GCL(80,40,20 mg/kg)and free 5-Fu(40mg/kg)were injected intravenously into *** tissue distribution of 5-Fu-GCL(40mg/kg)and free 5-Fu(40mg/kg)was investigated,and concentration-timeprofile of the two preparations in the liver were *** were analyzed by3p97 ***:Serum concentration-time curves of 5-Fu-GCL and free5-Fu conformed to one compartment model of first order absorption.5-Fu-GCLat 80,40,and 20 mg/kg had T1/2Keof 25.8±4.2,27.3±4.4,and 28.2±5.6 min;C0of24.9±4.9,17.7±3.6,and 11.5±2.7 mg/L;and AUC of 990.0±45.2,622.5±38.3,and 340.4±25.6 ***.L-1,*** contrast free 5-Fu at 40 kg/mg hadT1/2Keof 15.8±2.2min,C0of 35.8±6.2mg/L,AUC of 639.0±35.9 *** distribution of 5-Fu-GCL in the liver and immune organs was significantlyincreased,while in heart and kidney it was remarkably *** AUC of 5-Fu-GCL in the liver was 3 times higher than that of free ***:Thepharmacokinetics and tissue distribution of 5-Fu-GCL appears to be linear-re-lated and dose-dependent,and exhibits sustained-release and hepatic targetcharacteristics.

关键词： 5-fluorouracil galactosylceramide liposomes pharmacokinetics

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-yun Fang Chengyihan Gu Yinghan Chen Wencheng yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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特低渗透油藏窜流通道识别及其分布规律研究——以鄂尔多斯盆地西缘吴起油田某区块为例

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内蒙古石油化工 2022年第10期48卷 114-116页

作者：云彦舒延安职业技术学院陕西延安716000

窜流通道的识别一直是改善水驱油藏开发效果和提高采收率的关键。尤其对于特低渗透油藏,微裂缝发育且非均质强,窜流通道的分级识别和预警判断难度大。通过以鄂尔多斯盆地西缘吴起油田延长组长6油层为例,优选特低渗透油藏水驱关键影响因... 详细信息

窜流通道的识别一直是改善水驱油藏开发效果和提高采收率的关键。尤其对于特低渗透油藏,微裂缝发育且非均质强,窜流通道的分级识别和预警判断难度大。通过以鄂尔多斯盆地西缘吴起油田延长组长6油层为例,优选特低渗透油藏水驱关键影响因素和表现特征等预警评判指标,建立评价体系,充分结合该区块生产状况和数学分析进行权重分配赋值,运用模糊综合评判法,建立了窜流通道的预警识别模型,同时通过动静结合方法对模型可靠性进行了验证,结果表明,该方法对窜流通道进行了准确定位,为特低渗透油藏的有效开发调整方案制定提供了依据和保障。

关键词：特低渗透油藏窜流通道影响因素表现特征

非齐型空间上Fefferman-Stein加权向量值极大不等式

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北京理工大学学报 2009年第7期29卷 655-658页

作者：王杰颜书云郭锐陈爱华阴立波北京理工大学理学院北京100081

应用***的结果及对偶理论,将***和***的Fefferman-Stein加权向量值极大不等式从欧氏空间Rn推广到非齐型空间上.该文的证明思想对于欧氏空间上的向量值极大不等式的证明同样适用.

关键词：非齐型空间极大不等式加权向量值插值定理

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盐分胁迫对紫穗槐幼苗生理生化特性的影响

草业学报 2011年第3期20卷 84-90页

作者：邹丽娜周志宇颜淑云秦彧兰州大学草地农业科技学院甘肃兰州730020

本研究通过人为控制土壤盐分梯度,以盆栽当年生紫穗槐幼苗为材料,研究不同盐分条件下紫穗槐叶片光合速率、酶活性、有机渗透调节物质等生理特性,探讨紫穗槐耐盐机制。结果表明,随盐分胁迫程度的加剧,紫穗槐幼苗的净光合速率(Pn)、蒸腾速... 详细信息

本研究通过人为控制土壤盐分梯度,以盆栽当年生紫穗槐幼苗为材料,研究不同盐分条件下紫穗槐叶片光合速率、酶活性、有机渗透调节物质等生理特性,探讨紫穗槐耐盐机制。结果表明,随盐分胁迫程度的加剧,紫穗槐幼苗的净光合速率(Pn)、蒸腾速率(Tr)、气孔导度(Gs)、K+含量逐渐下降,超氧化物歧化酶(SOD)活性、过氧化物歧化酶(POD)活性、Na+、可溶性糖和游离脯氨酸含量则显著上升;叶绿素a、叶绿素b、叶绿素总量、类胡萝卜素含量随土壤盐分浓度的增加逐渐增大,而叶绿素a与叶绿素b含量之比无显著变化。以上生理指标反映出紫穗槐幼苗对盐渍环境的适应性变化,是其抵御逆境的一种积极调节机制。

关键词：紫穗槐盐胁迫生理生化特性

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干旱胁迫对紫穗槐幼苗生理生化特性的影响

干旱区研究 2011年第1期28卷 139-145页

作者：颜淑云周志宇邹丽娜秦彧兰州大学草地农业科技学院甘肃兰州730020

为揭示紫穗槐幼苗在干旱胁迫下的生理生态特性和适应性,以盆栽当年生紫穗槐幼苗为材料,通过人为控制土壤含水量,研究干旱胁迫对其生理生化指标的影响。结果表明:随着干旱胁迫程度的加剧,幼苗的净光合速率(Pn)、蒸腾速率(Tr)、气孔导度(... 详细信息

为揭示紫穗槐幼苗在干旱胁迫下的生理生态特性和适应性,以盆栽当年生紫穗槐幼苗为材料,通过人为控制土壤含水量,研究干旱胁迫对其生理生化指标的影响。结果表明:随着干旱胁迫程度的加剧,幼苗的净光合速率(Pn)、蒸腾速率(Tr)、气孔导度(Gs)逐渐下降,水分饱和亏缺(WSD)、水分利用效率(WUE)、超氧化物歧化酶(SOD)活性、过氧化物歧化酶(POD)活性、K含量、可溶性糖和游离脯氨酸含量则显著上升;叶绿素a、叶绿素b、叶绿素总量、类胡萝卜素含量随着土壤含水量的降低逐渐增大,而叶绿素a/叶绿素b无显著变化。这些生理指标反映出幼苗对干旱环境的适应性变化,是其抵御逆境的一种积极调节机制。

关键词：紫穗槐(Amorpha fruticosa) 干旱胁迫土壤含水量抗旱性

慢性HBV感染不确定期患者的临床治疗现状及展望

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世界华人消化杂志 2022年第10期30卷 436-443页

作者：陈阅高文康舒艳芸叶进华中科技大学同济医学院附属协和医院消化内科湖北省武汉市430022

慢性乙型肝炎病毒(chronic hepatitis B virus,HBV)感染的自然病程通常分为4个阶段:免疫耐受期、乙肝e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎(chronic Hepatitis B,CHB)(即免疫清除期)、免疫控制期、HBeAg阴性CHB(即再活动期).根据HBeAg、乙肝病毒脱氧核糖核酸(HBV deoxyribonucleic acid,HBV DNA)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)和肝脏组织学表现,将不适合上述任何一个阶段的不确定期患者分为以下四组:(1)免疫耐受期相关不确定期:其余指标符合免疫耐受期,但HBV DNA2×10^(3)IU/mL或有显著炎症和纤维化;(4)再活动期相关不确定期:其余指标符合再活动期,但HBV DNA<2×10^(3)IU/mL或ALT 1-2 ULN.据统计我国约有7000万人感染了慢性HBV,其中约有2000-3000万是CHB患者.此外我国肝硬化和肝细胞癌(hepatocellular carcinoma,HCC)患者中,由HBV感染引起的比例分别为77%和84%.慢性HBV感染严重威胁着人民的生命健康并给国家医疗卫生体系带来沉重的经济负担.虽然现有指南建议动态监测这部分不确定期患者血清ALT和HBV DNA水平并评估肝脏组织学,但是否对这部分患者进行抗病毒治疗仍存有争议.本文主要介绍了CHB免疫控制期及与其相关不确定期患者的临床治疗现状,和对这部分患者进行抗病毒治疗的展望.

关键词：慢性乙型肝炎免疫控制期不确定期抗病毒治疗