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Associations of serum D-dimer and glycosylated hemoglobin levels with third-trimester fetal growth restriction in gestational diabetes mellitus

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World Journal of Diabetes 2024年第5期15卷 914-922页

作者： ying Zhang Teng Li Chao-yan Yue yun Liu Department of Laboratory Medicine Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Interventional Radiology The People’s Hospital of Weifang CityWeifang 261041Shandong ProvinceChina Department of Hematology The People’s Hospital of Weifang CityWeifang 261041Shandong ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)is a special type of diabetes that commonly occurs in women during pregnancy and involves impaired glucose tolerance and abnormal glucose metabolism;GDM is diagnosed for the first time during pregnancy and can affect fetal growth and *** To investigate the associations of serum D-dimer(D-D)and glycosylated hemoglobin(HbA1c)levels with third-trimester fetal growth restriction(FGR)in GDM *** The clinical data of 164 pregnant women who were diagnosed with GDM and delivered at the Obstetrics and Gynecology Hospital of Fudan University from January 2021 to January 2023 were analyzed *** these women,63 whose fetuses had FGR were included in the FGR group,and 101 women whose fetuses had normal body weights were included in the normal body weight group(normal group).Fasting venous blood samples were collected from the elbow at 28-30 wk gestation and 1-3 d before delivery to measure serum D-D and HbA1c levels for comparative *** diagnostic value of serum D-D and HbA1c levels for FGR was evaluated by receiver operating characteristic analysis,and the influencing factors of third-trimester FGR in GDM patients were analyzed by logistic *** Serum fasting blood glucose,fasting insulin,D-D and HbA1c levels were significantly greater in the FGR group than in the normal group,while the homeostasis model assessment of insulin resistance values were lower(P<0.05).Regarding the diagnosis of FGR based on serum D-D and HbA1c levels,the areas under the curves(AUCs)were 0.826 and 0.848,the cutoff values were 3.04 mg/L and 5.80%,the sensitivities were 81.0%and 79.4%,and the specificities were 88.1%and 87.1%,*** AUC of serum D-D plus HbA1c levels for diagnosing FGR was 0.928,and the sensitivity and specificity were 84.1%and 91.1%,*** D-D and HbA1c levels were risk factors for third-trimester FGR in GDM patients(P<0.05).CONCLUSION D-D and HbA1c levels can

关键词： Gestational diabetes mellitus D-dimer Hemoglobin Fetal growth restriction Fasting blood glucose

Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu FANG yun yan yanG College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng yan yun Zhou Peichao Zhang Weidong Hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration

Microscale spherical TiO_(2)powder prepared by hydrolysis of TiCl_(4)solution:Synthesis and kinetics

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Particuology 2024年第1期84卷 60-71页

作者： Peiyi yan ying Zhang Shili Zheng School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Key Laboratory of Green Process and Engineering National Engineering Research Center of Green Recycling for Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua617000China

Hydrolysis of TiCl_(4)solution is capable of preparing microscale TiO_(2)*** research studied the synthesis of microscale spherical TiO_(2)powders and the hydrolysis *** effects of the flow field generated by different agitators and baffles in the crystallizer,the initial free acid concentration,the initial equivalent TiO_(2)concentration,and the temperature on the hydrolysis progress and powder morphology were systematically *** results show that the flow field in a crystallizer can significantly affect the morphology and particle size of the powders,and the axial flow can improve the sphericity of the *** increased free HCl and equivalent TiO_(2)concentrations in the pregnant solution inhibit the forward hydrolysis reaction,prolong the time to reach equilibrium,and reduce the *** appropriate temperature matching the compositions of the pregnant solution is crucial for the powder morphology and *** with sizes ranging from around 5 um-40μm can be tuned under controlled flow field,solution compositions,and temperature *** addition,the Cheng and Wunderlich modified Avrami equation was used for the crystallization kinetic *** effects of the free HCl concentration,equivalent TiO_(2)concentration,and hydrolysis temperature are reflected in the reaction rate constant and active nuclei reduction *** the free HCl and equivalent TiO_(2)concentrations will reduce the reaction rate constant and accelerate the deactivation of the active nuclei,thus increasing the final powder size,while increasing the temperature will lead to the opposite results.

关键词： TiCl_(4) Hydrolysis Microscale TiO_(2) Spherical Kinetics

Cascade reaction of 3-formylchromones:Highly selective synthesis of 4-oxo-3-(1H-pyrrol-3-yl)-4H-chromenes

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 94-101页

作者： ying Lv Li Chen Xinghan yun Kun Li Shengjiao yan Key Laboratory of Medicinal Chemistry for Natural Resource(yunnan University) Ministry of EducationSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091China

A novel method for the preparation of highly functionalized 4-oxo-3-(1H-pyrrol-3-yl)-4H-chromenes(OPCMs)from 3-formylchromones andα-isocyanoacetates via an unprecedented three-component[1+1+3]cycloaddition reaction in one pot was *** three-component cascade reaction was enabled by refluxing a mixture of the substrates in 1,4-dioxane in the presence of Ag_(2)CO_(3) as a Lewis acid *** a result,a series of functionalized pyrroles(OPCMs,3),was prepared regioselectively and in high yields(80%-88%)through the formation of three *** protocol can be used in the synthesis of OPCMs rather than through conventional,multi-step reactions and is suitable for both combinatorial and parallel syntheses of pyrroles.

关键词： 4-Oxo-3-(1H-pyrrol-3-yl)-4H-chromenes Three-component Cascade reaction [1+1+3]cycloaddition 3-Formylchromones

Normal sperm head morphometric reference values in fertile Asian males

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Asian Journal of Andrology 2024年第3期26卷 315-320页

作者： Ye-Lin Jia ying-Bi Wu Lin Yu yan Zheng Ting-Ting yang yan-yun Wang Bin Zhou Lin Zhang Fu-Ping Li Laboratory of Andrology West China Second University Hospital Human Sperm BankChengdu 610000China Laboratory of Molecular Translational Medicine Center for Translational MedicineChengdu 610061China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610061China NHC Key Laboratory of Chronobiology West China Second University HospitalSichuan UniversityChengdu 610000China

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive *** are available to analyze sperm head morphology,but they are limited by poor methodology comparability and *** study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads infertile Asian *** automated sperm morphology analysis system captured 23152 stained spermatozoa from confirmed *** these samples,1856 sperm head images were annotated by three experienced laboratory technicians as“normal”.Weemployed 14 novel morphometric features to describe sperm head size(head length,head width,length/width ratio,and girth),shape(ellipse intersection over union,girth intersection over union,short-axis symmetry,and long-axis symmetry),area(head,acrosome,postacrosomal areas,and acrosome area ratio),and degrees of acrosome and nuclear *** straight-forwardmethod for the morphometric analysis of sperm by accurate visual measurements is clinically *** measured parameterspresent valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian *** detailed measurement data will be valuable for interlaboratory comparisons and technician *** vitro fertilizationand andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing malefertilization potential.

关键词： fertile Asian males head morphometric reference value normal spermatozoa

Efficacy of Chinese Medicine Treatment Based on Syndrome Differentiation for Primary Insomnia:A Randomized Placebo Controlled Triple-Blinded Trial

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Chinese Journal of Integrative Medicine 2024年第10期30卷 867-876页

作者： XIONG Zhi-yi LU ying HE Li-yun ZHANG Run-shun ZHOU Xue-zhong LI Peng LIU yan-jiao ZHU Jian-gui yan Shi-yan LIU Bao-yan International Acupuncture and Moxibustion Innovation Institute School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijing100029China Department of Biomedical Data Science Stanford University School of MedicineStanfordCA94305USA Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing100044China Beijing Xicheng District Community Healthcare Center Beijing100120China China Academy of Chinese Medical Sciences Beijing100700China

Objective:To assess efficacy of Chinese medicine(CM)on insomnia considering characteristics of treatment based on syndrome ***:A total of 116 participants aged 18 to 65 years with moderate and severe primary insomnia were randomized to the placebo(n=20)or the CM group(n=96)for a 4-week treatment and a 4-week *** CM clinicians independently prescribed treatments for each patient based on syndromes *** primary outcome was change in total sleep time(TST)from *** endpoints included sleep onset latency(SOL),wake time after sleep onset(WASO),sleep efficiency,Pittsburgh Sleep Quality Index(PSQI)and CM ***:The CM group had an average 0.6 h more(95%confidence interval(CI):0.3–0.9,P<0.001)TST and 34.1%(10.3%–58.0%,P=0.005)more patients beyond 0.5 h TST increment than that of the placebo *** was changed–3.3(–3.8 to–2.7)in the CM group,a–2.0(–3.2 to–0.8,P<0.001)difference from the placebo *** CM symptom score in the CM group decreased–2.0(–3.3 to–0.7,P=0.003)more than the placebo *** and WASO changes were not significantly different between *** analysis of prescriptions by these clinicians revealed blood deficiency and Liver stagnation as the most common *** for these clinicians displayed relative stability,while the herbs *** adverse events were mild and were not related to study ***:CM treatment based on syndrome differentiation can increase TST and improve sleep quality of primary *** is effective and safe for primary *** future studies,the long-term efficacy validation and the exploratory of eutherapeutic clinicians'fixed herb formulas should be addressed.(Registration ***01613183).

关键词： primary insomnia Chinese medicine syndrome differentiation randomized controlled trial

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： ying LUO Fei GUO yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity

Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： ying-yan Wang yun-Qing Zhou Li-Juan Luo Cui-Jin Wang Nan Shen Hao Li Ji-Wen Wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1