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Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： yan-NAN LI yun-HONG XIU yan-JUN TANG JING-LONG CAO WEN-SHUANG HOU AN-QI WANG TIAN-ZHU LI CHENG-HAO JIN Department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina Department of Food Science and Engineering Heilongjiang Bayi Agricultural UniversityDaqingChina Department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals Engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

Experimental study of the elastic scattering of 10Be on 208Pb at the energy of around three times the Coulomb barrier

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Chinese Physics C 2020年第2期44卷 72-79页

作者： Fang-Fang Duan yan-yun yang Dan-yang Pang Bi-Tao Hu Jian-Song Wang Kang Wang Guo yang Valdir Guimarães Peng Ma Shi-Wei Xu Xing-Quan Liu Jun-Bing Ma Zhen Bai Qiang Hu Shu-Ya Jin Xin-Xin Sun Jia-Sheng Yao Hang-Kai Qi Zhi-Yu Sun School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100080China School of Physics and Nuclear Energy Engineering Beihang UniversityBeijing 100191China School of Science Huzhou UniversityHuzhou 313000China Instituto de Física Universidade de Sãn PauloRua do Matão1371Sãn Paulo 05508-090SPBrazil Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China

Elastic scattering of 10Be on a 208Pb target was measured at ELab=127 MeV,which corresponds to three times the Coulomb *** secondary 10Be beam was produced at the Radioactive Ion Beam Line in Lanzhou of the Heavy-Ion Research Facility in *** angular distribution of elastic scattering in the 10 Be+208Pb system shows a typical Fresnel diffraction *** model analysis of the angular distribution was performed using the Woods-Saxon,double-folding and global *** the global potential,different density distributions were *** results indicate that different density distributions for the projectile induce distinct effects in the angular distribution.

关键词： elastic scattering radioactive ion beam angular distribution optical model density distribution

Association between glucose-lowering drugs and circulating insulin antibodies induced by insulin therapy in patients with type 2 diabetes

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World Journal of Diabetes 2024年第7期15卷 1489-1498页

作者： Peng Zhang Qing Jiang Bo Ding Reng-Na yan yun Hu Jian-Hua Ma Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGROUND Insulin antibodies(IAs)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and IAs in patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional,retrospective study included 1863 patients with T2DM who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and IA levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive IAs(IA level>5%),with a mean IA level of 11.06%(10.39%-11.72%).IA levels were positively correlated with high fasting blood glucose(odds ratio=1.069,P<0.001).The proportion of positive IAs was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),P<*** IA levels in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all P<0.05).CONCLUSION Nearly half of patients on insulin therapy have positive IA antibodies,and IA antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower IA levels.

关键词： Insulin antibodies Insulin therapy Glucose-lowering drugs Glargine Type 2 diabetes

On-spot preparation of EDTA solution for the treatment of band keratopathy:a case report

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 767-769页

作者： yan-Ting Li Bin Chen Tian-Hong Wu Bo Jiang yun-Feng Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Suzhou EENT HospitalSuzhou 215000Jiangsu ProvinceChina

Dear Editor,We report a case of band keratopathy who experienced several ocular surgeries,secondary uveitis and glaucoma which eventually led to severe band *** use commonly-used vacuum blood collection tubes with ethylenediaminetetraacetic acid dipotassium salt(EDTA-K2)to prepare chelation solution on-spot to remove the calcium deposits on the corneal *** is proved to be relatively safety,efficacy,cost-effective.

关键词： glaucoma eventually preparation

Boosting rate performance of layered lithium-rich cathode materials by oxygen vacancy induced surface multicomponent integration

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Journal of Energy Chemistry 2024年第5期92卷 250-262页

作者： Youyou Fang Yuefeng Su Jinyang Dong Jiayu Zhao Haoyu Wang yun Lu Bin Zhang Hua yan Feng Wu Lai Chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China Yibin Libode New Materials Co. Ltd.Yibin 64400SichuanChina School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina

The rapid development of electric vehicles and portable energy storage systems demands improvements in the energy density and cost-effectiveness of lithium-ion batteries,a domain in which Lithium-rich layered cathode(LLO)materials inherently ***,these materials face practical challenges,such as low initial Coulombic efficiency,inferior cycle/rate performance,and voltage decline during cycling,which limit practical *** study introduces a surface multi-component integration strategy that incorporates oxygen vacancies into the pristine LLO material Li1.2Mn_(0.6)Ni_(0.2)O_(2).This process involves a brief citric acid treatment followed by calcination,aiming to explore rate-dependent degradation *** induced surface oxygen vacancies can reduce surface oxygen partial pressure and diminish the generation of O_(2)and other highly reactive oxygen species on the surface,thereby facilitating the activation of Li ions trapped in tetrahedral sites while overcoming transport ***,the formation of a spinel-like phase with 3D Li+diffusion channels significantly improves Li^(+)diffusion kinetics and stabilizes the surface *** optimally modified sample boasts a discharge capacity of 299.5 mA h g^(-1)at a 0.1 C and 251.6 mA h g^(-1)at a 1 C during the initial activation cycle,with an impressive capacity of 222.1 mA h g^(-1)at a 5 *** notably,it retained nearly 70%of its capacity after 300 cycles at this elevated *** straightforward,effective,and highly viable modification strategy provides a crucial resolution for overcoming challenges associated with LLO materials,making them more suitable for practical application.

关键词： Lithium-ion battery Layered lithium rich cathode Surface multicomponent integration Rate-dependent degradation and Li^(+) diffusion kinetics

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一种自适应最大拒绝鉴别分析及其鉴别矢量集

模式识别与人工智能 2010年第4期23卷 501-507页

作者：郭志波严云洋杨静宇赵春霞扬州大学信息工程学院扬州225009 南京理工大学计算机科学与技术学院南京210094 淮阴工学院计算机科学与技术学院淮阴223003

针对MRC-Boosting方法中的弱分类器二值化以及鉴别矢量不正交等问题,提出一种自适应最大拒绝鉴别分析(AdaMRDA),进一步提高分类性能.通过已抽取的鉴别特征到期望中心的距离,设计一种自适应权重调整方法,使得后面得到的鉴别矢量更加有利... 详细信息

针对MRC-Boosting方法中的弱分类器二值化以及鉴别矢量不正交等问题,提出一种自适应最大拒绝鉴别分析(AdaMRDA),进一步提高分类性能.通过已抽取的鉴别特征到期望中心的距离,设计一种自适应权重调整方法,使得后面得到的鉴别矢量更加有利于分类,并且给出最佳正交鉴别矢量集的求解方程.最后,通过在2个数据库上的实验证明,AdaMRDA方法在分类性能上明显优于MRC-Boosting方法及相关方法.

关键词：特征抽取最大拒绝分类器(MRC) 线性鉴别分析(LDA) Boosting

Creep property and microstructural evolution of DD11 alloy under high temperature and low stress

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Rare Metals 2024年第2期43卷 810-816页

作者： yan-Fei Liu Jiang-Bo Sha yun-Song Zhao Chen-Guang Liu Yuan-Yuan Guo Jian Zhang Yu-Shi Luo School of Materials Science and Engineering Beihang UniversityBeijing100191China Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing100095China

In this paper,the interrupted and ruptured creep tests were carried out in a novel second generation single crystal superalloy named DD11 at 1100℃/130 *** alloy exhibited typical creep curve including primary,steady,and tertiary three creep *** microstructural evolution at different stages of the creep were analyzed by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The results show that theγ′phases transform into rafted structure at the early stage of the steady creep and keep stable during the steady creep *** the creep goes on,the rafted structure further coarsens and the topological inversion *** addition,at the primary creep,the dislocations mainly move in theγmatrix and pile up in theγ/γ′interface since the matrix channels widen *** formation of the regular interfacial dislocation networks occurs at the early stage of the steady *** the low stress,the dominated deformation mechanism during steady creep stage is the climbing of the〈010〉type edge ***,the effect of the deformation mechanism on creep property was discussed in detail.

关键词： DD11 alloy Creep property Interrupted creep test Rafted structure Deformation mechanism

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基于样本分布相似度的期望分布鉴别分析

模式识别与人工智能 2007年第6期20卷 751-756页

作者：郭志波杨静宇郑宇杰严云洋南京理工大学计算机科学与技术学院

主分量分析(PCA)和线性鉴别分析(LDA)是模式识别领域使用广泛的两种特征抽取方法.本文针对两种方法的不足之处,并从样本分布相似度出发提出一种期望分布鉴别分析(EDDA)方法,抽取到的鉴别特征的总体分布和设定的期望分布最为相近.即通过 ... 详细信息

主分量分析(PCA)和线性鉴别分析(LDA)是模式识别领域使用广泛的两种特征抽取方法.本文针对两种方法的不足之处,并从样本分布相似度出发提出一种期望分布鉴别分析(EDDA)方法,抽取到的鉴别特征的总体分布和设定的期望分布最为相近.即通过 EDDA 得到的投影向量可以抽取出最接近理想分布的鉴别特征.EDDA 在投影向量的求解问题上不存在小样本问题,抽取的鉴别特征维数小,并且整体识别性能得到增强.在 ORL、Yale 人脸库上的实验结果证明本文方法在人脸识别精度上优于 PCA 和 LDA 方法.

关键词：期望分布鉴别分析(EDDA) 线性鉴别分析(LDA) 主分量分析(PCA) 特征抽取

Untargeted metabolomic profiling， nutritional composition and enzyme changes on Bigeye tuna(Thunnus obesus) during cold storage by HPLC-MS coupled with logistic regression

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Food Science and Human Wellness 2024年

作者： Xin-yun Wang Zi-Xuan Zhao Jun yan Jing Xie Shanghai Engineering Research Center of Aquatic Product Processing & Preservation， Shanghai Ocean University The International Peace Maternity and Child Health Hospital， School of Medicine， Shanghai Jiao Tong University National Experimental Teaching Demonstration Center for Food Science and Engineering， Shanghai Ocean University College of Food Science & Technology， Shanghai Ocean University

Bigeye tuna is a protein-rich fish that is susceptible to spoilage during cold storage， however， there is limited information on untargeted metabolomic profiling of bigeye tuna concerning spoilage-associated enzymes and metabolites. This study aimed to investigate how cold storage affects enzyme activities， nutrient composition， tissue microstructures and spoilage metabolites of bigeye tuna. The activities of cathepsin B， H， L increased， while Na+/K+-ATPase and Mg2＋-ATPase decreased， α-glucosidase （AG） and β-1，4-N-acetylglucosaminidase （NAG）， lipase and lipoxygenase first increased and then decreased during cold storage， suggesting that proteins undergo degradation and ATP metabolism occurs at a faster rate during cold storage. Nutrient composition （moisture， protein， and lipid content）， free amino acids， total amino acids decreased， suggesting that the nutritional value of bigeye tuna was reduced. Besides， a logistic regression equation has been established as a food analysis tool and assess the dynamics and correlation of the enzyme of bigeye tuna during cold storage. Based on untargeted metabolomic profiling analysis， a total of 484 metabolites were identified as significantly differential metabolites in the bigeye tuna contained several spoilage metabolites involved in lipid metabolism （1-Acyl-sn-glycero-3phosphocholine， Glycerophosphocholine， Choline phosphate）， amino acid metabolism (L-Histidine， 5-Deoxy-5'-（methylthio）adenosine， 5-Methylthioadenosine)， carbohydrate metabolism （D-Gluconicacid， beta-D-Fructose 1，6-bisphosphate， D-Glyceraldehyde 3-phosphate）. The results of tissue microstructures of tuna showed a looser network and visible deterioration of tissue fiber during cold storage. Therefore， metabolomic analysis and tissue microstructures provide insight into the spoilage mechanism investigations on bigeye tuna during cold storage.

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