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MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination

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Neuroscience Bulletin 2024年第4期40卷 483-499页

作者： Xiaohong Dong Zhi Zhang Xin Shu Zi Zhuang Pinyi Liu Renyuan Liu Shengnan Xia Xinyu Bao yun Xu yan Chen Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing210008China Department of Neurology Drum Tower Hospital of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China

Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter *** phagocytosing myelin debris in a timely manner can promote remyelination and contribute to the repair of white ***,milk fat globule-epidermal growth factor-factor 8(MFG-E8),a microglial phagocytosis-related protein,has not been well studied in hypoperfusion-related cognitive *** found that the expression of MFG-E8 was significantly decreased in the brain of mice after bilateral carotid artery stenosis(BCAS).MFG-E8 knockout mice demonstrated more severe BCAS-induced cognitive impairments in the behavioral *** addition,we discovered that the deletion of MFG-E8 aggravated white matter damage and the destruction of myelin microstructure through fluorescent staining and electron ***,MFG-E8 overexpression by AAV improved white matter injury and increased the number of mature oligodendrocytes after ***,in vitro and in vivo experiments showed that MFG-E8 could enhance the phagocytic function of microglia via theαVβ3/αVβ5/Rac1 pathway and IGF-1 production to promote the differentiation of oligodendrocyte progenitor cells into mature ***,we found that MFG-E8 was mainly derived from astrocytes,not *** findings suggest that MFG-E8 is a potential therapeutic target for cognitive impairments following cerebral hypoperfusion.

关键词： White matter injury Cognitive dysfunction MFG-E8 Remyelination Microglial phagocytosis

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Pars plana vitrectomy with internal limiting membrane plugging assisted by autologous blood for optic disc pit associated with vitreomacular traction

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1957-1959页

作者： Bin Chen yan-Ting Li Tian-Hong Wu Ya-Ping Yuan yun-Feng Lu Department of Ophthalmology Suzhou EENT HospitalSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

Dear Editor,We report a case of optic disc pit(ODP)associated with vitreomacular traction which has been successfully treated by a combined *** have obtained the written informed consent from the patient,and this case... 详细信息

关键词： technique. traction macular

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Unleashing the Power of Bio-based Thermotropic Liquid Crystal Modifiers:Toughening and Reinforcing Petroleum-based Epoxy Resin without Compromising Other Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1093-1102页

作者： Qing-yun Lu Hong-Wei Gu Jia-Hui Li Qian-Qian Fan Bei-Tao Liu yan Kou Xi-Gao Jian Zhi-Huan Weng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsLiaoning Technology Innovation Center of High Performance Resin MaterialsDepartment of Polymer Science&EngineeringDalian University of TechnologyDalian 116024China Thermochemistry Laboratory Liaoning Province Key Laboratory of Thermochemistry for Energy and MaterialsDalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Toughening the petroleum-based epoxy resin blends with bio-based modifiers without compromising their modulus,mechanical strength,and other properties is still a big challenge in view of the *** this study,a bio-based liquid crystal epoxy resin(THMT-E P)with an s-triazine ring structure was utilized to modify a petroleum-based bisphenol A epoxy resin(E51)with 4,4'-diaminodiphenylsulfone(DDS)as a curing agent,and the blended systems were evaluated for their thermal stability,mechanical properties,and flame *** results showed that the impact strength of the blended system initially increased and then decreased with the increase in THMT-EP content,and it reached the a maximum value of 26.5 kJ/m^(2)when the THMT-EP content was 5%,which was 31.2%higher than that of E51/***,the flexural strength,modulus,and glass transition tem perature of the blended system were all simultaneously improved with the addition of *** the same time,the addition of THMT-EP enhanced the flame retardancy of the system by increasing the char yield at 700℃and decreasing the peak heat release rate and total heat release *** work paves the way for a more sustainable improvement in the comprehensive performance of epoxy resin.

关键词： Epoxy resin Toughening Bio-based Thermotropic liquid crystal

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基于差空间的双向2DPCA和SVM人脸识别算法

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计算机科学 2012年第12期39卷 268-271页

作者：汪洋严云洋王洪元常州大学信息科学与工程学院常州213164 淮阴工学院计算机工程学院淮安223003

为降低SVM人脸识别算法对样本进行训练和识别的时间,提出了一种改进的基于差空间的双向2DPCA(Bidirectional two dimensions PCA)和SVM相结合的人脸识别算法。该方法充分考虑了表情和光照对人脸图像的影响,不但利用小波变换对人脸图像... 详细信息

为降低SVM人脸识别算法对样本进行训练和识别的时间,提出了一种改进的基于差空间的双向2DPCA(Bidirectional two dimensions PCA)和SVM相结合的人脸识别算法。该方法充分考虑了表情和光照对人脸图像的影响,不但利用小波变换对人脸图像进行预处理,而且成功地把类内平均引入到双向2DPCA的计算中,并结合了SVM在分类识别方面的优势,有效节省了算法所需的时间。在Yale人脸库上的实验表明,它不但可以提高识别率,而且所用时间明显减少。

关键词：差空间小波变换双向2DPCA 支持向量机人脸识别

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Thermally modulated photoelectronic synaptic behavior in HfS_(2)/VO_(2) heterostructure

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Rare Metals 2024年第8期43卷 3798-3809页

作者： Le Wang Lin Wang Xiao-yun Ye Xiong-Hu Xu Li-yan Shang Ya-Wei Li Jin-Zhong Zhang Liang-Qing Zhu Zhi-Gao Hu Technical Center for Multifunctional Magneto-Optical Spectroscopy(Shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of PhysicsSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Neuromorphic computing is known for its efficient computational speed,low latency,and reduced power consumption,which is considered a pivotal technology to overcome the von Neumann *** synapses are an indispensable component of neuromorphic computational artificial neural *** guarantee effective and precise processing of optical signals,it must have a high responsivity,detectivity,and the ability to adapt to various ***,a synaptic transistor based on the HfS_(2)/VO_(2) heterojunction with a responsivity of8.6×10^(3) A·W^(-1)and a detectivity of 1.26×10^(14)Jones at405 nm laser was ***,the typical synaptic behavior was successfully simulated,including postsynaptic currents(PSCs),the transition from shortterm plasticity(STP)to long-term plasticity(LTP).When VO_(2) converts from the semiconductor state to the metal state,the HfS_(2)/VO_(2) heterojunction transforms into a Schottky heterojunction from a TypeⅡheterojunction with ***'s important,the heterojunction still exhibits excellent responsivity and detectivity,as well as stability of synaptic *** addition,the classical Pavlovian conditioning experiment is simulated under different laser intensity to study the brain's associative learning *** results demonstrate that the HfS_(2)/VO_(2) heterojunction synapse exhibits significant responsivity and detectivity and is adaptable to high-temperature environments,showing great potential for neuromorphic computational applic ations.

关键词： HfS_(2) VO_(2) Phase transition Photoelectric synapse Heterojunction

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Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

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Neural Regeneration Research 2024年第5期19卷 1105-1111页

作者： Tao Liu Ziqian Ma Liang Liu Yilun Pei Qichao Wu Songjie Xu Yadong Liu Nan Ding yun Guan yan Zhang Xueming Chen Department of Orthopedic Surgery Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Stomatology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord ***,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains *** the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem *** found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial *** addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1β*** results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord ***,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.

关键词： BV2 conditioned medium dental pulp stem cells GSDMD microglia neuroinflammation NLRP3 pyroptosis spinal cord injury

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融合多尺度多特征的人脸识别方法

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南京理工大学学报 2009年第1期33卷 47-52页

作者：严云洋郭志波陈伏兵杨静宇淮阴工学院计算机工程系江苏淮安223001 南京理工大学计算机科学与技术学院江苏南京210094 扬州大学信息学院江苏扬州225009

为降低光照、噪音、姿态等变化的影响,减少有效局部信息的损失,提出了使用图像的变换特征,及多尺度分块线性鉴别分析的算法。将图像进行多尺度划分,对划分后的每个子图像分别抽取其低频部分或奇异值,组合起来作为该图像的特征向量,进行... 详细信息

为降低光照、噪音、姿态等变化的影响,减少有效局部信息的损失,提出了使用图像的变换特征,及多尺度分块线性鉴别分析的算法。将图像进行多尺度划分,对划分后的每个子图像分别抽取其低频部分或奇异值,组合起来作为该图像的特征向量,进行线性鉴别分析。针对单一特征表示图像时的局限性,又提出了融合多尺度低频特征和多尺度奇异值特征进行人脸识别的方法。在ORL和Yale人脸库上的实验结果显示,所提出的算法识别精度明显提高,泛化能力较强。

关键词：多尺度低频奇异值特征融合人脸识别

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基于上下文的短信文本分类方法

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计算机工程 2011年第10期37卷 41-43页

作者：刘金岭严云洋淮阴工学院计算机工程学院江苏淮安223003

针对海量短信文本数据中大量词语共现的特点,提出一种基于上下文的短信文本分类方法。利用词语的上下文关系,定义词语相似度和基于上下文的词语权值,科学地表达词语在该类别中的语义表示,以提高短信文本分类效率。实验结果表明,与传统... 详细信息

针对海量短信文本数据中大量词语共现的特点,提出一种基于上下文的短信文本分类方法。利用词语的上下文关系,定义词语相似度和基于上下文的词语权值,科学地表达词语在该类别中的语义表示,以提高短信文本分类效率。实验结果表明,与传统的简单向量距离分类法相比,该方法的分类效果较优。

关键词：短信文本词语共现上下文词语相似度短信文本分类

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Biochar with self-doped N to activate peroxymonosulfate for bisphenol-A degradation via electron transfer mechanism:The active edge graphitic N site

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Chinese Chemical Letters 2024年第9期35卷 351-355页

作者： yun-Xin Huang Lin-Qian Yu Ke-Yu Chen Hao Wang Shou-yan Zhao Bao-Cheng Huang Ren-Cun Jin School of Engineering Hangzhou Normal UniversityHangzhou 311121China Zhejiang Provincial Key Laboratory of Urban Wetlands and Regional Change Hangzhou 311121China

Environmental endocrine disruptors,represented by bisphenol A(BPA),have been widely detected in the environment,bringing potential health risks to human ***-containing biocarbon catalyst can activate peroxymonosulfate(PMS)to degrade BPA in water,but its active sites remain ***,in this work,nitrogen-containing biochar,i.e.,C–Nedge,enriched with graphitic-N defects at the edges was prepared by one-pot co-pyrolysis of chitosan and potassium *** results showed that the C–Nedge/PMS system can effectively degrade 98%of BPA(50 mg/L).The electron transfer based non-radical oxidation mechanism was responsible for BPA *** graphitic-N doping endows biochar with strong electron transfer *** catalyst had good recovery and reuse *** catalytic oxidation was also feasible for other refractory pollutants removal and worked well for treating practical *** work may provide valuable information in unraveling the N doping configurationactivity relationship during activating PMS by biochar.

关键词： Peroxymonosulfate Carbon-based catalysts Edge graphitic-N Non-radicals Bisphenol A

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基于改进粒子群算法的图像阈值分割方法

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计算机科学 2012年第9期39卷 289-291,301页

作者：章慧龚声蓉严云洋淮阴工学院计算机工程学院淮安223003 苏州大学计算机科学与技术学院苏州215006

针对图像提取问题,最优阈值选取是否合理对图像分割效果至关重要。在处理不同种类图像区域时,粒子群算法(PSO)由于早熟现象难以准确计算最优分割阈值,因此导致图像分割准确率低。为了提高图像分割准确率且准确地提取出图像目标,提出一... 详细信息

针对图像提取问题,最优阈值选取是否合理对图像分割效果至关重要。在处理不同种类图像区域时,粒子群算法(PSO)由于早熟现象难以准确计算最优分割阈值,因此导致图像分割准确率低。为了提高图像分割准确率且准确地提取出图像目标,提出一种基于混沌粒子群算法(CPSO)的图像阈值分割方法。受益于混沌运行的遍历性、对初始条件的敏感性等优点,CPSO很好地解决了PSO的粒子群过早聚集和陷入局部最优等难题,加快了全局搜索最优解的能力。采用具体图像对CPSO算法图像分割性能进行仿真实验,结果表明,相比于其它图像分割算法,CPSO不仅加快了运算速度,提高了图像分割效率,而且提高了图像分割准确率,非常适合于图像实时分割处理。

关键词：图像分割粒子群算法阈值分割

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