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Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第9期11卷 647-653页

作者： yan-qin huang ying YUAN Wei-ting GE Han-guang HU Su-zhan ZHANG Shu ZHENG Key Laboratory of Cancer Prevention and Intervention of Ministry of Education Key Laboratory of Molecular Biology in Medical Science of Zhejiang Province Cancer Institute the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective:The purpose of this study was to determine the unique and universal features of microsatellite instability-high(MSI-H) colorectal cancer(CRC) and MSI-H gastric cancer(GC) in the Chinese ***:A new panel of mononucleotide MSI markers,BAT25,BAT26,NR21,NR24,and MONO-27,was used to define MSI status in 303 CRC and 288 GC *** features of both types of MSI-H tumors were *** analysis in the hMLH1 promoter region by methylation specific polymerase chain reaction(PCR) and mutation detection of hMSH2/hMLH1 genes by denaturing high-performance liquid chromatography(DHPLC) were carried out ***:MSI-H CRCs and MSI-H GCs account for 11.9% and 8.0% of unselected sporadic CRCs and GCs,***-H CRCs are strongly characterized by early onset,right-side location,low differentiation,mucinous tumor,less infiltration,less lymphatic metastasis,and more often familial ***-H GCs only showed site preference for the antrum and less lymphatic *** and epigenetic analyses were positive in 6/36 MSI-H CRCs and 0/23 MSI-H GCs with pathological mutation in major mismatch repair genes,and in 7/36 MSI-H CRCs and 18/23 MSI-H GCs with methylated hMLH1 promoter(P<0.01),***:Although there are many differences in the genetic basis and clinicopathological features between MSI-H CRC and MSI-H GC,when compared with their microsatellite stable(MSS) counterparts,site preference and lymphatic metastasis are features common to both types of MSI-H tumors.

关键词： Microsatellite instability Colorectal cancer Gastric cancer Mutation DNA methylation

Syngas production in a novel perovskite membrane reactor with co-feed of CO_2

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Chinese Chemical Letters 2011年第12期22卷 1492-1496页

作者： yan ying Wei Liu huang Jun Tang Ling Yi Zhou Zhong Li Hai Hui Wang School of Chemistry ＆ Chemical Engineering South China University of Technology Guangzhou 510640 China

Partial oxidation of methane（POM） co-fed with CO_2 to syngas in a novel catalytic BaCo_（0.6）Fe_（0.2）Ta_（0.2）O_（3-δ） oxygen permeable membrane reactor was successfully *** CO_2 to the partial oxidation of methane reaction not only alters the ratio of CO/H_2,but also increases the oxygen permeation flux and CH_4 *** 96%CH_4 conversion with more than 93%CO_2 conversion and 100%CO selectivity is achieved,which shows an excellent reaction performance.A steady oxygen permeation flux of 15 mL/（cm^2 min） is obtained during the 100-h operation,which shows good stability as well.

关键词： POM Oxygen separation CO_2 Perovskite Membrane reactor

π-Extension of Isoindigos(IIDs)through C—H/N—H Activation and Alkyne Annulation

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Chinese Journal of Chemistry 2023年第20期41卷 2589-2596页

作者： Kang Wang Liangliang Chen yan-ying huang Liyuan Qin Cheng Li Xi-Sha Zhang Feixian Luo Zheng Duan Guanxin Zhang Deqing Zhang College of Chemistry Green Catalysis CenterZhengzhou UniversityZhengzhouHenan450000 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouGansu730000 China Key Laboratory of Ecology and Environment in Minority Areas Minzu University of ChinaNational Ethnic Affairs CommissionBeijing100081 China

Isoindigo(IID)is widely used as organic dye and conjugated unit in opto-electronic *** of IID to increase its structural complexity is demanding for obtaining diversity ***,we developed a direct C-H/N-H activation method of IIDs via double alkyne annulations and synthesizedπ-extended IIDs with two pairs of 5/7 membered *** structure of theπ-extended IIDs was characterized and confirmed by^(1)H NMR,^(13)C NMR,HRMS and X ray crystal *** physical properties were characterized by UV-vis absorption,cyclic voltammetry and thermogravimetric *** absorption coefficient of the annulated products enhanced significantly compared with the non-annulated analogue.

关键词： Isoindigo C-H N-H activation Alkyne annulation Opto-electronic function Synthetic methods Functionalized Units

RGB-guided hyperspectral image super-resolution with deep progressive learning

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 679-694页

作者： Tao Zhang ying Fu Liwei huang Siyuan Li Shaodi You Chenggang yan School of Computer Science and Technology Beijing Institute of TechnologyBeijingChina Satellite Information Intelligent Processing and Application Research Laboratory Beijing Institute of Remote SensingBeijingChina Key Laboratory of Spectral Imaging Technology Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of SciencesXi'anChina Institute of Informatics University of AmsterdamAmsterdamNetherlands School of Communication Engineering Hangzhou Dianzi UniversityHangzhouChina

Due to hardware limitations,existing hyperspectral(HS)camera often suffer from low spatial/temporal ***,it has been prevalent to super-resolve a low reso-lution(LR)HS image into a high resolution(HR)HS image with a HR RGB(or mul-tispectral)image *** approaches for this guided super-resolution task often model the intrinsic characteristic of the desired HR HS image using hand-crafted ***,researchers pay more attention to deep learning methods with direct supervised or unsupervised learning,which exploit deep prior only from training dataset or testing *** this article,an efficient convolutional neural network-based method is presented to progressively super-resolve HS image with RGB image ***-ically,a progressive HS image super-resolution network is proposed,which progressively super-resolve the LR HS image with pixel shuffled HR RGB image ***,the super-resolution network is progressively trained with supervised pre-training and un-supervised adaption,where supervised pre-training learns the general prior on training data and unsupervised adaptation generalises the general prior to specific prior for variant testing *** proposed method can effectively exploit prior from training dataset and testing HS and RGB images with spectral-spatial *** has a good general-isation capability,especially for blind HS image *** experimental results show that the proposed deep progressive learning method out-performs the existing state-of-the-art methods for HS image super-resolution in non-blind and blind cases.

关键词： computer vision deep neural networks image processing image resolution unsupervised learning

Astronomical influence of the development of Paleogene thin coal seam groups in offshore Lacustrine basins:A case study of the ZhuⅠDepression's Enping Formation located in the northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 136-150页

作者： yan Liu Shengbing huang Dongdong Wang Nan Li Yuting Yin ying Chen Zengxue Li College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China CNOOC Research Institute Co. Ltd.Beijing 100028China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK

The development of the Paleogene coal seams in China's offshore basin areas generally had the characteristics of coal measures with large thicknesses,large numbers of coal seams,thin single coal seams,poor stability,scattered vertical distribution,and a wide distribution *** study selected the Enping Formation of the ZhuⅠDepression in the northern section of the South China Sea as an example to determine the macro-control factors of the development of the Paleogene coal seam *** analysis was carried out on the influencing effects and patterns of the astronomical cycles related to the development of the thin coal seam groups in the region.A floating astronomical time scale of the Enping Formation was established,and the sedimentary time limit of the Enping Formation was determined to be approximately 6.15 Ma±.In addition,the cyclostratigraphy analysis results of the natural gamma-ray data of Well XJ in the Enping Formation of the Xijiang Sag revealed that the development of the thin coal seams had probably been affected by short eccentricity and precession *** formation process of coal seams was determined to have been affected by high seasonal contrast,precipitation,and *** the periods with high values of short eccentricity,the seasonal contrasts tended to be *** those periods,fluctuations in the precession controls resulted in periodic volume changes in precipitation and insolation of the region,resulting in the development of thin coal *** was also found that the periods with low precession were the most conducive to coal seam *** that basis,combined with such factors as sedimentary environmental conditions conducive to the development of thin coal seam groups,this study established a theoretical model of the comprehensive influences of short eccentricity and precession on the development and distribution of Paleogene thin coal seam groups in offshore lacustrine *** patterns of the Paleogene astrono

关键词： Paleogene Pearl(Zhujiang)River Mouth Basin coal seam development astronomical cycles

Microscale spherical TiO_(2)powder prepared by hydrolysis of TiCl_(4)solution:Synthesis and kinetics

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Particuology 2024年第1期84卷 60-71页

作者： Peiyi yan ying Zhang Shili Zheng School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Key Laboratory of Green Process and Engineering National Engineering Research Center of Green Recycling for Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua617000China

Hydrolysis of TiCl_(4)solution is capable of preparing microscale TiO_(2)*** research studied the synthesis of microscale spherical TiO_(2)powders and the hydrolysis *** effects of the flow field generated by different agitators and baffles in the crystallizer,the initial free acid concentration,the initial equivalent TiO_(2)concentration,and the temperature on the hydrolysis progress and powder morphology were systematically *** results show that the flow field in a crystallizer can significantly affect the morphology and particle size of the powders,and the axial flow can improve the sphericity of the *** increased free HCl and equivalent TiO_(2)concentrations in the pregnant solution inhibit the forward hydrolysis reaction,prolong the time to reach equilibrium,and reduce the *** appropriate temperature matching the compositions of the pregnant solution is crucial for the powder morphology and *** with sizes ranging from around 5 um-40μm can be tuned under controlled flow field,solution compositions,and temperature *** addition,the Cheng and Wunderlich modified Avrami equation was used for the crystallization kinetic *** effects of the free HCl concentration,equivalent TiO_(2)concentration,and hydrolysis temperature are reflected in the reaction rate constant and active nuclei reduction *** the free HCl and equivalent TiO_(2)concentrations will reduce the reaction rate constant and accelerate the deactivation of the active nuclei,thus increasing the final powder size,while increasing the temperature will lead to the opposite results.

关键词： TiCl_(4) Hydrolysis Microscale TiO_(2) Spherical Kinetics

Interpenetrating network-reinforced gel polymer electrolyte for ultra-stable lithium−iodine batteries

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Carbon Energy 2024年第6期6卷 234-247页

作者： ying Jiang Peng huang Minman Tong Bingxin Qi Tao Sun Zhongyun Xian Wen yan Chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhouJiangsuChina

Li-I_(2) batteries have attracted much interest due to their high capacity,exceptional rate performance,and low *** so,the problems of unstable Li anode/electrolyte interface and severe polyiodide shuttle in Li-I_(2) batteries need to be ***,the interfacial reactions on the Li anode and I_(2) cathode have been effectively optimized by employing a well-designed gel polymer electrolyte strengthened by cross-linked Ti-O/Si-O(GPETS).The interpenetrating network-reinforced GPETS with high ionic conductivity(1.88×10^(-3)S cm^(-1)at 25℃)and high mechanical strength endows uniform Li deposition/stripping over 1800 h(at 1.0mA cm^(-2),with a plating capacity of 3.0mAh cm^(-2)).Moreover,the GPETS abundant in surface hydroxyls is capable of capturing soluble polyiodides at the interface and accelerating their conversion kinetics,thus synergistically mitigating the shuttle *** from these properties,the use of GPETS results in a high capacity of 207 mAh g^(-1)(1 C)and an ultra-low fading rate of 0.013%per cycle over 2000 cycles(5 C).The current study provides new insights into advanced electrolytes for Li-I_(2) batteries.

关键词： electrode/electrolyte interface gel polymer electrolytes lithium dendrites lithium−iodine batteries polyiodide shuttle

Evaluation and application of kinetic models for Cu-catalyzed acetylene hydrochlorination

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Chinese Journal of Chemical Engineering 2024年第8期72卷 209-219页

作者： Tianxiao huang Binhang yan Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The development of environmentally friendly catalysts has become a top priority for acetylene ***,difficulties remain in systematic studies on the applicability of kinetic models for the industrialization of Cu-based ***,a strategy involving reactor modeling,parameter estimation,and model testing is developed to evaluate the predictive ability of kinetic *** order to search for reliable and widely applicable reaction kinetic models for Cu-based catalysts,a case study is *** possible kinetic models derived from the power law,adsorption mechanism,and reaction path are sifted through collecting and testing activity data from tens of Cu-based *** optimum applicable ranges of these kinetic models are *** to the comparative analysis on their applications in various industrial scenarios,this research suggests that kinetic models derived from reaction path exhibits the best extrapolation ability and has the greatest potential for application in the scale-up design of reactors.

关键词： Acetylene hydrochlorination Cu-based catalysts Reaction kinetics Model Reactors

Mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

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Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian Man Fulin Zhu Yaqi huang Yuhao Piao yan Su Shengyuan Deng ying Wan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on *** an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and *** key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold ***“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the *** the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive *** by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection ***,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and *** field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.

关键词： Chloramphenicol and enrofloxacin Aptasensor Gold nanoburs Smartphone fluorimetric suite Digitized image postprocessing