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转录因子IRF3充分活化在调节先天抗病毒免疫反应中的作用机制解析

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中国兽医科学 2024年第2期54卷 282-282页

作者： Wei-Wei Li Xu-Xu Fan Zi-Xiang Zhu Xue-Jing Cao Zhao-Yu Zhu Dan-Shi Pei yi-Zhuo wang Ji-yan Zhang yan-yi wang Hai-Xue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary Medicine Lanzhou University Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Center for Biosafety Mega-Science Chinese Academy of Sciences Wuhan China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou China

翻译后修饰在调节Ⅰ型干扰素分泌过程中发挥关键作用。转录因子IRF3作为关键接头分子,其活性受到多种翻译后修饰的严格调控,包括磷酸化、de SUMOylation、泛素化和乙酰化等。目前,关于TBK1介导的IRF3磷酸化如何驱动IRF3完全活化的文献... 详细信息

翻译后修饰在调节Ⅰ型干扰素分泌过程中发挥关键作用。转录因子IRF3作为关键接头分子,其活性受到多种翻译后修饰的严格调控,包括磷酸化、de SUMOylation、泛素化和乙酰化等。目前,关于TBK1介导的IRF3磷酸化如何驱动IRF3完全活化的文献报道非常有限。因此,了解IRF3磷酸化和活化状态之间的关联性具有重要的生理学意义。

关键词： Ⅰ型干扰素生理学意义翻译后修饰转录因子活化状态分泌过程文献报道泛素化

Innate immune responses to DNA viruses

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Protein & Cell 2013年第1期4卷 1-7页

作者： ying Nie yan-yi wang Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China Graduate University of Chinese Academy of Sciences Beijing 100049China

The innate immune system acts as the first line of defense against pathogens,which is also essen-tial for initiation of adaptive *** immune responses are initiated by pattern-recognition receptors(PRRs),which recognize conserved molecular structures of pathogens called patho-gen-associated molecular patterns(PAMPs).The infection of virus triggers a series of signaling events leading to transcriptional induction of type I interferons(IFNs)and proinflammatory *** recent years,the mechanisms of viral RNA recognition and RNA virus-triggered signaling pathways have been well ***,it remains unclear on how DNA virus infection is sensed by host cells and triggers the host antiviral *** ten potential viral DNA sen-sors have been reported,none of them is validated as a generally used sensor for distinct DNA viruses in divergent cell types and ***,we provide a summary and perspective on recent advances in innate immune responses to DNA viruses.

关键词： initiated nat pattern

Generation of sustained optimal entropy squeezing of a two-level atom via non-Hermitian operation

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Chinese Physics B 2018年第11期27卷 506-511页

作者： yan-yi wang Mao-Fa Fang Synergetic Innovation Center for Quantum Effects and Application and Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education School of Physics and Electronics Hunan Normal University Changsha 410081 China

We investigate the entropy squeezing of a two-level atom in the Jaynes–Cummings model, and provide a scheme to generate the sustained optimal entropy squeezing of the atom via non-Hermitian operation. Our results show that the squeezing degree and the persistence time of entropy squeezing of atomic polarization components greatly depend on the non-Hermiticity intensity in non-Hermitian operation. Especially, under a proper choice of non-Hermiticity parameters, the sustained optimal entropy squeezing of the atom can be generated even though the atom is initially prepared in a no entropy squeezing state.

关键词： entropy squeezing non-Hermitian dynamics quantum optics Jaynes-Cummings model

Quantum speed limit time of a non-Hermitian two-level system

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Chinese Physics B 2020年第3期29卷 89-94页

作者： yan-yi wang Mao-Fa Fang Synergetic Innovation Center for Quantum Effects and Application and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of EducationSchool of Physics and ElectronicsHunan Normal UniversityChangsha 410081China

We investigated the quantum speed limit time of a non-Hermitian two-level system for which gain and loss of energy or amplitude are present. Our results show that, with respect to two distinguishable states of the non-Hermitian system, the evolutionary time does not have a nonzero lower bound. The quantum evolution of the system can be effectively accelerated by adjusting the non-Hermitian parameter, as well as the quantum speed limit time can be arbitrarily small even be zero.

关键词： quantum speed limit time non-Hermitian dynamics quantum optics

Preparation, Electrochemical Property and Application in Bulk-modified Electrode of Dawson-type Phospho-molybdate-doped Polypyrrole Composite Nanoparticles

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Chemical Research in Chinese Universities 2006年第5期22卷 556-559页

作者： wang Xiu-li ZHAO Hai-yan wang yi-fei Faculty of Chemistry and Chemical Engineering Bohai University Jinzhou 121000 P. R. China

A kind of inorganic-organic hybrid semiconductor composite nanoparticles： Dawson-type phosphomolybdate- doped polypyrrole （P2Mo18-PPy） was designed and prepared using microemulsion oxidation-polymerization at room temperature and characterized by TEM and IR. The P2Mo18-PPy was used as a bulk-modifier to fabricate a chemically modified carbon paste electrode（CPE） by direct mixing, which represents the example of polyoxometalates（ POMs）- doped semiconductor polymer nanoparticles modified electrode. Both the advantage of POMs-doped polymer and the surface-renewal property of the CPE were fully utilized. The electrochemical behavior of the P2Mo18-PPY bulk-modified CPE（P2Mo18-PPy-CPE） was investigated with cyclic voltammetry. Three couples of reversible redox peaks were observed in the range from ＋ 800 to 0 mV, which corresponded to the reduction and oxidation through two-, four- and six-electron processes, respectively. The P2 Mo18-PPY-CPE showed a high electrocatalytic activity for the reduction of nitrite, which expanded the application of POMs-doped semiconductor polymer nanoparticles.

关键词： Dawson-type phosphomolybdate Polypyrrole Composite nanoparticles Bulk-modified Carbon paste electrode Electrocatalysis

The Regulation of cGAS

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Virologica Sinica 2018年第2期33卷 117-124页

作者： Meiguang Xiong Suyun wang yan-yi wang Yong Ran Wuhan Institute of Virology Chinese Academy of Science

The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage, mitochondria damage, gene mutations, which results in autoimmune diseases. Therefore, the cGAS-MITA pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. The regulation of cGAS-MITA pathway at MITA-level have been extensively explored and reviewed elsewhere,here we provide a summary and perspective on recent advances in understanding of the cGAS regulation.

关键词： cGAS DNA sensing Regulation Autoimmune

Localization effect in single crystal of RuAs_(2)

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Chinese Physics B 2024年第4期33卷 195-200页

作者：易哲铠刘琪光双魁徐升岳小宇梁慧李娜周颖吴丹丹孙燕李秋菊程鹏夏天龙孙学峰王义炎 Anhui Key Laboratory of Magnetic Functional Materials and Devices Institute of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Department of Physics and Key Laboratory of Strongly-Coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano Devices Renmin University of ChinaBeijing 100872China School of Optical and Electronic Information Suzhou City UniversitySuzhou 215104China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

We report the magnetotransport and thermal properties of RuAs_(2) single ***_(2) exhibits semiconductor behavior and localization *** crossover from normal state to diffusive transport in the weak localization(WL)state and then to variable range hopping(VRH)transport in the strong localization state has been *** transitions can be reflected in the measurement of resistivity and Seebeck *** magnetoresistance(NMR)emerges with the appearance of localization effect and is gradually suppressed in high magnetic *** temperature dependent phase coherence length extracted from the fittings of NMR also indicates the transition from WL to *** measurement of Hall effect reveals an anomaly of temperature dependent carrier concentration caused by localization *** findings show that RuAs_(2) is a suitable platform to study the localized state.

关键词： weak localization variable range hopping RuAs_(2) single crystal

PROMOTION EFFECT OF MELAMINE ON FLAME RETARDANCY OF EPOXY RESINS CONTAINING CAGED BICYCLIC PHOSPHATE

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Chinese Journal of Polymer Science 2007年第6期25卷 581-588页

作者： Jing-ping Hu Dao Li yan Qin Xing-yi wang Laboratory for Advanced Materials Research Institute of Industrial Catalysis East China University of Science ＆ Technology Shanghai 200237 China

Caged bicyclic phosphate （CBP） and its dimelamine salt （PDS） were synthesized and added to epoxy resins to obtain the flame retarded epoxy resin composites. The flammability of the composites was characterized by the limiting oxygen index （LOI） and cone calorimeter tests. The LOI values of flame retarded composites increase consistently with the increase of flame retardant amounts, and they are almost the same when the loading of CBP is the same as that of PDS, although the phosphorus content of PDS is much lower than that of CBP. The total heat release increases in the order of CBP30/ER 〈 PDS30/ER 〈 PDS15/ER 〈 CBPI5/ER, whereas that of specific extinction area is CBP15/ER 〉 CBP30/ER 〉 PDS30/ER ≌ PDS15/ER. PDS exhibits more effective inhibition of oxidation of combustible gases. In the tests of thermogravimetric analyses （TG） and Fourier transform infrared spectroscopy （FT-IR）, it is found that the degradation of the composites is influenced greatly by the addition of flame retardants. By scanning electron microscopy （SEM）, a thick and tight char-layer is observed for PDS30/ER, resulting from the interaction of nitrogen species with phosphorus species. Therefore, the combination of CBP with melamine in the flame retarded system can improve the flame retardancy greatly.

关键词： Flame retardancy Thermal degradation Melamine Caged bicyclic phosphate Epoxy resin.

Microstructural stability of 9-12%Cr ferrite/martensite heat-resistant steels

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Frontiers of Materials Science 2013年第1期7卷 1-27页

作者： Wei yan Wei wang yi-yin SHAN Ke yanG Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

The microstructural evolutions of advanced 9–12%Cr ferrite/martensite heat-resistant steels used for power generation plants are reviewed in this article. Despite of the small differences in chemical compositions, the steels share the same microstructure of the as-tempered martensite. It is the thermal stability of the initial microstructure that matters the creep behavior of these heat-resistant steels. The microstructural evolutions involved in 9–12%Cr ferrite heat-resistant steels are elaborated, including (1) martensitic lath widening, (2) disappearance of prior austenite grain boundary, (3) emergence of subgrains, (4) coarsening of precipitates, and (5) formation of new precipitates, such as Laves-phase and Z-phase. The former three microstructural evolutions could be retarded by properly disposing the latter two. Namely improving the stability of precipitates and optimizing their size distribution can effectively exert the beneficial influence of precipitates on microstructures. In this sense, the microstructural stability of the tempered martensite is in fact the stability of precipitates during the creep. Many attempts have been carried out to improve the microstructural stability of 9–12%Cr steels and several promising heat-resistant steels have been developed.

关键词： heat-resistant steel microstructure martensite precipitate microstructural evolution