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Electroacupuncture activates AMPKa1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第05期 588-599页

作者： Wei-wei Jia Hua-wei Lin Min-guang yang Ya-ling Dai yan-yi ding Wen-shan Xu Si-nuo Wang Ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine The Institute of Rehabilitation Industry Fujian University of Traditional Chinese Medicine National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese Medicine Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese Medicine

Objective: Studies have shown that electroacupuncture(EA) can alleviate cognitive impairments from Alzheimer's disease(AD) by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK), but the specific mechanism involved remains to be elucidated. Therefore, this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial ***: The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKa1-subunit conditional knockout(AMPKa1-cKO) were used for experiments. To evaluate the effects of EA treatment on cognitive function, the T-maze and Morris water maze were used. In addition,chemical exchange saturation transfer, thioflavin staining, transmission electron microscopy, mitochondrial membrane potential, and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 ***: Both APP/PS1 mice and AMPKa1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory impairment. Inactivation of the AMPK/peroxisome proliferatoractivated receptor-γ coactivator-1a(PGC-1a) pathway increased pathological amyloid-β(Aβ) deposition and aggravated the dysfunction in mitochondrial dynamics. In addition, EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1a pathway, specifically by reducing pathological Aβ deposition, normalizing energy metabolism, protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins, and downregulating the expression of fission proteins. However, the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by ***: The regulation of hippocampal mitochondrial dynamics and reduction in Aβ deposition via the AMPK/PGC-1a pathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

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CoO/g-C_(3)N_(4)/CC光催化剂的制备与表征

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吉林师范大学学报（自然科学版） 2024年第2期45卷 7-12页

作者：李雪飞刘炎杨梦寒闫亦玎柳娜吉林师范大学物理学院吉林四平136000

设计并制备了用于光催化降解有机污染物的新型CoO/g-C_(3)N_(4)/CC(碳布)纳米复合材料.采用煅烧法在CC上生长形貌均匀的片状g-C_(3)N_(4),然后通过电沉积法在片状g-C_(3)N_(4)上沉积一氧化钴.所得的CoO/g-C_(3)N_(4)/CC复合材料比g-C_(3... 详细信息

设计并制备了用于光催化降解有机污染物的新型CoO/g-C_(3)N_(4)/CC(碳布)纳米复合材料.采用煅烧法在CC上生长形貌均匀的片状g-C_(3)N_(4),然后通过电沉积法在片状g-C_(3)N_(4)上沉积一氧化钴.所得的CoO/g-C_(3)N_(4)/CC复合材料比g-C_(3)N_(4)/CC具有更高的太阳能利用效率,从而对有机污染物的降解具有更高的光催化活性.在可见光条件下,CoO/g-C_(3)N_(4)/CC光催化剂对甲基橙(MO)的降解率为95%.循环实验表明,CoO/g-C_(3)N_(4)/CC具有良好的催化稳定性.由于g-C_(3)N_(4)与CoO之间形成的界面协同作用,使得CoO/g-C_(3)N_(4)/CC复合材料的光催化性能显著提高.

关键词：光催化剂片状g-C_(3)N_4 一氧化钴甲基橙

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Policy Gradient Adaptive Dynamic Programming for Model-Free Multi-Objective Optimal Control

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1060-1062页

作者： Hao Zhang yan Li Zhuping Wang yi ding Huaicheng yan the Department of Control Science and Engineering Tongji UniversityShanghai 200092China the Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education School of Information Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Dear Editor,In this letter,the multi-objective optimal control problem of nonlinear discrete-time systems is investigated.A data-driven policy gradient algorithm is proposed in which the action-state value function is... 详细信息

关键词： policy gradient Optimal

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IoV environment exploring coordination:A federated learning approach

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Digital Communications and Networks 2024年第1期10卷 135-141页

作者： Tong ding Lei Liu yi Zhu Lizhen Cui Zhongmin yan School of Software Shandong UniversityJinan250101China

Exploring open fields with coordinated unmanned vehicles is popular in academia and *** of the most impressive applicable approaches is the Internet of Vehicles(lov).The IoV connects vehicles,road infrastructures and communication facilities to provide solutions for exploration ***,the coordination of acquiring information from multi-vehicles may risk data *** this end,sharing high-quality experiences instead of raw data has become an urgent *** paper employs a Deep Reinforcement Learning(DRL)method to enable IoVs to generate training data with prioritized experience and states,which can support the IoV to explore the environment more ***,a Federated Learning(FL)experience sharing model is established to guarantee the vehicles'*** numerical results show that the proposed method presents a better successful sharing rate and a more stable convergence within the comparison of fundamental *** experiments also suggest that the proposed method could support agents without full information to achieve the tasks.

关键词： Internet of vehicle Deep reinforcement learning Federated learning Data privacy

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Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exo-somal lnc-TRPM2-AS

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Chinese Journal of Natural Medicines 2024年第6期22卷 530-540页

作者： HU yan WANG Mengqing XIE Jing JIAO Luojia ding yi LUO yinhe Department of Pediatrics The First Hospital of Hunan University of Chinese MedicineChangsha 410007China Hunan University of Chinese Medicine Changsha 410208China Department of Rehabilitation Medical CollegeChangsha Civil Affairs Vocational and Technical CollegeChangsha 410004Hunan ProvinceChina Teaching and Research Office of Chinese and Western Combination Hunan University of Chinese MedicineChangsha 410208China

Although various anti-inflammatory medications,such as ephedrine,are employed to manage cough-variant asthma,their underlying mechanisms are yet to be fully *** studies suggest that exosomes derived from airway epithelial cells(AECs)contain components like messenger RNAs(mRNAs),micro-RNAs(miRNAs),and long noncoding RNA(lncRNA),which play roles in the occurrence and progression of airway *** study investigates the influence of AEC-derived exosomes on the efficacy of ephedrine in treating cough-variant *** established a mouse model of asthma and measured airway resist-ance and serum inflammatory cell ***-time polymerase chain reaction(RT-qPCR),Western blotting,and enzyme-linked im-munosorbent assay(ELISA)analyses were used to assess gene and protein expression *** were isolated and *** immunoprecipitation(RIP)and RNA pull-down assays were conducted to examine the interaction between hnRNPA2B1 and *** the ovalbumin(OVA)-challenged mouse model,ephedrine treatment reduced inflammatory responses,air-way resistance,and Th1/Th2 cell *** from OVA-treated AECs showed elevated levels of lnc-TRPM2-AS1,which were diminished following ephedrine *** exosomal lnc-TRPM2-AS1 mediated the Th1/Th2 imbalance in CD4^(+)T cells,with its packaging into exosomes being facilitated by *** study unveils a novel mechanism by which ephedrine ameli-orates OVA-induced CD4^(+)T cell imbalance by suppressing AEC-derived exosomal *** findings could provide a theoretical framework for using ephedrine in asthma treatment.

关键词： Asthma Ephedrine Exosomal lnc-TRPM2-AS1 Th1/Th2 imbalance HnRNPA2B1 Airway epithelial cells

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Equivalent linear model for seismic damage evaluation of single-degree-of-freedom systems representing reinforced concrete structures considering cyclic degradation behavior

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 637-648页

作者： Lulu yan ding-Hao Yu Research Center for Geotechnical and Structural Engineering Technology of Liaoning Province Dalian UniversityDalian116622China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for implementing the proposed equivalent damping ratio model for use in seismic damage evaluation is *** this end,Ibarra’s peak-oriented model,which incorporates an energy-based degradation rule,is selected for representing hysteretic behavior of RC structure,and the optimized equivalent damping for predicting the maximum displacement response is presented by using the empirical method,in which the effect of cyclic degradation is ***,the relationship between the hysteretic energy dissipation of the inelastic system and the elastic strain energy of the equivalent linear system is established so that the proposed equivalent linear system can be directly integrated with the Park-Ang seismic model to implement seismic damage *** to the simplicity of the equivalent linearization method,the proposed method provides an efficient and reliable way of obtaining comprehensive insight into the seismic performance of RC *** verification demonstrates the validity of the proposed method.

关键词： degrading system equivalent linear system equivalent damping seismic damage RC structures

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Excitation of the abdominal ganglion affects the electrophysiological activity of indirect flight muscles of the honeybee Apis mellifera

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Insect Science 2024年第4期31卷 1187-1199页

作者： Haojia ding Shaoze yan State Key Laboratory of Tribology in Advanced Equipment(SKLT) Division of Intelligent and Biomechanical SystemsDepartment of Mechanical EngineeringTsinghua UniversityBeijingChina

Our understanding of the nervous tissues that affect the wing flapping of insects mainly focuses on the brain,but wing flapping is a rhythmic movement related to the central pattern generator in the ventral nerve *** verify whether the neural activity of the abdominal ganglion of the honeybee(Apis mellifera)affects the flapping-wing flight,we profiled the response characteristics of indirect flight muscles to abdominal ganglion ***,a change in the neural activity of ganglion 3 or ganglion 4 has a stronger effect on the electrophysiological activity of indirect flight muscles than that of ganglion *** electrophysiological activity of vertical indirect flight muscles is affected more by the change in neural activity of the abdominal ganglion than that of lateral indirect flight ***,the change in neural activity of the abdominal ganglion mainly causes the change in the muscular activity of indirect wing muscles,but the activity patterns change relatively little and there is little change in the complicated *** work improves our understanding of the neuroregulatory mechanisms associated with the flapping-wing flight of honeybees.

关键词： abdominal ganglion electromyography flapping wing honeybee indirect flight muscle muscular activity

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Structural evolution and zero-field SMM behaviour in ferromagnetically-coupled disk-type Co_(7)clusters bearing exclusively end-on azido bridges

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Chinese Chemical Letters 2024年第8期35卷 567-571页

作者： yijia Jiao Yuzhu Li Yuting Zhou Peipei Cen yi ding yan Guo Xiangyu Liu State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021China College of Public Health College of Basic Medical ScienceNingxia Medical UniversityYinchuan 750021China

Concise chemistry leads to a family of heptanuclear Co^(Ⅱ)-clusters,[Co_(7)(N_(3))_(12)(CH_(3)CN)_(12)][Y_(2)(NO_(3))_(4)(piv)_(4)]·2CH_(3)CN(DC1)(pivH=pivalic acid),[Co_(7)(N_(3))_(12)(CH_(3)CN)_(10)(NO_(3))_(0.4)(Cl)_(1.6)]·4CH_(3)CN(DC2)and[Co_(7)(N_(3))_(12)(CH_(3)CN)_(10)(NO_(3))_(2)]·4CH_(3)CN(DC3),in which the metal ions are exclusively bridged by end-on azido ligands to stabilize a beautiful disk-like *** resulting clusters exhibit interesting structural transformations and thermodynamically-distinct steady states verified by theoretical *** studies reveal the first observation of zero-field SMM behaviour in disk-like heptanuclear Co^(Ⅱ)complexes.

关键词： Multinuclear Co^(Ⅱ)-clusters Disk-like motif Structural modulation Ferromagnetic coupling Zero-field SMM

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Bilateral choroidal ganglioneuroma:a comprehensive analysis of vision decline in a 6-year-old boy

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1755-1759页

作者： yi-Zhe Cheng Li-Mei Sun Min-Er Yuan Lin-yan Zhang Shu-Ya Ke Xiao-yan ding State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Guangdong Provincial Clinical Research Center for Ocular Diseases Guangzhou 510060Guangdong ProvinceChina

Dear Editor,We write to present a 6-year-old boy with bilateral choroidal ganglioneuroma(CG)by comprehensive multimodal imaging(MMI)in a duration of 6-year *** our knowledge,this is the first case report with elaborate data to delineate the natural history of visual function and MMI in a boy with rare bilateral CG,confirmed by choroid biopsy.

关键词： comprehensive modal fir

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 458-474页

作者： Wei ding Wei-Wei Chen yi-Qin Wang Xue-Zhong Xu yi-Bo Wang Yong-Min yan Yu-Lin Tan Department of General Surgery Wujin Hospital Affiliated with Jiangsu UniversityChangzhou 213003Jiangsu ProvinceChina Changzhou Medical Center Nanjing Medical UniversityChangzhou 213017Jiangsu ProvinceChina Department of General Surgery The Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213003Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal ***710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRNA)that is upregulated in GC *** To assess the correlation between ZNF710-AS1-201 and immune microenvir-onment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC *** We obtained data from The Cancer Genome Atlas and Wujin *** assessed cell growth,migration,invasion,and programmed cell death using cell counting kit-8,EdU,scratch,Transwell,and flow cytometry *** real-time polymerase chain reaction(qRT-PCR)was used to identify the potential downstream targets of *** In GC tissues with low ZNF710-AS1-201 expression,immunoassays detected significant infiltration of various antitumor immune cells,such as memory CD8 T cells and activated CD4 T *** the low-expression group,the half-maximal inhibitory concentrations(IC_(50)s)of 5-fluorouracil,cisplatin,gemcitabine,and trametinib were lower,whereas the IC_(50)s of dasatinib and vorinostat were *** malignant degree of GC was higher and the stage was later in the high-expression ***,patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival *** vitro,the overexpression of ZNF710-AS1-201 greatly enhanced growth,metastasis,and infiltration while suppressing cell death in HGC-27 *** contrast,the reduced expression of ZNF710-AS1-201 greatly hindered cell growth,enhanced apoptosis,and suppressed the metastasis and invasion of MKN-45 *** expression changes in ZNF710 were significant,but the corresponding changes in isocitrate dehydrogenase-2,Semaphorin 4B,ARHGAP10,RGMB,hsa-miR-93-5p,and ZNF710-AS1-202 were not consistent or statistically significant after overexpression or knockdown of ZNF710-AS1-201,as determined by ***

关键词： Gastric cancer ZNF710-AS1-201 Proliferation Metastasis Invasion Apoptosis

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