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Effect of hypoxic preconditioning on miRNA expression in ischemic cortex of mice with middle cerebral artery occlusion

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Effect of hypoxic preconditioning on miRNA expression in isc...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Cui-Ying liu,yan LU,yan-yan liu,Nan ZHANG,Song HAN,Jun-Fa LI~* Department of Neurobiology and Beijing Institute for Neuroscience,Capital Medical University,Beijing 100069,China

＜正＞Objective:Ischemic/hypoxic preconditioning（I/HPC） is a phenomenon in which ischemic/hypoxic exposure protects the tissue/organ against damage caused by a subsequent ischemic/hypoxic *** cerebral I/ HPC-induced neuroprotection may provide a new strategy for treating cerebral ischemic/hypoxic injuries in clinical practice,but the molecular mechanism underlying cerebral I/HPC is *** present study is designed to indentify which miRNAs might be involved in cerebral ischemic/hypoxic injury and the development of cerebral ***:Using our established HPC and middle cerebral artery occlusion（MCAO）-induced focal cerebral ischemia mouse model,miRNA microarray was used to determine the effect of HPC on miRNA expression in ischemic penumbra of MCAO treated ***:There were 17 miRNAs with significant alterations in cerebral cortex of HPC mice,including 4 up and 13 down regulated miRNAs.65 miRNAs changed significantly in ischemic penumbra of MCAO mice,in which 26 and 39 miRNAs were up- and downregulated,*** addition,33 miRNAs were observed in ischemic penumbra of MCAO mice after HPC exposure,which includes 11 upregulation and 22 *** compared the significantly changed miRNAs in above three groups and found that let- 7g*,miR-144:9.1,miR-297a,miR-30c-2*,miR-465c-5p,miR-466a-5p,miR-466f,miR-615-3p,miR-654-5p and miR-679 were downregulated both in cerebral cortex of HPC mice and ischemic penumbra of MCAO+HPC mice, indicating the involvement of the cerebral *** cerebral cortex of HPC mice and ischemic penumbra of MCAO mice,miR-30a and miR-598 were upregulated and downregulated respectively,showing the induction of cerebral *** HPC pretreatment could relieve the downregulation of miR-134,miR-181b,miR-22*,miR-331- 3p,miR-378 and miR-665,and inhibit the upregulation of solexa-231-1844 in ischemic penumbra of MCAO mice, suggesting the key role in HPC-induced nueroprotection against cerebral ischemic ***

关键词： hypoxic preconditioning(HPC) middle cerebral artery occlusion(MCAO) microarray miRNA

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附壁油膜蒸发模型

燃烧科学与技术 2016年第6期22卷 527-530页

作者：闫燕安刘红奚溪殷宝振大连理工大学能源与动力学院海洋能源利用与节能教育部重点实验室大连116024

针对附壁油膜显著影响内燃机的性能和污染物排放的现象,应用解析方法,创新性地建立了一维非稳态附壁油膜加热蒸发的简化模型.模型中考虑了油膜与壁面的热传导,油膜与高温环境气体的对流换热,以及油膜自身蒸发的影响.应用该模型模拟了正... 详细信息

针对附壁油膜显著影响内燃机的性能和污染物排放的现象,应用解析方法,创新性地建立了一维非稳态附壁油膜加热蒸发的简化模型.模型中考虑了油膜与壁面的热传导,油膜与高温环境气体的对流换热,以及油膜自身蒸发的影响.应用该模型模拟了正十四烷在高温高压环境中的瞬态加热蒸发过程,考虑了油膜物性随温度的变化,最终得到附壁油膜温度分布的解析解.重点讨论了壁面温度以及环境压力对附壁油膜加热蒸发过程的影响.结果表明:提高壁面温度和降低环境压力可以有效促进附壁油膜蒸发.

关键词：附壁油膜蒸发模型解析方法内燃机正十四烷

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang liu-Pan yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying liu Juntang yan Congai Chen yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

N-P fertilization did not reduce AMF abundance or diversity but alter AMF composition in an alpine grassland infested by a root hemiparasitic plant

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N-P fertilization did not reduce AMF abundance or diversity ...

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

中国菌物学会2018年学术年会

作者： Xue-Zhao Wang Xiao-Lin Sui yan-yan liu Lei Xiang Ting Zhang Ai-Rong Li Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of Sciences Department of Grassland Science College of Animal Science and TechnologyNorthwest A&F University Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences

Fertilization has been shown to have suppressive effects on arbuscular mycorrhizal fungi（AMF） and root hemiparasites separately in numerous investigations, but its effects on AMF in the presence of root hemiparasites remain untested. In view of the contrasting nutritional effects of AMF and root hemiparasites on host plants, we tested the hypothesis that fertilization may not show strong suppressive effects on AMF when a plant community was infested by abundant hemiparasitic plants. Plants and soil samples were collected from experimental field plots in Bayanbulak Grassland, where N and P fertilizers had been applied for three continuous years for control against a spreading root hemiparasite, Pedicularis kansuensis. Shoot and root biomass of each plant functional group were determined. Root AMF colonization levels, soil spore abundance, and extraradical hyphae length density were measured for three soil depths（0-10 cm, 10-20 cm, 20-30 cm）. Partial 18 S rRNA gene sequencing was used to detect AMF diversity and community composition. In addition, we analyzed the relationship between relative abundance of different AMF genera and environmental factors using Spearman’s correlation method. In contrast to suppressive effects reported by many previous studies, fertilization showed no significant effects on AMF root colonization or AMF species diversity in the soil. Instead, a marked increase in soil spore abundance and extraradical hyphae length density were observed. However, fertilization altered relative abundance and AMF composition in the soil. Our results support the hypothesis that fertilization does not significantly influence the abundance and diversity of AMF in a plant community infested by P. kansuensis.

关键词： Arbuscular mycorrhizal fungi fertilization community structure alpine grassland ecosystem root hemiparasitic plants Pedicularis

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Synthetic control of chiral pore surfaces in covalent organic frameworks for enantioselective separation of chiral drugs

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Science China Chemistry 2025年

作者： Shiguo Fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia Yong Cui yan liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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Broadband low-frequency sound absorption of multifunctional composite metastructure

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Science China Technological Sciences 2025年

作者： Yilong yanG Shanshan liu yan LI Tong GAO Yongdong PAN Yong LI Yabin JIN School of Aerospace Engineering and Applied Mechanics Tongji University Institute of Acoustics School of Physics Science and Engineering Tongji University Shanghai Institute of Aircraft Mechanics and Control State International Joint Research Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical University Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science and Technology

In this study, we fabricated multifunctional metastructures from carbon fiber-reinforced plastic composites using additive manufacturing technology. These metastructures are characterized by their lightweight, load-bearing capacity, and broadband low-frequency sound absorption properties. The metastructure consists of 36 unit cells, and non-local coupling mechanism was considered for designing the sound absorption performance. We developed an acoustic impedance theory tailored for the metastructure, facilitating an analysis of thermal and viscous dissipation mechanisms. It is proven theoretically and experimentally that the proposed composite metastructure can achieve a noise reduction with an average sound absorption coefficient greater than 0.9 across frequencies in the rage of 330–1500 Hz. We also studied the metastructure’s quasi-static and cyclic compression performance, confirming its efficient absorption capabilities after cyclic compression. The proposed design and additive manufacturing method for composite metastructures provides a novel pathway for creating lightweight, multifunctional structures with diverse applications, such as aerospace engineering.

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Dynamic performance enhancement in Ti/Au ohmic contacts on β-Ga2O3-on-Si C substrates: evidence from pulsed measurements

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Science China(Information Sciences) 2025年第1期68卷 400-401页

作者： Chenyu liu Yibo WANG Wenhui XU Shuqi HUANG Chunxiao YU Zeyu yanG Xiaole JIA Xiaoxi LI Bochang LI Zhengdong LUO Cizhe FANG yan liu Tiangui YOU Xin OU Genquan HAN School of Microelectronics Xidian University Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Hangzhou Institute of Technology Xidian University

Titanium/Gold （Ti/Au） metals have been widely employed as ohmic metal contacts on n+Ga2O3,exhibiting the specific contact resistance （ρc） of 10-5-10-6Ω·cm2[1].But previous studies have revealed the presence of a defective Ga2O3layer and reactive Ti-Ga2O3layer at the annealed Ti/*** an interfacial layer can afect the performance of ohmic contact,which may become more pronounced in power devices subjected to electrical stress and high-frequency ***,there have been no reports on the impact of bias stress effects and dynamic degradation of Ti/Au ohmic contacts on n+Ga2O3.

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