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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Cui-Ying liu,yan LU,yan-yan liu,Nan ZHANG,Song HAN,Jun-Fa LI~* Department of Neurobiology and Beijing Institute for Neuroscience,Capital Medical University,Beijing 100069,China

＜正＞Objective:Ischemic/hypoxic preconditioning（I/HPC） is a phenomenon in which ischemic/hypoxic exposure protects the tissue/organ against damage caused by a subsequent ischemic/hypoxic *** cerebral I/ HPC-induced neuroprotection may provide a new strategy for treating cerebral ischemic/hypoxic injuries in clinical practice,but the molecular mechanism underlying cerebral I/HPC is *** present study is designed to indentify which miRNAs might be involved in cerebral ischemic/hypoxic injury and the development of cerebral ***:Using our established HPC and middle cerebral artery occlusion（MCAO）-induced focal cerebral ischemia mouse model,miRNA microarray was used to determine the effect of HPC on miRNA expression in ischemic penumbra of MCAO treated ***:There were 17 miRNAs with significant alterations in cerebral cortex of HPC mice,including 4 up and 13 down regulated miRNAs.65 miRNAs changed significantly in ischemic penumbra of MCAO mice,in which 26 and 39 miRNAs were up- and downregulated,*** addition,33 miRNAs were observed in ischemic penumbra of MCAO mice after HPC exposure,which includes 11 upregulation and 22 *** compared the significantly changed miRNAs in above three groups and found that let- 7g*,miR-144:9.1,miR-297a,miR-30c-2*,miR-465c-5p,miR-466a-5p,miR-466f,miR-615-3p,miR-654-5p and miR-679 were downregulated both in cerebral cortex of HPC mice and ischemic penumbra of MCAO+HPC mice, indicating the involvement of the cerebral *** cerebral cortex of HPC mice and ischemic penumbra of MCAO mice,miR-30a and miR-598 were upregulated and downregulated respectively,showing the induction of cerebral *** HPC pretreatment could relieve the downregulation of miR-134,miR-181b,miR-22*,miR-331- 3p,miR-378 and miR-665,and inhibit the upregulation of solexa-231-1844 in ischemic penumbra of MCAO mice, suggesting the key role in HPC-induced nueroprotection against cerebral ischemic ***

关键词： hypoxic preconditioning(HPC) middle cerebral artery occlusion(MCAO) microarray miRNA

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附壁油膜蒸发模型

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燃烧科学与技术 2016年第6期22卷 527-530页

作者：闫燕安刘红奚溪殷宝振大连理工大学能源与动力学院海洋能源利用与节能教育部重点实验室大连116024

针对附壁油膜显著影响内燃机的性能和污染物排放的现象,应用解析方法,创新性地建立了一维非稳态附壁油膜加热蒸发的简化模型.模型中考虑了油膜与壁面的热传导,油膜与高温环境气体的对流换热,以及油膜自身蒸发的影响.应用该模型模拟了正... 详细信息

针对附壁油膜显著影响内燃机的性能和污染物排放的现象,应用解析方法,创新性地建立了一维非稳态附壁油膜加热蒸发的简化模型.模型中考虑了油膜与壁面的热传导,油膜与高温环境气体的对流换热,以及油膜自身蒸发的影响.应用该模型模拟了正十四烷在高温高压环境中的瞬态加热蒸发过程,考虑了油膜物性随温度的变化,最终得到附壁油膜温度分布的解析解.重点讨论了壁面温度以及环境压力对附壁油膜加热蒸发过程的影响.结果表明:提高壁面温度和降低环境压力可以有效促进附壁油膜蒸发.

关键词：附壁油膜蒸发模型解析方法内燃机正十四烷

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N-P fertilization did not reduce AMF abundance or diversity but alter AMF composition in an alpine grassland infested by a root hemiparasitic plant

N-P fertilization did not reduce AMF abundance or diversity ...

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中国菌物学会2018年学术年会

作者： Xue-Zhao Wang Xiao-Lin Sui yan-yan liu Lei Xiang Ting Zhang Ai-Rong Li Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of Sciences Department of Grassland Science College of Animal Science and TechnologyNorthwest A&F University Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences

Fertilization has been shown to have suppressive effects on arbuscular mycorrhizal fungi（AMF） and root hemiparasites separately in numerous investigations, but its effects on AMF in the presence of root hemiparasites remain untested. In view of the contrasting nutritional effects of AMF and root hemiparasites on host plants, we tested the hypothesis that fertilization may not show strong suppressive effects on AMF when a plant community was infested by abundant hemiparasitic plants. Plants and soil samples were collected from experimental field plots in Bayanbulak Grassland, where N and P fertilizers had been applied for three continuous years for control against a spreading root hemiparasite, Pedicularis kansuensis. Shoot and root biomass of each plant functional group were determined. Root AMF colonization levels, soil spore abundance, and extraradical hyphae length density were measured for three soil depths（0-10 cm, 10-20 cm, 20-30 cm）. Partial 18 S rRNA gene sequencing was used to detect AMF diversity and community composition. In addition, we analyzed the relationship between relative abundance of different AMF genera and environmental factors using Spearman’s correlation method. In contrast to suppressive effects reported by many previous studies, fertilization showed no significant effects on AMF root colonization or AMF species diversity in the soil. Instead, a marked increase in soil spore abundance and extraradical hyphae length density were observed. However, fertilization altered relative abundance and AMF composition in the soil. Our results support the hypothesis that fertilization does not significantly influence the abundance and diversity of AMF in a plant community infested by P. kansuensis.

关键词： Arbuscular mycorrhizal fungi fertilization community structure alpine grassland ecosystem root hemiparasitic plants Pedicularis

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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan liu yan-Ping Guo yan-Mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng Wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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IL-17A基因多态性与儿童哮喘易感性的相关性研究

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中国当代儿科杂志 2016年第12期18卷 1264-1268页

作者：钟芳芳邹艳刘春艳刘文君西南医科大学附属医院儿科四川泸州646000

目的探讨儿童IL-17A启动子区域（-197G/A和-692C/T）基因多态性与儿童哮喘易感性的关系,为能进一步寻找到哮喘的候选基因从而为患病高风险儿童早期预防奠定基础。方法选取2013年8月至2015年8月门诊随访或住院的哮喘患儿65例为哮喘组,另... 详细信息

目的探讨儿童IL-17A启动子区域（-197G/A和-692C/T）基因多态性与儿童哮喘易感性的关系,为能进一步寻找到哮喘的候选基因从而为患病高风险儿童早期预防奠定基础。方法选取2013年8月至2015年8月门诊随访或住院的哮喘患儿65例为哮喘组,另选取同期行健康体检儿童70例为健康对照组,采集两组儿童外周静脉血,应用序列特异性引物聚合酶链反应（SSP-PCR）法检测IL-17A基因-197G/A和-692C/T两个位点的单核苷酸多态性（SNP）,统计分析两组间基因型及等位基因分布频率的差异。结果 IL-17A基因-692C/T位点哮喘组患儿TT基因型的分布频率（29%）显著高于健康对照组（16%）（P=0.012）;哮喘组-692T等位基因分布频率（52%）显著高于健康对照组（42%）（P=0.039）;罹患儿童哮喘的风险T等位基因携带者是C等位基因携带者的1.413倍（OR=1.413,95%CI：1.015~1.917）;而IL-17A基因-197G/A位点基因型及等位基因分布频率在哮喘组和健康对照组间比较差异无统计学意义（P〉0.05）。结论 IL-17A基因启动子区域-692C/T位点基因多态性与儿童哮喘的易感性相关,-692T等位基因携带者更易罹患儿童哮喘,而IL-17A-197G/A位点多态性与儿童哮喘的易感性无显著相关。

关键词： IL-17A 哮喘易感性单核苷酸多态性儿童

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GPU并行加速的边折叠简化算法

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计算机工程与设计 2016年第11期37卷 3051-3057页

作者：范豪刘峻孙宇陆向艳刘艳广西大学计算机与电子信息学院广西南宁530004 广西信息科学实验中心广西桂林541004 广西大学广西多媒体通信与网络技术重点实验室培育基地广西南宁530004 国家气象中心北京100081

针对目前串行的网格简化算法速度过慢,忽略模型细节特征的问题,提出一种基于GPU的边折叠网格简化算法。将三角网格模型划分为一系列强独立区域,采用二次误差测度计算边折叠代价,将独立区域内的所有强独立边中的最小折叠代价作为强独立... 详细信息

针对目前串行的网格简化算法速度过慢,忽略模型细节特征的问题,提出一种基于GPU的边折叠网格简化算法。将三角网格模型划分为一系列强独立区域,采用二次误差测度计算边折叠代价,将独立区域内的所有强独立边中的最小折叠代价作为强独立区域排序值,取各个强独立区域中折叠代价最小的边并行地进行折叠操作。实验结果表明,该算法具有较快的简化速率,较好的细节特征保持能力,简化模型具有较好的拓扑连接关系和较小的几何误差。

关键词：网格简化边折叠强独立区域二次误差测度图形处理单元

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Structure-based multi-ligand molecular modeling to predict the synergistic effects of limonin and obacunone from Simiao pill against nitric oxide synthase 3 associated with hyperuricemia

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Precision Medicine Research 2023年第3期5卷 11-15页

作者： Qing-Hong Chen Xiao-Mei Chen Xiao-Hu Chen yan-Ting You Shu-Xuan yang Chuang-Hai Wu Mei-Lin Chen Ming-Di Li Akari Komori yan-yan liu Andrew Hung Xiao-Shan Zhao Hong Li Department of Traditional Chinese Medicine Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Centre of General Practice The Seventh Affiliated HospitalSouthern Medical UniversityFoshan 528244China Department of Preventive Health Care Qingdao Hiser Hospital Affiliated to Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Science STEM CollegeRMIT UniversityMelbourneVictoria 3000Australia

Hyperuricemia(HUA)mainly occurs because of purine metabolism *** recently proposed that limonin from Simiao pill may have therapeutic effects on nitric oxide synthase 3(NOS3)that is related to ***,our previous work employed a new method,structure-based multi-ligand molecular modeling,to identify potential agents from a herbal formula that may produce synergistic effects and may have the potential to develop combination ***,we employed multi-ligand modeling to seek compounds with potential synergistic effects with limonin against *** obtained 403 multi-ligand docking results between 403 compounds and the limonin-NOS3 complex(average affinity–8.297 kcal/mol).Then we selected the top 10 highest binding affinity compounds for virtual pharmacokinetic and toxicity screening and we found that only obacunone passed all *** further subjected obacunone,bound to limonin and NOS3,to molecular dynamics *** found that the NOS3-limonin-obacunone complex was more stable than the NOS3-limonin complex,based on the root mean square deviation of backbone Cαatoms and root mean square fluctuation,which suggests that synergistic effects may exist between limonin and *** cell and animal experimental research is required to verify our results.

关键词： hyperuricemia synergistic mechanism Chinese herbal medicine complementary and alternative medicine molecular docking molecular dynamics simulations in silico analysis

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轨道约束对铁路桥梁纵向地震反应特性的影响

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铁道学报 2002年第5期24卷 124-128页

作者：黄艳阎贵平刘林北方交通大学土木建筑工程学院北京100044

采用非线性弹簧单元模拟道床的纵向位移阻力关系,建立了地震作用下桥梁与轨道共同作用的线桥一体化模型,分析轨道约束对铁路桥梁纵向抗震性能的影响。研究表明,在地震中当桥墩刚度相近时,轨道约束对桥墩是有利的;当桥墩刚度相差较大时,... 详细信息

采用非线性弹簧单元模拟道床的纵向位移阻力关系,建立了地震作用下桥梁与轨道共同作用的线桥一体化模型,分析轨道约束对铁路桥梁纵向抗震性能的影响。研究表明,在地震中当桥墩刚度相近时,轨道约束对桥墩是有利的;当桥墩刚度相差较大时,轨道约束对刚度较大桥墩有时是不利的。文章还分析了道床阻力、桥梁跨数等因素对桥梁抗震的影响。

关键词：影响铁路桥梁轨道约束纵向地震反应

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