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Quench sensitivity of novel Al-Zn-Mg-Cu alloys containing different Cu contents

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Rare Metals 2020年第12期39卷 1395-1401页

作者： Jin-Sheng chen Xi-Wu Li Bai-Qing Xiong Yony-An Zhang Zhi-Hui Li Hong-Wei yan Hong-Wei Liu Shu-Hui Huang State Key Laboratory of Nonferrous Metals and Processes General Research Institute for Nonferrous MetalsBeijing100088China

The effect of copper content on quench sensitivity in novel Al-Zn-Mg-Cu alloys containing high zinc content was investigated by Jominy end quench *** conductivity and hardness test,temperature collecting,and transmission electron microscopy(TEM)technique were adopted for the properties and microstructure characterization of three alloys with different copper *** results indicate that the electrical conductivity of all three alloys increases with the increase of distance from the quenched end,while the hardness shows an opposite *** the dropping of 10%hardness is defined as the critical evaluation standard of quenching,the depth of quenched layer of AlloysⅠ,Ⅱ,andⅢare 70,55,and 40 mm,*** precipitation behavior on grain boundaries of three alloys is similar except for a little difference in size,while the size of precipitates in grains of AlloyⅢwith higher copper content is larger than those of the other two alloys at the same *** all results,the stability of the supersaturated solid solution of AlloyⅢis lower than those of the other two alloys,meaning that AlloyⅢshows the highest quench *** copper content leads to higher quench sensitivity in novel Al-Zn-Mg-Cu alloys with the same content of magnesium,zinc,and other trace elements.

关键词： Al-Zn-Mg-Cu alloy Copper content Quench sensitivity Jominy end quench test Precipitates

MRI-guided photothermal/photodynamic immune activation combined with PD-1 inhibitor for the multimodal combination therapy of melanoma and metastases

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Regenerative Biomaterials 2024年第4期3卷 38-51页

作者： Changqiang Wu Wei chen Shuang yan Jie Zhong Liang Du chenwu yang Yu Pu yang Li Jiafu Lin Mei Zeng Xiaoming Zhang Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging North Sichuan Medical CollegeNanchong 637000P.R.China Department of Radiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000P.R.China Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsSchool of PharmacyChengdu UniversityChengdu 610106P.R.China Institute of Basic Medicine and Forensic Medicine North Sichuan Medical College and Institute of Rheumatology and ImmunologyThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000P.R.China

Non-invasive image-guided precise photothermal/photodynamic therapy(PTT/PDT)has been proven to be an effective local treatment modality but incompetent against ***,the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor ***,a magnetic resonance imaging(MRI)-visualized PTT/PDT agent(SIDP NMs)was constructed,and the efficacy of its multimodal combination with a programmed cell death 1(PD-1)inhibitor in the treatment of melanoma and metastases was *** to the hydrophobic encapsulation of indocyanine green within the micellar core,SIDP NMs exhibited excellent photothermal/photodynamic properties and stability under an 808 nm near-infrared *** vitro cell experiments showed that SIDP NMs had a good killing *** incubating with B16-F10 cells for 24 h and irradiating with an 808-nm laser for 10 min,cell viability decreased *** resonance imaging experiments in melanoma-bearing mice have shown that the dynamic distribution of SIDP NMs in tumor tissue could be monitored by T2WI and T2-MAP non-invasively due to the presence of superparamagnetic iron oxide nanocrystal in SIDP *** the 808 nm laser was irradiated at the maximum focusing time point shown by MRI,the temperature of the tumor area rapidly increased from 32℃to 60.7℃in 5 *** mouse melanoma ablation and distant tumor immunotherapy studies,SIDP NMs provided excellent MRI-guided PTT/PDT results and,when combined with PD-1 inhibitor,have great potential to cure primary tumors and eradicate metastases.

关键词： photothermal therapy photodynamic therapy immunotherapy magnetic resonance imaging multimodal treatment

Inhibition of the immunoproteasome LMP_(2) ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

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Military Medical Research 2022年第4期9卷 404-418页

作者： Xing-Yong chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityNo.134DongjieGulou DistrictFuzhou 350001China Fujian Academy of Medical Science Fuzhou 350o01China Key Testing Laboratory of Fujian Province Fuzhou 350001China.

Background:Disruption of the blood–brain barrier(BBB)after a stroke can lead to brain injury and neurological *** work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2(LMP2)in the pathophysiology of ischemia ***,the relationship between the immunoproteasome LMP2 and the BBB remains ***:Adult male Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion(MCAO/R).Three days before MCAO,the rats were treated with lentivirus-mediated LMP2 shRNA preparations by stereotactical injection into the ipsilateral hemispheric *** rat brain microvascular endothelial cell(RBMVEC)line was exposed to oxygen–glucose deprivation/reperfusion(OGD/R)to mimic ischemic conditions in *** RNA interference-mediated knockdown of LMP2 orβ-catenin was analysed in vivo and in *** of the quantity of extravasated Evans blue(EB)and cerebral fluorescent angiography were performed to evaluate the integrity of the *** and Western blotting were employed to detect the expression of target *** migration was evaluated using a scratch migration *** results of immunofluorescence,Western blotting and cell migration were quantified using the software ImageJ(Version 1.53).Parametric data from different groups were compared using one-way ANOVA followed by the least significant difference(LSD)***:Cerebral ischemia led to lower levels of structural components of the BBB such as tight junction proteins[occludin,claudin-1 and zonula occludens(ZO-1)]in the MCAO/R group compared with the sham group(P<0.001).However,inhibition of the immunoproteasome LMP2 restored the expression of these proteins,resulting in higher levels of occludin,claudin-1 and ZO-1 in the LMP2-shRNA group compared with the control-shRNA group(P<0.001).In addition,inhibition of the immunoproteasome LMP2 contributed to higher microvascular density and decreased BBB perm

关键词： Immunoproteasome Blood–brain barrier Wnt/β-catenin pathway Oxygen–glucose deprivation/reperfusion Cerebral ischemia

Supramolecular host-guest nanosystems for overcoming cancer drug resistance

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Cancer Drug Resistance 2023年第4期6卷 805-827页

作者： Sha Wu Miaomiao yan Minghao Liang Wenzhi yang Jingyu chen Jiong Zhou Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819LiaoningChina Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632GuangdongChina

Cancer drug resistance has become one of the main challenges for the failure of chemotherapy,greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer *** emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld,providing a potential solution to this *** with conventional chemotherapeutic platforms,supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake,reducing drug efflux,activating drugs,and inhibiting DNA ***,we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this *** is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems.

关键词： Supramolecular nanosystems host-guest interaction cancer drug resistance

Exploration of an Efficient Simultaneous Molecular Detection Method of HIV,HCV,and Syphilis from a Single Dried Blood Spot

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Biomedical and Environmental Sciences 2021年第4期34卷 257-264页

作者： MA Jie Qiong XU Qing Qing HE Lin HE Xiao Xia chen Kai WANG Yue Hua XING Wen Ge JIANG yan National HIV Reference Laboratory National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective The aim of the present study was to evaluate the performance of the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV RNA using one dried blood spot(DBS)as an alternative sample to *** A total of 571 paired DBS/plasma samples were collected from men who have sex with men(MSM)and injection drug users(IDUs),and serological and molecular assays were *** plasma results as the reference standard,the performance of DBS tests for HIV-1 RNA,HIV-1 DNA,and HCV RNA was ***’s correlation coefficients and Bland-Altman analysis were performed to assess the correlation and concordance between DBS and *** Among paired plasma/DBS samples with detectable HIV-1 RNA and HCV RNA,five samples(5/32)were not detectable in DBS,while measurable HIV-1 RNA levels were present in plasma(1.44 to3.99 log10 copies/m L).There were two samples(2/94)with undetectable HCV RNA in DBS,while measurable HCV RNA levels were present in plasma(-5 to 5.99 log10 copies/m L).The correlation between HIV-1 RNA light chain variable region(VL)values obtained from plasma and DBS showed that r=0.683(P<0.01),n=27 and r=0.612(P<0.01),n=89 in HCV ***-Altman analysis revealed that in HIV-1 RNA,the mean(±SD)difference between HIV-1 RNA in plasma and DBS was 1.00±1.01 log10 copies/m L,and all samples were within±1.96 SD(-0.97 to 2.97 log10 copies/m L)for *** mean difference(±SD)in HCV RNA was 0.15±1.08 log10 copies/m L,and 94.38%(84/89)were within±1.96 SD(-1.96 to 2.67 log10 copies/m L).Overall,HIV-1 RNA and HCV RNA levels obtained from a DBS were lower than those obtained from ***-1 DNA in a DBS showed concordant results with HIV-1 RNA in ***-1 DNA RT-PCR using a DBS showed acceptable *** The performance of the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV RNA using one DBS was ***,as an alternative sample to plasma,may be a viable option for the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV R

关键词： Dried blood spot(DBS) Correlation Bland-Altman HIV-1 RNA HIV-1 DNA HCV RNA

Serum Total Bilirubin and Risk of Progressing Diabetes:A Prospective Cohort Study

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Biomedical and Environmental Sciences 2021年第8期34卷 632-636页

作者： ZHANG Jie ZHANG Yin Fei HU Chun yan ZHANG Yi QI Hong yan LIN Lin XU Yu XU Min LU Jie Li BI Yu Fang WANG Wei Qing NING Guang chen Yu Hong Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrinology Jiading Central HospitalShanghai University of Medicine&Health SciencesShanghai 201800China

Diabetes has become a serious public health concern worldwide,and China is the epidemic *** China,the prevalence of type 2 diabetes(T2D)was 11.6%among adults aged≥18 years[1].Cardiovascular disease(CVD)occurs earlier and with greater severity in patients with T2D than in individuals without T2D[2].Thus,potential risk factors for screening T2D are needed to prevent such poor clinical outcomes.

关键词： Diabetes Serum clinical

Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution of Active Flavonoid Biosynthesis

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Genomics, Proteomics & Bioinformatics 2020年第3期18卷 230-240页

作者： Zhichao Xu Ranran Gao Xiangdong Pu Rong Xu Jiyong Wang Sihao Zheng yan Zeng Jun chen Chunnian He Jingyuan Song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering Research Center of Chinese Medicine Resource Ministry of EducationBeijing 100193China China National Traditional Chinese Medicine Co. LtdBeijing 102600China

Scutellaria baicalensis(***)and Scutellaria barbata(***)are common medicinal plants of the Lamiaceae *** produce specific flavonoid compounds,including baicalein,scutellarein,norwogonin,and wogonin,as well as their glycosides,which exhibit antioxidant and antitumor ***,we report chromosome-level genome assemblies of *** and *** with quantitative chromosomal variation(2 n=18 and 2 n=26,respectively).The divergence of *** and *** occurred far earlier than previously reported,and a whole-genome duplication(WGD)event was *** insertion of long terminal repeat elements after speciation might be responsible for the observed chromosomal expansion and *** genome analysis of the congeneric species revealed the species-specific evolution of chrysin and apigenin biosynthetic genes,such as the ***-specific tandem duplication of genes encoding phenylalanine ammonia lyase and chalcone synthase,and the ***-specific duplication of genes encoding 4-Co A *** addition,the paralogous duplication,colinearity,and expression diversity of CYP82 D subfamily members revealed the functional divergence of genes encoding flavone hydroxylase between *** and *** these Scutellaria genomes reveals the common and species-specific evolution of flavone biosynthetic ***,these findings would facilitate the development of molecular breeding and studies of biosynthesis and regulation of bioactive compounds.

关键词： Scutellaria Whole-genome duplication Flavonoid biosynthesis Tandem duplication Species-specific evolution

Multi-exit self-distillation with appropriate teachers

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 585-599页

作者： Wujie SUN Defang chen Can WANG Deshi YE yan FENG Chun chen College of Computer Science and Technology Zhejiang UniversityHangzhou 310000China

Multi-exit architecture allows early-stop inference to reduce computational cost,which can be used in resource-constrained *** works combine the multi-exit architecture with self-distillation to simultaneously achieve high efficiency and decent performance at different network ***,existing methods mainly transfer knowledge from deep exits or a single ensemble to guide all exits,without considering that inappropriate learning gaps between students and teachers may degrade the model performance,especially in shallow *** address this issue,we propose Multi-exit self-distillation with Appropriate TEachers(MATE)to provide diverse and appropriate teacher knowledge for each *** MATE,multiple ensemble teachers are obtained from all exits with different trainable *** exit subsequently receives knowledge from all teachers,while focusing mainly on its primary teacher to keep an appropriate gap for efficient knowledge *** this way,MATE achieves diversity in knowledge distillation while ensuring learning *** results on CIFAR-100,TinyImageNet,and three fine-grained datasets demonstrate that MATE consistently outperforms state-of-the-art multi-exit self-distillation methods with various network architectures.

关键词： Multi-exit architecture Knowledge distillation Learning gap

Electrical, Thermal, and Mechanical Properties of Cu/Ti3AlC2 Functional Gradient Materials Prepared by Low-temperature Spark Plasma Sintering

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Journal of Wuhan University of Technology(Materials Science) 2019年第4期34卷 876-882页

作者： chen yanlin WU Chonggang School of Materials and Chemical Engineering Hubei University of TechnologyWuhan 430068China Hubei Provincial Key Labo ratory of Green Materials for Light Industry Hubei University of TechnologyWuhan 430068China Collaborative Innovation Center of Green Light-weight Materials and Processing Hubei University of TechnologyWuhan 430068China

Cu/Ti3AlC2 composite and functional-gradient materials with excellent electrical conductivity and thermal conductivity as well as good flexural properties were prepared by low-temperature spark plasma sintering of Cu and Ti3AlC2 powder mixtures. The phase compositions of the materials were analyzed by X-ray diffraction, and their microstructure was characterized by scanning electron microscopy and energy dispersive X-ray spectroscopy. Further, the electrical conductivity, thermal conductivity, and flexural properties of the materials were tested. Results show that, for the composite materials, the resistivity rises from 0.75 × 10^-7 Ω·m only to 1.32 × 10^-7 Ω·m and the thermal diffusivity reduces from 82.5 mm^2/s simply to 39.8 mm^2/s, while the flexural strength improves from 412.9 MPa to 471.3 MPa, as the content of Ti3AlC2 is increased from 5 wt%to 25 wt%. Additionally, the functional-gradient materials sintered without interface between the layers exhibit good designability, and their overall electrical conductivity, thermal conductivity, and flexural strength are all higher than those of the corresponding uniform composite material.

关键词： Cu/Ti3AlC2 functional gradient material electrical conductivity thermal conductivity