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The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

Acta Pharmaceutica Sinica B 2024年第2期14卷 712-728页

作者： Xiaoxuan Zhong Xiang Wei yan Xu Xuehai Zhu Bo Huo Xian guo Gaoke Feng Zihao Zhang xin Feng Zemin Fang Yuxuan Luo xin Yi Ding-Sheng Jiang Division of Cardiovascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart ***,we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum-and PDGF-BB-induced vascular smooth muscle cells(VSMCs),and in tissues of carotid artery injury-induced neointimal ***2 overexpression in VSMCs(Smyd2-vTg)facilitates,but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in *** sequencing revealed that SMYD2 knockdown represses the expression of serum response factor(SRF)target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC ***3 directly interacts with and deacetylates SRF,which enhances SRF transcriptional activity in ***,SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its ***966,a specific inhibitor of HDAC3,not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs,but also inhibits carotid artery injury-induced neointima formation in ***3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent *** results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia.

关键词： Neointimaformation Histonemethylation Histoneacetylation SRFacetylation SMYD2 HDAC3 LLY-507 RGFP966

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LASPM:the LAMOST stellar parameter pipeline for M-type stars and application to the sixth and seventh data release(DR6 and DR7)

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Research in Astronomy and Astrophysics 2021年第8期21卷 181-192页

作者： Bing Du A-Li Luo Shuo Zhang Xiao Kong yan-xin guo Yin-Bi Li Fang Zuo You-Fen Wang Jian-Jun Chen Yong-Heng Zhao CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China

The molecular-rich atmospheres of M type stars complicate our understanding to their atmospheric ***,great progress has been made in atmospheric modeling of M-type stars,and we take advantage of the updated BT-Settl model grid to develop a pipeline LAS PM to measure atmospheric parameters(Teff,log g,[M/H]) of M-type stars from low-resolution *** pipeline was applied to the sixth and seventh data release(DR6 & DR7) of Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),which released atmospheric parameters for 610419 and 680 185 Mtype spectra,*** key algorithm is to find the best-matching for templates in the synthetic spectral library for an observed spectrum,and then minimizing χ^(2) through a linear combination of five best-matching *** intrinsic precisions of the parameters were estimated by using the multiple epoch observations for the same stars,which are 118 K,0.20 dex,0.29 dex for Teff,log g,and [M/H]*** Teff and log g are consistent with the spectral and luminosity classifications by LAMOST 1D pipeline,and the loci of giants and dwarfs both on spectral index and color-magnitude diagrams show the *** metallicities of LASPM are also checked with the selected members of four open clusters(NGC 2632,Melotte 22,ASCC16,and ASCC19),which are consistent without any *** the results between LASPM and the APOGEE Stellar Parameter and Chemical Abundance Pipeline(ASPCAP),there is a scatter of 73 K,0.22 dex,0.21 dex for Teff,log g,and [M/H],respectively.

关键词： atmospheric parameters data analysis spectrographs

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Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 687-698页

作者： Juan Lin Zhu-Feng Chen guo-Dong guo xin Chen Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Pathology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Internal Medicine Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND The Alcian blue(AB)and periodic acid Schiff(PAS)stains are representative mucus markers in gastric signet ring cell carcinoma(SRCC).They are low-cost special staining methods used to detect acidic mucus and neutral mucus,***,the clinical importance of the special combined AB and PAS stain is *** To investigate AB expression,PAS expression and the AB-to-PAS(A/P)ratio in gastric SRCC patients and to assess patient *** Paraffin-embedded sections from 83 patients with gastric SRCC were stained with AB and PAS,and signet ring cell positivity was assessed ***-histochemical staining for Ki67,protein 53(P53)and human epidermal growth factor receptor 2(HER2)was performed *** cancer-specific survival(CSS)rate was estimated via Kaplan-Meier *** proportional hazards models were used for univariate and multivariate survival *** Kaplan-Meier survival analysis revealed that the 3-year CSS rate was significantly greater in the high-PAS-expression subgroup than in the low-PAS-expression subgroup(P0.5 group(P=0.042).Univariate Cox regression analysis revealed that the factors affecting prognosis included tumor diameter,lymph node metastasis,vessel carcinoma embolus,tumor stage,the A/P ratio and the expression of Ki67,P53 and the *** multivariate regression analysis confirmed that low PAS expression[hazard ratio(HR)=3.809,95%confidence interval(CI):1.563-9.283,P=0.003]and large tumor diameter(HR=2.761,95%CI:1.086-7.020,P=0.033)were independent risk factors for poor *** A/P>0.5 is potentially a risk factor for prognosis,and low PAS expression is an independent risk factor in the prognosis of gastric *** expression and the A/P ratio could help in predicting the clinical prognosis of patients with SRCC.

关键词： Alcian blue Periodic acid-Schiff Prognosis Gastric Signet ring cell carcinoma

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Mechanism of a dual-phase Ti-Nb alloy exhibiting near-linear elastic deformation

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Rare Metals 2024年第5期43卷 2282-2289页

作者： yan guo Wang Ding Wen Ma Shun guo Hao-Dong Meng Nian-Yao Xu School of Automotive Engineering Changzhou Institute of TechnologyChangzhou 213032China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Youke Publishing Co. LtdChina Grinm Group Co.LtdBeijing 100088China

In this work,the underlying mechanism responsible for the near-linear elastic deformation behavior of a dual-phase Ti-Nb alloy consisting of β and α'' phase with large recoverable strain was systematically *** on in situ synchrotron X-ray diffraction(SXRD)analyses,it was found that besides intrinsic elastic deformation,a slight reversible β-α'' stress-induced martensitic(SIM)transformation,which proceeded in a consecutive mode under the retarding effect of micro-defects,took place during the near-linear elastic *** unloading,a small amount of residual macroscopic strain remained in the specimen due to the incomplete reverse α''→β transformation on *** high near-linear elastic deformability of the cold drawing(CD)Ti-Nb alloy has been revealed to be attributed to the coupling actions of intrinsic elasticity as well as the consecutive and reversible β-α'' SIM *** research may contribute to a new avenue for the design and development of novel dual-phase Ti-based alloys with desirable elastic deformability.

关键词： Titanium alloys Dual-phase Near-linear elastic deformation Martensitictransformation

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Numerical Simulation of the Seismic Response of a Horizontal Storage Tank Based on a SPH-FEM Coupling Method

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1655-1678页

作者： Peilei yan Endong guo HouliWu Liangchao Zhang Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin150080China

A coupled numerical calculation method combining smooth particle hydrodynamics(SPH)and the finite element method(FEM)was implemented to investigate the seismic response of horizontal storage *** of a horizontal storage tank featuring a free liquid surface under seismic action was constructed using the SPH–FEM coupling *** stored liquid was discretized using SPH particles,while the tank and supports were discretized using the *** interaction between the stored liquid and the tank was simulated by using the meshless particle contact ***,the numerical simulation results were compared and analyzed against seismic simulation shaking table test data to validate the ***,a series of numerical models,considering different liquid storage volumes and seismic effects,were constructed to obtain time history data of base shear and top center displacement,which revealed the seismic performance of horizontal storage *** simulation results and experimental data showed good agreement,with an error rate of less than 18.85%.And this conformity signifies the rationality of the SPH-FEM coupling *** base shear and top center displacement values obtained by the coupled SPH-FEM method were only 53.3% to 69.1% of those calculated by the equivalent mass method employed in the current *** the stored liquid volume increased,the seismic response of the horizontal storage tank exhibited a gradual upward trend,with the seismic response increasing from 73% to 388% for every 35% increase in stored liquid *** maximum von Mises stress of the tank and the supports remained below the steel yield strength during the *** coupled SPH-FEM method holds certain advantages in studying the seismic problems of tanks with complex structural forms,particularly due to the representation of the flow field distribution during earthquakes by involving reservoir fluid participation.

关键词： SPH-FEM coupling method horizontal storage tank seismic response sloshing

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Exceptional reversed yield strength asymmetry in a rare-earth free Mg alloy containing quasicrystal precipitates

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Journal of Magnesium and Alloys 2024年第2期12卷 687-699页

作者： Qiang yang Shuhui Lv Zixiang yan Zefeng Xie xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China School of Materials Science and Engineering Changchun University of Science and Technology130022PR China

This work reports an exceptional reversed yield strength asymmetry at room temperature for a rare-earth free magnesium alloy containing a mass of fine dispersed quasicrystal(I-phase)*** exhibiting traditional basal texture,it owns an exceptional CYS/TYS as high as~*** back-scattered diffraction(EBSD)and transmission electron microscopy(TEM)examinations indicate pyramidal and prismatic dislocations plus tensile twinning being activated after immediate yielding in compression while basal and non-basal dislocations in tension.I-phase particles transferred the concentrated stress by self-twinning to provide the driving force for tensile twin initiating in neighboring grains,thereby significantly increasing the critical resolved shear stress of tensile twinning to possibly the level of pyramidal slip,finally leading to the dominance of pyramidal slip plus tensile twinning in texture *** results in a higher contribution on yield strength by~55 MPa in compression than in tension,which reasonably agrees with the experimental yield strength difference(~38 MPa).It can be concluded that I-phase particles influence deformation modes in tension and in compression,finally result in reversed yield strength asymmetry.

关键词： Magnesium alloy Reversed yield strength asymmetry Transmission electron microscopy(TEM) Twinning Dislocations

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A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research International 2024年第1期31卷 74-91页

作者： yan yan Guang-hao Shang Li-ping Zhang Shao-ying Li Han-jie guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

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High-throughput fluorescent screening of thioredoxin reductase inhibitors to inhibit Mycobacterium tuberculosis

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Chinese Chemical Letters 2024年第3期35卷 358-362页

作者： Fei yan xin Zhao Ruibo Li Xiuyan Han Qiulong yan Lei Feng Xiulan xin Jingnan Cui Xiaochi Ma Second Affiliated Hospital Dalian Medical UniversityDalian 116044China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China College of Bioengineering Beijing PolytechnicBeijing 100029China

Tuberculosis(TB)is a chronic infectious disease,which is caused by the pathogen Mycobacterium tuberculosis(Mtb)and reemerged as a global health risk with a significant proportion of multi-drug resistant and extensively drug resistant TB *** is very urgent to find some novel high-confidence drug targets in Mtb for discovering the effective anti-TB *** reductase(TrxR)has been identified to be a highly viable target for anti-TB drugs for its important role in protecting the pathogen from thiol-specific oxidizing stress,regulating intracellular dithiol/disulfide homeostasis and DNA replication and *** the present work,a near-infrared(NIR)fluorescent probe DDAT was developed for the detection of TrxR activity and used to high-throughput screen the TrxR inhibitors from natural *** screened TrxR inhibitors from Sappan Lignum and microbial metabolites that were further used to inhibit Mycobacterium *** the results indicate that DDAT is a practical fluorescent molecular tool for the discovery of potential anti-TB drugs.

关键词： Thioredoxin reductase NIR fluorescent probe Fluorescence imaging High-throughput screening inhibitors Inhibit Mycobacterium tuberculosis

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Simulating the Escaping Atmosphere of GJ 436 b with Two-fluid Magnetohydrodynamic Models

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Research in Astronomy and Astrophysics 2024年第6期24卷 273-286页

作者： Lei xing Jianheng guo Chuyuan yang Dongdong yan Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China International Centre of Supernovae Yunnan Key LaboratoryKunming 650216China

Observations of transmission spectra reveal that hot Jupiters and Neptunes are likely to possess escaping atmospheres driven by stellar *** models predict that magnetic fields may exert significant influences on the atmospheres of hot ***,the escaping atmospheres are not entirely ionized,and magnetic fields only directly affect the escape of ionized components within *** the chemical reactions between ionized components and neutral atoms,as well as collision processes,magnetic fields indirectly impact the escape of neutral atoms,thereby influencing the detection signals of planetary atmospheres in transmission *** order to simulate this process,we developed a magnetohydrodynamic multi-fluid model based on MHD code *** an initial exploration,we investigated the impact of magnetic fields on the decoupling of H^(+)and H in the escaping atmosphere of the hot Neptune *** to the strong resonant interactions between H and H^(+),the coupling between them is tight even if the magnetic field is *** course,alternatively,our work also suggests that merging H and H^(+)into a single flow can be a reasonable assumption in MHD simulations of escaping ***,our simulation results indicate that under the influence of magnetic fields,there are noticeable regional differences in the decoupling of H^(+)and *** the increase of magnetic field strength,the degree of decoupling also *** heavier particles such as O,the decoupling between O and H^(+)is more *** findings provide important insights for future studies on the decoupling processes of heavy atoms in the escaping atmospheres of hot Jupiters and hot Neptunes under the influence of magnetic fields.

关键词： magnetohydrodynamics(MHD) planets and satellites:atmospheres hydrodynamics

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An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

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Petroleum Science 2024年第2期21卷 885-902页

作者： xin Zhang Yun-Hu Lu yan Jin Mian Chen Bo Zhou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum *** deep learning technique has been receiving more interest due to the great potential to deal with pore pressure ***,most of the traditional deep learning models are less efficient to address generalization *** fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic ***,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss *** machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure *** CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining Eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few *** validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization *** adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1D convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

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