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Ionic conductivity of infiltrated Ln (Ln = Gd, Sm, Y)-doped ceria

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Rare Metals 2018年第9期37卷 734-742页

作者： Jiang-Wei Ju Dao-Ming Huan yan-xiang zhang Chang-Rong Xia Guang-Lei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bio-energy and Bio-process Technology Chinese Academy of Sciences Qingdao 266101 China Qingdao Key Laboratory of Solar Energy Utilization and Energy Storage Technology Qingdao Institute of Bio-energy and Bio- process Technology Chinese Academy of Sciences Qingdao 266101 China CAS Key Laboratory of Materials for Energy Conversion Department of Materials Science and Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China Hefei 230026 China National Key Laboratory for Precision Hot Pressing of Metals School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

This work studies the ionic conductivity of nanosized Gd-, Sm-, and Y-doped ceria prepared by the infiltration/impregnation method. The nanoparticles were deposited onto porous pure ceria substrates via infiltration- heating processes, and the conductivity was determined with the electrochemical impedance spectroscopy （EIS） using the conductive model for infiltrated phases. The conductivity of the infiltrated doped ceria changes with the doping amount, and Gd0.25Ce0.75O2-δ, Sm0.2Ce0.8O2-δ, and Y0.15Ce0.85O2-δ show the highest values of 2.56, 3.01, and 2.07 × 10-3 ***-1 at 600 ℃, respectively. Overall, Sin-doped samples show the highest conductivity, whileY-doped samples show the lowest conductivity. In con- sideration of the Bruggeman factor, the intrinsic conduc- tivity of the infiltrated doped ceria was calculated. Compared with the bulk doped ceria, the intrinsic con- ductivity is higher while the activation energy is lower, which may suggest different conduction mechanisms. Besides, co-doping effects on the conductivity of the infiltrated sample are less obvious than those of the bulk sample.

关键词： Doped ceria Infiltration Ionic conductivity Solid oxide fuel cell Nanoparticle

Naringenin protects against isoniazid- and rifampicininduced apoptosis in hepatic injury

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World Journal of Gastroenterology 2016年第44期22卷 9775-9783页

作者： Chao Wang Rui-Qin Fan yan-xiang zhang Hao Nie Kan Li Department of Laboratory Medicine Medical School Yangtze University Clinical and Molecular Immunology Research Center Yangtze University Department of Hepatic Disease the Second Hospital of Jingzhou

AIM To explore the protective effects and mechanisms of naringenin(NRG) on hepatic injury induced by isoniazid(INH) and rifampicin(RIF).METHODS Male mice were randomly divided into four groups and treated for 14 d as follows: normal control group was administered intragastrically with normal saline solution alone; model group was administered intragastrically with INH(100 mg/kg) and RIF(100 mg/kg); lowand high-dosage NRG pretreatment groups were administered intragastrically with different doses of NRG(50 or 100 mg/kg) 2 h before INH and RIF challenge. Mice were killed 16 h after the last dose of drug treatment to determine activity of serum transaminases. Oxidative stress was evaluated by measuring hepatic glutathione(GSH) and superoxide dismutase(SOD) and malondialdehyde(MDA) levels. Histopathological changes in hepatic tissue were observed under the optical microscope. Hepatocyte apoptosis was measured by TUNEL assay and caspase-3 activation. Expression of Bcl-2 and Bax in liver was determined by western *** Both low- and high-dosage NRG pretreatment obviously alleviated serum levels of alanine aminotransferase and aspartate aminotransferase, liver index, hepatic MDA content, and increased hepatic GSH content and SOD activity compared with the INH and RIF-treated group(44.71 ± 8.15 U/L, 38.22 ± 6.64 U/L vs 58.15 ± 10.54 U/L; 98.36 ± 14.78 U/L, 92.41 ± 13.59 U/L vs 133.05 ± 19.36 U/L; 5.34% ± 0.26%, 4.93% ± 0.25% vs 5.71% ± 0.28%; 2.76 ± 0.67 nmol/mgprot, 2.64 ± 0.64 nmol/mgprot vs 4.49 ± 1.12 nmol/mgprot; 5.91 ± 1.31 mg/gprot, 6.42 ± 1.42 mg/gprot vs 3.11 ± 0.73 mg/gprot; 137.31 ± 24.62 U/mgprot, 148.83 ± 26.75 U/mgprot vs 102.34 ± 19.22 U/mgprot; all P < 0.01 or 0.05). Histopathological evaluation showed obvious necrosis and inflammatory cell infiltration in liver of mice administered INH and RIF; however, mice pretreated with NRG showed minor hepatic injury. In addition, INH and RIF resulted in hepatocyte apoptosis, and NRG pretreatment dramatically su

关键词： Naringenin Isoniazid Rifampicin Oxidative stress Apoptosis Hepatic injury

Unexplained elevation of erythrocyte sedimentation rate in a patient recovering from COVID-19:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1394-1401页

作者： Sheng-Lan Pu xiang-yan zhang Dai-Shun Liu Ba-Ning Ye Jian-Quan Li Department of General Medicine The First People's Hospital of ZunyiZunyi 563000Guizhou ProvinceChina Department of General Medicine The Third Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Respiratory Institute Guizhou Provincial People's HospitalGuiyang 550000Guizhou ProvinceChina NHC Key Laboratory of Pulmonary Immune related Disease Guiyang 550000Guizhou ProvinceChina Respiratory Department The First People's Hospital of ZunyiZunyi 563000Guizhou ProvinceChina Respiratory Department The Third Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Intensive Care Unit Guizhou Provincial People's HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND A disease caused by a novel coronavirus virus,named coronavirus disease 2019(COVID-19),broke out in Wuhan,China in December 2019,and spread around the *** of March 4,2020,93090 confirmed cases and 2984 deaths have been reported in more than 80 countries and *** has triggered global public health ***,the features and prognosis of COVID-19 are incompletely *** SUMMARY We here report that the erythrocyte sedimentation rate(ESR)increased in a confirmed COVID *** high level of ESR sustained for a long time even after the patient recovered from COVID-19,while all results related to tumor,tuberculosis,rheumatic diseases,anemia,*** explain the abnormal elevation of ESR presented in this *** Although the increased ESR cannot be explained by all existing evidence,it possibly links the abnormal pathologic change in some COVID-19 patients and negative prognosis,and provides the clue to dissect the mechanism of illness progressing in COVID-19 and its prognosis.

关键词： COVID-19 Erythrocyte sedimentation rate Prognosis SARS-CoV-2 Joint damage Case report

Diagnosis and surgical treatment of esophageal gastrointestinal stromal tumors

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World Journal of Gastroenterology 2015年第18期21卷 5630-5634页

作者： Fang-Biao zhang Hong-Can Shi Yu-Sheng Shu Wei-Ping Shi Shi-Chun Lu xiang-yan zhang Shao-Song Tu Department of Cardiothoracic Surgery Lishui Center Hospital Department of Cardiothoracic Surgery Clinical College Yangzhou University

AIM: To retrospectively evaluate our experience with the diagnosis and surgical resection of esophageal gastrointestinal stromal tumors(GISTs).METHODS: Between January 2003 and August 2014, five esophageal GIST cases were admitted to our hospital. In this study, the hospital records, surgery outcomes, tumor recurrence and survival of these patients were retrospectively ***: The median age of the patients was 45.6 years(range: 12-62 years). Three patients presented with dysphagia, and one patient presented with chest discomfort. The remaining patient was asymptomatic. Four patients were diagnosed with esophageal GISTs by a preoperative endoscopic biopsy. Three patients underwent esophagectomy, and two patients underwent video-assisted thoracoscopic surgery. The mean operating time was 116 min(range: 95-148 min), and the mean blood loss was 176 m L(range: 30-300 m L). All tumors were completely resected. The mean length of postoperative hospital stay was 8.4 d(range: 6-12 d). All patients recovered and were discharged successfully. The median postoperative follow-up duration was 48 mo(range: 29-72 mo). One patient was diagnosed with recurrence, one patient was lost to follow-up, and three patients were asymptomatic and are currently being managed with close radiologic and clinical ***:Surgery is the standard,effective and successful treatment for esophageal *** follow-up is required to monitor recurrence and metastasis.

关键词： Esophagus Gastrointestinal stromal tumors Recurrence

The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension

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Chinese Medical Journal 2008年第1期121卷 43-48页

作者： SUN yan-xiang zhang Hai-yan WEI Yu-miao ZHU Feng WANG Min LIAO Yu-hua Laboratory of Cardiovascular Immunology Institute ot CardiologyUnion Hospital Tongji Medical College of Huazhong Universityof Science and Technology Wuhan Hubei 430022 China

Background Autoantibodies against angiotensin AT1 receptor have been discovered in patients with preeclampsia or malignant hypertension. Some studies have demonstrated that the autoantibodies are involved in the immunopathogenesis of hypertension and have an agonist effect similar to angiotensin II. Methods Autoantibodies against AT1 receptor were purified from sera of patients with primary hypertension by affinity chromatography. Proliferation of cultured rat vascular smooth muscle cells was detected by bromodeoxyuridine incorporation and activation of signalling molecules detected by Western blotting and electrophoretic mobility shift assay. Results The AT1-RAb caused a significant proliferation similar to the Ang II during first 24 hours. The levels of nuclear factor-KB （NF-KB）, phosphorylated JAK2., phosphorylated STAT1 （pSTAT1） and phosphorylated STAT3 （pSTAT3） molecules were increased in response to the autoantibodies. In contrast, the activations of NF-KB and JAK-STAT were blocked by Iosartan, pyrrolidinedithiocarbamate （a specific inhibitor of NF-KB） and AG490 （a specific inhibitor of the JAK2. tyrosine kinase）. The expressions of NF-KB, pSTAT1 and pSTAT3 reached peak levels at different times. Moreover, the relative densities of electrophoretic bands showed that activation of pSTAT3 was more significant than STAT1 induced by AT1 -RAb. Conclusions These results suggest that the autoantibodies against AT1 receptor have an agonist effect similar to Ang II in proliferation of VSMCs and the NF-KB and JAK-STAT proteins play essential roles. The effect is different from Angll in that STAT3 is the main downstream activating molecule in JAK-STAT signalling pathway.

关键词： autoantibody angiotensin AT1 receptor proliferation Janus kinase-signal transduction activation of transcription nuclear factor-xB

Unveiling solid-solid contact states in all-solid-state lithium batteries:An electrochemical impedance spectroscopy viewpoint

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Journal of Energy Chemistry 2025年第2期101卷 16-22页

作者： Jin-Liang Li Liang Shen Zi-Ning Cheng Jun-Dong zhang Ling-Xuan Li Yu-Tong zhang yan-Bin Gao Chunli Guo xiang Chen Chen-Zi Zhao Rui zhang Qiang zhang Tsinghua Center for Green Chemical Engineering Electrification Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University College of Materials Science and Engineering Taiyuan University of Technology Advanced Research Institute of Multidisciplinary Science School of Materials Science and Engineering Beijing Institute of Technology Beijing Huairou Laboratory Institute for Carbon Neutrality Tsinghua University Shanxi Research Institute for Clean Energy Tsinghua University

All-solid-state lithium batteries（ASSLBs） are strongly considered as the next-generation energy storage devices for their high energy density and intrinsic *** solid-solid contact between lithium metal and solid electrolyte plays a vital role in the performance of working ASSLBs,which is challenging to investigate quantitatively by experimental *** work proposed a quantitative model based on the finite element method for electrochemical impedance spectroscopy simulation of different solid-solid contact states in *** the assistance of an equivalent circuit model and distribution of relaxation times,it is discovered that as the number of voids and the sharpness of cracks increase,the contact resistance Rcgrows and ultimately dominates the battery *** accurate fitting,inverse proportional relations between contact resistance Rcand（1-porosity） as well as crack angle was *** contribution affords a fresh insight into clarifying solid-solid contact states in ASSLBs.

关键词： All-solid-state lithium batteries Distribution of relaxation times Electrochemical impedance spectroscopy Equivalent circuit model Finite element method Solid-solid contacts

Atomically dispersed Cu-based metal-organic framework directly for alkaline polymer electrolyte fuel cells

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Chinese Chemical Letters 2025年第2期36卷 579-585页

作者： Wenbiao zhang Bolong yang Zhonghua xiang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Sungrow Hydrogen Sci.&Tech.Co. Ltd.

Atomically dispersed Cu-based single-metal-site catalysts （Cu-N-C） have emerged as a frontier for electrocatalytic oxygen reduction reactions （ORR） because they can effectively optimize the D-band center of the Cu active site and provide appropriate adsorption/desorption energy for oxygen-containing ***-organic frameworks （MOFs） show excellent prospects in many fields because of their structural regularity and designability,but their direct use for electrocatalysis has been rarely reported due to the low intrinsic ***,a MOF material （Cu-TCNQ） with highly regular single-atom copper active centers was successfully prepared using a solution chemical reaction ***,Cu-TCNQ and graphene oxide （GO） were directly self-assembled to form a Cu-TCNQ/GO composite,which improved the conductivity of the catalyst while maintained the atomically precise *** resistivity of the Cu-TCNQ/GO decreased by three orders of magnitude （1663.6–2.7 W/cm） compared with pure *** half-wave potential was as high as 0.92 V in 0.1 mol/L KOH,even better than that of commercial 20%Pt/*** alkaline polymer electrolyte fuel cells （APEFCs）,the open-circuit voltage and power density of Cu-TCNQ/GO electrode reached 0.95 V and 320 m W/cm2,respectively,which suggests that Cu-TCNQ/GO has a good potential for application as a cathode ORR catalyst.

关键词： Alkaline polymer electrolyte fuel cells Cu-TCNQ/GO Metal-organic frameworks Oxygen reduction reaction Single-metal-site catalysts

Duodenal-jejunal bypass surgery on type 2 diabetic rats reduces the expression of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in the thoracic aorta

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Chinese Medical Journal 2014年第13期127卷 2423-2428页

作者： Maimaitiyusufu Wubulikasimu Han Haifeng yan Zhibo zhang xiang Liu Shaozhuang zhang Guangyong Kasimu Aimaiti Hu Sanyuan Department of General Surgery Qilu Hospital of ShandongUniversity Jinan Shandong 250012 China

Background Bariatric surgery offers a productive resolution of type 2 diabetes mellitus （T2DM）.The development of T2DM vasculopathy is due to chronic inflammation,which increases matrix metalloproteinase-9 （MMP-9） and tissue inhibitor of matrix metalloproteinase-1 （TIMP-1） *** study sought to examine MMP-9 and TIMP-1 expression in the thoracic aorta after duodenal-jejunal bypass （DJB） surgery on a T2DM rat model induced by a high-fat diet and low dose streptozotocin （STZ）.Methods Twenty-one T2DM Wistar rats induced by high-fat diet and low dose STZ were randomly divided into DJB and sham duodenal-jejunal bypass （S-DJB） *** Wistar rats were fed a normal diet as a *** of gastrointestinal function post-operation and resumption of a normal diet completed the *** weight,blood glucose,blood lipid levels,and MMP-9 and TIMP-1 expression levels in aortic endothelial cells were measured *** DJB rats showed significant weight loss 2 weeks post-operation compared with S-DJB *** surgery,DJB rats showed significant improvement and steady glycemic control with improved insulin sensitivity and glucose *** also exhibited improved lipid metabolism with a decrease in fasting free fatty acids （FFAs） and triglycerides （all P ＜0.05）.Immunohistochemistry showed decreased MMP-9 and TIMP-1 expression 12 weeks after surgery （P ＜ 0.01）.Conclusions DJB surgery on an induced T2DM rat model improves blood glucose levels and lipids,following a high-fat diet and low dose STZ *** addition,DJB decreased MMP-9 and TIMP-1 expression in vascular endothelial cells,which may play an important role in delaying the development of T2DM vascular disease.

关键词： type 2 diabetes mellitus vasculopathy matrix metalloproteinase-9 tissue inhibitor of matrix metalloproteinase-1 duodenal-jejunal bypass

Influence of Rhamnolipids Biosurfactant on the Anodic Electrochemical Performance in Marine Sediment Microbial Fuel Cell and the Acceleration Degradation of Crude Petroleum

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Journal of Ocean University of China 2025年第1期24卷 139-146页

作者： HOU Luyao ZAI Xuerong MENG Yao LIANG Shengkang CAO Yali CHEN yan zhang Huaijing HUANG xiang FU Yubin College of Materials Science and Engineering Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China College of Marine Geosciences Ocean University of ChinaQingdao 266100China

Crude petroleum pollution causes some serious ecological disasters in the *** sediment microbial fuel cells(MSMFCs)have been utilized as a novel method for in-situ degradation and a long-term power ***,the effect of different concentrations of rhamnolipids biosurfactant on the electrochemical performance of MSMFCs anode and the higher efficiency of oil degradation are creatively *** results indicate that the anode in sediment containing rhamnolipids effectively enriches the indigenous electrogenic Pseudophaeobacter and Pseudomonas,which significantly enhances the electrochemical performance of the *** rhamnolipids at the concentration of 200 mg kg^(-1)in sediment,the anode specific capacitance(401.45 Fm^(-2)),exchange current density(4.87×10^(-2)mAm^(-2)),and cell maximum power density(140.24 mWm^(-2))increase by 2.50,38.65,and 2.11 times,respectively,in comparison with its natural *** the oil degradation rate(40.06%)was higher than the blank(17.55%).It demonstrates that the synergistic effect between electrochemical catalytic degradation and emulsifying solubilization of rhamnolipids surfactant directly accelerates the degradation of petroleum in marine sediment,which will provide a novel method and theoretical guidance for in-situ degradation and efficient removal of crude petroleum on ocean floor.

关键词： marine sediment microbial fuel cells petroleum pollution rhamnolipids biosurfactant electrochemical performance