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World Journal of Gastroenterology 2024年第38期30卷 4232-4238页

作者： Yi-Fan Jia Fei-Fan Chen Li yang Yun-Xia Ye Yi-Zhu Gao wen-yan zhang Jin-Lin yang Department of Gastroenterology and Hepatology University of Oxford Huaxi Joint Centre for Gastrointestinal CancerFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Emergency West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Composite tumors are neoplasms comprising two distinct,yet intermingling,cell *** paper reports a rare phenomenon where early gastric signet-ring cell carcinoma(SRCC)and gastric mucosa-associated lymphoid tissue(MALT)lymphoma coexist within the same *** SUMMARY A 40-year-old woman presented to the West China Hospital for examination,which revealed a whitish,shallow,and uneven mucosal lesion in the *** lesion was diagnosed as a poorly differentiated adenocarcinoma,including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection,based on histopathological examination of the biopsy *** lesion was excised using segmental ***,histological exami-nation of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT *** two entities were stage I and coexisted in the same *** It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct *** resection is effective for these lesions.

关键词： Gastric cancer Composite tumors Early stage Signet-ring cell carcinoma Mucosa-associated lymphoid tissue lymphoma Case report

MODEL ANALYSIS AND PARAMETER EXTRACTION FOR MOS CAPACITOR INCLUDING QUANTUM MECHANICAL EFFECTS

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Journal of Computational Mathematics 2006年第3期24卷 401-411页

作者： Hai-yan Jiang Ping-wen zhang LMAM CCSE and School of Mathematical Sciences.Peking University Beijing 100871 China

The high frequency CV curves of MOS capacitor have been studied. It is shown that semiclassical model is a good approximation to quantum model and approaches to classical model when the oxide layer is thick. This conclusion provides us an efficient （semiclassical） model including quantum mechanical effects to do parameter extraction for ultrathin oxide device. Here the effective extracting strategy is designed and numerical experiments demonstrate the validity of the strategy.

关键词： Poisson Equation SchrSdinger Equation MOS Capacitor Quantum Effect,Sensitivity Parameter Extraction.

On Ekeland's Variational Principle for Set-Valued Mappings

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 141-148页

作者： Sheng-jie Li wen-yan zhang College of Mathematics and Science Chongqing University Chongqing 400044 China

In this paper, we derive a general vector Ekeland variational principle for set-valued mappings, which has a dosed relation to εk^0 -efficient points of set-valued optimization problems. The main result presented in ... 详细信息

关键词： Vector Ekeland variational principle nonlinear scalarization function metric space set-valued mapping

Response of nearshore circulation outside yangtze Estuary to El Nino events

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Water Science and Engineering 2016年第2期9卷 145-154页

作者： wen-yan zhang Zheng Gong Chang-kuan zhang Wei Tan State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 China CCCC Third Harbor Consultants Co. Ltd. Shanghai 210030 China Jiangsu Key Laboratory of Coast Ocean Resources Development and Environment Security Hohai University Nanjing 210098 China

With consideration of the comprehensive effects of runoff from the yangtze River, East China Sea background circulation, and tidal currents,a regional circulation model, including the yangtze Estuary, Hangzhou Bay, and adjacent sea areas was established. The 2002/2003 El Ni^no event was chosen for study of the anomalies of circulation outside the yangtze Estuary. The coastal and ocean current systems of the East China Sea and the current structure outside the yangtze Estuary were accurately described. The results of vertical circulation analysis basically coincide with those of horizontal circulation analysis, showing that the circulation outside the yangtze Estuary is mainly affected by the Taiwan warm current, runoff from the yangtze Estuary, and the tide-induced residual current. The El Ni^no event weakens yangtze Estuary circulation to a certain degree, and the impacts are more significant in summer than in winter. During the 2002/2003 El Ni^no event, the flux of the Taiwan warm current decreases, and the northward component of the Taiwan warm current decreases by half in February 2003 compared to the previous year. However, its path is relatively stable.

关键词： El Nino Princeton ocean model yangtze Estuary Circulation Taiwan warm current

Clinical and genetic diagnosis of autosomal dominant osteopetrosis typeⅡin a Chinese family:A case report

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World Journal of Clinical Cases 2023年第3期11卷 700-708页

作者： Hong-Ping Gong yan Ren Pan-Pan Zha wen-yan zhang Jin zhang Zhi-wen zhang Chun Wang International Medical Center Ward General Practice Medical CenterSichuan University West China HospitalChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism The People’s Hospital of LeshanLeshan 614003Sichuan ProvinceChina

BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of ***,80%of autosomal dominant osteopetrosis type II(ADO-II)patients were usually affected by heterozygous dominant mutations in the chloride voltage-gated channel 7(ClCN7)gene and present early-onset osteoarthritis or recurrent *** this study,we report a case of persistent joint pain without bone injury or underlying *** SUMMARY We report a 53-year-old female with joint pain who was accidentally diagnosed with *** clinical diagnosis was based on increased bone density and typical radiographic *** heterozygous mutations in the ClCN7 and Tcell immune regulator 1(TCIRG1)genes by whole exome sequencing were identified in the patient and her *** missense mutation(c.857G>A)occurred in the CLCN7 gene p.R286Q,which is highly conserved across *** TCIRG1 gene point mutation(c.714-20G>A)in intron 7(near the splicing site of exon 7)had no effect on subsequent *** This ADO-II case had a pathogenic CLCN7 mutation and late onset without the usual clinical *** the diagnosis and assessment of the prognosis for osteopetrosis,genetic analysis is advised.

关键词： Osteopetrosis Autosomal dominant osteopetrosis typeⅡ Diagnosis Genetic analysis Case report

Antitumor triterpene saponins from Anemone flaccida

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Chinese Chemical Letters 2008年第2期19卷 190-192页

作者： Lan Tian zhang yan wen zhang Yoshihisa Takaishi Hong Quan Duan School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China School of Pharmaceutical Sciences Basic Medical Research Center of Tianjin Tianjin Medical University Tianjin 300070 China Faculty of Pharmaceutical Sciences University of Tokushima Shomachi 1-78 Tokushima 770-8505 Japan

A new triterpenoid saponin, 3-O-[（6′-butyryl）-β-D-glucopyranosyl]-28-O-[α-L-rhamnopyranosyl-（1→4）-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl] oleanolic acid, as well as three known triterpenoid saponins were isolated from the rhizomes of Anemone flaccida. Their structures were elucidated by spectroscopic methods. These compounds showed significant antitumor activities.

关键词： Anemone flaccida Triterpene saponins Cytotoxic activities

Multi-objective optimization and experiment of nylon cord rubber in expandable packer

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Petroleum Science 2021年第1期18卷 269-284页

作者： yan-wen zhang Han-Xiang Wang Jia-Qi Che Ming-Chao Du Hong-Jie zhang College of Mechanical and Electronic Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina

Nylon cord rubber has the advantages of small residual deformation and is easy to lift and lower the tubing string in low-permeability oil and gas ***,it is associated with low-pressure resistance and poor sealing *** enhance the performance of nylon cord rubber,a three-dimensional numerical model of the nylon cord rubber was established and its accuracy experimentally *** Plackett-Burman test,the Steepest climbing test and the Response surface method were used to acquire the polynomial response surface model connecting structural parameters with bearing and sealing *** genetic algorithms,optimal structural parameters of nylon cord rubber were determined depending on field *** reliability of the optimized results was verified by laboratory *** was shown that after optimization,the bearing capacity of the expandable packer increased by 25%while the sealing performance increased by 66%.In addition,the bearing pressure was 70 MPa while the sealing pressure was 50 *** measurements effectively met the on-site requirements of high-pressure and fine fracturing in low-permeability oil and gas reservoirs.

关键词： Low-permeability reservoirs Nylon cord rubber Numerical simulation Response surface method Multi-objective genetic algorithm Laboratory test

A new iridoid glycoside from Veronica sibirica

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Chinese Chemical Letters 2008年第4期19卷 450-452页

作者： Jie Teng Fu Geng zhang yan wen zhang Yoshihisa Takaishi Hong Quan Duan School of Pharmaceutical Sciences Basic Medical Research Center of TianjinTianjin Medical UniversityTianjin 300070China Tianjin Huanhu Hospital Tianjin 300060China Faculty of Pharmaceutical Sciences University of TokushimaShomachi 1-78Tokushima 770-8505Japan

A new iridoid glycoside,versibirioside（1）,and a known iridoid glycoside,verbaspinoside（2）,were isolated from the whole plant of Veronica sibirica *** structures were elucidated by spectroscopic methods,including 2... 详细信息

关键词： Veronica sibirica L. Versibirioside Iridoid glycoside

Immunosuppressive terpenoids from Tripterygium wilfordii

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Chinese Chemical Letters 2008年第4期19卷 453-456页

作者： Qian Shen ZhiYao Yoshihisa Takaishi yan wen zhang Hong Quan Duan School of Pharmaceutical Sciences Basic Medical Research Center of TianjinTianjin Medical UniversityTianjin 300070China Department of Immunology Tianjin Medical UniversityTianjin 300070China Faculty of Pharmaceutical Sciences University of TokashimaTokushima 770-8505Japan

Two new terpenes,triptobenzene P（1）and wilforone（2）were isolated from Tripterygium wilfordii,as well as 10 known *** structures were elucidated by spectroscopic *** 2-4,8,10,and 11 showed significant immunosuppres... 详细信息

关键词： Tripterygium wilfordii Diterpene Triterpene Immunosuppressive activity

An analytical model of hot rolling force for a thick plate by combining globally optimal approximation yield criterion and egg-circular velocity field

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Journal of Iron and Steel Research International 2024年第3期31卷 647-659页

作者： Shun-hu zhang Yi zhang wen-hao Tian yan Li Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

For the sake of solving the problem that it is difficult to be integrated for the Mises specific plastic power due to its nonlinearity,a new linear criterion,named the globally optimal approximation criterion,is constructed by the polygonal approximation to the Mises *** new criterion is proved to be the linear function of the principal stress componentsσ1,σ2 andσ3 and the trajectory of it on theπ-plane is a non-equiangular but equilateral dodecagon intersecting the Mises *** theoretical results of the current criterion described by the Lode stress parameters are in excellent accordance with the experimental ***,according to the trend that the metallic flow velocity between rollers aggrandizes gradually from the inlet to the outlet during the hot rolling of a thick plate,a biomimetic velocity field is proposed in which the horizontal velocity component fits the egg-circular curve *** velocity field and its simulated results agree quite ***,using the determined linear criterion,energy analysis of the constructed velocity field is utilized to obtain the interior deformation power,while the vector decomposition approach is utilized to obtain the frictional power and shear *** this basis,the overall power is obtained and the analytical solutions are generated for the rolling torque,rolling force and the coefficient of the stress state under different egg curves by minimizing the neutral ***,the parameter optimization of the characteristic parameterρwhich affects the slope of the egg-circular curve is carried out and the best egg-circular curve which can minimize the energy consumption is *** best agreement between the theoretical and observed values of rolling force and rolling torque is under this curve,and the mean relative errors of the rolling torque and rolling force are no more than 2.93%,while the maximum error is no more than 8.35%.

关键词： Yield criterion Plastic deformation Rolling force Velocity field Analytical solution