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Asian Journal of Andrology 2014年第1期16卷 101-106页

作者： yan-wei sha Lu Ding Ping Li Reproductive Medicine Center Maternal and Child Health Hospital of Xiamen Xiamen China

Kartagener＇s syndrome （KS） is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia （PCD）. As it is accompanied by many complications, PCD/KS severely affects the patient＇s quality of life. Therapeutic approaches for PCD/KS aim to enhance prevention, facilitate rapid definitive diagnosis, avoid misdiagnosis, maintain active treatment, control infection and postpone the development of lesions. In male patients, sperm flagella may show impairment in or complete absence of the ability to swing, which ultimately results in male infertility. Assisted reproductive technology will certainly benefit such patients. For PCD/KS patients with completely immotile sperm, intracytoplasmic sperm injection may be very important and even indispensable. Considering the number of PCD/KS susceptibility genes and mutations that are being identified, more extensive genetic screening is indispensable in patients with these diseases. Moreover, further studies into the potential molecular mechanisms of these diseases are required. In this review, we summarize the available information on various aspects of this disease in order to delineate the therapeutic objectives more clearly, and clarify the efficacy of assisted reproductive technology as a means of treatment for patients with PCD/KS-associated infertility.

关键词： assisted reproductive technology clinical diagnosis and treatment genetic mechanism Kartagener's syndrome malefertifity, primary ciliary dyskinesia

Genetic factors contributing to human primary ciliary dyskinesia and male infertility

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Asian Journal of Andrology 2017年第5期19卷 515-520页

作者： Zhi-Yong Ji yan-wei sha Lu Ding Ping Li The Center for Reproductive Medicine Xiamen Maternity and Child Care Hospital No. 10 Zhenhai Road Xiamen China

Primary ciliary dyskinesia （PCD） is an autosomal-recessive disorder resulting from the loss of normal ciliary function. Symptoms include neonatal respiratory distress, chronic sinusitis, bronchiectasis, situs inversus, and infertility. However, only 15 PCD-associated genes have been identified to cause male infertility to date. Owing to the genetic heterogeneity of PCD, comprehensive molecular genetic testing is not considered the standard of care. Here, we provide an update of the progress on the identification of genetic factors related to PCD associated with male infertility, summarizing the underlying molecular mechanisms, and discuss the clinical implications of these findings. Further research in this field will impact the diagnostic strategy for male infertility, enabling clinicians to provide patients with informed genetic counseling, and help to adopt the best course of treatment for developing directly targeted personalized medicine.

关键词： genetic factors Kartagener syndrome male infertility primary ciliary dyskinesia

First successful pregnancy outcome after intracytoplasmic sperm injection with short-tailed sperm from an infertile Han Chinese man

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Asian Journal of Andrology 2017年第5期19卷 613-614页

作者： yan-wei sha Qing Zhang Lu Ding Ping Li The Center for Reproductive Medicine Xiamen Maternity and Child Care HospitalXiamen Fujian Province China

Dear Editor, Short-tailed sperms are rarely encountered in clinical practice, but they make achieving fertilization difficult. We encountered a very rare case of an infertile man having short-tailed sperm. A 32-year-old Chinese farmer and his 27-year-old wife were referred to Xiamen Maternity and Child Care Hospital for a fertility evaluation.

关键词： clinical practice

A successful pregnancy by intracytoplasmic sperm injection using ejaculate sperm from an infertile man with 46, XX/46, XY true hermaphrodite

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Asian Journal of Andrology 2017年第6期19卷 721-722页

作者： yan-wei sha yan-Kun sha Lu Ding shao-Bin Lin Zhi-Yong Ji Xu Wang Yue-Qiang Song Ping Li Center for Reproductive Medicine Xiamen Maternity and Child Care HospitalXiamen 361003 China Department of Nephrology First Affiliated Hospital ofLiaoning Medical University Jinzhou 121000 China.

Dear Editor, True hermaphroditism is a condition in which the gonads, genital morphology, and sexuality simultaneously show both male and female characteristics （ovaries and testes） or in which both types of gonadal tissue exist in a single gonad （known as an ovariotestis）. True hermaphroditism associated with a chimeric or 46, XX/46, XY karyotype is extremely rare, and the genitalia of those affected can be characterized as female, male, or mixed.1-3 The cause of true hermaphroditism has not been determined because the condition is relatively rare and has a diverse phenotype.4

关键词： intracytoplasmic ejaculate hermaphrodite

Case study of a patient with cryptozoospermia associated with a recessive TEX15 nonsense mutation

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Asian Journal of Andrology 2018年第1期20卷 101-102页

作者： Xiong Wang Hai-Rong Jin Yuan-Qing Cui Jie Chen yan-wei sha Zhen-Li Gao Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao University 20 Yuhuangding East Road Yantai 264000 China Department of Urological Surgery Affiliated Yantai Yuhuangding Hospital of Qingdao University 20 Yuhuangding East Road Yantai 264000 China Department of Reproductive Medicine Xiamen Maternity and Child Care Hospital No. 10 Zhenhai Road Xiamen 361003. China

Dear Editor, Male infertility, which affects approximately 20 million people worldwide, is commonly caused by spermatogenic dysfunctions, including severe oligozoospermia, cryptozoospermia, and nonobstructive azoospe... 详细信息

关键词： nonobstructive azoospermia

Diagnosis of a Chinese man with 45,X/46,X,i（Y）（q10）/47,X,i（Y）（q10） ×2 mosaic Turner syndrome

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Asian Journal of Andrology 2018年第2期20卷 205-207页

作者： yan-wei sha Lu Ding Zhi-Yong Ji Yun-Sheng Ge Hui Kong Qing Zhang Yu-Lin Zhou Ping Li Department of Reproductive Medicine Maternal and Child Health Hospital of Xiamen Xiamen 361005 China Genetics Laboratory Maternal and Child Health Hospital of Xiamen Xiamen 361005 China

Turner syndrome （TS）, characterized by the complete or partial absence of an X chromosome, is the only known viable chromosomal monosomy. It is one of the most common sex chromosome abnormalities in women, but it ca...

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Globozoospermic infertility associated with balanced DPY19L2 translocation/gene deletion at the chromosomal breakpoint

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Asian Journal of Andrology 2018年第2期20卷 210-211页

作者： yan-wei sha Li-Bin Mei Liang-Kai Zheng Rui-Hua Tian Lu Ding Zhi-Yong Ji Qing Zhang Ping Li Center for Reproductive Medicine Women and Children's Hospital of Xiamen Xiamen 361003 China Department of Pathology Women and Children's Hospita of Xiamen Xiamen 361003 China

We report here a rare case ofDPY19L2 gene deletion at chromosome 12 breakpoints caused by a 46, XY, t （4; 12）; （q27; qlS） balanced translocation. The patient eventually developed globozoospermia. A 32-year-old male had experienced infertility issues for 4 *** patient exhibited normal appearance, intelligence, and body type, with a height of 175 cm and a weight of 75 kg.

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Biallelic mutations in spermatogenesis and centriole-associated 1 like(SPATC1L)cause acephalic spermatozoa syndrome and male infertility

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Asian Journal of Andrology 2022年第1期24卷 67-72页

作者： You-Zhu Li Na Li Wen-Sheng Liu yan-wei sha Rong-Feng Wu Ya-Ling Tang Xing-Shen Zhu Xiao-Li wei Xiao-Ya Zhang Yi-Feng Wang Zhong-Xian Lu Fu-Xing Zhang Reproductive Medicine Center The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Intensive Care Unit Fujian Medical University Xiamen Humanity HospitalXiamen 361009China Obstetrics and Gynecology Center Department of Obstetrics and GynecologyZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Pharmaceutical Sciences State Key Laboratory of Cellular Stress BiologyXiamen UniversityXiamen 361102China Department of Andrology United Diagnostic and Research Center for Clinical GeneticsWomen and Children’s Hospital and School of MedicineXiamen UniversityXiamen 361005China Department of Obstetrics and Gynecology First Affiliated Hospital of Xiamen UniversityXiamen 361003China Department of General Surgery First Affiliated Hospital of Xiamen UniversityXiamen 361003China

Acephalic spermatozoa syndrome is a rare type of teratozoospermia that severely impairs the reproductive ability of male patients,and genetic defects have been recognized as the main cause of acephalic spermatozoa *** and centrioleassociated 1 like(SPATC1L)is indispensable for maintaining the integrity of sperm head-to-tail connections in mice,but its roles in human sperm and early embryonic development remain largely ***,we conducted whole-exome sequencing(WES)of 22 infertile men with acephalic spermatozoa *** in silico analysis of the candidate variants was conducted,and WES data analysis was performed using another cohort consisting of 34 patients with acephalic spermatozoa syndrome and 25 control subjects with proven *** identified biallelic mutations in SPATC1L(c.910C>T:***304Cys and c.994G>T:***332X)from a patient whose sperm displayed complete *** SPATC1L variants are rare and ***1L is mainly expressed at the head–tail junction of elongating *** containing pathogenic variants decreased the level of SPATC1L in ***,none of the patient’s four attempts at intracytoplasmic sperm injection(ICSI)resulted in a transplantable embryo,which suggests that SPATC1L defects might affect early embryonic *** conclusion,this study provides the first identification of SPATC1L as a novel gene for human acephalic spermatozoa ***,WES might be applied for patients with acephalic spermatozoa syndrome who exhibit reiterative ICSI failures.

关键词： acephalic spermatozoa syndrome biallelic mutations spermatogenesis and centriole-associated 1 like whole-exome sequencing

Solar cycles during the seventeenth century revealed by equatorial aurora records

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Earth and Planetary Physics 2025年第1期9卷 182-187页

作者： Yong wei LiMei yan Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Solar cycles are fundamental to astrophysics,space exploration,technological infrastructure,and Earth's climate.A better understanding of these cycles and their history can aid in risk mitigation on Earth,while also deepening our knowledge of stellar physics and solar system *** the solar cycles between 1600 and 1700-especially the post-1645 Maunder Minimum,characterized by significantly reduced solar activity-poses challenges to existing solar activity *** study utilizes a new red equatorial auroral catalog from ancient Korean texts to establish solar cycle patterns from 1623 to ***,a further reevaluation of the solar cycles between 1610 and 1755 identified a total of 13 cycles,diverging from the widely accepted record of 12 cycles during that *** research enhances our understanding of historical solar activity,and underscores the importance of integrating diverse historical sources into modern analyses.

关键词： solar cycle Maunder Minimum solar activity red equatorial aurora West Pacific geomagnetic anomaly

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen wei Yufei Mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area