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Occurrence and risk assessment of azole fungicides during the urban water cycle:A year-long study along the yangtze River,China

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Journal of Environmental Sciences 2024年第7期141卷 16-25页

作者： yangyang Zhang Xinjie Gu Xiuwen li Qiuyun Zhao Xiaodong Hu Rui Huang Jixiong Xu Zilong Yin Qing Zhou Aimin li Peng Shi State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Jiangsu Province Hydraulic Research Institute Nanjing 210023China

Azole fungicides(AFs)play an important role in the prevention and treatment of fungal diseases in agricultural ***,limited studies are addressing the fate and ecological risk of AFs in the urban water cycle at a large watershed *** address this gap,we investigated the spatiotemporal distribution and ecological risk of twenty AFs in the lower reaches of the yangtze River across four ***(CBA),tebuconazole(TBA),tricyclazole(TCA),and propiconazole(PPA)were found to be the dominant *** highest concentrations were measured in January(188.3 ng/L),and November(2197.1 ng/L),July(162.0 ng/L),and November(1801.9 ng/L),*** comparison between wastewater treatment plants(WWTPs)effluents and surface water suggested that industrial WWTPs are major sources of AFs in the yangtze *** particular,TBA and PPA were found to be the most recalcitrant AFs in industrial WWTPs,while difenoconazole(DFA)was found to be the most potent pollutant in municipal WWTPs,with an average removal rate of less than60%.The average risk quotient(RQ)for the entire AFs was 6.45 in the fall,which was higher than in January(0.98),April(0.61),and July(0.40).This indicates that AFs in surface water posed higher environmental risks during the dry ***,the exposure risk of AFs via drinking water for sensitive populations deserves more *** study provides benchmark data on the occurrence of AFs in the lower reaches of the yangtze River,and offers suggestions for better reduction of AFs.

关键词： Azole fungicides Spatiotemporal distribution Ecological risk Urban water cycle the yangtze River

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Seeing is believing: observation of migrasomes

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Biophysics Reports 2024年第2期10卷 67-81页

作者： Yuwei Huang li Yu School of Basic Medical Sciences Translational Medicine Institute Xi'an Jiaotong University State Key Laboratory of Membrane Biology Tsinghua University-Peking University Joint Center for Life SciencesBeijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University

Migrasomes are a novel type of cell organelle that form on the retraction fibers at the rear of migrating cells. In recent years, numerous studies have unveiled the mechanisms of migrasome formation and have highlighted significant roles of migrasomes in both physiological and pathological *** upon the strategies outlined in published works and our own research experiences, we have compiled a comprehensive set of protocols for observing migrasomes. These step-by-step instructions encompass various aspects such as cell culture, labeling, imaging, in vitro reconstitution, and statistical analysis. We believe that these protocols serve as a valuable resource for researchers exploring migrasome biology.

关键词： Migrasome Labeling Imaging In vitro reconstitution

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B细胞激活因子及其靶向药物与炎症性肠病的研究进展

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中国当代儿科杂志 2024年第3期26卷 315-320页

作者：李琳刘海燕(综述) 王立俊(审校) 山东第一医科大学附属省立医院儿科山东济南250000

B细胞激活因子(B-cell activating factor,BAFF)作为B细胞的关键调节因子,参与多种自身免疫性疾病。炎症性肠病(inflammatory bowel disease,IBD)是一组病因尚不明确的慢性、反复发作的肠道炎症性疾病,近年来全球发病率呈上升趋势。多... 详细信息

B细胞激活因子(B-cell activating factor,BAFF)作为B细胞的关键调节因子,参与多种自身免疫性疾病。炎症性肠病(inflammatory bowel disease,IBD)是一组病因尚不明确的慢性、反复发作的肠道炎症性疾病,近年来全球发病率呈上升趋势。多种因素引起的异常免疫反应与IBD发病密切相关,B细胞异常活化及自身抗体产生增加在溃疡性结肠炎的发病中已得到证实,而BAFF是否参与IBD发病机制尚不明确。该文就目前关于BAFF在IBD发病机制中的潜在作用以及在IBD中针对BAFF的靶向治疗研究进行综述,旨在为IBD靶向治疗提供思路。

关键词：炎症性肠病 B细胞激活因子靶向治疗

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Environmental arsenic(As)and its potential relationship with endemic disease in southwestern China

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Journal of Environmental Sciences 2024年第5期139卷 46-59页

作者： Donglin li Hucai Zhang Fengqin Chang lizeng Duan yang Zhang Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650500China Southwest United Graduate School Kunming 650500China

Many cases of an unknown disease exhibiting the clinical features of limb gangrene,blisters,ulceration,and exfoliation have been reported in Daping village(DV)in southwestern ***,the pathogenesis is unknown and has puzzled doctors for many years.A preliminary study on heavy metals and symptoms indicated that arsenic might pose the greatest threat to the health of local ***,to explore the sources of and factors influencing arsenic enrichment in DV,whose residents exhibit signs of arsenic poisoning,the As contents in soil,water,and plants were systematically *** results indicated high As contents in plant and soil samples obtained from the area,and the source of As may be linked to the weathering of black shale *** of soil and consumption of plants were the two main As exposure pathways among children and adults,respectively,and children exhibited a higher health risk than *** presume and emphasize that when extreme drought events occur,humans might face unusual risks resulting from exposure to toxic elements and the direct consumption of highly polluted *** study provides a new perspective and sheds light on the environmental geochemistry and health links of this disease.

关键词： Endemic disease Arsenic(As) Risk assessment Black shale Climate change

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嵌入式类蜂窝结构面外力学性能研究

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机械设计与制造 2024年第9期403卷 331-334,339页

作者：李响宋小俊王艳苗曹祥斌三峡大学水电机械设备设计与维护湖北省重点实验室湖北宜昌443002 三峡大学机械与动力学院湖北宜昌443002

提出一种嵌入式类蜂窝结构,采用能量法推导其单(双)壁厚夹芯结构的面外等效力学参数公式,利用数值模拟方法验证其力学模型及公式的正确性;研究嵌入式类蜂窝芯层结构尺寸对其面外力学性能的影响,结果表明:在其他结构尺寸一定的情况下,当... 详细信息

提出一种嵌入式类蜂窝结构,采用能量法推导其单(双)壁厚夹芯结构的面外等效力学参数公式,利用数值模拟方法验证其力学模型及公式的正确性;研究嵌入式类蜂窝芯层结构尺寸对其面外力学性能的影响,结果表明:在其他结构尺寸一定的情况下,当四边形壁厚与八边形壁厚之比a增大时,该结构的面外等效弹性模量和剪切模量随之增大,当八边形边长与其壁厚之比β增大时,该结构的面外等效弹性模量和剪切模量随之减小,并且β值到达50左右时,剪切模量趋于稳定,由此发现面外等效弹性模量受尺寸参数影响较剪切模量明显。此研究为后续嵌入式类蜂窝结构在工程中的应用提供了理论支撑。

关键词：嵌入式类蜂窝面外力学性能力学模型能量法数值模拟结构尺寸

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Ferroelectric perovskite PbTiO3for advanced photocatalysis

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Rare Metals 2024年第9期43卷 4038-4055页

作者： Shuang Zhao Shi-Shi Shen Lu Han Bo-Chao Tian Na li Wei Chen Xi-Bao li School of Materials and Metallurgy University of Science andTechnology Liaoning School of Materials Science and Engineering Nanchang Hangkong University Department of Chemistry National University of Singapore

The ferroelectric semiconductor material PbTiO3exhibits remarkable spontaneous polarization and photoelectric properties, positioning it as a promising polar photocatalyst. The internal electric field of ferroelectrics can separate photocarriers and enhance the catalytic performance of photocatalysts. Moreover, when combined with other semiconductors, PbTiO3contributes to the construction of a depolarization field, extending the catalytic applications of PbTiO3catalysts. PbTiO3exhibits optical absorption, semiconductor, and piezoelectric properties. Its piezoelectric polarization field enhances charge separation, modulates band structure, surface charge conduction, and heterojunction interface charge conduction,thereby amplifying photocatalytic activity. This paper begins by examining the structure, properties, and preparation methods of PbTiO3. Subsequently, it delves into the optimization of PbTiO3's structure and performance,exploring applications in photocatalysis as a ferroelectric photocatalyst. Emphasis is placed on the detailed discussion of surface modification, heterostructure formation, and ferroelectric polarization of PbTiO3ferroelectrics. These aspects are thoroughly explored for their role in regulating activity and optimizing the performance of photocatalysis and photopiezoelectric catalysis. In conclusion, the paper addresses the current research status of PbTiO3ferroelectric materials and highlights the challenges that lie *** intention is to provide valuable references for the ongoing research in PbTiO3ferroelectric materials.

关键词： Polarization

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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO liu-jing liU li-ya CHEN You-qin HAN Yu-ying WEI li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG Ying Thomas J.Sferra liU Hui-xin li li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (Plity, cell cycle arrest and cell apoptosis in vitro (Pliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (Pliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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An Adaptive Strategy-incorporated Integer Genetic Algorithm for Wind Farm Layout Optimization

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Journal of Bionic Engineering 2024年第3期21卷 1522-1540页

作者： Tao Zheng Haotian li Houtian He Zhenyu Lei Shangce Gao Faculty of Engineering University of ToyamaToyama9300887Japan

Energy issues have always been one of the most significant concerns for scientists *** the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of *** energy is a readily available and sustainable energy *** farm layout optimization problem,through scientifically arranging wind turbines,significantly enhances the efficiency of harnessing wind ***-heuristic algorithms have been widely employed in wind farm layout *** paper introduces an Adaptive strategy-incorporated Integer Genetic Algorithm,referred to as AIGA,for optimizing wind farm layout *** adaptive strategy dynamically adjusts the placement of wind turbines,leading to a substantial improvement in energy utilization efficiency within the wind *** this study,AIGA is tested in four different wind conditions,alongside four other classical algorithms,to assess their energy conversion efficiency within the wind *** results demonstrate a notable advantage of AIGA.

关键词： Wind farm layout optimization problem Meta-heuristic algorithms Adaptive Integer genetic algorithm

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二维光子晶体中的双波段半狄拉克锥与零折射率材料

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物理学报 2024年第18期73卷 88-97页

作者：纪雨萱张明楷李妍曲阜师范大学物理工程学院曲阜273165

设计了一种由椭圆介电柱子组成的正方晶格光子晶体结构.通过调节椭圆柱子的大小和放置角度,在布里渊区中心同时实现两个不同频率的双重偶然简并,并获得两个不同波段的半狄拉克锥.更有趣的是,这两个半狄拉克锥沿椭圆柱子长轴和短轴两个... 详细信息

设计了一种由椭圆介电柱子组成的正方晶格光子晶体结构.通过调节椭圆柱子的大小和放置角度,在布里渊区中心同时实现两个不同频率的双重偶然简并,并获得两个不同波段的半狄拉克锥.更有趣的是,这两个半狄拉克锥沿椭圆柱子长轴和短轴两个方向表现出的线性和非线性色散关系正好相反,k·p微扰理论也进一步证实了这种奇异的色散关系.数值计算结果表明在两个半狄拉克点频率附近,本文所设计的正方晶格光子晶体在线性色散所在方向上等效为阻抗匹配的双零折射率材料,而在非线性色散所在方向上只能等效为单零折射率材料,即沿椭圆柱子长轴和短轴两个方向的等效零折射率展现出差异性.而两个不同波段的半狄拉克锥所对应的这种等效零折射率的各向异性截然相反,因此可利用“Y”型光子晶体板将两种不同频率的电磁波成功分离.

关键词：光子晶体半狄拉克锥零折射率材料

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UV-B irradiation enhances the accumulation of beneficial glucosinolates induced by melatonin in Chinese kale sprout

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Horticultural Plant Journal 2024年第4期10卷 995-1006页

作者： Mengyu Wang Jiansheng Wang Yuhe yang Zhiqing li Ghazala Mustafa Yubo li lihong liu Zuofa Zhang Qiaomei Wang Zhejiang Academy of Agricultural Sciences HangzhouZhejiang 310021China Key Laboratory of Horticultural Plant Growth Development and Quality ImprovementMinistry of AgricultureDepartment of HorticultureZhejiang UniversityHangzhouZhejiang 310058China Department of Plant Sciences Quaid-i-Azam UniversityIslamabad 45320Pakistan

Cruciferous sprout is a new form of vegetable product rich in bioactive compounds,especially *** studies have focused on increasing the accumulation of glucosinolates in cruciferous sprouts by applying different chemical regulators,with a particular focus on their contribution to nutritional quality and health ***,the effects of melatonin and UV-B irradiation on glucosinolate biosynthesis remain *** this study,it was found that changes in melatonin concentrations significantly affected the contents of individual as well as total aliphatic and indolic *** 5μmol·L^(-1)melatonin was decided as the optimum concentration that could increase the content of beneficial glucosinolates including glucoraphanin and 4-methoxy glucobrassicin in Chinese kale ***,the enhancement of glucosinolate accumulation by melatonin treatment could be further amplified by UV-B ***,our results showed that R2R3-MYB transcription factor BoaMYB28 and BoaMYB51,which are central regulators of aliphatic and indolic glucosinolate biosynthesis respectively,were both involved in the regulation of glucosinolate biosynthesis by melatonin and UV-B ***,the expression of glucosinolate biosynthetic genes,including BoaCYP79F1,BoaCYP83A1,BoaSUR1,BoaUGT74B1,BoaCYP79B2,BoaCYP79B3,and BoaCYP83B1 participated in the formation of core structures and BoaFMOGS-OX5,BoaAOP2,BoaCYP81F2,and BoaIGMT1 involved in the sidechain modification of aliphatic and indolic glucosinolate,was regulated by melatonin or UV-B *** together,these findings provide a potential strategy for improving the nutritional quality and resistance of Chinese kale sprouts.

关键词： Melatonin Chinese kale sprouts UV-B Glucosinolates Nutritional quality Second metabolism

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