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岩土力学 2007年第10期28卷 2115-2117页

作者：舒阳闫澍旺杨兵刘润天津大学建筑工程学院天津300072 中国科学院力学所北京100080

简要介绍了自洽方法和爆炸法处理软土地基的工作原理,并用自洽方法计算爆炸法处理的软土地基的回弹模量,计算结果和试验结果符合较好。试验证明了用自洽方法计算爆炸法处理软土地基的回弹模量是可行的。

关键词：软土地基爆炸压入法自洽方法回弹模量

Epidemiological Investigation of Risk Factors of the Pregnant Women with Early Spontaneous Abortion in Beijing

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Chinese Journal of Integrative Medicine 2017年第5期23卷 345-349页

作者： ZHOU Li-ying ZHANG Hong-xia LAN Yong-lian LI Ying LIANG Yu YU Lan MA yan-min JIA Chan-wei WANG shu-yu Department of Reproduction Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing (100026) China Department of Reproduction Peking University Third Hospital Beijing (100191 ) China

Objective： To determine the risk factors of the pregnant women with early spontaneous abortion in Beijing. Methods： A total of 34,417 cases of pregnant women were participated in the survey from January 2000 to December 2013. A questionnaire was informed to each woman. The content of questionnaire includes four parts： general condition, obstetrical history, past history and family history, and living environment and habits. The mental condition was evaluated with Self-Rating Anxiety Scale（SAS） and Self-Rating Depression Scale（SDS）. Results： A total of 32,296 questionnaires were collected. The spontaneous abortion rate in the total sample was 3.0%. There was no significant difference between the normal pregnancy group and spontaneous abortion group in terms of general condition, obstetrical and past history（P〉0.05）. Significant differences between the two groups were found in terms of decoration during pregnancy, keeping pets, near mobile communication base station within 100 m around the residence, drinking during pregnancy, having a cold during pregnancy and SAS（P〈0.05）. Having a cold during pregnancy, decoration during pregnancy, near mobile communication base station within 100 m around the residence, keeping pets and high SAS were determined the independent risk factors of spontaneous abortion by Logistic regression analysis. Conclusions： Having a cold during pregnancy, decoration, keeping pets, near mobile communication base station within 100 m around the residence and high SAS are the independent risk factors of spontaneous abortion in Beijing.

关键词： epidemiological risk factors spontaneous abortion living environment habit

Promotion of osteochondral repair through immune microenvironment regulation and activation of endogenous chondrogenesis via the release of apoptotic vesicles from donor MSCs

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Bioactive Materials 2024年第11期41卷 455-470页

作者： Guangzhao Tian Han Yin Jinxuan Zheng Rongcheng Yu Zhengang Ding Zineng yan Yiqi Tang Jiang Wu Chao Ning Xun Yuan Chenxi Liao Xiang Sui Zhe Zhao shuyun Liu Weimin guo Quanyi guo School of Medicine Nankai UniversityTianjin300071China Institute of Orthopedies Department of OrthopedicsThe Fourth Medical Center of PLA General HospitalNational Clinical Research Center for OrthopedicsSports Medicine&Rehabilitation51 Fucheng RoadHaidian DistrictBeijing100142China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou510055China Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Orthopedics and TraumatologyFirst Affiliated Hospital Sun Yat-Sen UniversityGuangzhou510080China

Utilizing transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain *** after HUMSCs delivery to the defects,we observed substantial *** released apoptotic vesicles(apoVs)of HUMSCs promoted cartilage regeneration by alleviating the chondro-immune *** triggered M2 polarization in macrophages while simultaneously facilitating the chondrogenic differentiation of endogenous ***,in macrophages,miR-100-5p delivered by apoVs activated the MAPK/ERK signaling pathway to promote M2 *** MSCs,let-7i-5p delivered by apoVs promoted chondrogenic differentiation by targeting the eEF2K/p38 MAPK ***,a cell-free cartilage regeneration strategy using apoVs combined with a decellularized cartilage extracellular matrix(DCM)scaffold effectively promoted the regeneration of osteochondral ***,new mechanisms of cartilage regeneration by transplanted MSCs were unconcealed in this ***,we provided a novel experimental basis for cell-free tissue engineering-based cartilage regeneration utilizing *** transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain *** after HUMSCs delivery to the defects,we observed substantial *** released apoptotic vesicles(apoVs)of HUMSCs promoted cartilage regeneration by alleviating the chondro-immune *** triggered M2 polarization in macrophages while simultaneously facilitating the chondrogenic differentiation of endogenous ***,in macrophages,miR-100-5p delivered by apoVs activated the MAPK/ERK signaling pathway to promote M2 *** MSCs,let-7i-5p delivered by apoVs promoted chondrogenic differentiation by targeting the eEF2K/p38 MAPK ***,a cell-free cartilage regener

关键词： Apoptotic vesicles Cartilage regeneration Human umbilical cord mesenchymal stem cells Macrophage polarization Tissue engineering

The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure

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Asian Journal of Andrology 2009年第2期11卷 183-192页

作者： Min Wang Jian-Li Shi guo-yan Cheng yan-Qing Hu Chen Xu Department of Histology&Embryology Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory for Reproductive Medicine Shanghai 200025China

To study whether the antibody against the testis form of the nuclear autoantigenic sperm protein(tNASP)could result in reproductive failure,we successfully cloned and expressed a 339-bp cDNA fragment of mouse tNASP(mtNASP).Using mouse as a model,recombinant mtNASP(rmtNASP)and a synthetic peptide,human tNASP393-408(htNASP393-408),were investigated for their antifertility *** immunization with rmtNASP or the synthesized peptide raised high antibody titers in the immunized ***-egg binding and fusion assay were carried out in 8-10-week-old BALB/c ***-egg binding and in vitro fertilization of mouse oocytes were inhibited by co-incubation of zona-free mouse oocytes with capacitated mouse spermatozoa in the presence of varying concentrations of the antisera against *** was a significant antifertility effect in animals immunized with rmtNASP or the synthesized *** effect on fertility in the mice immunized with the synthesized peptide was *** data indicate that active immunization with rmtNASP antigen may induce a strong antibody response that causes an inhibition of fertility.

关键词： antifertility gene expression nuclear autoantigenic sperm protein(NASP) sperm-egg binding sperm-egg fusion

Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第40期20卷 14950-14957页

作者： Hong Ma Fan Cui Jing-Jing Dong guo-Ping You Xiang-Jiu yang Hua-Dong Lu yan-Ling Huang Department of Endocrinology Zhongshan Hospital Xiamen University Department of Endocrinology Xiamen Zhongshan Teaching Hospital of Fujian Medical University Department of Pathology Zhongshan Hospital Xiamen University

AIM: To explore the therapeutic role of globular adiponectin (gAd) in high-fat diet/streptozotocin (STZ)-induced type 2 diabetic rats with nonalcoholic fatty liver disease (NAFLD).

关键词： Adiponectin Insulin secretion Insulin receptor Steatosis

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非典型子宫内膜异位症163例临床病理分析

中华妇产科杂志 2008年第11期43卷 831-834页

作者：郭东辉庞淑洁申彦天津市中心妇产科医院病理科 300052

目的探讨非典型子宫内膜异位症（AEM）的临床病理特点及其与肿瘤性病变的关系。方法对2004年1月-2006年12月天津市中心妇产科医院病理科的163例AEM标本进行临床与病理资料的回顾性分析，观察其腺上皮、间质与背景组织的病理学改变，以... 详细信息

目的探讨非典型子宫内膜异位症（AEM）的临床病理特点及其与肿瘤性病变的关系。方法对2004年1月-2006年12月天津市中心妇产科医院病理科的163例AEM标本进行临床与病理资料的回顾性分析，观察其腺上皮、间质与背景组织的病理学改变，以及伴发的肿瘤性病变。结果163例AEM占同期子宫内膜异位症（EM）的4．38％（163／3724）。172例次AEM中，168例次发生于卵巢，4例次发生于输卵管、宫颈及子宫浆膜。卵巢AEM的发生率为6．81％（161／2363），共26例（15．95％）、27例次AEM伴发同侧卵巢肿瘤，15例次（56％）为恶性，9例次（33％）为交界性，3例次（11％）为良性。AEM的上皮细胞主要以表面上皮细胞形式排列，镜下表现为中、重度细胞异型，上皮细胞拥挤，形成簇状与芽状突起。AEM病灶的囊壁由上皮、子宫内膜样间质与纤维胶原3层组成，子宫内膜样间质通常较薄，纤维胶原则较厚，伴瘢痕化背景。15例AEM伴发的恶性肿瘤中，14例（93％）可见AEM与肿瘤组织的移行。结论AEM兼具EM与肿瘤组织的部分特征，有更大的肿瘤倾向与恶变潜能，EM病灶经历的长期损伤与修复可能参与EM向AEM发展并衍化为肿瘤的过程。

关键词：子宫内膜异位症卵巢肿瘤病理学临床

High quantum efficiency long-/long-wave dual-color type-Ⅱ InAs/GaSb infrared detector

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Chinese Physics B 2019年第3期28卷 386-390页

作者： Zhi Jiang Yao-Yao Sun Chun-yan guo Yue-Xi Lv Hong-Yue Hao Dong-Wei Jiang guo-Wei Wang Ying-Qiang Xu Zhi-Chuan Niu State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

A long-/long-wave dual-color detector with N-M-π-B-π-M-N structure was developed based on a type-Ⅱ InAs/GaSb superlattice. The saturated responsivity was achieved under low bias voltage for both channels. The device could be operated as a single detector for sequential detection and showed high quantum efficiencies. The peak quantum efficiencies of long-wavelength infrared band-1(blue channel) and long-wavelength infrared band-2(red channel) were 44% at 6.3 μm under 20 mV and 57% at 9.1 μm under-60 mV, respectively. The optical performance for each channel was achieved using a 2 μm thickness absorber. Due to the high QE, the specific detectivities of the blue and red channels reached5.0×10^(11) cm·Hz^(1/2)/W at 6.8 μm and 3.1×10^(11) cm·Hz1^(1/2)/W at 9.1 μm, respectively, at 77 K.

关键词： infrared detector InAs/GaSb superlattice dual-color molecular beam epitaxy

The method of p-harmonic approximation and optimal interior partial regularity for energy minimizing p-harmonic maps under the controllable growth condition

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Science China Mathematics 2007年第1期50卷 105-115页

作者： shu-hong CHEN Zhong TAN School of Mathematical Science Xiamen UniversityXiamen 361005China

In this paper, we are concerned with the partial regularity for the weak solutions of energy minimizing p-harmonic maps under the controllable growth condition. We get the interior partial regularity by the p-harmonic approximation method together with the technique used to get the decay estimation on some Degenerate elliptic equations and the obstacle problem by Tan and yan. In particular, we directly get the optimal regularity.

关键词： p-harmonic approximation controllable growth condition regularity 35J70 35J60 35D10 35B65

论科学成果的视觉表达——以Nature、Science、Cell为例

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科学学研究 2013年第10期31卷 1472-1476页

作者：王国燕汤书昆中国科学技术大学科学传播研究与发展中心安徽合肥230026

中国的科研能力正在快速提升,越来越多的研究成果发表在Nature、Science、Cell等顶级学术期刊上。封面故事成果的学术影响力和业界关注度远高于普通成果的表达。目前中国顶级基础科学成果的视觉表达对美国的科学图片创作机构有较高的依... 详细信息

中国的科研能力正在快速提升,越来越多的研究成果发表在Nature、Science、Cell等顶级学术期刊上。封面故事成果的学术影响力和业界关注度远高于普通成果的表达。目前中国顶级基础科学成果的视觉表达对美国的科学图片创作机构有较高的依赖,自主创作能力明显不足,这反映了中国基础科研与人文艺术素养的割裂。准确理解科学内容并进行恰当的视觉表达,实现科学与视觉艺术的交叉创新,中国也可以有更多的成果登上Nature、Science、Cell等期刊封面。

关键词：视觉表达封面故事科学期刊科学传播

Thermal Stress Analysis of Floating-Gate Tunneling Oxide Electrically Erasable Programmable Read Only Memory During Manufacturing Process

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Chinese Physics Letters 1998年第10期15卷 767-769页

作者： ZONG Xiang-fu WANG Xu WENG Yu-min yan Ren-jin TANG guo-an ZHANG Zhao-qiang Institute of Materials Science Fudan UniversityShanghai 200433 Department of Mechanics Fudan UniversityShanghai 200433

In this study,finite element modeling was used to evaluate the residual thermal stress in floating-gate tunneling oxide electrically erasable programmable read only memory(FLOTOX E2PROMs)manufacturing *** attention is paid to the tunnel oxide region,in which high field electron injection is the basis to E2PROMs *** results show the presence of large stresses and stress gradients at the fringe:This may contribute to the invalidation of E2PROMs.A possible failure mechanism of E2PROM related to residual thermal stress-induced leakage is proposed.

关键词： E2PROM stress floating