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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

喷涂法制备单壁碳纳米管柔性透明导电薄膜及其性能研究

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合成材料老化与应用 2017年第5期46卷 51-56页

作者：胡晓燕李家权陈蓓蓓耿宏章贵州分析测试研究院贵州贵阳550001 天津工业大学材料科学与工程学院天津300387

采用喷涂的方法将以十二烷基苯磺酸钠为分散剂分散在去离子水中的单壁碳纳米管喷涂到聚对苯二甲酸乙二酯基底上制备了柔性透明导电薄膜,研究了薄膜透光率与面电阻的关系、表面形貌及其弯曲状态的面电阻,结果表明这种透明导电薄膜具有高... 详细信息

采用喷涂的方法将以十二烷基苯磺酸钠为分散剂分散在去离子水中的单壁碳纳米管喷涂到聚对苯二甲酸乙二酯基底上制备了柔性透明导电薄膜,研究了薄膜透光率与面电阻的关系、表面形貌及其弯曲状态的面电阻,结果表明这种透明导电薄膜具有高柔韧性、高透光度和低面电阻等优点,在柔性显示器、触摸屏、有机发光器件等方面有广阔的应用前景。

关键词：单壁碳纳米管柔性透明导电薄膜喷涂面电阻

Thermo-elasto-visco-plastic finite element analysis on formation and propagation of off-corner subsurface cracks in bloom continuous casting

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Journal of Iron and Steel Research International 2017年第11期24卷 1159-1168页

作者： Yu-jun Li Huan Li Peng Lan Hai-yan Tang jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The formation and propagation of the popular off-corner subsurface cracks in bloom continuous casting were investigated through thermo-mechanical analysis using three coupled thermo-mechanical models. A two-dimensional thermo-elasto-visco-plastic finite element model was developed to predict the mould gap evolution, temperature profiles and deformation behavior of the solidified shell in the mould region. Then, a three-dimensional model was adopted to calculate the shell growth, tempera- ture history and the development of stresses and strains of the shell in the following secondary cooling zones. Finally, another three-dimensional model was used to analyze the stress distributions in the straightening region, The results showed that the off-corner cracks in the shell originated from the mould owing to the tensile strain developed in the crack sensitive regions of the solidification front, and they could be driven deeper by the possible severe surface temperature rebound and the extensive tensile stress in the secondary cooling zone, especially upon the straightening operation of the bloom casting. It is revealed that more homogenous shell temperature and thickness can be obtained through optimization of mould corner radius, casting speed and secondary cooling scheme, which help to decrease stress and strain concentration and therefore prevent the initiation of the cracks.

关键词： Thermo elasto-visco-plastic finite element model Off-corner subsurface crack Mould corner radius Temperature rebound Straightening operation Bloom continuous casting

Regulation of carbon distribution to construct high-sulfur-content cathode in lithium-sulfur batteries

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Journal of Energy Chemistry 2021年第5期30卷 203-208页

作者： Meng Zhao yan-Qi Peng Bo-quan Li Xue-Qiang Zhang jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Lithium-sulfur(Li-S)battery is regarded as one of the most promising next-generation energy storage systems due to the ultra-high theoretical energy density of 2600 Wh kg^(-1).To address the insulation nature of sulfur,nanocarbon composition is essential to afford acceptable cycling capacity but inevitably sacrifices the actual energy density under working ***,rational structural design of the carbon/sulfur composite cathode is of great significance to realize satisfactory electrochemical performances with limited carbon ***,the cathode carbon distribution is rationally regulated to construct high-sulfur-content and high-performance Li-S ***,a double-layer carbon(DLC)cathode is prepared by fabricating a surface carbon layer on the carbon/sulfur *** surface carbon layer not only provides more electrochemically active surfaces,but also blocks the polysulfide ***,the DLC configuration with an increased sulfur content by nearly 10 wt%renders an initial areal capacity of 3.40 mAh cm^(-2) and capacity retention of 83.8%during 50 cycles,which is about two times than that of the low-sulfur-content *** strategy of carbon distribution regulation affords an effective pathway to construct advanced high-sulfur-content cathodes for practical high-energy-density Li-S batteries.

关键词： Lithium-sulfur batteries High sulfur content High areal loading Double-layer carbon High energy density

Simulation and experiment investigations on fabrication of Fe-based amorphous powders by a novel atomization process equipped with assisted gas nozzles

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Journal of Iron and Steel Research International 2023年第6期30卷 1142-1155页

作者： jia-qi Liu yan-nan Dong Pu Wang Huan Zhao Jing Pang Xiao-yu Li jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Qingdao Yunlu Advanced Materials Technology Co. Ltd.Qingdao 266232ShandongChina

Based on computational fluid dynamics method,the effect of atomization gas pressure on the atomization efficiency of Laval nozzle was studied,and then a discrete phase model was established and combined with industrial trials to study the effect of a new type of assisted gas nozzles(AGNs)on powder size distribution and amorphous powder *** results show that increasing the atomization pressure can effectively improve the gas velocity for the Laval nozzle;however,it will decrease the aspiration pressure,and the optimal atomization pressure is 2.0 *** with this,after the application of AGNs with the inlet velocity of 200 m s^(-1),assisted gas jet can increase the velocity of overall droplets in the break-up and solidification area by 40 m s^(-1) and the maximum cooling rate is increased from 1.9×10^(4) to 2.3×10^(4) K s^(-1).The predicted particle behavior is demonstrated by the industrial trails,that is,after the application of AGNs,the median diameter of powders d50 is decreased from 28.42 to 25.56 lm,the sphericity is increased from 0.874 to 0.927,the fraction of amorphous powders is increased from 90.4% to 99.4%,and only the coercivity is increased slightly due to the accumulation of internal *** is illustrated that the AGNs can improve the yield of fine amorphous powders,which is beneficial to providing high-performance raw powders for additive manufacturing technology.

关键词： Computational fluid dynamics Atomization Assisted gas nozzle Discrete phase model Amorphous powder

A review on the failure and regulation of solid electrolyte interphase in lithium batteries

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Journal of Energy Chemistry 2021年第8期30卷 306-319,I0007页

作者： Jun-Fan Ding Rui Xu Chong yan Bo-quan Li Hong Yuan jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology100081 BeijingChina

Solid electrolyte interphase(SEI)has been widely recognized as the most important and the least understood component in lithium *** the intrinsic instability in both chemical and mechanical,the failure of SEI is inevitable and strongly associated with the performance decay of practical working *** this Review,the failure mechanisms and the corresponding regulation strategies of SEI are ***,the fundamental properties of SEI,including the formation principles,and the typical composition and structures are briefly ***,the common SEI failure modes involving thermal failure,chemical failure,and mechanical failure are classified and discussed,*** that,the regulation strategies of SEI with respect to different failure modes are further ***,the future endeavor in further disclosing the mysteries of SEI is prospected.

关键词： Solid electrolyte interphase Failure mechanism Regulation strategy Lithium batteries

Reversible Plasticity Shape Memory Effect in SEBS/Crystallizable Paraffin: Influence of Paraffin Content

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Chinese Journal of Polymer Science 2022年第12期40卷 1697-1705,I0011页

作者： Shao-quan Zhao jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University Yiwu 322000China

Polymers with reversible plasticity shape memory effect(RPSME)have attracted considerable attention due to their simple programming and large ***,the exact mechanisms of RPSME are still not thoroughly *** this work,the RPSME of SEBS/crystallizable paraffin was investigated by comparatively analyzing the performances and microstructures of samples with different paraffin *** was found the shape fixing ratios(Rfs)of samples increased with the paraffin content,and interestingly,a significant improvement in Rf was observed when the paraffin content exceeded 60 wt%.Tensile test results showed that the deformation characteristics of samples changed from elastic to plastic as the paraffin content increased above 60 wt%.By exploring the crystallization behaviors of paraffin in various SEBS/paraffin samples,it was revealed that the microstructures of SEBS/paraffin were different when the paraffin content was below 50 wt%and above 60 wt%.In samples with low paraffin content(below 50 wt%),nearly all paraffin was co-crystallized with ethylene-co-butylene(EB)chains and its crystallization was severely restricted;while in samples with high paraffin content(above 60 wt%),“excess”paraffin appeared and this part of paraffin crystallized on the template of the EB/paraffin co-crystals,which might be responsible for the elastic-to-plastic transition and the sharp increase in *** on the above results,a possible structural model was proposed to explain the exact mechanism of RPSME in SEBS/paraffin.

关键词： Reversible plasticity shape memory effect Poly(styrene-b-(ethylene-co-butylene)-b-styrene) Crystallizable paraffin Paraffin content

C–C formation mediated by photoinduced electrons from crystallized carbon nitride nanobelts under visible light irradiation

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Journal of Energy Chemistry 2019年第3期28卷 152-161页

作者： Qiaohui jia Sufen Zhang quan Gu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University

Crystal structure and crystallinity of carbon nitride support, size and dispersity of active-metal nanoparticles(NPs), and surface engineering of composites have great roles in generation and separation of photogenerated charge carries and photocatalyzed organic reactions for the conversion of solar energy into chemical energy. Herein, we deposited well-dispersed Pd NPs with small size on crystallized carbon nitride(CN–C) to construct a Schottky-type Pd/CN–C hybrid for photocatalyzed Ullmann C–C homocoupling of aryl halides under visible light irradiation at room temperature. Compared to Pd NPs supported g-C_3N_4(Pd/g-C_3N_4), Pd/CN–C exhibits excellent visible light photocatalytic activity for Ullmann C–C coupling of aryl halides due to high crystallinity of CN–C support, high dispersion and smaller size of Pd NPs, and the interfacial heterojunction of Pd/CN–C. Upon visible light irradiation, more photogenerated electrons from CN–C flow across the Schottky junction to metallic Pd and trigger the Ullmann C–C coupling of aryl halides. The photogenerated holes on CN–C surface are captured by a protic solvent(such as EtOH). In the presence of base K_2CO_3, the solvent undergoes dissociation, dehydrogenation, and finally can be oxidized by captured photogenerated holes. Moreover, Pd/CN–C has general applicability for various substrates and shows excellent stability and reusability for more than nine cycles.

关键词： Crystallized carbon nitride Pd nanoparticles Photocatalyst C–C coupling Ullmann reaction

Hybrid social cognitive optimization algorithm for constrained nonlinear programming

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The Journal of China Universities of Posts and Telecommunications 2012年第3期19卷 91-99页

作者： SUN jia-ze GENG Guo-hua WANG Shu-yan ZHOU Ming-quan School of Information Science and Technology Northwest University Xi 'an 710127 China School of Computer Science and Technology Xi 'an University of Posts and Telecommunications Xi 'an 710121 China

To improve the global convergence speed of social cognitive optimization （SCO） algorithm, a hybrid social cognitive optimization （HSCO） algorithm based on elitist strategy and chaotic optimization is proposed to solve constrained nonlinear programming problems （NLPs）. The proposed algorithm partitions learning agents into three groups in proportion： elite learning agents, chaotic learning agents and common learning agents. The common learning agents work in the search way of traditional SCO, chaotic learning agents search via chaotic search （CS） algorithm based on tent map which helps to avoid the premature convergence, elite learning agents search via elitist selection which helps to improve the global searching performance. Additionally, a chaotic search process is incorporated into local searching operation so as to enhance the local searching efficiency in the neighboring areas of the feasible solutions. Simulation results on a set of benchmark problems show that the proposed algorithm has high optimization efficiency, good global performance, and stable optimization outcomes for constrained NLPs.

关键词： SCO elitist strategy CS tent map NLPs