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Chinese Physics B 2024年第4期33卷 640-648页

作者：陈登辉羊志付新宇秦申奥严岩王传奎李宗良邱帅 Shandong Key Laboratory of Medical Physics and Image Processing&Shandong Provincial Engineering and Technical Center of Light Manipulations School of Physics and ElectronicsShandong Normal UniversityJinan 250358China

Orientation-dependent transport properties induced by anisotropic molecules are enticing in single-molecule ***,using the first-principles method,we theoretically investigate spin transport properties and photoresponse characteristics in trimesic acid magnetic single-molecule junctions with different molecular adsorption orientations and electrode contact *** transport calculations indicate that a single-molecule switch and a significant enhancement of spin transport and photoresponse can be achieved when the molecular adsorption orientation changes from planar geometry to upright *** maximum spin polarization of current and photocurrent in upright molecular junctions exceeds 90%.Moreover,as the Ni tip electrode moves,the tunneling magnetoresistance of upright molecular junctions can be increased to 70%.The analysis of the spin-dependent PDOS elucidates that the spinterfaces between organic molecule and ferromagnetic electrodes are modulated by molecular adsorption orientation,where the molecule in upright molecular junctions yields higher spin *** theoretical work paves the way for designing spintronic devices and optoelectronic devices with anisotropic functionality base on anisotropic molecules.

关键词： molecular spintronics spin polarization tunneling magnetoresistance photocurrent single-molecule junctions

极小化加权完工时间的多资源工序的资源分配问题

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控制与决策 2024年第8期39卷 2765-2772页

作者：翁武燕储诚斌吴鹏福州大学经济与管理学院福州350108

针对现实中广泛存在的多资源工序的资源分配问题,考虑基于资源使用的优先次序约束,以最小化加权完工时间为优化目标,构建一类新的资源分配混合整数线性规划模型.其次,提出Benders分解和禁忌搜索的混合算法,该混合算法以Benders分解为基... 详细信息

针对现实中广泛存在的多资源工序的资源分配问题,考虑基于资源使用的优先次序约束,以最小化加权完工时间为优化目标,构建一类新的资源分配混合整数线性规划模型.其次,提出Benders分解和禁忌搜索的混合算法,该混合算法以Benders分解为基本框架,将原问题分为提供资源分配方案的主问题和计算工序加权完工时间的子问题,并通过改进数学模型和添加禁忌搜索提高混合算法的收敛速度.最后,通过300个随机仿真算例测试结果表明,在相同时间下求解小规模问题时,所提的Benders分解混合算法能获得距离商业求解器CPLEX最优解平均差距为0.86%的满意解;在求解大规模问题时,所提出的算法的性能表现优于CPLEX、禁忌搜索算法、变邻域搜索算法和Benders分解嵌入遗传算法的混合方法,能给出更好的资源分配方案,与CPLEX相比,上界和下界分别改善了4.74%和9.62%.

关键词：资源分配多资源工序基于资源使用的先后次序 Benders分解禁忌搜索算法

The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power Laser Science and Engineering 2024年第3期 14-24页

作者： Ye Cui Xiao-Hu yang yan-Yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze Li Fu-qiu Shao Jie Zhang Department of Nuclear Science and Technology National University of Defense Technology Collaborative Innovation Centre of IFSA Shanghai Jiao Tong University College of Advanced Interdisciplinary Studies National University of Defense Technology Department of Physics National University of Defense Technology Key Laboratory for Laser Plasmas (Ministry of Education) School of Physics and Astronomy Shanghai Jiao Tong University

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,respectively. Our results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.

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利用HVSR方法探测四川理县西山村滑坡速度结构

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地球物理学报 2024年第4期67卷 1515-1526页

作者：孙晓倩储日升曾求盛敏汉危自根中国科学院精密测量科学与技术创新研究院大地测量与地球动力学国家重点实验室武汉430077 中国科学院大学地球与行星科学学院北京100049 湖北省地质局地球物理勘探大队武汉430056

HVSR(Horizontal-to-Vertical Spectral Ratio)是地震背景噪声水平分量与垂直分量的频谱比,常被用来探测起伏地形较小的浅地表速度结构.然而,高起伏地形下该方法的适用性还需要仔细研究.本文探讨利用HVSR方法探测四川理县西山村滑坡的... 详细信息

HVSR(Horizontal-to-Vertical Spectral Ratio)是地震背景噪声水平分量与垂直分量的频谱比,常被用来探测起伏地形较小的浅地表速度结构.然而,高起伏地形下该方法的适用性还需要仔细研究.本文探讨利用HVSR方法探测四川理县西山村滑坡的速度结构.我们首先将ENZ坐标系下三分量地震数据旋转到垂直于地形自由面的LQT坐标系,分别计算了两个坐标系下2 h地震背景噪声数据的HVSR曲线,对比结果发现,LQT坐标系下三分量数据的HVSR峰值频率更能反映地下结构信息.然后,本文反演了29个台站LQT坐标系的HVSR曲线,获得了滑坡体堆积物及基岩的一维S波速度结构.西山村滑坡体堆积物的S波速度范围为50~1000 m·s^(-1),滑坡厚度23~130 m.滑坡体西侧边缘地下40~120 m处存在10~20 m的低速层,表明该位置抗剪强度相对较弱,是潜在的滑动危险区域.对数据进行坐标系转换后,HVSR方法能够利用较短的观测数据获取可靠的滑坡体速度结构,为滑坡体积估算、脆弱位置识别、灾害评估提供重要信息.

关键词：理县西山村滑坡 HVSR S波速度结构地震背景噪声

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan Luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen Feiteng Lu Miaozhen qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua Zhan Ting Zhou qiuyun Luo Wentao Pan Lin Zhang Chaozhuo Lin yan Huang Li Zhang Dajun yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APG-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages NLRP3

Exploration for the Priority of HIV Intervention:Modelling Health Impact and Cost-Effectiveness—Six Cities,Eastern China,2019-2028

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China CDC weekly 2024年第20期6卷 463-468,I0008-I0014页

作者： Youran Zhang Lili Wang Zhen Jiang Hongjing yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong Cheng Qiyan Leng Qisui Long Zimian Liang Jing Wang Liang Liang yanchao qiu Lin Chen Hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina Division of Prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Zhenjiang Center for Disease Control and Prevention Zhenjiang CityJiangsu ProvinceChina Wuxi Center for Disease Control and Prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and Prevention Jinan CityShandong ProvinceChina yantai Center for Disease Control and Prevention Yantai CityShandong ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Foshan Center for Disease Control and Prevention Foshan CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang Center for Disease Control and Prevention Shijiazhuang CityChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Ningbo Center for Disease Control and Prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to enhance the effectiveness of resource allocation,regions must tailor their responses to their specific epidemiological and economic ***:Utilizing Spectrum software,we projected the cost-effectiveness of 10 chosen HIV interventions in six cities in eastern China from 2019 to *** assessed three scenarios—Base,Achievable,and Idealized—for each *** analysis included the projected number of HIV infections and deaths averted,as well as the incremental costeffectiveness ratios for each intervention in the six ***:In Shijiazhuang,Wuxi,yantai,and Zhenjiang,cities with initially low antiretroviral therapy(ART)coverage,ART showed significant effectiveness,especially for ***,in Foshan and Ningbo,where ART coverage was notably high,oral pre-exposure prophylaxis(PrEP)for men who have sex with men(MSM)proved effective in the Idealized *** outreach,ART for males,and ART for females demonstrated cost-effectiveness across all six cities in both Achievable and Idealized scenarios at the predefined thresholds for each ***:Maintaining an appropriate coverage rate for outreach to MSM can lead to *** cities with low ART coverage,scaling up ART remains a crucial *** regions with high ART coverage,consideration may be given to the utilization of oral PrEP for MSM individuals,requiring budget allocation.

关键词： Eastern Ningbo Impact

A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease

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World Journal of Pediatrics 2024年第2期20卷 189-200页

作者： Shu-Na Sun yan Zhou Xing Fu Yuan-Zheng Zheng Cao Xie Guo-You Qin Fang Liu Chen chu Feng Wang Cheng-Long Liu Qing-Tong Zhou De-Hua yang Di Zhu Ming-Wei Wang Yong-Hao Gui Children's Hospital of Fudan University National Children's Medical CenterShanghai 201102China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Accuramed Technology(Shanghai)Ltd. Shanghai 200233China School of Pharmacy Fudan UniversityShanghai 201203China School of Public Health Fudan UniversityShanghai 200032China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 570288China

Kawasaki disease(KD)is a disorder of immune *** prevalence of KD among 100,000 children aged 0-4 years was 71.9-110.0 in China,170.9-194.9 in Korea,and 18.1-21.3 in the USA[1].The most severe complication of KD is coronary artery lesions(CALs),including coronary dilatation and coronary aneurysms,which may even lead to myocardial ischemia,myocardial infarction,and sudden death.

关键词： coronary ischemia differentiated

Favorable outcomes of front-line risk-adapted therapy in young patients with diffuse large B-cell lymphoma with clinically or biologically high-risk features

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Chinese Medical Journal 2024年第13期137卷 1620-1622页

作者： Hesong Zou Wei Liu Yi Wang Dandan Shan Ting Xie Ru Li Huimin Liu Wenyang Huang Mingwei Fu Tingyu Wang Rui Lyu Shuhui Deng Weiwei Sui yan Xu Shuhua Yi Gang An Lugui qiu Dehui Zou State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Science&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China

To the Editor:Diffuse large B-cell lymphoma(DLBCL)exhibits clinical significance and biological *** the last two decades,rituximab with cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)has substantially improved outcomes for DLBCL ***,approximately one-third of DLBCL cases continue to experience disease progression,resulting in long-term survival ranging from 50%to 60%.[1]Efforts to improve DLBCL patient outcomes by modifying R-CHOP dosing schedules have yielded limited success,and the addition of new drugs has benefited only specific patient ***,intensive immunochemotherapy(IIC)has demonstrated promise and cost-effectiveness in recent *** regimen of dose-adjusted etoposide.

关键词： CHOP drugs chemotherapy

社会比较理论视角下企业员工创新身份“双刃剑”效应形成机制探讨——基于追踪问卷调查有效数据的实证检验

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中央财经大学学报 2024年第9期 104-114页

作者：赵景华严秋燕中央财经大学政府管理学院中央财经大学商学院

企业员工创新身份的“双刃剑”效应缘于对其工作行为共存的创新行为效应和偏离行为效应。笔者基于社会比较理论,在构建了一个企业员工创新身份“双刃剑”效应研究模型的基础上,以来自对高新技术企业员工三个时点追踪调查问卷的有效数据... 详细信息

企业员工创新身份的“双刃剑”效应缘于对其工作行为共存的创新行为效应和偏离行为效应。笔者基于社会比较理论,在构建了一个企业员工创新身份“双刃剑”效应研究模型的基础上,以来自对高新技术企业员工三个时点追踪调查问卷的有效数据,运用路径分析和bootstrap方法,实证检验了企业员工创新身份与其创新行为和偏离行为之“双刃剑”效应的关联性。检验结果证实:企业员工创新身份通过创新过程参与感与其创新行为正相关;企业员工创新身份通过心理特权感与其偏离行为正相关;企业员工创新身份的“双刃剑”效应,受制于创新普遍性氛围且因之高、低不同而调节方向相反。本研究通过尝试性地将员工创新过程参与感、心理特权感和创新普遍性氛围等相关变量引入探究企业员工创新身份与其创新行为和偏离行为相对应之积极影响和消极影响的关联中,扩展了社会比较理论的应用边界,丰富了组织行为学研究领域的现有相关文献,研究结论有助于为企业有效管理员工创新身份提供理论依据。

关键词：员工创新身份创新普遍性氛围创新过程参与感心理特权感创新行为偏离行为

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数字化转型能否降低企业资本成本

财经理论与实践 2024年第1期45卷 83-90页

作者：邱妍王治江媛长沙理工大学经济与管理学院湖南长沙410076 湖南财政经济学院会计学院湖南长沙410205

依据2007—2020年我国上市公司数据,考量数字化转型对企业资本成本的影响。结果显示,数字化转型可以有效降低企业资本成本;机制检验结果表明,数字化转型通过缓解信息不对称、强化企业创新动能、提高内部控制质量等路径降低企业资本成本... 详细信息

依据2007—2020年我国上市公司数据,考量数字化转型对企业资本成本的影响。结果显示,数字化转型可以有效降低企业资本成本;机制检验结果表明,数字化转型通过缓解信息不对称、强化企业创新动能、提高内部控制质量等路径降低企业资本成本。进一步研究发现,高科技企业以及企业面临较高环境不确定性时,数字化转型降低企业资本成本的效果更显著。结论从降低企业资本成本的视角为企业如何推进数字化转型战略提供了经验证据。

关键词：数字化转型资本成本信息不对称创新动能内部控制