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The relationship between serum miR-21 levels and left atrium dilation in elderly patients with essential hypertension

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Journal of Geriatric Cardiology 2022年第11期19卷 833-842页

作者： yan wang Guang-Ping FU qiu-yan wang Ting-Ting ZHANG Li-Li HE Qing-Juan ZUO Chang-Lei ZHANG Yi-Fang GUO Department of Geriatric Cardiology Hebei General HospitalShijiazhuangHebeiChina Hebei Key Laboratory of Forensic Medicine Department of Forensic MedicalHebei Medical UniversityShijiazhuangHebeiChina Hebei Medical University ShijiazhuangHebeiChina

BACKGROUND MicroRNA-21(miR-21)is related to hypertension and cardiac *** atrium(LA)dilation is highly sensitive to small haemodynamic changes in the left ventricle(LV)that are induced by *** study aimed to elucidate the relationship between miR-21 expression and LA dilation in elderly patients with essential hypertension(EH).METHODS In this cross-sectional study,one hundred elderly patients with EH were recruited for the *** to their left atrium diameters(LADs),the patients were divided into the LA dilation group[42 patients(42%)]and the no-LA dilation group[58 patients(58%)].The serum levels of miR-21 and chemical biomarkers used in the clinic,such as creatinine,blood urea nitrogen,uric acid,fasting blood glucose,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDLC),low-density lipoprotein cholesterol(LDL-C),very-low-density lipoprotein cholesterol,Lp(a),apolipoprotein A1(apoA1),and apolipoprotein B,were *** the patients underwent echocardiographic examination,and the LAD,interventricular septum(IVS),right atrium diameter(RAD),right ventricle diameter(RVD),left ventricular end-systolic diameter(LVESD),left ventricular end-systolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)were *** The levels of miR-21[8.02(5.21,14.39)vs.6.05(3.81,8.95),P=0.011]and LVEF(67.02±3.82 vs.64.14±4.43,P=0.001)were higher in the LA dilation *** levels of creatinine[70.40(64.45,80.15)vs.63.9(60.1,73.43)],P=0.020]were higher in the no-LA dilation *** levels of HDLC(r=-0.209,P=0.037),apoA1(r=-0.269,P=0.007)and RAD(r=0.203,P=0.043)were significantly correlated with miR-21 *** LAD was significantly correlated with the RAD(r=0.287,P=0.004),RVD(r=0.450,P<0.001),LVEDD(r=0.248,P=0.013)and LVEF(r=0.232,P=0.020).Multivariate logistic regression revealed that miR-21 significantly influenced LA dilation in elderly patients with EH(P<0.05).CONCLUSIONS Circulating serum levels o

关键词： patients hypertension atrium

Wavelength-dependent Photodissociation Dynamics of Benzaldehyde

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Chinese Journal of Chemical Physics 2009年第6期22卷 587-591,J0001页

作者： Ben-kang Liu Bing-xing wang yan-qiu wang Li wang State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Dalian115023 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

The ultrafast dynamics of benzaldehyde upon 260, 271, 284, and 287 nm excitations have been studied by femtosecond pinup-probe time-of-flight mass spectrometry. A bi-exponential decay component model was applied to fit the transient profiles of benzaldehyde ions and fragment ions. At the S2 origin, the first decay of the component was attributed to the internal conversion to the high vibrational levels of S1 state. Lifetimes of the first component decreased with increasing vibrational energy, due to the influence of high density of the vibrational levels. The second decay was assigned to the vibrational relaxation of the S1 whose lifetime was about 600 fs. Upon 287 nm excitation, the first decay became ultra-short （-56 fs） which was taken for the intersystem cross from S1 to T2, while the second decay component was attributed to the vibrational relaxation. The pump-probe transient of fragment was also studied with the different probe intensity at 284 nm pump.

关键词： Benzaldehyde Ultrafast process Femtosecond pump-probe

Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs

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World Journal of Gastroenterology 1998年第5期4卷 58-62页

作者： XIAO Bing, SHI Yong Quan, ZHAO yan qiu, YOU Han, wang Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming

AIM To compare the expression level of Fas gene and Bcl-2 gene in gastric cancer cells SGC7901 and gastric cancer MDR (multidrug resistant) cells SGC7901/VCR, to transduce Fas cDNA and Bcl-2 antisense nucleic acid into SGC7901/VCR cells respectively, and to observe the expression of two genes in transfectants and non-transfectants as well as their drug *** Eukaryotic expression vector pBK-Fas cDNA and pDOR-anti Bcl-2 were constructed and transfected into SGC7901/VCR cells by lipofectamine, respectively. Northern blot and Western blot were used to detect the expression of mRNA and protein in SGC7901/VCR and SGC7901 cells and transfectants, and drug sensitivity of transfectants for VCR, CDDP and 5-FU was analyzed with MTT *** After gene transfection, 80 for Fas and 120 for antisense Bcl-2 drug-resistant clones were selected from 2×105 cells, transfection rate being 0.04% and 0.06%. Two clones of SGC7901 Fas/VCR cells and SGC7901 anti Bcl-2/VCR cells were randomly selected for further incubation. Hybridization results showed that the expression level of Fas mRNA and protein in SGC7901/VCR cells was much lower, but that of Bcl-2 mRNA and protein was higher than that in SGC7901 cells. The expression of Fas mRNA and protein in SGC7901 Fas/VCR cells was higher, and of Bcl-2 mRNA and protein was lower in SGC7901 anti Bcl-2/VCR cells than that in non-transfectants. MTT assay showed that transfectants were more sensitive to VCR, CDDP, 5-FU than *** Bcl-2 gene displayed high expression while Fas gene had low expression in drug resistant gastric cancer cells. Expression of Bcl-2 protein was effectively blocked in SGC7901 anti Bcl-2/VCR cells by gene transfection. In contrast, the expression of Fas mRNA and protein in SGC7901 Fas/VCR cells increased. Fas gene and Bcl-2 antisense nucleic acid transfection sensitized drug resistant gastric cancer cells to chemotherapeutic drugs. These results suggest cell apoptosis plays an import

关键词： stomach neoplasms Fas gene Bcl 2 gene antisense nucleic acid drug resistance, multiple gene transduction apoptosis

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格栅颗粒复合堆积床内流动传热的实验研究

工程热物理学报 2017年第10期38卷 2225-2228页

作者：王晶钰杨剑胡映学刘衍王秋旺西安交通大学热流科学与工程教育部重点实验室西安710049

颗粒有序堆积床相比于颗粒无序堆积床具有压降较小的优点,但在实际操作中,有序堆积床的实现具有一定的难度,本文设计了一种可快速实现有序堆积的新结构,即带有格栅的复合颗粒堆积结构。采用萘升华热质比拟方法对格栅颗粒复合堆积结构中... 详细信息

颗粒有序堆积床相比于颗粒无序堆积床具有压降较小的优点,但在实际操作中,有序堆积床的实现具有一定的难度,本文设计了一种可快速实现有序堆积的新结构,即带有格栅的复合颗粒堆积结构。采用萘升华热质比拟方法对格栅颗粒复合堆积结构中的颗粒-流体对流传热系数进行了研究。结果表明,格栅复合堆积结构相比于简单立方堆积结构,压降略高,但传热系数也有大幅度提高;而相比于无序结构,在传热系数下降不多的情况下,压降大大减低。格栅颗粒复合堆积结构的综合传热系数最高,可为堆积床的设计提供一种新的思路。

关键词：格栅颗粒复合堆积颗粒有序堆积床热质比拟萘升华对流传热

选择性激光小梁成形术治疗开角型青光眼的研究进展

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国际眼科杂志 2011年第5期11卷 828-829页

作者：王秋燕胡竹林云南省第二人民医院眼科中国云南省昆明市650106

激光用于青光眼的治疗已有近35a的历史。近年来,选择性激光小梁成形术(SLT)以其安全、有效降眼压、并发症少等优点逐渐成为开角型青光眼的首选治疗。选择性激光小梁成形术是治疗开角型青光眼的一种新型激光手术,它应用倍频Q-开关、波长5... 详细信息

激光用于青光眼的治疗已有近35a的历史。近年来,选择性激光小梁成形术(SLT)以其安全、有效降眼压、并发症少等优点逐渐成为开角型青光眼的首选治疗。选择性激光小梁成形术是治疗开角型青光眼的一种新型激光手术,它应用倍频Q-开关、波长532nm的Nd:YAG激光,选择性作用于色素性小梁组织达到降低眼压目的。与氩激光小梁成形术(argonlasertrabeculoplasty,ALT)相比,两者降眼压效果相似,但是相对于ALT对小梁网的凝固性损伤,SLT选择性作用于色素性小梁细胞,无凝固性损伤,对小梁网组织轻微破坏,是一种安全且可重复治疗的手段。

关键词：选择性激光小梁成形术开角型青光眼眼压

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静电悬浮下铌异质形核及枝晶生长

Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1333-1346页

作者：王艳秋郑福陆潇晓孙志斌中国科学院国家空间科学中心北京100190 中国科学院大学北京101499

采用无容器静电悬浮实验技术,对纯度99.7%和99.95%铌材料的过冷程度和形核凝固机制进行了系统研究。通过经典形核理论分析测量和计算得到材料样品在形核和凝固过程的热物理参数和热动力学参数。实验结果统计分析表明:铌样品的最大过冷度... 详细信息

采用无容器静电悬浮实验技术,对纯度99.7%和99.95%铌材料的过冷程度和形核凝固机制进行了系统研究。通过经典形核理论分析测量和计算得到材料样品在形核和凝固过程的热物理参数和热动力学参数。实验结果统计分析表明:铌样品的最大过冷度为455.7 K,临界过冷度约为739 K。系统分析并计算得到铌样品最大概率形核过冷度、指前系数、成核活化能、固液界面自由能和关键晶核尺寸。样品的枝晶生长速度与过冷度呈幂函数关系,在过冷度454 K时,枝晶生长速度达到42.1 m/s。考虑非等温条件下界面能的各向异性对自由枝晶生长的影响,理论预测结果与实验获得实验结果一致。

关键词：液态铌异质形核枝晶生长形核凝固机制无容器静电悬浮

Vector Correlations and Product Rotational Alignments of Reactions Ca+RBr→CaBr+R(R=CH_(3),C_(2) H_(5) and n-C_(3) H_(7))

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Chinese Journal of Chemical Physics 2006年第2期19卷 117-122页

作者：马建军丛书林张志红王艳秋大连理工大学物理系大连116024

The quasiclassical trajectory method is used to study the vector correlations of the reactions Ca＋RBr （R=CH3, C2H5 and n-C3H7Br） and the rotational alignment of product CaBr. The product rotational alignment parameters at different collision energies and the vector correlations between the reagent and product are numerically calculated. The vector correlations are described by using the angle distribution functions P（θr）, P（φr）, P（θr, φr） and the polarization-dependent differential cross sections （PDDCSs）. The peak values of P（θr） of the product CaBr from Ca＋CH3Br are larger than those from Ca＋C2H5Br and Ca＋n-C3H7Br. The peak of P（θr） at φr= 3π/2 is apparently stronger than that at φr= x/2 for the three reactions Ca＋RBr. The calculation results show that the rotational angular momentum of the product CaBr is not only aligned, but also oriented along the direction which is perpendicular to the scattering *** product CaBr molecules are strongly scattered forward. The orientation and alignment of the product angular momentum will affect the scattering direction of the product molecules to varying degrees.

关键词： Quasiclassical trajectory Vector correlation Orientation and alignment

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen wang Wei Ming Longfu Chen Tianliang Song Moxi Yele Hao Zhang Long yang Gegen Sarula Benliang Liang Luting yan Guangsheng wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

ADP-ribosyl cyclase display an altered role in isoproterenol-induced cardiac hypertrophy in young and aged mice

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中国病理生理杂志 2012年第11期 2063-2063页

作者： LI Yu-ming,LI Hai-tao,ZHAO yan-zhi,CUI yan-qiu,wang Xin-fang,LI Zhong-qiu,wang Jun-ya,ZHANG Dong-mei,LI Shu-yuan (Department of Physiology and Pathophysiology,Capital Medical University yanjing Medical College,Beijing 101300,China)

AIM:To examine the potential role of ADP-ribosyl cyclase(ADPRclase)in the pathogenesis of isoproterenol(ISO)-induced cardiac ***:Both young(8～12 weeks old)and aged(20～24 months old)mice were divided into four groups,

关键词： ADP-ribosyl cyclase display an altered role in isoproterenol-induced cardiac hypertrophy in young and aged mice ISO