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Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy:Dynamic analysis on cytotoxic effects of LW-218

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3178-3192页

作者： Po Hu Hui Li Wenzhuo Sun Hongzheng Wang Xiaoxuan Yu Yingjie qing Zhanyu Wang Mengyuan Zhu Jingyan Xu qinglong guo Hui Hui State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionChina Pharmaceutical UniversityNanjing 210009China Department of Pharmacology School of Medicine&Holostic Integrative MedicineNanjing University of Chinese MedicineNanjing 210046China Department of Hematology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

The integrity of lysosomes is of vital importance to survival of tumor *** demonstrated that LW-218,a synthetic flavonoid,induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological ***-218-induced lysosomal damage and lysosome-dependent cell death were mediated by cathepsin D,as the lysosomal damage and cell apoptosis could be suppressed by depletion of cathepsin D or lysosome alkalization agents,which can alter the activity of ***,was initiated for cell self-rescue after LW-218 treatment and correlated with calcium release and nuclei translocation of transcription factor ***-218 treatment enhanced the expression of autophagy-related genes which could be inhibited by intracellular calcium *** exposure to LW-218 exhausted the lysosomal capacity so as to repress the normal ***-218-induced enlargement and damage of lysosomes were triggered by abnormal cholesterol deposition on lysosome membrane which caused by interaction between LW-218 and NPC intracellular cholesterol transporter ***,LW-218 inhibited the leukemia cell growth in ***,the necessary impact of integral lysosomal function in cell rescue and death were illustrated.

关键词： LW-218 Lysosomal damage Lysophagy Lysosomal membrane permeabilization Lysosome-dependent cell death Cholesterol Cathepsin D Hematological malignancies

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Protocol to establish auxiliary diagnostic model for knee osteoarthritis functional testing equipment

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Journal of Traditional Chinese Medicine 2023年第2期43卷 379-385页

作者： guo Zhuang WANG Junwen LI Zhonglong CHEN Zhongjie CHEN Li yan Shiyan LU Hongrong LI Zhigeng LI Guanying Institute of Basic Theory of Chinese Medicine China Academy of Chinese Medical ScienceBeijing 100700China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture Moxibustion and MassageBeijing HospitalBeijing 100000China Department of Acupuncture Moxibustion and MassageWuhan Hongshan Chinese Medicine HospitalHubei 430070China School of Humanities Beijing University of Chinese MedicineBeijing 100029China

In China,50%of Knee Osteoarthritis(KOA)patients will be treated with Traditional Chinese Medicine or a combination of Traditional Chinese and Western Medicine,which call for objective efficacy evaluation *** collection,processing and fusion of multisource data were taken as the main methods,with 150 KOA patients and 100 healthy people as an example to design prospective clinical *** were collected with tongue inspection APP,infrared instrument and channel instrument,*** the analysis,screening,fusion and modelling of multi-source data were *** traditional clinical tests have been combined with the customized information platform in this study,which is convenient for clinical tests,medical follow-ups and timely feedback to statistical analysis of data.

关键词： osteoarthritis knee multi-source data efficacy evaluation prospective clinical test diagnostic tests routine protocol

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Effect of synthetic fibers on the mechanical performance of asphalt mixture:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第3期10卷 331-348页

作者： Haichuan Jia yanping Sheng Ping guo Shane Underwood Huaxin Chen Y.Richard Kim yan Li qingwei Ma School of Materials Science and Engineering Chang'an UniversityXi'an 710064China Department of Civil Constructionand Environmental EngineeringNorth Carolina State UniversityRaleighNC 27695USA Engineering Research Center of Transportation Materials of Ministry of Education School of Materials Science and EngineeringChang'an UniversityXi'an 710064China Xi'an Highway Research Institute Co. Ltd.Xi'an 710065China

Numerous studies showed that synthetic fibers are effective for reinforcing the mechanical performance of the asphalt mixture due to their high strength properties,ductility,and durability *** this paper,the objective is to present a review of the reinforcement effect of synthetic fiber on the mechanical performance of the asphalt *** paper reviews the relevant literature on the characterizations and applications of synthetic fibers to improve different mechanical properties of asphalt mixes,which can provide a reference for the applications and development of synthetic fibers in asphalt *** characteristics of common synthetic fibers are introduced and the utilization of synthetic fibers in asphalt mixture is *** surface treatment methods for fiber are reviewed and it is found that surface treatment can improve the performance of the synthetic fibers in asphalt mixtures,especially the chemical surface treatment *** influence of synthetic fiber addition on the mechanical properties of the asphalt concrete such as rutting resistance,tensile strength,water stability performance,and cracking resistance are then *** research results show that aramid,glass,and polyester fibers improve the fatigue cracking resistance of asphalt *** fibers,polyamide fibers,and carbon fibers are used to improve resistance to the permanent deformation of asphalt pavement.

关键词： Fiber reinforced asphalt mixture Synthetic fibers Fiber characteristics Mechanical performance

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Entrance Channel Dependence of the Isospin Effects of the Nuclear Stopping in Intermediate Energy Heavy-Ion Collisions

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Chinese Physics Letters 2001年第8期18卷 1040-1043页

作者： yanG yan-Fang LIU Jian-Ye ZUO Wei guo Wen-Jun ZHAO Qiang Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion AcceleratorLanzhou 730000 Institute of Modern Physics Chinese Academy of SciencesP.O.Box 31Lanzhou 730000

The entrance channel dependence of the isospin effects of nuclear stopping in intermediate energy heavy-ion collisions has been studied by using an isospin-dependent quantum molecular dynamics with three different kinds of symmetry *** is shown that nuclear stopping is sensitive to the beam energy,the impact parameter and the mass of the colliding system,specially very sensitive to the isospin dependence of in-medium nucleon-nucleon cross section,but insensitive to symmetry potential and the ratio of neutron to proton of colliding *** this *** is proposed that nuclear stopping can be used as a new probe to extract the information on the isospin dependence of in-medium nucleon-nucleon cross section in intermediate energy heavy-ion collisions.

关键词： symmetry Collisions quantum

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Clinicopathological Analysis of 155 Patients with Persistent Isolated Hematuria

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Chinese Medical Sciences Journal 2014年第3期29卷 148-155页

作者： Rong-rong Li Hang Li Yu-bin Wen qing-yuan Huang Lin Duan yan Li Department of Clinical Nutrition Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objectives To reveal etiologies of persistent isolated hematuria （PIH） through ultrastructural pathological examination, to disclose clinicopathological correlation in cases with PIH, and to summarize appropriate management of patients with PIH. Methods we retrospectively studied 155 P1H patients receiving renal biopsy between January, 2003 and December, 2008 in Peking Union Medical College Hospital. All the clinical data and follow-up result were analyzed. Results All subjects included 38 children and 117 adults, with mean age of 11.38±3.25 years for children and 35.17±8.44 years for adults. Thin basement membrane nephropathy （TBMN） was the most common pathology （55.3% of children and 49.6% of adults）, followed by IgA nephropathy （18.4% of children and 32.5% of adults, mainly grade 2-3） and mesangial proliferative glomerulonephritis （MsPGN） without IgA deposition （13.2% of children and 12.8% of adults）. Besides, A1port syndrome （2.6% of children） and membrane nephropathy （2.6% of children and 0.9% of adults） were demonstrated as other causes of PIH. Elevated mean arteral pressure or protein excretion rate, as well as episodic macrohematuria, indicated higher risk for MsPGN rather than TBMN. On the other hand, severity of microhematuria was irrelevant to pathological types of PIH. Totally, 86 patients were followed up and 37 cases therein stayed on track for long term （mean duration 41.11±28.92 months, range 8-113 months）. Most cases had benign clinical course except 3 cases with TBMN, 5 cases with IgA nephropathy, 1 case with MsPGN （without IgA deposition）, and 1 case with Alport syndrome, who developed hypertension or proteinuria. All of them were administered timely intervention. Conclusions Close follow-up should be required as the primary management for PIH. Equally important is careful monitoring for early identification of undesirable predictors; while renal biopsy and other timely intervention are warranted if there is hypertension, significant proteinuri

关键词： isolated hematuria renal biopsy pathology IgA nephropathy thin basement membrane nephropathy

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Analysis of the Spatio-Temporal Characteristics of Winter Surface Urban Heat Island:A Case Study in Beijing,China

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Journal of Earth Science 2024年第5期35卷 1640-1653页

作者： Shanshan Lu Fujiang Liu Yunshuang Ye Jiayu Tang Peng Li Weihua Lin yan guo Ruqiang Ma Jun Wang School of Geography and Information Engineering China University of GeosciencesWuhan 430074China AutoNavi Software Co. Ltd.Beijing 100102China School of Computer Science China University of GeosciencesWuhan 430078China yantai Geological Survey of Coastal Resources Center Yantai 264000China

This study reveals the temporal and spatial evolution characteristics of the winter nighttime urban heat island(UHI)effect in the case of Beijing,*** land surface temperature(LST)is retrieved by radiative transfer equation by using the remote sensing data from Landsat ETM+/OLI_TIRS from 2007 to 2017 for the winter nighttime period,and LST is then divided by the mean-standard deviation method into different levels of thermal landscapes.A combination of the migration calculation of gravity center and multi-directional profile analysis is used to study the directional differentiation characteristics of LST and the migratory characteristics of the gravity center of ***,the overall temporal and spatial evolution characteristics of winter nighttime surface urban heat island(SUHI)in Beijing are studied,and the possible reasons for the changes are *** show that Beijing's UHI effect first increased and subsequently decreased from 2007 to *** winter heat island in the urban area developed from low-density agglomeration to high-density agglomeration to lowdensity ***,the high-level thermal landscapes migrated to the southwest along with the city center of gravity,and the expansion rate is fastest in the southwest,which is directly linked to the changes in the urban construction ***,the overall spatial distribution of winter nighttime LST is high in the east and south and low in the west and north,and is influenced by topography,land cover,urbanization,anthropogenic heat,and other factors as well.

关键词： land surface temperature urban heat island spatio-temporal characteristics winter environmentgeology

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Optimization of extraction of phenolics from leaves of Ficus virens

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第10期14卷 903-915页

作者： Xiao-xin CHEN Xiao-bing WU Wei-ming CHAI Hui-ling FENG yan SHI Han-tao ZHOU qing-xi CHEN Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems School of Life Sciences Xiamen University

In this research,the conditions for extraction of phenolics from leaves of Ficus virens were optimized using response surface methodology(RSM).The extraction abilities of phenolics(EAP) and flavonoids(EAF),the 2,2-diphenyl-1-pierylhydrazyl(DPPH) free-radical scavenging potential,and the ferric reducing/antioxidant power(FRAP) were used as quality *** results of single-factor experiments showed that temperature,ethanol concentration,extraction time,and the number of extraction cycles were the main influencing variables,and these provided key information for the central composite *** results of RSM fitted well to a second degree polynomial model and more than 98% of the variability was *** ideal extraction conditions for EAP,EAF,DPPH free-radical scavenging potential,and FRAP were *** the four quality indicators overall,the ideal extraction conditions were 58% ethanol at 57 °C for 37 min with three extraction *** the ideal extraction conditions,the values of EAP,EAF,DPPH free-radical scavenging potential,and FRAP were 5.72%,3.09%,58.88 mg ascorbic acid equivalent(AAE)/g dry weight(DW),and 15.86 mg AAE/g DW,*** addition,linear correlations were observed between EAP,EAF,and antioxidant potential.

关键词： Ficus virens Phenolics Flavonoids Antioxidants Response surface methodology(RSM)

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Global population estimate and conservation gap analysis for the Nordmann's Greenshank(Tringa guttifer)

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Avian Research 2023年第2期14卷 250-256页

作者： Ranxing Cao Waner Liang Jia guo Hongyan yang Lili Sun qing Chen Tao Yu Sicheng Ren Cai Lu Guangchun Lei Yifei Jia School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing100083China Center for East Asian-Australasian Flyway Studies Beijing Forestry UniversityBeijing100083China Shenzhen Mangrove Wetlands Conservation Foundation Shenzhen518040China qingdao Birding Association Qingdao266100China

Nordmann's Greenshank(Tringa guttifer)is a globally endangered species that has received little research *** is threatened by rapid habitat loss,an incomplete network of protected sites,and lack of long-term data on population *** science data can be combined with survey data to support population estimation and conservation gap *** 2020 to 2021,Nordmann's Greenshank was surveyed in Tiaozini,Xiaoyangkou,and Dongling on the southern coast of Jiangsu Province,China,and the global population of the species was re-evaluated using the data *** integrated citizen science data from eBird and the China Bird Report from 2000 to 2020 with the survey results to identify important habitats harboring over 1%of its total population,and compared this data with existing protected areas to identify gaps in its global *** survey found that Tiaozini supported at least 1194 ***,its global population was reestimated to be ***,45 important habitats were identified based on citizen data and survey *** 44.4%and 50.0%of the priority sites in the world and China,respectively,are located outside protected areas,the Conservation Effectiveness Index(C)is 68.4%and 71.1%,respectively,showing that the current coverage of protected areas for this part of its range is *** study presents the most complete and recent population data to *** is the most important migration stopover site for Nordmann's *** species is under threat in terms of breeding,wintering,and stopover ***,we suggest improving monitoring,establishing new protected sites to complete the habitat protection network,and improving the effectiveness of existing habitat protection strategies,including further developing high tide roosting sites.

关键词： Citizen science Conservation gaps Nordmann's Greenshank Population estimate

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Effects of Spinning Process on Intergranular Corrosion Behavior of 5A06 Aluminum Alloy

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 231-236页

作者：张谦君付永康 ZHAO Wenlong 李青 ZHANG Rulin guo Yong LI Rongbin School of Materials Science Shanghai Dianji UniversityShanghai 201306China Hiwing Aerospace Materials Research Institute(SuZhou)Company Limited Suzhou 215100China School of Electrical Engineering Shanghai Dianji UniversityShanghai 201306China

Aluminum alloy tubes were prepared by tube *** intergranular and electrochemical corrosion tests were used to investigate the intergranular corrosion behavior of the 5A06 aluminum alloy blank sample and the spinning *** showed that the intergranular corrosion resistance of the spinning sample was higher than that of the blank *** addition,the electrochemical corrosion resistance of the spinning sample was higher than that of the blank *** EDS maps indicated a uniform element distribution pattern of aluminum and ***,the phase composition and lattice constant of the samples were obtained by XRD *** differences in microstructure between the aluminum alloy subjected to the spinning process and the untreated aluminum alloy were determined by *** differences were mainly attributed to the complex interactions among grain size,dislocations and grain boundaries.

关键词： spinning process 5A06 aluminum alloy intergranular corrosion EBSD

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中高端苏酒的紫外荧光特性对比研究

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光谱学与光谱分析 2010年第7期30卷 1806-1810页

作者：郑磊朱拓陈国庆孔艳江南大学通信与控制工程学院江苏无锡214122 江南大学理学院江苏无锡214122

针对苏酒中最具代表性的国缘系列和洋河蓝色经典系列两种中高端白酒进行研究,得出三维荧光光谱图,并对两种白酒的各自独有的荧光特征加以分析。发现国缘白酒在280～400 nm激发波长范围内具有明显的荧光特征,包含一个主要的荧光峰;洋河... 详细信息

针对苏酒中最具代表性的国缘系列和洋河蓝色经典系列两种中高端白酒进行研究,得出三维荧光光谱图,并对两种白酒的各自独有的荧光特征加以分析。发现国缘白酒在280～400 nm激发波长范围内具有明显的荧光特征,包含一个主要的荧光峰;洋河蓝色经典白酒在200～450 nm激发波长范围内包含5个明显的荧光峰。两个系列白酒在激发波长310～350 nm内具有明显的荧光特征,此范围内的有机化合物为主要的呈香呈味物质,对苏酒的口感香型起决定性作用。该研究成果对改善苏酒勾兑工艺,提高苏酒品质提供了科学的参考依据和量化标准。

关键词：光谱分析三维荧光光谱国缘白酒洋河蓝色经典品质

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