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A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong yan Xu yang Peng Yuping qian Guanmeng Zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

Anomalous thermal expansion and enhanced magnetocaloric effect in<001>-textured Mn_(x)Fe_(5-x)Si_(3) alloys

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Rare Metals 2024年第5期43卷 2263-2274页

作者： Yong Gong Xue-Fei Miao Tapas Samanta Chris Taake Jun Liu Feng-Jiao qian yan-yan Shao Yu-Jing Zhang Qing-Yong Ren Luana Caron Feng Xu MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing210094China Department of Physics Bielefeld University33501BielefeldGermany College of Physics Nanjing University of Aeronautics and AstronauticsNanjing210016China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803China Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology Dongguan523803China Department of Physics Bielefeld University33501BielefeldGermany Helmholtz-Zentrum Berlin für Materialien und Energie12489BerlinGermany

The development of zero and negative therma expansion(i.e.,ZTE and NTE)materials is of crucial importance to the control of undesirable thermal expansion for high-precision *** the present work,ZTE and NTE were obtained in directionally-solidified Mn_(x)Fe_(5-x)Si_(3)alloys with a strongtexture,in striking contrast to positive thermal expansion in their isotropic counterparts Magnetometry and in-situ X-ray diffraction(XRD)measurements were performed to uncover the origin of the anomalous thermal *** measurements indicate a strong easy-plane magnetocrystalline anisotropy in the textured samples,where the magnetic moments are aligned within the ab plane of the hexagonal structure Temperature-dependent XRD on the x=1 sample reveals a ZTE character in the ab plane that is coupled to a ferromagnetic *** a result,the macroscopic ZTE(~0.22×10^(-6)K^(-1))in the x=1 sample can be attributed to the microscopic magneto volume effect within the ab plane,which is realized by the introduction of the-textured ***,the competition between antiferromagnetic and ferromagnetic exchange coupling leads to NTE in textured x=1.5 and 2 ***,textured x=1 sample displays enhanced magnetocaloric properties as compared to the conventional counterparts with randomly-oriented *** this work demonstrates a new strategy toward the exploration of anomalous thermal expansion properties as well as the enhancement of magnetocaloric properties for materials with a strong magnetocrystalline anisotropy.

关键词： MnFeySis Magnetocaloric effect Magnetic phase transition Negative thermal expansion

Mobile genetic elements facilitate the transmission of antibiotic resistance genes in multidrug-resistant Enterobacteriaceae from duck farms

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Food Science and Human Wellness 2024年第2期13卷 729-735页

作者： Xin’er Zheng Dingting Xu Jinchang yan Min qian Peng Wang Davood Zaeim Jianzhong Han Daofeng Qu School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310035China The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 311100China Agricultural and rural Bureau of Wangdian Town Xiuzhou DistrictJiaxing 314011China

Multidrug-resistant(MDR)Enterobacteriaceae critically threaten duck farming and public *** phenotypes,genotypes,and associated mobile genetic elements(MGEs)of MDR Enterobacteriaceae isolated from 6 duck farms in Zhejiang Province,China,were investigated.A total of 215 isolates were identified as Escherichia coli(64.65%),Klebsiella pneumoniae(12.09%),Proteus mirabilis(10.23%),Salmonella(8.84%),and Enterobacter cloacae(4.19%).Meanwhile,all isolates were resistant to at least two *** isolates carried tet(A)(85.12%),blaTEM(78.60%)and sul1(67.44%)resistance *** co-occurrence analysis showed that the resistance genes were associated with IS26 and integrons.A conjugative IncFII plasmid pSDM004 containing all the above MGEs was detected in Proteus mirabilis isolate *** isolate was resistant to 18 antibiotics and carried the blaNDM-5 ***,especially plasmids,are the primary antibiotic resistance gene transmission route in duck *** findings provide a theoretical basis for the rational use of antibiotics in farms which are substantial for evaluating public health and food safety.

关键词： Duck farm Mobile genetic element Antibiotic resistance gene Plasmid Food safety

The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients

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Food Science and Human Wellness 2024年第2期13卷 1079-1092页

作者： Qingqing Xu Weifei Wang Dongxiao Sun-Waterhouse qian Zou Menglei yan Xuan Liu Dongming Lan Yonghua Wang School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural and Agri-Food Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510610China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand Guangdong Youmei Institute of Intelligent Bio-manufacturing Co. Ltd.Foshan 528200China

The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diacylglycerols(DAGs)are potential good lipid sources for these *** oil-based DAG(LD)and linseed oil(LT)were ***-based emulsion((83.74±1.23)%)had higher lipolysis degree than LT-based emulsion((74.47±1.16)%)when monitoring the GI tract of normal population as previously *** conditions seriously decreased the digestive degree of LT-based emulsion((40.23±2.48)%-(66.50±3.70)%)while showed less influence on LD-based emulsion((64.18±2.41)%-(81.85±3.45)%).As opposed to LT-based emulsion,LD-based emulsion exhibited preference for releasing unsaturated fatty acids(especially oleic acid andα-linolenic acid)due to their different glycerolipid ***-based emulsion showed potential for providing lipids and nutrients(including essential fatty acids)for lipid indigestion patients.

关键词： Diacylglycerol In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency

Could the EU carbon border adjustment mechanism promote climate mitigation?An economy-wide analysis

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Advances in Climate Change Research 2024年第3期15卷 557-571页

作者： Kun ZHANG Yun-Fei YAO Xiang-yan qian Yu-Fei ZHANG Qiao-Mei LIANG Yi-Ming WEI College of Economics and Management Beijing University of TechnologyBeijing 100124China Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Energy Economics and Environmental Management Beijing 100081China Sinopec Research Institute of Petroleum Engineering SinopecBeijing 100101China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095China

Due to concerns about carbon leakage and sectoral competitiveness,the European Union(EU)proposed implementing the carbon border adjustment mechanism(CBAM).The effectiveness and potential negative consequences of CBAM have aroused extensive *** the perspective of the economy-wide analysis,this study uses a global computable general equilibrium model to explore the rationality of CBAM from the aspects of socioeconomic impact and the effects of promoting climate ***,the potential alternative mechanism of CBAM is *** results show that CBAM can reduce the EU's gross domestic product(GDP)loss;however,the GDP loss in all other regions ***,CBAM raises household welfare losses in most regions,including the ***,although CBAM can reduce the marginal abatement cost in eight regions,it comes at the cost of greater economic ***,the economic and household welfare cost of raising emissions reduction targets in regions like the USA and Japan is substantially higher than the impact of passively accepting the CBAM;therefore,CBAM's ability to drive ambitious emission reduction initiatives may be ***,for the potential alternative mechanism,from the perspective of reducing economic cost and household welfare losses,the EU could implement domestic tax cuts in the short-term and promote global unified carbon pricing in the long-term.

关键词： Border adjustment mechanism Computable general equilibrium model Carbon price Climate policy Global carbon pricing

Nomogram based on liver stiffness and spleen area with ultrasound for posthepatectomy liver failure:A multicenter study

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World Journal of Gastroenterology 2024年第27期30卷 3314-3325页

作者： Guang-Wen Cheng yan Fang Li-Yun Xue Xiao-Hui Qiao Xue-Qi Li yan Zhang Jia Guo Xiao-yan xie Hong Ding Department of Ultrasound Huashan HospitalFudan UniversityShanghai 200040China Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Medical Ultrasonics Institute of Diagnostic and Interventional UltrasoundSun Yat-sen University First Affiliated HospitalGuangzhou 510080Guangdong ProvinceChina Institute of Ultrasound in Medicine and Engineering Shanghai Cancer CenterShanghai 200040China Department of Ultrasound Eastern Hepatobiliary Surgical HospitalSecond Military Medical UniversityShanghai 200433China Department of Ultrasound National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Liver stiffness(LS)measurement with two-dimensional shear wave elastography(2D-SWE)correlates with the degree of liver fibrosis and thus indirectly reflects liver function *** size of the spleen increases due to tissue proliferation,fibrosis,and portal vein congestion,which can indirectly reflect the situation of liver fibrosis/*** was reported that the size of the spleen was related to posthepatectomy liver failure(PHLF).So far,there has been no study combining 2D-SWE measurements of LS with spleen size to predict *** prospective study aimed to investigate the utility of 2D-SWE assessing LS and spleen area(SPA)for the prediction of PHLF in hepatocellular carcinoma(HCC)patients and to develop a risk prediction *** To investigate the utility of 2D-SWE assessing LS and SPA for the prediction of PHLF in HCC patients and to develop a risk prediction *** This was a multicenter observational study prospectively analyzing patients who underwent hepatectomy from October 2020 to March *** 1 wk before partial hepatectomy,ultrasound examination was performed to measure LS and SPA,and blood was drawn to evaluate the patient’s liver function and other *** absolute shrinkage and selection operator logistic regression and multivariate logistic regression analysis was applied to identify independent predictors of PHLF and develop a *** performance was validated *** diagnostic performance of the nomogram was evaluated with receiver operating charac-teristic curve compared with the conventional models,including the model for end-stage liver disease(MELD)score and the albumin-bilirubin(ALBI)*** A total of 562 HCC patients undergoing hepatectomy(500 in the training cohort and 62 in the validation cohort)were enrolled in this *** independent predictors of PHLF were LS,SPA,range of resection,blood loss,international normalized ratio,and total *** diagnostic performanc

关键词： Shear-wave elastography Spleen Hepatectomy Posthepatectomy liver failure Hepatocellular carcinoma

3D-printable Boron Nitride/Polyacrylic Hydrogel Composites with High Thermal Conductivities

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1303-1310页

作者： DAI Jialei XUE Bingyu qian Qi HE Wenhao ZHU Chenglong LEI Liwen WANG Kun xie Jingjing Hubei Longzhong Laboratory Xiangyang 441000China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Polyacrylic acid(PAA)hydrogel composites with different hexagonal boron nitride(h-BN)fillers were synthesized and successfully 3D-printed while their thermal conductivity was systematically *** the content of h-BN increasing from 0.1 wt%to 0.3 wt%,the thermal conductivity of the 3D-printed composites has been ***,through the shear force given by the 3D printer,a complete thermal conductivity path is obtained inside the hydrogel,which significantly improves the thermal conductivity of the h-BN hydrogel *** maximum thermal conductivity is 0.8808 W/(m·K),leading to a thermal conductive enhancement of 1000%,compared with the thermal conductivity of pure PAA *** study shows that using h-BN fillers can effectively and significantly improve the thermal conductivity of hydrogelbased materials while its 3D-printable ability has been maintained.

关键词： hydrogel composites boron nitride 3D printing thermal conductivity

The secretory function of adipose tissues in metabolic regulation

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Life Metabolism 2024年第2期3卷 9-23页

作者： yang Liu Shu-Wen qian yan Tang Qi-Qun Tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan HospitalFudan UniversityShanghai 200032China

In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in response to physiological stimulation and met-abolic *** secretory factors,through autocrine and paracrine mechanisms,regulate various processes within adipose *** processes include adipogenesis,glucose and lipid metabolism,inflammation,and adaptive thermogenesis,all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment.A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite,cognitive function,energy expenditure,insulin secretion and sensitivity,gluconeogenesis,cardiovascular remodeling,and exercise *** this review,we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating meta-bolic ***,we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions,shedding light on potential pharmacological treatment strategies for related diseases.

关键词： adipokines autocrine paracrine endocrine metabolic regulation

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基于多种群与协同量子化的哈里斯鹰优化算法

控制与决策 2024年第7期39卷 2169-2176页

作者：李岩钱谦昆明理工大学信息工程与自动化学院昆明650500 昆明理工大学云南省计算机技术应用重点实验室昆明650500

哈里斯鹰优化算法(Harris Hawks optimization,HHO)存在探索能力和开发能力平衡性不足等问题,导致算法收敛速度较慢,寻优精度较低,容易陷入局部最优.针对这些问题,引入多种群策略解决初始化种群单一的问题,提出基于多种群的多能量策略... 详细信息

哈里斯鹰优化算法(Harris Hawks optimization,HHO)存在探索能力和开发能力平衡性不足等问题,导致算法收敛速度较慢,寻优精度较低,容易陷入局部最优.针对这些问题,引入多种群策略解决初始化种群单一的问题,提出基于多种群的多能量策略模拟两只体能不同的猎物的逃跑过程,使两个种群向不同的方向进化,以提高探索阶段与开发阶段的搜索能力.此外,协同量子化策略的加入在迭代前期可避免算法陷入局部极值,在迭代后期可提高算法的寻优精度.最后,通过对测试函数的优化结果进行分析可以得出,与其他一些经典或最新的算法相比,改进后的算法可大大提高最优解的收敛速度和寻优精度,同时具有更强的跳出局部最优的能力.

关键词：哈里斯鹰优化算法多种群多能量策略量子化协同群优化