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Effect of microstructure on the low temperature toughness of high strength pipeline steels

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International Journal of Minerals,Metallurgy and Materials 2015年第3期22卷 254-261页

作者： yan-ping zeng Peng-yu Zhu Ke Tong School of Materials Science and Engineering University of Science and Technology Beijing CNPC Tubular Goods Research Institute

Microstructure observations and drop-weight tear test were performed to study the microstructures and mechanical properties of two kinds of industrial X70 and two kinds of industrial X80 grade pipeline steels. The effective grain size and the fraction of high angle grain boundaries in the pipeline steels were investigated by electron backscatter diffraction analysis. It is found that the low temperature toughness of the pipeline steels depends not only on the effective grain size, but also on other microstructural factors such as martensite-austenite （MA） constituents and precipitates. The morphology and size of MA constituents significantly affect the mechanical properties of the pipeline steels. Nubby MA constituents with large size have significant negative effects on the toughness, while smaller granular MA constituents have less harmful effects. Similarly, larger Ti-rich nitrides with sharp corners have a strongly negative effect on the toughness, while fine, spherical Nb-rich carbides have a less deleterious effect. The low temperature toughness of the steels is independent of the fraction of high angle grain boundaries.

关键词： high strength pipe steels microstrucmre low temperature toughness influencing factors

Effects of the shape and size of rectangular inclusions on the fatigue cracking behavior of ultra-high strength steels

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International Journal of Minerals,Metallurgy and Materials 2013年第4期20卷 360-364页

作者： yan-ping zeng Hong-mei Fan Xi-shan Xie School of Materials Science and Engineering University of Science and Technology Beijing

The fatigue cracking behavior of ultra-high strength steels containing rectangular inclusions of small sizes were investigated based on in situ observations by scanning electron microscopy （SEM）. The size and shape of rectangular inclusions affect markedly the initiation site and propagation path of a fatigue crack. Especially, the initiation site of a fatigue crack depends strongly on the angle between the long-axis of a rectangle inclusion and the loading direction, and the length/width ratio of this rectangle inclusion because the residual stress distribution fields vary with these conditions. The results coincide very well with those of finite element analysis.

关键词： high strength steel inclusions fatigue of materials crack initiation crack propagation

Effect of long-term service on the precipitates in P92 steel

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International Journal of Minerals,Metallurgy and Materials 2018年第8期25卷 913-921页

作者： yan-ping zeng Jin-dou Jia Wen-he Cai Shu-qing Dong Zhi-chun Wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China North China Electric Power Research Institute Co. Ltd.Beijing 100045China

The precipitates in P92 steel after long-term service in an ultra-supercritical unit were investigated by field-emission scanning electron microscopy and transmission electron microscopy and were found to mainly consist of M23 C6 carbides,Laves phase,and MX *** Z-phase was observed.M23 C6 carbides and Laves phase were found not only on prior austenite grain boundaries,martensite lath boundaries,and subgrain boundaries but also in lath interiors,where two types of MX carbonitrides—Nb-rich and V-rich particles—were also observed but the "winged" complexes were hardly *** kind of precipitate within the martensite laths exhibited multifarious morphologies,suggesting that a morphological change of precipitates occurred during long-term *** M23 C6 carbides and Laves phase coarsened substantially,and the latter grew faster than the ***,MX carbonitrides exhibited a relatively low coarsening *** effect of the evolution of the precipitate phases on the creep rupture strength of P92 steel was discussed.

关键词： precipitate P92 steel long-term service ultra supercritical unit

Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway

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Acta Pharmacologica Sinica 2019年第8期40卷 1049-1057页

作者： Xue-mei Liu Xiao-min Zhao Chao Deng yan-ping zeng Chang-hua Hu School of Pharmaceutical Sciences Southwest University Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control School of Medicine University of Wollongong Antipsychotic Research Laboratory Illawarra Health and Medical Research Institute

Second-generation antipsychotic drug(SGA)-induced metabolic abnormalities,such as dyslipidemia,are a major clinical problem for antipsychotic *** evidences have shown the efficacy of statins in reducing SGA-induced dyslipidemia,but the underlying mechanisms are *** this study,we explored whether mTOR signaling was involved in olanzapine(OLZ)-induced dyslipidemia as well as the lipid-lowering effects of cotreatment of simvastatin(Sim)in *** rats received OLZ(1.0 mg/kg,t.i.d.)for 7 weeks;from the third week a group of model rats were cotreatment of Sim(3.0 mg/kg,t.i.d.)for 5 *** found that OLZ treatment significantly increased the plasma triglyceride(TG)and total cholesterol(TC)levels,and promoted lipid accumulation in the liver,whereas cotreatment of Sim reversed OLZ-induced *** mTORC1 and p-mTORC1 expression was accelerated in the OLZ treatment group,with upregulation of mRNA expression of sterol regulatory element-binding protein 1 c(SREBP1 c)and its target genes,whereas these alterations were ameliorated by Sim *** HepG2 cells,rapamycin(a mTOR inhibitor)significantly reduced the OLZ-stimulated hepatocellular lipid contents and weakened the ability of Sim to lower lipids via a mechanism associated with the upregulation of SREBP1 c-mediated de novo *** data suggest that OLZ induces lipid accumulation in both plasma and liver,and Sim ameliorates OLZ-induced lipid metabolic dysfunction through its effects on mTOR signaling via reducing SREBP1 c activation and the downregulation of gene expression involved in *** data provide a new insight into the prevention of metabolic side effects induced by antipsychotic drugs.

关键词： olanzapine dyslipidemia simvastatin SREBP1c de novo fatty acid synthesis mTOR signaling pathway

Placenta-derived mesenchymal stem cells attenuate secondary brain injury after controlled cortical impact in rats by inhibiting matrix metalloproteinases

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BIOCELL 2024年第1期48卷 149-162页

作者： ping yanG YUANXIANG LAN ZHONG zeng yan WANG HECHUN XIA Department of Neurosurgery School of Clinical MedicineNingxia Medical UniversityYinchuanChina Key Laboratory of Ningxia Stem Cell and Regenerative Medicine General Hospital of Ningxia Medical UniversityYinchuanChina Department of Neurosurgery Xi’an International Medical Center HospitalXi’anChina

Background:As a form of biological therapy,placenta-derived mesenchymal stem cells(PDMSCs)exhibit considerable promise in addressing the complex pathological processes of traumaticbrain injury(TBI)due to their multi-target and multi-pathway mode of ***&Methods:This study investigates the protective mechanisms and benefits of PDMSCs in mitigating the effects of controlled cortical impact(CCI)in rats and glutamate-induced oxidative stress injury in HT22 cells in *** primary objective is to provide evidence supporting the clinical application of ***:In the in vivo arm of our investigation,we observed a swift elevation of matrix metalloproteinase-9(MMP-9)in the proximal cortex of injured brain tissues after ***,distinguished by their heightened expression of metalloproteinase tissue inhibitors-1 and-2(TIMP-1 and TIMP-2):were intravenously administered via the caudal *** intervention yielded significant reductions in the permeability of the blood-brain barrier(BBB):the extent of brain edema,the levels of inflammatory cytokines IL-1βand TNF-αin damaged brain tissue,and the activation status of microglia in CCI-afflicted *** the realm of in vitro experiments,PDMSC-conditioned media demonstrated substantial reductions in mortality rates and cleaved caspase-3 levels in glutamate-induced HT22 cells compared with conventional ***,this advantage was negated upon the introduction of neutralizing antibodies targeting TIMP-1 and ***:Collectively,our findings underscore the potential of PDMSCs in alleviating oxidative stress injury and secondary brain injury in the pathological process of TBI.

关键词： Traumatic brain injury Mesenchymal stem cells Oxidative stress Matrix metalloproteinases

Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells

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Current Medical Science 2024年第4期44卷 789-798页

作者： Chai-ming zeng Bin SHAO yan-ping CHEN Gui-sheng DING Department of Geriatric Medicine Shengli Clinical Medical College of Fujian Medical UniversityFujian Key Laboratory of Geriatrics DiseasesFujian Provincial Center for GeriatricsFujian Provincial HospitalFuzhou350001China Department of Rehabilitation Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou350001China Department of Gynecology Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou350001China Department of Ultrasonography Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou350001China

Objective Mitofusin-2(MFN2)is a mitochondrial membrane protein that plays a critical role in regulating mitochondrial fusion and cellular *** further elucidate the impact of MFN2,this study aimed to investigate its significance on hepatocellular carcinoma(HCC)cell function and its potential role in mediating *** This study investigated the effects of silencing and overexpressing MFN2 on the survival,proliferation,invasion and migration abilities,and sorafenib resistance of MHCC97-L HCC *** experiments were conducted using XAV939(aβ-catenin inhibitor)and HLY78(aβ-catenin activator)to further validate these *** Silencing MFN2 significantly promoted the survival and proliferation of MHCC97-L cells,enhanced their invasion and migration capacities,increased the IC50 of sorafenib,reduced the percentage of TUNEL-positive cells,and decreased the expression of proapoptotic ***,silencing MFN2 markedly induced the nuclear translocation ofβ-catenin,increasedβ-catenin acetylation levels and enhanced the expression of the downstream regulatory proteins Snail1 and Vimentin while inhibiting E-cadherin ***,overexpressing MFN2 reversed the effects observed in MHCC97-L cells mentioned *** results confirmed that silencing MFN2 activated theβ-catenin/epithelial-mesenchymal transition(EMT)pathway and reduced the sensitivity of cells to sorafenib,which could be reversed by XAV939 ***,overexpression of MFN2 inhibited theβ-catenin/EMT pathway and increased the sensitivity of cells to sorafenib,which could be altered by *** Low expression of MFN2 in HCC cells promotes the nuclear translocation ofβ-catenin,thereby activating the EMT pathway and mediating resistance to sorafenib.

关键词： mitofusin-2 epithelial-mesenchymal transition sorafenib resistance apoptosis hepatocellular carcinoma

Eureka lemon zinc finger protein ClDOF3.4 interacts with citrus yellow vein clearing virus coat protein to inhibit viral infection

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Journal of Integrative Agriculture 2024年第6期23卷 1979-1993页

作者： ping Liao Ting zeng Mengyang Huangfu Cairong Zheng Jiequn Ren Changyong Zhou yan Zhou Integrative Science Center of Germplasm Creation in Western China(CHONGQING)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China National Citrus Engineering Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China Chongqing Three Gorges Academy of Agricultural Science Chongqing Three Gorges UniversityChongqing 404020China

Citrus yellow vein clearing virus(CYVCV)is a new citrus virus that has become an important factor restricting the development of China’s citrus industry,and the CYVCV coat protein(CP)is associated with viral *** this study,the Eureka lemon zinc finger protein(ZFP)ClDOF3.4 was shown to interact with CYVCV CP in vivo and in *** expression of ClDOF3.4 in Eureka lemon induced the expression of salicylic acid(SA)-related and hypersensitive response marker genes,and triggered a reactive oxygen species burst,ion leakage necrosis,and the accumulation of free ***,the CYVCV titer in ClDOF3.4 transgenic Eureka lemon plants was approximately 69.4%that in control plants 6 mon after inoculation,with only mild leaf chlorotic spots observed in those transgenic *** together,the results indicate that ClDOF3.4 not only interacts with CP but also induces an immune response in Eureka lemon by inducing the SA *** is the first report that ZFP is involved in the immune response of a citrus viral disease,which provides a basis for further study of the molecular mechanism of CYVCV infection.

关键词： citrus yellow vein clearing virus coat protein ClDOF3.4 plant immune response

Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

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Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin Han Yibo zeng Yinghua Lu ping zeng Liang Shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

CFD-DEM study of impacts of the porous distributor medium on fluidization characteristics of a 2D-fluidized bed

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Particuology 2024年第4期87卷 54-73页

作者： Fei Wang Yishan zeng Hao yan School of Mechanical Engineering Hefei University of TechnologyHefei230009China

Gas-solid bubbling fluidized beds are widely used in chemical,energy,construction,and other industrial fields due to their excellent fluidization performance.2D-fluidized beds with planar rectangular columns of finite thickness are widely used in fluidized bed studies,and it is essential for understanding the hydrodynamics of gas-particle ***,the distributor(porous medium)at the bottom of the bed has a crucial influence on the fluidization performance of the 2D-fluidized *** this work,the fluidization mechanism and gas-solid dynamic characteristics of the fluidized bed under three porous media are studied by CFD-DEM coupled with the porous medium model,and the accuracy of numerical simulation is verified by a high-speed photography *** show that with the increase in the flow resistance of the porous medium,the average and standard deviation of the bubble diameter decrease,and the time and position of particles in the dead zone to participate in the core-annular flow *** a low fluidization velocity,the dead zone in the bed can be considerably reduced by increasing the flow resistance.

关键词： Fluidized bed CFD-DEM Porous medium Bubble dynamics Solid mixing