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Intrinsic feature extraction using discriminant diffusion mapping analysis for automated tool wear evaluation

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Frontiers of Information Technology & Electronic Engineering 2018年第11期19卷 1352-1361页

作者： Yi-xiang HUANG Xiao liU Cheng-liang liU yan-ming li State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Aerospace Equipment Manufacturer Shanghai 200245China

We present a method of discriminant diffusion maps analysis(DDMA) for evaluating tool wear during milling processes. As a dimensionality reduction technique, the DDMA method is used to fuse and reduce the original features extracted from both the time and frequency domains, by preserving the diffusion distances within the intrinsic feature space and coupling the features to a discriminant kernel to refine the information from the high-dimensional feature space. The proposed DDMA method consists of three main steps:(1) signal processing and feature extraction;(2) intrinsic dimensionality estimation;(3) feature fusion implementation through feature space mapping with diffusion distance preservation. DDMA has been applied to current signals measured from the spindle in a machine center during a milling experiment to evaluate the tool wear status. Compared with the popular principle component analysis method, DDMA can better preserve the useful intrinsic information related to tool wear status. Thus, two important aspects are highlighted in this study: the benefits of the significantly lower dimension of the intrinsic features that are sensitive to tool wear, and the convenient availability of current signals in most industrial machine centers.

关键词： Tool condition monitoring Manifold learning Dimensionality reduction Diffusion mapping analysis Intrinsic feature extraction

Assembling and releasing performance of supramolecular hydrogels formed from simple drug molecule as the hydrogelator

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Chinese Chemical Letters 2007年第8期18卷 1009-1012页

作者： Yu Jiang Wang liang yan li ming Tang Jian Yu Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084 China

A simple drug compound, 4-oxo-4-（2-pyridinylamino） butanoic acid （defined as AP）, was able to gel water at 4 wt% concentration under various conditions. In the superstructure, AP molecules assembled into fibrous aggregates driving by hydrogen bonds and π-π stacking interaction. The gels with different backbone structures released drug molecules in different speeds.

关键词： Supramolecular hydrogel Hydrogelator Releasing

Genome-wide identification and expression analysis of anthocyanin biosynthetic genes in Brassica juncea

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Journal of Integrative Agriculture 2020年第5期19卷 1250-1260页

作者： ZHANG Da-wei liU li-li ZHOU Ding-gang liU Xian-jun liU Zhong-song yan ming-li School of life Science Hunan University of Science and TechnologyXiangtan 411201P.R.China Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization Xiangtan 411201P.R.China College of life Sciences Resources and Environment SciencesYichun UniversityYichun 333600P.R.China Oilseed Research Institute Hunan Agricultural UniversityChangsha 410128P.R.China

Anthocyanins confer the wide range of colors for plants and also play beneficial health roles as potentially protective factors against heart disease and cancer. Brassica juncea is cultivated as an edible oil resource and vegetable crop worldwide, thus elucidating the anthocyanin biosynthetic pathway would be helpful to improve the nutritional quality of Brassica juncea through the breeding and cultivating of high anthocyanin content varieties. Herein, 129 genes in B. juncea were identified as orthologs of 41 anthocyanin biosynthetic genes(ABGs) in Arabidopsis thaliana by comparative genomic analyses. The B. juncea ABGs have expanded by whole genome triplication and subsequent allopolyploidizatoin, but lost mainly during the whole genome triplication between B. rapa/B. nigra and A. thaliana, rather than the allopolyploidization process between B. juncea and B. rapa/B. nigra, leading to different copy numbers retention of A. thaliana homologous genes. Although the overall expansion levels ABGs were similar to the whole genome, more negative regulatory genes were retained in the anthocyanin biosynthesis regulatory system. Transcriptional analysis of B. juncea with different anthocyanin accumulation showed that BjDFR, BjTT19, BjTT8 are significantly up-regulated in plants with purple leaves as compared with green leaves. The overexpression of BjTT8 and these target genes which were involved in late anthocyanin biosynthesis and transport might account for increasing levels of anthocyanin accumulation in purple leaves. Our results could promote the understanding of the genetic mechanism of anthocyanin biosynthesis in B. juncea.

关键词： anthocyanin biosynthetic genes B.juncea comparative genomic analysis transcriptome leaf color

A New Diterpenoid from Hydroclathrus tenuis

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Chinese Chemical Letters 2001年第8期12卷 709-710页

作者： Xiao Hua XU Xiao CHEN Jian Hua LU Guang Min YAO yan ming li Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071

A new dolabellane diterpene 1, named as hydroclathrol, has been isolated from the alga Hydroclathrus tenuis. Its structure has been determined on the basis of spectral analysis as 1, 4, 8-trimethyl-14-isopropyl-bicycl... 详细信息

关键词： Hydroclathrus tenui hydroclathrol spectral analysis

Antitumor effects of different Ganoderma lucidum spore powder in cell-and zebrafish-based bioassays

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Journal of Integrative Medicine 2021年第2期19卷 177-184页

作者： Yue-jiao Shi Hua-xian Zheng Zhu-ping Hong Han-bo Wang Ying Wang ming-yan li Zhen-hao li Zhejiang Shouxiangu Pharmaceutical Co. LtdWuyi 321200Zhejiang ProvinceChina Zhejiang Shouxiangu Botanical Drug Institute Co. LtdHangzhou 310012Zhejiang ProvinceChina Zhejiang Engineering Research Center of Rare Medicinal Plants Wuyi 321200Zhejiang ProvinceChina Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310012Zhejiang ProvinceChina

Objective:Ganoderma lucidum spore(GLS)is gaining recognition as a medicinal part of *** and has been reported to possess various pharmacological properties,such as antitumor *** this work,wall-broken GLS powder(BGLSP)and wall-removed GLS powder(RGLSP),two kinds of GLS powder with different manufacturing techniques,were compared in terms of contents of active constituents and in vivo and in vitro antitumor ***:The ultraviolet and visible spectrophotometry method was used to determine the contents of polysaccharides and total triterpenoids in BGLSP and *** individual triterpenoids were further quantified using ultra-high-performance liquid chromatography and quantitative analysis of multicomponents by single *** antitumor effects of BGLSP and RGLSP were evaluated using in vitro cell viability assay against human gastric carcinoma SGC-7901,lung carcinoma A549 and lymphoma Ramos and further validated by in vivo zebrafish xenograft models with transplanted SGC-7901,A549 and Ramos,Results:The results showed that the contents of polysaccharides,total triterpenoids and individual triterpenoids of RGLSP were significantly higher than those of *** both BGLSP and RGLSP inhibited the three tumor cell lines in vitro in a dose-dependent manner,the inhibitory effects of RGLSP were much better than those of *** the in vivo zebra fish assay,RGLSP exhibited more potent inhibitory activities against tumors transpla nted into the zebra fish compared with BGLSP,and the inhibition rates of RGLSP reached approximately 78%,31%and 83%on SGC-7901,A549 and Ramos,***:The results indicated that the antitumor effects of GLS were positively correlated with the contents of the polysaccha rides and triterpenoids and demonstrated that the wall-removing manufacturing technique could significantly improve the levels of active constituents,and thereby enhance the antitumor activity.

关键词： Ganoderma lucidum Tumor Cancer cell Zebrafish Wall-broken Ganoderma lucidum spore powder Wall-removed Ganoderma lucidum spore powder

A New Sesquiterpene from the Alga Caloglossa Leprieurii

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Chinese Chemical Letters 2002年第10期13卷 953-954页

作者： Xiao Hua XU Chang Jian liN Jian Hua LU Guang Min YAO yan ming li Institute of Elemento-Organic Chemistry Nankai UniversityTianjin 300071

A new bromo-sesquiterpene 1, has been isolated from the alga Caloglossa leprieurii collected from the XiSha islands in south china sea. Its structure has been determined on the basis of spectral analysis. and The rela... 详细信息

关键词： Caloglossa leprieuriii hydroclathrol spectral analysis.

Inetetamab combined with S-1 and oxaliplatin as first-line treatment for human epidermal growth factor receptor 2-positive gastric cancer

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World Journal of Gastroenterology 2024年第40期30卷 4367-4375页

作者： Ying Kong Qi Dong Peng Jin ming-yan li li Ma Qi-Jun Yi Yu-E Miao Hai-yan liu Jian-Gang liu Department of Oncology The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina

BACKGROUND Patients with human epidermal growth factor receptor 2(HER2)-positive advanced gastric cancer have poor *** combined with chemotherapy is the first-line standard treatment for HER2-positive advanced gastric *** is a novel anti-HER2 drug,and its efficacy and safety in gastric cancer have not yet been *** To evaluate the efficacy and safety of the S-1 plus oxaliplatin(SOX)regimen combined with inetetamab as a first-line treatment for HER2-positive advanced gastric *** Thirty-eight patients with HER2-positive advanced gastric cancer or gastroeso-phageal junction adenocarcinoma were randomly divided into two groups:One group received inetetamab combined with the SOX regimen,and the other group received trastuzumab combined with the SOX *** 4-6 cycles,patients with stable disease received maintenance *** primary endpoints were progression-free survival(PFS)and overall survival(OS),and the secondary endpoints were the objective response rate,disease control rate,and adverse events(AEs).RESULTS Thirty-seven patients completed the trial,with 18 patients in the inetetamab group and 19 patients in the trastuzumab *** the inetetamab group,the median PFS was 8.5 months,whereas it was 7.3 months in the trastuzumab group(P=0.046);this difference was *** median OS in the inetetamab group vs the trastuzumab group was 15.4 months vs 14.3 months(P=0.33),and the objective response rate was 50%vs 42%(P=0.63),respectively;these differences were not *** AEs included leukopenia,thrombocytopenia,nausea,and *** incidence rates of grade≥3 AEs were 56%in the inetetamab group and 47%in the trastuzumab group(P=0.63),with no significant *** In the first-line treatment of HER2-positive advanced gastric cancer,inetetamab and trastuzumab showed comparable *** inetetamab group showed superior PFS,and both groups had good safety.

关键词： Human epidermal growth factor receptor 2-positive Advanced gastric cancer Inetetamab Trastuzumab Efficacy Safety

Inetetamab combined with tegafur as second-line treatment for human epidermal growth factor receptor-2-positive gastric cancer: A case report

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World Journal of Clinical Cases 2024年第4期12卷 820-827页

作者： Jing-Hao Zhou Qi-Jun Yi ming-yan li yan Xu Qi Dong Cong-Ying Wang Hai-yan liu Department of Oncology The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina

BACKGROUND Human epidermal growth factor receptor-2(HER-2)plays a vital role in tumor cell proliferation and ***,the prognosis of HER2-positive gastric cancer is ***,a novel anti-HER2 targeting drug independently developed in China,exhibits more potent antibody-dependent cell-mediated cytotoxicity than trastuzumab,which is administered as the first-line treatment for HER2-positive gastric cancer in combination with *** this case,the efficacy and safety of inetetamab combined with tegafur was investigated as a second-line treatment for HER2-positive gastric *** SUMMARY A 52-year-old male patient with HER2-positive gastric cancer presented with abdominal distension,poor appetite,and fatigue two years after receiving six cycles of oxaliplatin combined with tegafur as first-line treatment after surgery,followed by tegafur monotherapy for six *** patient was diagnosed with postoperative recurrence of gastric *** received 17 cycles of a combination of inetetamab,an innovative domestically developed anti-HER2 monoclonal antibody,and tegafur chemotherapy as the second-line treatment(inetetamab 200 mg on day 1,every 3 wk combined with tegafur twice daily on days 1–14,every 3 wk).Evaluation of the efficacy of the second-line treatment revealed that the patient achieved a stable condition and progression-free survival of 17 *** tolerated the treatment well without exhibiting any grade 3-4 adverse *** Inetetamab combined with chemotherapy for the treatment of metastatic HER2-positive gastric cancer demonstrates significant survival benefits and acceptable safety.

关键词： Inetetamab Gastric cancer Human epidermal growth factor receptor-2 protein Tegafur Case report

Enantioseparation of Aminoglutethimide by High-speed Countercurrent Chromatography Using Carboxymethly-β-cyclodextrin as Chiral Selector

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Chinese Chemical Letters 2006年第6期17卷 787-790页

作者： Ping AI Jia Chuan liU Min ZI Zhi Hua DENG Zhi Hong yan li ming YUAN Department of Chemistry Yunnan Normal University Kunming 650092

Enantioseparation of aminoglutethimide was performed by high-speed counter-current chromatography with a two-phase system composed of ethyl acetate： methanol： water = 10： 1： 9. The lower phase contained 20 mmol/L of carboxymethly-β-cyclodextrin as chiral selector. The enantiomers were separated in 1.2 h and identified by chiral HPLC. This method was very efficient for the chiral preparative separation.

关键词： High speed countercurrent chromatography enantioseparation aminoglutethimide,carboxymethly-β-cyclodextrin.