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Multi-modality measurement and comprehensive analysis of hepatocellular carcinoma using synchrotron-based microscopy and spectroscopy

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Nuclear Science and Techniques 2021年第9期32卷 136-149页

作者： Gong-Xiang Wei Sui-Xia Zhang Zhao Li Fu-Li Wang yan-ling xue Te Ji Hui-Qiang Liu School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China State Key Laboratory of Pathogenesis PreventionTreatment of Central Asian High Incidence DiseasesFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Oncology Department ZiBo Central HospitalZibo 255000China SSRF Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201800China

The visualization and data mining of tumor multidimensional information may play a major role in the analysis of the growth,metastasis,and microenvironmental changes of tumors while challenging traditional imaging and data processing *** this study,a general trans-scale and multi-modality measurement method was developed for the quantitative diagnosis of hepatocellular carcinoma(HCC)using a combination of propagation-based phase-contrast computed tomography(PPCT),scanning transmission soft X-ray microscopy(STXM),and Fourier transform infrared micro-spectroscopy(FTIR).Our experimental results reveal the trans-scale micro-morpho-logical HCC pathology and facilitate quantitative data analysis and comprehensive *** results include some visualization features of PPCT-based tissue microenvironments,STXM-based cellular fine structures,and FTIR-based bio-macromolecular spectral characteris-tics during HCC tumor differentiation and *** proposed method provides multidimensional feature data support for constructing a high-accuracy machine learning algorithm based on a gray-level histogram,gray-gradient co-occurrence matrix,gray-level co-occurrence matrix,and back-propagation neural network ***-dimensional information analysis and diagnosis revealed the morphological pathways of HCC pathological evolution and we explored the relationships between HCC-related feature changes in inflammatory microenviron-ments,cellular metabolism,and the stretching vibration peaks of biomolecules of lipids,proteins,and nucleic ***,the proposed methodology has strong potential for the visualization of complex tumors and assessing the risks of tumor differentiation and metastasis.

关键词： Propagation based phase contrast tomography Soft X-ray microscopy Infrared micro spectroscopy Machine learning Tumor microenvironment and metastasis

Methodology development and application of X-ray imaging beamline at SSRF

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Nuclear Science and Techniques 2020年第10期31卷 74-94页

作者： Hong-Lan Xie Biao Deng Guo-Hao Du Ya-Nan Fu Han Guo yan-ling xue Guan-Yun Peng Fen Tao ling Zhang Ti-Qiao Xiao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

This paper introduces some latest developments regarding the X-ray imaging methodology and applications of the X-ray imaging and biomedical application beamline(BL13W1)at Shanghai Synchrotron Radiation Facility in the past 5 *** photon energy range of the beamline is 8–72.5 *** sets of X-ray imaging detectors with different pixel sizes(0.19–24 lm)are used to realize X-ray microcomputed tomography(X-ray micro-CT)and X-ray in-line phase-contrast *** satisfy the requirements of user experiments,new X-ray imaging methods and image processing techniques are *** vivo dynamic micro-CT experiments with living insects are performed in 0.5 s(sampling rate of 2 Hz,2 tomograms/s)with a monochromatic beam from a wiggler source and in 40 ms(sampling rate of 25 Hz,25 tomograms/s)with a white beam from a bending magnet source.A new X-ray imaging method known as move contrast X-ray imaging is proposed,with which blood flow and moving tissues in raw images can be distinguished according to their moving frequencies in the time ***,X-ray speckle-tracking imaging with twice exposures to eliminate the edge enhancement effect is developed.A high-precision quantification method is realized to measure complex three-dimensional blood vessels obtained via X-ray micro-CT.X-ray imaging methods such as three-dimensional X-ray diffraction microscopy,small-angle X-ray scattering CT,and X-ray fluorescence CT are developed,in which the X-ray micro-CT imaging method is combined with other contrast mechanisms such as diffraction,scattering,and fluorescence contrasts ***,an X-ray nano-CT experiment is performed with a 100 nm spatial *** user experimental results from the fields of material science,biomedicine,paleontology,physics,chemistry,and environmental science obtained on the beamline are provided.

关键词： X-ray imaging X-ray in-line phase-contrast imaging X-ray micro-CT Dynamic micro-CT X-ray speckle-tracking imaging 3DXRD SAXS-CT X-ray fluorescence CT X-ray nano-CT Move contrast X-ray imaging

The new X-ray imaging and biomedical application beamline BL13HB at SSRF

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Nuclear Science and Techniques 2023年第12期34卷 190-205页

作者： Jian‑Feng Ji Han Guo yan‑ling xue Rong‑Chang Chen Ya‑Nan Fu Guo‑Hao Du Biao Deng Hong‑Lan Xie Ti‑Qiao Xiao Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics China Academy of ScienceShanghai 201800China

A new X-ray imaging and biomedical application beamline(BL13HB)has been implemented at the Shanghai Radiation Synchrotron Facility(SSRF)as an upgrade to the old X-ray imaging and biomedical application beamline(BL13W1).This is part of the Phase II construction project of the *** BL13HB is dedicated to 2D and 3D static and dynamic X-ray imaging,with a field of view of up to 48.5 mm×5.2 mm and spatial resolution as high as 0.8μm.A super-bending magnet is used as the X-ray source in BL13HB,which has a maximum magnetic field of 2.293 *** energy range of monochromatic X-ray photons from a double-multiplayer monochromator was 8–40 keV,and the white beam mode was provided on the beamline for dynamic X-ray imaging and dynamic X-ray *** maintaining the previous experimental setup of BL13W1,new equipment was added to the beamline experimental *** beamline is equipped with different sets of X-ray imaging detectors for several experimental methods such as micro-CT,dynamic micro-CT,and pair distribution *** experimental station of BL13HB is designed specifically for various in situ dynamic experiments,and BL13HB has been open to users since June 2021.

关键词： X-ray imaging Dynamic micro-CT Shanghai Synchrotron Radiation Facility

P2X7 Receptor Antagonism Attenuates the Intermittent Hypoxia-induced Spatial Deficits in a Murine Model of Sleep Apnea Via Inhibiting Neuroinflammation and Oxidative Stress

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Chinese Medical Journal 2015年第16期128卷 2168-2175页

作者： yan Deng xue-ling Guo Xiao Yuan Jin Shang Die Zhu Hui-Guo Liu Department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China

Background：The mechanism of the neural injury caused by chronic intermittent hypoxia （CIH） that characterizes obstructive sleep apnea syndrome （OSAS） is not clearly *** purpose of this study was to investigate whether P2X7 receptor （P2X7R） is responsible for the CIH-induced neural injury and the possible pathway it ***：Eight-week-old male C57BL/6 mice were *** each exposure time point,eight mice divided in room air （RA） and IH group were assigned to the study of P2X7R *** in the 21 days-Brilliant Blue G （BBG,a selective P2X7R antagonist） study,48 mice were randomly divided into CIH group,BBG-treated CIH group,RA group and BBG-treated RA *** hippocampus P2X7R expression was determined by Western blotting and real-time polymerase chain reaction （PCR）.The spatial learning was analyzed by Morris water *** nuclear factor kappa B （NFκB） and NADPH oxidase 2 （NOX2） expressions were analyzed by Westem *** expressions of tumor necrosis factor α,interleukin 1 β （IL-β）,IL-18,and IL-6 were measured by real-time *** malondialdehyde and superoxide dismutase levels were detected by colorimetric *** damage was evaluated by Hematoxylin and Eosin staining and Terminal Transferase dUTP Nick-end Labeling ***：The P2X7R mRNA was elevated and sustained after 3-day IH exposure and the P2X7R protein was elevated and sustained after 7-day IH *** the BBG study,the CIH mice showed severer neuronal cell damage and poorer performance in the behavior *** increased NFκB and NOX2 expressions along with the inflammation injury and oxidative stress were also observed in the CIH *** alleviated CIH-induced neural injury and consequent functional ***：The P2X7R antagonism attenuates the CIH-induced neuroinflammation,oxidative stress,and spatial deficits,demonstrating that the P2X7R is an important therapeutic target in the cognition deficits accompanied OSAS.

关键词： Inflammation Intermittent Hypoxia Oxidative Stress P2X7 Receptor Sleep Apnea

X-ray fluorescence microtomography based on polycapillary- focused X-rays from laboratory source

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Nuclear Science and Techniques 2018年第6期29卷 85-91页

作者： Bing-Gang Feng Fen Tao Yi-Ming yang Tao Hu Fei-Xiang Wang Guo-Hao Du yan-ling xue Ya-Jun Tong Tian-Xi Sun Biao Deng Ti-Qiao Xiao Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China Beijing Normal University Beijing 100875 China

X-ray fluorescence microtomography(μXFCT)is a nondestructive analytical technique and has been widely used to nondestructively detect and quantify the elemental composition and distributions in samples. Usually, synchrotron radiation X-rays are used for μXFCT, due to its high flux density. In this paper, a laboratory-sourcebased μXFCT system was developed, in which a polycapillary lens is employed to focus the X-ray beam and improve the flux density. The maximum likelihood expectation maximization algorithm was used to reconstruct the computed tomography slices at a limited number of projections. The experimental results demonstrated that the developed system could reveal the elemental distribution inside the test sample, with an elemental sensitivity of 1000 ppm.

关键词：检查荧光实验室期望最大化算法采购非破坏性同步加速器断层摄影术

Determination of decabromodiphenyl ether in water samples by single-drop microextraction and RPHPLC

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Determination of decabromodiphenyl ether in water samples by...

Poly（ethylene glycol） Supported Synthesis of Quinazoline-2,4-diones

中国化学会第十四届有机分析及生物分析学术研讨会

作者： LI yan-yan FU ling-yan WANG xue-dong~* ZHANG Tao-zhi (Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Central China Normal University)

＜正＞This paper describes the development of a new method using single-drop microextraction （SDME） and RP-HPLC for the determination of decabromodiphenyl ether （BDE-209） in water samples. The effects of SDME parameters such as extraction solvent,microdrop volume,extraction time,stirring speed,salt concentration,and sample pH on the extraction performance are *** optimal extraction conditions （extraction solvent,toluene;solvent drop volume,3.0 μL;extraction time,15 min;stirring speed,600 rpm;no addition of salt and change of sample pH）,the calibration curve was drawn by plotting peak area against a series of BDE-209 concentrations （0.001～1 μg/mL） in aqueous solution;the correlation coefficient （r） was *** limit of detection was 0.7 ng/*** enrich- ment factor was *** precision of this method was obtained by six successive analyses of a 100 ng/ mL standard solution of BDE-209,and BSD was 4.8%.This method was successfully applied to the ex- traction of BDE-209 from tap and east lake water samples with relative recoveries ranging from 92.5% to 102.8% and from 91.5% to 96.2%,respectively,and the relative standard deviations （a=3） were 4.4% and 2.2%.The proposed method is acceptable for the analysis of BDE-209 in water samples.

关键词： Decabromodiphenyl ether Reversed phase high performance liquid chromatography Single drop microextraction Water samples

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Poly（ethylene glycol） Supported Synthesis of Quinazoline-2...

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

中国化学会第四届有机化学学术会议

作者： HUANG, yan-ling MU, xue-ling yanG, Gui-Chun CHEN, Zu-Xing (Faculty of Chemistry & Material, Hubei University, Wuhan 430062) (Technical College of jingmen, Jingmen 448000)

＜正＞The liquid phase method has been recently applied to the synthesis of small organic molecules and to combinatorial chemistry. Using soluble polymers support such as polyethylene glycol （PEG）, this method combines the strategical features of solution and solid phase methods. The quinazolinedione template appears in a wide range of bioactive molecules that interact with G-protein coupled receptors （GPCRs;adrenergic, serotonergic, dopaminer-gic, endothelin ETA）, and enzymes （cyclooxygenase, collagenase, aldose reductase, and carbonic anhydrase）. So, we describe a practical liquid phase synthesis of quinazoline-2,4-diones using poly （ethylene glycol）（PEG） 3400 as soluble polymer, starting with anthranilic acids, diversity is added in a combinatorial manner followed by quinazolinedione formation and simultaneous product release from the PEG （Scheme 1）.

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

"口味无争辩"?——高低收入阶层膳食健康上的不平等及其分解

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管理科学学报 2021年第1期24卷 50-70页

作者：马超李宜威贾建民闫雪凌东南大学经济管理学院南京211189 东南大学公共卫生学院南京210009 岭南大学市场及国际企业学系中国香港999077 香港中文大学(深圳)经济管理学院深圳518172 四川大学经济学院成都610005

我国高低收入阶层间存在着严重的膳食健康上的不平等现象,在讨论其背后的机制时,鲜有文献涉及到口味因素.传统理念认为口味差异天生给定,无需争辩;Becker开创性地认为可以用经济学工具争辩口味问题.通过采用中国家庭追踪调查(CFPS)2010... 详细信息

我国高低收入阶层间存在着严重的膳食健康上的不平等现象,在讨论其背后的机制时,鲜有文献涉及到口味因素.传统理念认为口味差异天生给定,无需争辩;Becker开创性地认为可以用经济学工具争辩口味问题.通过采用中国家庭追踪调查(CFPS)2010年~2014年三期面板数据进行分析,加入个体固定效应的再中心化影响函数回归,消除了"不可争辩的口味";在此基础.上进行无条件分位数分解,将相同特征条件下系数不同导致的不平等定义为"可争辩的口味"效应.结果显示:在包含收入阶层流动的情况下,"可争辩的口味"和社会经济地位分别可以解释膳食健康不平等的54.3%和44.5%;在不包含收入阶层流动的情况下,二者分别可以解释37.1%和62.3%.人口学特征、个体健康、供给因素的作用很小。结论表明,收入政策只能起到部分作用,政策制定者需要重视对口味的教育引导.这在"健康中国2030"背景下,对于促进全民健康有着重要启示.

关键词：膳食健康食物多样性不平等 FFL分解口味经济学