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Comparison scoring model of severe viral hepatitis and model of end stage liver disease for the prognosis of patients with liver failure in China

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World Journal of Gastroenterology 2007年第21期13卷 2999-3002页

作者： Li Zhou pei-ling Dong Hui-Guo Ding Department of GI and Hepatology Beijing You'an Hospital affiliated to Capital Medical University Beijing 100069 China

AIM:To estimate the prognosis of patients with liver failure using a scoring model of severe viral hepatitis (SMSVH) and a model of end stage liver disease (MELD) to provide a scientific basis for clinical decision of treatment. METHODS:One hundred and twenty patients with liver failure due to severe viral hepatitis were investigated with SMSVH established. Patients with acute,subacute,and chronic liver failure were 40,46 and 34,respectively. The follow-up time was 6 mo. The survival rates of patients with liver failure in 2 wk,4 wk,3 mo and 6 mo were estimated with Kaplan-Meier method. Comparison between SMSVH and MELD was made using ROC statistic analysis. RESULTS:The survival curves of group A (at low risk,SMSVH score ≤ 4) and group B (at high risk,SMSVH score ≥ 5) were significantly different (The 4-wk,3-mo,6-mo survival rates were 94.59%,54.05%,43.24% in group A,and 51.81%,20.48%,12.05% in group B,respectively,P < 0.001). The survival curves of group C (SMSVH scores unchanged or increased),group D (SMSVH scores decreased by 1) and group E (SMSVH scores decreased by 2 or more) were significantly different .The survival rates of groups C,D and E were 66.15%,100%,100% in 2-wk; 40.0%,91.18%,100% in 4-wk; 0%,58.82%,80.95% in 3-mo and 0%,38.24%,61.90% in 6-mo,respectively,P < 0.001). The area under the ROC curve (AUC) of SMSVH scores at baseline and after 2 wk of therapy was significantly higher than that under the ROC curve of MELD scores (0.804 and 0.934 vs 0.689,P < 0.001). CONCLUSION:SMSVH is superior to MELD in theestimation of the prognosis of patients with severe viral hepatitis within 6 mo. SMSVH may be regarded as a criterion for estimation of the efficacy of medical treatment and the decision of clinical treatment.

关键词： Liver failure Survival analysis Scoring model

Double contrast-enhanced ultrasonography improves diagnostic accuracy of T staging compared with multi-detector computed tomography in gastric cancer patients

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World Journal of Gastroenterology 2024年第23期30卷 3005-3015页

作者： yan-Fen Xu Hui-Yun Ma Gui-ling Huang Yu-Ting Zhang Xue-yan Wang Ming-Jie Wei Xiao-Qing pei Department of Ultrasound State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Radiology State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Medical Ultrasound State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Gastric cancer(GC)is the most common malignant tumor and ranks third for cancer-related deaths among the *** disease poses a serious public health problem in China,ranking fifth for incidence and third for *** of the invasive depth of the tumor is vital to treatment *** To evaluate the diagnostic performance of double contrast-enhanced ultrasonography(DCEUS)for preoperative T staging in patients with GC by comparing with multi-detector computed tomography(MDCT).METHODS This single prospective study enrolled patients with GC confirmed by preoperative gastroscopy from July 2021 to March *** underwent DCEUS,including ultrasonography(US)and intravenous contrast-enhanced ultrasonography(CEUS),and MDCT examinations for the assessment of preoperative T *** of GC were identified on DCEUS and criteria developed to evaluate T staging according to the 8th edition of AJCC cancer staging *** diagnostic performance of DCEUS was evaluated by comparing it with that of MDCT and surgical-pathological findings were considered as the gold *** A total of 229 patients with GC(80 T1,33 T2,59 T3 and 57 T4)were *** accuracies were 86.9%for DCEUS and 61.1%for MDCT(P<0.001).DCEUS was superior to MDCT for T1(92.5%vs 70.0%,P<0.001),T2(72.7%vs 51.5%,P=0.041),T3(86.4%vs 45.8%,P<0.001)and T4(87.7%vs 70.2%,P=0.022)staging of *** DCEUS improved the diagnostic accuracy of preoperative T staging in patients with GC compared with MDCT,and constitutes a promising imaging modality for preoperative evaluation of GC to aid individualized treatment decision-making.

关键词： Double contrast-enhanced ultrasonography Multi-detector computed tomography Gastric cancer T staging

Effective assignment of positional isomers in dimeric shikonin and its analogs by ^(1)H NMR spectroscopy

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Chinese Chemical Letters 2024年第5期35卷 223-226页

作者： ling-Hao Zhao Hai-Wei yan Jian-Shuang Jiang Xu Zhang Xiang Yuan Ya-Nan yang pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and ***,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/*** chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,*** reported ambiguous structures were corrected by this ***,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.

关键词： Arnebia euchroma Dimeric hydroxyl naphthoquinones Positional isomers ^(1)H NMR spectroscopy Chemical shift difference

A negative regulator of synaptic development:MDGA and its links to neurodevelopmental disorders

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World Journal of Pediatrics 2019年第5期15卷 415-421页

作者： Rui Wang Jia-Xian Dong Lu Wang Xin-yan Dong Eitan Anenberg pei-Fang Jiang ling-Hui Zeng Yi-Cheng Xie Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Department of Clinical Medicine Zhejiang University City CollegeHangzhou 310015China

Background Formation of protein complexes across synapses is a critical process in neurodevelopment,having direct implications on brain function and animal ***,we present the understanding,importance,and potential impact of a newly found regulator of such a key *** sources A systematic search of the literature was conducted on PubMed(Medline),Embase,and Central-Cochrane *** Membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins(MDGAs)were recently discovered to regulate synaptic development and transmission via suppression of neurexins-neuroligins transsynaptic complex *** also regulate axonal migration and *** the context of their physiological role,we begin to consider the potential links to the etiology of certain neurodevelopmental *** present the gene expression and protein structure of MDGAs and discuss recent progress in our understanding of the neurobiological role of MDGAs to explore its potential as a therapeutic *** MDGAs play a key role in neuron migration,axon guidance and synapse development,as well as in regulating brain excitation and inhibition balance.

关键词： Adhesion molecule E/I balance Neurodevelopmental disorders Synapse

A Pohozaev Identity for the Fractional Hnon System

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Acta Mathematica Sinica,English Series 2017年第10期33卷 1382-1396页

作者： pei MA Feng Quan LI yan LI Institute of Mathematics School of Mathematical Sciences Nanjing Normal University Nanjing 210023 P. R. China Department of Mathematical Sciences Yeshiva University New York NY 10033 USA School of Mathematical Sciences Dalian University of Technology Dalian 116024 P. R. China

In this paper, we study the Pohozaev identity associated with a Henon-Lane-Emden sys- tem involving the fractional Laplacian：{（-△）^su=｜x｜^aυ^p,x ∈Ω,（-△）^sυ=｜x｜^av^p,x ∈Ω u=υ=0, x∈R^b／Ω,in a star-shaped and bounded domain Ω for s E （0, 1）. As an application of our identity, we deduce the nonexistence of positive solutions in the critical and supercritieal cases.

关键词： Pohozaev identity fractional Laplacian Henon system nonexistence of solutions

How do Cats Resist Landing Injury:Insights into the Multi-level Buffering Mechanism

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Journal of Bionic Engineering 2020年第3期17卷 600-610页

作者： Xueqing Wu Baoqing pei Yuyang pei Wei Wang yan Hao Kaiyuan Zhou School of Biological Science and Medical Engineering Beihang UniversityBeijing 100083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100083China School of Public Health Nanjing Medical UniversityNanjing 211166China

When humans jump down from a high position,there is a risk of serious injury to the lower ***,cats can jump down from the same heights without any injury because of their excellent ability to attenuate impact *** present study aims to investigate the macro/micro biomechanical features of paw pads and limb bones of cats,and the coordination control of joints during landing,providing insights into how cats protect themselves from landing ***,histological analysis,radiological analysis,finite element method,and mechanical testing were performed to investigate the mechanical properties,microstructure,and biomechanical response of the pads and limb *** addition,using a motion capture system,the kinematic/kinetic data during landing were analysed based on inverse *** results show that the pads and limb bones are major contributors to non-impact-injuries,and cats actively couple their joints to adjust the parameters of movement to dissipate the higher ***,the paw pads,limb bones,and coordinated joints complement each other and constitute a multi-level buffering mechanism,providing the cat with the sophisticated shock absorption *** biomechanical analysis can accordingly provide biological inspiration for new approaches to prevent human lower limb injuries.

关键词： cat multi-level buffering paw pads limb bones coordinated joints

Withdrawal of immunosuppression in liver transplantation and the mechanism of tolerance

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 470-476页

作者： Chi-Xian Zhang pei-Hao Wen Yu-ling Sun Institute of Hepatobiliary and Pancreatic Diseases Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhengzhou University School of Medicine

BACKGROUND： Immunosuppression reagents have side effects and cause considerable long-term morbidity and mortality in patients after liver transplantation. Sufficient evidences showed that minimization or withdrawal of immunosuppression reagents does not deteriorate the recipient＇s immune response and physiological function and therefore, is feasible in some recipients of liver transplantation. However, the mechanisms are not clear. The present review was to update the current status of immunosuppression in liver transplantation and the mechanism of minimization or withdrawal of immunosuppression in liver *** SOURCES： We searched articles in English on minimization or withdrawal of immunosuppression in liver transplantation in Pub Med. We focused on the basic mechanisms of immune tolerance in liver transplantation. Studies on immunosuppression minimization or withdrawal protocols and biomarker in tolerant recipients were also ***： Minimization or withdrawal of immunosuppression can be achieved by the induction of immune tolerance, which may not be permanent and can be affected by various factors. However, accurately evaluating immune status post-transplant is a prerequisite to achieve individualized immunosuppression. Numerous mechanisms for immune tolerance have been found, including immunophenotypic shift of memory CD8＋ T cells and CD4＋ T cell subsets. Activation of the inflammasome through apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain（ASC） in dendritic cells is associated with rejection after liver transplantation. CONCLUSIONS： Minimization or withdrawal of immunosuppression can be achieved by the induction of immune toler-ance via different mechanisms. This process could be affected by immunophenotypic shift of memory CD8＋ T cells and CD4＋ T cell subsets, which may be correlated with activation of the inflammasome through ASC in dendritic cells.

关键词： liver transplantation immunosuppression minimization withdrawal tolerance

离子束抛光对单晶硅表面质量影响的分子动力学模拟研究

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原子与分子物理学报 2025年第6期42卷 113-121页

作者：赵仕燕郭海林黄思玲张旭夏超翔王大森聂凤明裴宁李晓静中国兵器科学研究院宁波分院宁波315103

离子束抛光作为一种超精密加工技术,被应用于材料表面抛光的精抛阶段,而其原子量级的去除效果使得它的加工过程与加工效果难以直接观察,因此为了能够从微观尺度研究离子束抛光的加工效果以及加工参数对材料表面粗糙度与表面损伤的影响,... 详细信息

离子束抛光作为一种超精密加工技术,被应用于材料表面抛光的精抛阶段,而其原子量级的去除效果使得它的加工过程与加工效果难以直接观察,因此为了能够从微观尺度研究离子束抛光的加工效果以及加工参数对材料表面粗糙度与表面损伤的影响,提出使用分子动力学模拟的方法研究离子束抛光过程,通过对氩离子轰击单晶硅的仿真模拟,分析加工参数对单晶硅表面粗糙度与晶格损伤的影响规律,指导实际的加工工艺设计.研究发现,在不同加工角度下,离子剂量对于表面粗糙度的影响规律不同,低角度(0°~40°)低剂量以及高角度(>50°)高剂量的加工有助于达到较低的表面粗糙度;随着加工角度的增加,离子束对晶体表面造成的损伤逐渐减少,当加工角度大于40°时能够大幅度减少晶格损伤.模拟结果显示在实际的离子束抛光过程中,为了得到高质量的表面,应该采取高角度高剂量的加工方式以达到既降低材料表面粗糙度又减小对材料表面晶格产生损伤的目的.

关键词：离子束抛光表面质量分子动力学单晶硅加工角度

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Numerical Investigation on Wet Steam Non-equilibrium Condensation Flow in Turbine Cascade

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Journal of Thermal Science 2012年第6期21卷 525-532页

作者： JU Feng-ming yan pei-gang HAN Wan-jin School of Energy Science & Engineering Harbin Institute of Technology Harbin 150001 China

Based on the two-phase wet steam flow with spontaneous condensation, experimental verification and flow analysis on nozzle and 2D cascade are carried out. The 3D Reynolds-Averaged gas-liquid two-phase flow control equation solver is explored with k-e-kp turbulence model. Furthermore, 3D flow numerical simulation on the last stage stator of the steam turbine is carried out. The results show that a sudden pressure rise on blade suction surface is mainly caused by the droplet growth in condensation flow. The more backward the condensation position is in cascade passage, the less the sudden pressure rise from condensation is, and the larger the nucleation rate is, the maximum under-cooling and the number of droplets per unit volume are. Interaction of condensation wave and shock wave has imposed greater influence on the parameters of the blade cascade outlet.

关键词： turbine cascade wet steam non-equilibrium condensation two-phase flow