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MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids

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Chinese Chemical Letters 2024年第4期35卷 464-468页

作者： Jing Chen Peisi Xie Pengfei Wu Yu He Zian lin Zongwei cai Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350116China Department of Chemistry State Key Laboratory of Environmental and Biological AnalysisHong Kong Baptist UniversityHong KongChina College of Forestry Nanjing Forestry UniversityNanjing 210018China

Cancer cell spheroids(CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI) to investigate the spatial distribution of endogenous compounds(e.g., lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization(MALDI-2) and trapped ion mobility spectrometry(TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies.

关键词： Matrix-assisted laser desorption/ionization(MALDI) Mass spectrometry imaging MALDI coupled with laser-postionization Trapped ion mobility spectrometry Cancer cell spheroids

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TiC strengthened CoCrNi medium entropy alloy:Dissolution and precipitation of TiC and its effect on microstructure and performance

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Transactions of Nonferrous Metals Society of China 2022年第7期32卷 2266-2275页

作者： Yong-gang TONG yan-lin cai Yong-le HU Hong-feng HUANG Xian-cheng ZHANG Hao ZHANG College of Automobile and Mechanical Engineering Changsha University of Science and TechnologyChangsha 410114China Key Laboratory of New Processing Technology for Nonferrous Metal&Materials Ministry of EducationGuilin University of TechnologyGuilin 541004China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

In order to improve the strength and corrosion resistance of CoCrNi medium entropy alloy,TiC strengthened CoCrNi medium entropy alloy(CoCrNi/(TiC)_(x)(x=0.1,0.2,0.4))was designed by addition of different amounts of *** effects of TiC content on the microstructure,mechanical properties,and corrosion resistance of the alloy were *** was found that the precipitation morphologies of TiC changed from lamellar eutectic to needle structure with the increase of TiC content,and finally formed mixed needled and bulk TiC *** appears as a dissolution−precipitation phenomenon in the CoCrNi alloy,which is important for the mechanical properties and corrosion resistance of the CoCrNi/(TiC)_(x) *** strength of alloy was enhanced obviously after the addition of *** compressive yield strength of CoCrNi/(TiC)_(0.4) alloy reached 746 MPa,much larger than that of the CoCrNi medium entropy alloy,108 ***,the addition of TiC was found to improve the corrosion resistance of CoCrNi medium entropy alloy in the salt solution.

关键词： medium entropy alloy TiC corrosion resistance microstructure mechanical properties

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Utilizing interpretable stacking ensemble learning and NSGA-Ⅲ for the prediction and optimisation of building photo-thermal environment and energy consumption

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Building Simulation 2024年第5期17卷 819-838页

作者： Yeqin Shen Yubing Hu Kai Cheng Hainan yan Kaixiang cai Jianye Hua Xuemin Fei Qinyu Wang School of Arts Jiangsu UniversityZhenjiang212013China School of Architecture and Urban Planning Nanjing UniversityNanjing210093China School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang212013China

This study develops an approach consisting of a stacking model integrated with a multi-objective optimisation algorithm aimed at predicting and optimising the ecological performance of *** integrated model consists of five base models and a meta-model,which significantly improves the prediction ***,the R2 value was improved by 9.19% and the error metrics MAE,MSE,MAPE,and CVRMSE were reduced by 69.47%,79.88%,67.32%,and 57.02%,respectively,compared to the single prediction *** to the research on interpretable machine learning,adding the SHAP value gives us a deeper understanding of the impact of each architectural design parameter on the *** the multi-objective optimisation part,we used the NSGA-Ⅲ algorithm to successfully improve the energy efficiency,daylight utilisation and thermal comfort of the ***,the optimal design solution reduces the energy use intensity by 31.6 kWh/m^(2),improves the useful daylight index by 39%,and modulated the thermal comfort index,resulting in a decrement of 0.69℃ for the summer season and an enhancement of 0.64℃ for the winter season,***,this study provides building designers and decision makers with a tool to make better design decisions at an early stage to achieve a better combination of energy efficiency,daylight utilisation and thermal comfort optimisation in an integrated manner,providing an important support for achieving sustainable building design.

关键词： building ecological performance ensemble learning multi-objective optimisation sustainable design explainable machine learning

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A long-term histological research on human frontalis muscle flap specimens from recurrent blepharoptosis patients

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1161-1163页

作者： Lu Zhou Yu-Cheng yan Jin-cai Fan Department of Plastic and Reconstructive Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China

Dear Editor,We present two patients with recurrent severe blepharoptosis after frontalis muscle(FM)flap *** we describe long-term histological changes of the FM flaps observed in revision *** flap suspension is widely applied in treating severe ptosis with poor levator function(<4 mm),and its effect is relatively stable and lasting[1].FM flap suspension is reliable and recurrent cases are observed only *** longterm research about FM flap is rare,we investigated tissue samples of revision surgery flaps which could reflect trends of morphological changes within the functioning FM flaps to some extent.

关键词： patients histological surgery

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New Insights into Microplastic Contamination in Different Types of Leachates: Abundances, Characteristics, and Potential Sources

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Engineering 2024年第6期37卷 62-68页

作者： Lei Zhang Wentao Zhao Liang Zhang Zhenxiao cai Ruiqi yan Xia Yu Damià Barceló Qian Sui State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China PerkinElmer Inc.Shanghai 201203China Maihai Environmental Protection Technology Co. Ltd.SuzhouJiangsu 215000China Department of Environmental Chemistry Institute of Environmental Assessment and Water ResearchSpanish Council for Scientific Research(IDAEA-CSIC)Barcelona 08034Spain

Municipal solid waste(MSW)is an important destination for abandoned *** the waste disposal process,large plastic debris is broken down into microplastics(MPs)and released into the ***,current research only focuses on landfill leachates,and the occurrence of MPs in other leachates has not been ***,herein,the abundance and characteristics of MPs in three types of leachates,namely,landfill leachate,residual waste leachate,and household food waste leachate,were studied,all leachates were collected from the largest waste disposal center in *** results showed that the average MP abundances in the different types of leachates ranged from(129±54)to(1288±184)MP particles per liter(particlesL1)and the household food waste leachate exhibited the highest MP abundance(pling process considerably affected the size distribution of MPs in leachates,leading to a higher percentage(>80%)of small MPs(20–100 lm)in landfill leachates compared to other *** the best of our knowledge,this is the first study discussing the sources of MPs in different leachates,which is important for MP pollution control during MSW disposal.

关键词： Microplastics Landfill leachate Residual waste leachate Household food waste leachate Source

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Ultrahigh strength and uniform corrosion in Zn-Li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications

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Rare Metals 2024年第10期43卷 5284-5304页

作者： Wan-Ying Li Yi-Long Dai Wen-Hao cai Si-Han lin lin Guo De-Chuang Zhang Yuncang Li Cuie Wen School of Materials Science and Engineering Xiangtan University Department of Prosthodontics Shanghai Ninth People′s HospitalShanghai Jiao Tong University Key Laboratory of Low Dimensional Materials&Application Technology Ministry of EducationXiangtan University School of Engineering RMIT UniversityMelbourne

Zn-Li alloys are considered promising candidate materials for biodegradable orthopedic implant applications due to their high mechanical performance and good ***,the presence of a large number of second-phase particles in this class of Zn alloys can lead to severe localized degradation due to micro-galvanic corrosion,which is detrimental to the mechanical integrity of the alloys during tissue healing in the human *** this study we report ultrahigh strength,uniform corrosion,good cytocompatibility,and effective antibacterial ability in Zn-x Li（x=0.3,0.5,0.7;wt%） alloys achieved through supersaturated solid solution treatment （SSST） at 375℃ under ultrahigh pressure of 3 GPa.A high concentration of β-LiZn4phases coexisted with the-Zn matrix in the as-cast Zn-x Li alloys,whereas almost all the Li dissolved into the-Zn matrix of SSST *** yield strength was 437 MPa for SSST Zn-0.3Li,592 MPa for SSST Zn-0.5 Li and 686 MPa for SSST *** SSST Zn-Li alloys showed uniform degradation with remarkably reduced degradation rates compared to their as-cast *** 25% concentration extracts of the Zn-x Li alloys demonstrated no cytotoxicity toward MC3T3-E1 cells,and the alloys exhibited effective antibacterial ability agains methicillin-resistant staphylococcus aureus.

关键词： Corrosion behavior Mechanical property Supersaturated solid solution treatment (SSST) Ultrahigh pressure Zn-Li alloy

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Advances in seismological methods for characterizing fault zone structure

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Earthquake Science 2024年第2期37卷 122-138页

作者： yan cai Jianping Wu yaning Liu Shijie Gao Institute of Geophysics China Earthquake AdministrationBeijing 100081China Key Laboratory of Earthquake Source Physics China Earthquake AdministrationBeijing 100081China

Large earthquakes frequently occur along complex fault *** seismic rupture and long-term fault evolution requires constraining the geometric and material properties of fault zone *** provide a comprehensive overview of recent advancements in seismological methods used to study fault zone structures,including seismic tomography,fault zone seismic wave analysis,and seismicity *** conditions limit our current ability to fully characterize fault zones,for example,insufficient imaging resolution to discern small-scale anomalies,incomplete capture of crucial fault zone seismic waves,and limited precision in event location *** seismic arrays can overcome these limitations and enable more detailed investigations of fault zone ***,we present new insights into the structure of the Anninghe-Xiaojiang fault zone in the southeastern margin of the Qinghai-Xizang Plateau based on data collected from a dense seismic *** found that utilizing a dense seismic array can identify small-scale features within fault zones,aiding in the interpretation of fault zone geometry and material properties.

关键词： fault zone structure tomography fault zone wave seismic activity Anninghe-Xiaojiang fault zone

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Facile surface regulation for highly efficient and thermally stable perovskite solar cells via chlormequat chloride

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Chinese Chemical Letters 2024年第10期35卷 517-523页

作者： Bo yang Pu-An lin Tingwei Zhou Xiaojia Zheng Bing cai Wen-Hua Zhang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China School of Physical Science and Technology Southwest UniversityChongqing 400715China Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies School of Materials and EnergyYunnan UniversityKunming 650000China

Defects at the surface and grain boundaries of the perovskite films are extremely detrimental to both the efficiency and stability of perovskite solar cells(PSCs).Herein,a simple and stable quaternary ammonium halide,named chlormequat chloride(i.e.,chlorinated choline chloride,CCC),is introduced to regulate the upper surface chemical environment of perovskite *** anion(Cl^(-))and cation[ClCH_(2)CH_(2)N(CH_(3))_(3)]+in CCC could effectively self-search and passivate positively and negatively charged ionic defects in per ovskites,respectively,which contributes to inhibited nonradiative recombination and reduced energy los in *** a result,the champion power conversion efficiency(PCE)of PSCs can be significantly enhanced from 22.82%to 24.07%.Moreover,the unencapsulated device with CCC modification retains 92.0%of it original PCE even subject to thermal aging at 85℃ for 2496 *** work provides guidance for the ratio nal design of functional molecules as defect passivators in PSCs,which is beneficial for the improvement in both device performance and stability.

关键词： Perovskite solarcells Quaternary ammonium halide Chlormequat chloride Surface modulation Thermal stability

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An isolated symmetrical 2T2R cell enabling high precision and high density for RRAM-based in-memory computing

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Science China(Information Sciences) 2024年第5期67卷 287-294页

作者： Yaotian linG Zongwei WANG Yuhang yanG lin BAO Shengyu BAO Qishen WANG Yimao cai Ru HUANG School of Integrated Circuits Beijing Advanced Innovation Center for Integrated Circuits Peking University State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

In-memory computing(IMC), leveraging emerging memories, holds significant promise in overcoming memory limitations and improving energy efficiency. However, the prevailing IMC array structure based on serially connected transistors and memory cells(1T1R/2T2R), along with the signed weight mapping scheme, can lead to asymmetrical weight sensing issues(AWS) due to electrical asymmetry within the1T1R/2T2R structure, particularly in highly scaled cells where the transistor's resistance becomes significant. In this paper, we propose and fabricate an electrically symmetric memory cell based on a physically isolated 2T2R structure for IMC. This design aims to enhance the precision and density of RRAM-based IMC arrays. The 2T2R cells are manufactured using the back-end-of-line(BEOL) process of a commercial40 nm technology platform. The feasibility of this design is verified through measured and simulated results,showcasing its capability to address the issue of AWS. Compared to conventional 2T2R cells, this design achieves a considerably smaller transistor footprint without compromising accuracy, while also improving integration density by 42.2%. These innovative memory cell advancements have the potential to further advance high-energy-efficient IMC technology.

关键词： RRAM 2T2R multi-level storage weight asymmetry in-memory computing

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Age of Information for Short-Packet Covert Communication with Time Modulated Retrodirective Array

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China Communications 2024年第4期21卷 23-37页

作者： Ma Yue Ma Ruiqian lin Zhi yang Weiwei cai Yueming Miao Chen Wu Wen Key Laboratory of Near-Range RF Sensing ICs&Microsystems(NJUST) Ministry of EducationSchool of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China College of Electronic Engineering National University of Defense TechnologyHefei 230037China College of Communications Engineering Army Engineering University of PLANanjing 210007China

In this paper,the covert age of information(CAoI),which characterizes the timeliness and covertness performance of communication,is first investigated in the short-packet covert communication with time modulated retrodirective array(TMRDA).Specifically,the TMRDA is designed to maximize the antenna gain in the target direction while the side lobe is sufficiently *** this basis,the covertness constraint and CAoI are derived in closed *** facilitate the covert transmission design,the transmit power and block-length are jointly optimized to minimize the CAoI,which demonstrates the trade-off between covertness and *** results illustrate that there exists an optimal block-length that yields the minimum CAoI,and the presented optimization results can achieve enhanced performance compared with the fixed block-length ***,we observe that smaller beam pointing error at Bob leads to improvements in CAoI.

关键词： age of information covert communication retrodirective array time modulation

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