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Epidemiology of liver diseases:global disease burden and forecasted research trends

Science China Life Sciences 2024年

作者： Jia Xiao Fei wang Yuan Yuan Jinhang Gao Lu Xiao Chao yan Feifei Guo Jiajun Zhong Zhaodi Che Wei Li Tian lan Frank Tacke Vijay H.Shah Cui Li Hua wang Erdan Dong Division of Gastroenterology and Hepatology Mayo Clinic Department of Health Sciences National Natural Science Foundation of China Department of Oncology The First Affiliated Hospital Institute for Liver Diseases of Anhui Medical University Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Medical University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Gastroenterology Qingdao Central Hospital University of Health and Rehabilitation Sciences Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen University School of Biological Sciences Jinan University Aier Institute of Ophthalmology Central South University Lab of Gastroenterology and Hepatology West China Hospital Sichuan University Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan University Faculty of Pharmaceutical Sciences Toho University Department of Hepatology and Gastroenterology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum and Campus Charité Mitte

We assessed the global incidence, mortality, and disability-adjusted life years(DALYs) associated with various liver diseases, including alcohol-related liver disease(ALD), hepatitis B/C virus infections(HBV or HCV), liver cancer, metabolic dysfunction-associated steatotic liver disease(MASLD), and other chronic liver diseases, from the 2019 Global Burden of Disease study. Additionally, we analyzed the global trends in hepatology research and drug development. From 2000 to 2019, prevalence rates increased for ALD, MASLD and other liver diseases, while they decreased for HBV, HCV, and liver cancer. Countries with a high socio-demographic index(SDI) exhibited the lowest mortality rates and DALYs. The burden of liver diseases varied due to factors like sex and region. In nine representative countries, MASLD,along with hepatobiliary cancer, showed highest increase in funding in hepatology research. Globally, the major research categories in hepatology papers from 2000 to 2019 were cancer, pathobiology, and MASLD. The United States(U.S.) was at the forefront of hepatology research, with China gradually increasing its influence over time. Hepatologists worldwide are increasingly focusing on studying the communication between the liver and other organs, while underestimating the research on ALD. Cancer, HCV, and MASLD were the primary diseases targeted for therapeutic development in clinical trials. However, the proportion of new drugs approved for the treatment of liver diseases was relatively low among all newly approved drugs in the U.S., China, Japan, and the European Union. Notably, there were no approved drug for the treatment of ALD in the world.

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EPSPS regulates cell elongation by disrupting the balance of lignin and flavonoid biosynthesis in cotton

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Journal of Integrative Agriculture 2024年第10期23卷 3437-3456页

作者： Qingdi yan Wei Hu Chenxu Gao lan yang Jiaxian yang Renju Liu Masum Billah Yongjun Lin Ji Liu Pengfei Miao Zhaoen yang Fuguang Li Wenqiang Qin State Key Laboratory of Cotton Bio‑breeding and Integrated Utilization/Institute of Cotton Research Chinese Academy ofAgricultural SciencesAnyang 455000China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Huazhong AgriculturalUniversityWuhan 430070China State Key Laboratory of Cotton Bio-breeding and Integrated Utilization/Zhengzhou University Zhengzhou 450066China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572025China

EPSPS is a key gene in the shikimic acid synthesis pathway that has been widely used in breeding crops with herbicide ***,its role in regulating cell elongation is poorly *** the overexpression of EPSPS genes,we generated lines resistant to glyphosate that exhibit an unexpected dwarf phenotype.A representative line,DHR1,exhibits a stable dwarf phenotype throughout its entire growth *** for plant height,the other agronomic traits of DHR1 are similar to its transgenic explants *** section observations showed that DHR1 internodes are shortened due to reduced elongation and division of the internode *** hormones confirmed that DHR1 is not a classical brassinolide(BR)-or gibberellin(GA)-related dwarfing *** analysis and fine mapping confirmed that the EPSPS gene is the causal gene for dwarfism,and the phenotype can be inherited in different *** and metabolome analyses showed that genes associated with the phenylpropanoid synthesis pathway are enriched in DHR1 compared with *** metabolites are enriched in DHR1,whereas lignin metabolites are *** enhancement of flavonoids likely results in differential expression of auxin signal pathway genes and alters the auxin response,subsequently affecting cell *** study provides a new strategy for generating dwarfs and will accelerate advancements in light simplification in the cultivation and mechanized harvesting of cotton.

关键词： EPSPS cotton T-DNA dwarfism herbicide resistance

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Psychosocial Stress Modifies the Acute Cardiac Health Effects of Traffic-Related Air Pollution

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Environment & Health 2024年第1期2卷 11-22页

作者： Tongjun Guo Wanzhou wang Xi Chen Huaqi Guo Kai wang Yating Ma Hongyan Deng Xianggui Li Anqi Shan Qian Wu Yaoyan Li Hongyu Li Qisijing Liu Juan Chen yang lan Jian Lei Furong Deng Zhiwei Sun Xinbiao Guo Shaowei Wu yan wang Naijun Tang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Department of Occupational and Environmental Health Tianjin Key Laboratory of EnvironmentNutrition and Public HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Department of Respiratory and Critical Care Medicine The Ninth People’s Hospital of Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Occupational and Environmental Health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710049China Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health Xi’anShaanxi 710049China Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province Xi’anShaanxi 710049China Institute of Social Psychology School of Humanities and Social SciencesXi’an Jiaotong UniversityXi’anShaanxi 710049China Qinglongqiao Community Health Service Centre Beijing 100091China Key Laboratory of Environment and Genes Related to Diseases(Xi’an Jiaotong University) Ministry of EducationXi’an 710061China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of HAI Management Tianjin Huanhu HospitalTianjin 300060China Office for National Clinical Research Center for Geriatric Diseases Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100005China Research Institute of Public Health School of MedicineNankai University300071 TianjinChina Department of Toxicology and Sanitary Chemistry School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China

Previous studies have shown that exposure to black carbon(BC,a tracer of traffic-related air pollution)and psychosocial stress are both associated with adverse cardiac effects,but whether psychosocial stress could modify the cardiac effects of BC is *** investigate the potential modifying effect of psychosocial stress on the associations between acute exposure to BC and typical cardiac health variables,real-time personal 24 h measurements were conducted in a repeated-measure study among adults with elevated blood pressure(high-risk group)and a panel study among normal adults(low-risk group)in *** cardiac health variables included ST-segment depression events,heart rate,and heart rate variability(HRV)*** Stress Scale,State Anxiety Inventory and Self-rating Depression Scale were used to assess the recent psychosocial stress status of the participants,and a composite stress index was established based on these *** linear mixed-effects model was used to analyze the associations between BC exposure and cardiac health variables and potential effect modification by psychosocial stress.A total of 9724 h measurements among 97 participants in the repeated-measure study and 20224 h measurements among 87 participants in the panel study were included in the final *** BC exposure was significantly associated with increased ST-segment depression events and heart rate and decreases in HRV in both *** marginal effects of acute BC exposure on most cardiac health variables generally tended to be amplified under higher vs low levels of psychosocial stress in both studies,with the composite stress index apparently modifying the associations of BC exposure with most ST-segment depression events and HRV *** findings suggest that psychosocial stress may increase the participants’cardiac susceptibility to BC exposure,which could be helpful for the identification of susceptible individuals in the context of traff

关键词： Air pollution Black carbon Cardiac health Effect modification Psychosocial stress

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Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： Han-Qing Zhang Shuang Wu Xin Chen Ya-Xuan Fang Qiu-Mei lan Zi-Jun Zhou yan-Heng Qiao Jie Li yan-Ru Zhao Ming Pei Bo yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

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LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function

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Research 2024年第1期2023卷 595-609页

作者： Yujie Li Dawei Huang Lianqun Jia Fugen Shangguan Shiwei Gong Linhua lan Zhiyin Song Juan Xu Chaojun yan Tongke Chen Yin Tan Yongzhang Liu Xingxu Huang Carolyn K.Suzuki Zhongzhou yang Guanlin yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

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材料去除过程中Rehbinder效应的研究进展

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中国表面工程 2024年第1期37卷 59-74页

作者：邱天言兰王福增谢鸿税妍张涛姜峰华侨大学制造工程研究院厦门361021 高性能工具全国重点实验室厦门361021 华侨大学机电及自动化学院厦门361021 东方汽轮机有限公司德阳618000

精密机械加工过程中,利用Rehbinder效应对工件表面特性的影响,可以更好地控制零件表面质量。不同工程材料的Rehbinder效应的微观表现形式有所差异,但宏观结果都是降低工件表面硬度,使材料去除过程更容易进行。回顾了Rehbinder效应概念... 详细信息

精密机械加工过程中,利用Rehbinder效应对工件表面特性的影响,可以更好地控制零件表面质量。不同工程材料的Rehbinder效应的微观表现形式有所差异,但宏观结果都是降低工件表面硬度,使材料去除过程更容易进行。回顾了Rehbinder效应概念的提出和发展过程并对其内涵和应用范围进行了阐述,为加工过程中的材料去除方法提供思路,对材料表面完整性的形成具有指导意义。列举了近年来科研人员对Rehbinder效应的相关研究成果,分析对比其在硬脆材料和塑性材料加工过程中的表现形式和微观作用机理,总结Rehbinder效应的影响因素,如极性分子的吸附活性、工件材料的晶粒尺寸等。揭示了Rehbinder效应中极性分子的吸附作用,以及吸附作用后的扩散、位错和间隙三种促进机制,并综述离散元法、有限元法和分子动力学等数值仿真方法对宏观尺度和微观尺度Rehbinder效应机理的研究。Rehbinder效应可以看作是一种对加工表面的改性机制,研究Rehbinder效应作用下的表面活性剂与被加工表面的匹配机制是提高材料表面完整性的关键,对推动精密制造工艺的发展有重要意义。

关键词：材料去除 Rehbinder效应机械加工数值仿真

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基于纳米复合PCM集蓄热构件的建筑太阳能供暖特性研究

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中南大学学报（自然科学版） 2024年第3期55卷 1168-1177页

作者：严婷徐国英王岚陈龙余佳恒东南大学能源与环境学院江苏南京210096

设计一种基于吸光型纳米复合相变材料(PCM)模块化集蓄热构件,将其应用于建筑太阳能采暖,以降低能耗和碳排放。开展石墨烯-石蜡复合相变材料的制备和物性测试,建立PCM集蓄热数学模型,并结合典型气候工况进行供热特性的数值模拟,研究定风... 详细信息

设计一种基于吸光型纳米复合相变材料(PCM)模块化集蓄热构件,将其应用于建筑太阳能采暖,以降低能耗和碳排放。开展石墨烯-石蜡复合相变材料的制备和物性测试,建立PCM集蓄热数学模型,并结合典型气候工况进行供热特性的数值模拟,研究定风量情况下蓄热层厚度和空气流道宽度对供暖特性的影响,分析通风速度对送风温度、日供热量以及太阳能供暖保证率的影响。研究结果表明:添加石墨烯后的纳米复合PCM相对于纯石蜡的集热效率约提升了60%;对于具有18 m^(2)采光面积的集蓄热构件,当通风速度为1.0 m/s时,太阳能集蓄热墙具有较为优异的供暖性能,此时供给室内的日供热量、日平均热效率和供暖保证率分别为112.5 MJ、67.6%和90.0%,室内能够达到20℃的设定温度的时间为13 h。

关键词：吸光型PCM 模块化集蓄热构件供暖通风速度

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Characterization of a 4.1 Mb inversion harboring the stripe rust resistance gene YR86 on wheat chromosome 2AL

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The Crop Journal 2024年第4期12卷 1168-1175页

作者： Qiang Cao Zhanwang Zhu Dengan Xu Jianhui Wu Xiaowan Xu yan Dong Yingjie Bian Fugong Ding Dehui Zhao yang Tu Ling Wu Dejun Han Caixia lan Xianchun Xia Zhonghu He Yuanfeng Hao College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Food Crops Institute Hubei Academy of Agricultural Sciences/Wheat Disease Biology Research Station for Central ChinaWuhan 430064HubeiChina Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina Hubei Hongshan Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina CIMMYT-China Office C/O CAASBeijing 100081China

Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with yangmai *** fine-map the YR86 locus,we developed two large F2 populations from crosses Emai 580/Zhongmai 895 and Avocet S/Zhongmai ***,both populations exhibited suppressed recombination in the same 2AL *** analysis across Chinese Spring,Aikang 58,and 10+wheat genomes revealed a 4.1 Mb chromosomal inversion spanning 708.5-712.6 Mb in the Chinese Spring reference *** markers were developed in the breakpoint and were used to assess a wheat cultivar panel,revealing that Chinese Spring,Zhongmai 895,and Jimai 22 shared a common sequence named InvCS,whereas Aikang 58,yangmai 16,Emai 580,and Avocet S shared the sequence named *** inverted configuration explained the suppressed recombination observed in all three bi-parental *** recombination was observed in a Jimai 22/Zhongmai 895 F2 population,facilitating mapping of YR86 to a genetic interval of 0.15 cM corresponding to 710.27-712.56 Mb falling within the inverted ***-three high-confidence genes were annotated in the interval using the Chinese Spring reference genome,with six identified as potential candidates for YR86 based on genome and transcriptome *** results will accelerate map-based cloning of YR86 and its deployment in wheat breeding.

关键词： Adult-plant resistance Chromosomal inversion Puccinia striiformis Triticum aestivum

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植被组合方式对坡面流水动力特性的影响

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水土保持研究 2024年第6期31卷 74-85页

作者：朱艳王平马岚胡杰北京林业大学水土保持学院北京100083

[目的]明晰坡面流水动力特性响应不同植被组合方式的趋势特征以及不同植被组合覆盖坡面的阻力构成,以期探究植被组合对坡面流的调控机制,为合理布设坡面蓄水保土工程提供参考依据。[方法]通过室内水槽试验,在不同植被组合方式(单一灌木... 详细信息

[目的]明晰坡面流水动力特性响应不同植被组合方式的趋势特征以及不同植被组合覆盖坡面的阻力构成,以期探究植被组合对坡面流的调控机制,为合理布设坡面蓄水保土工程提供参考依据。[方法]通过室内水槽试验,在不同植被组合方式(单一灌木、单一草被、灌草单行交替、灌草块状交替),3个坡度(1°,5°,9°),5种流量(20,30,40,60,80 L/min)条件下分析坡面流水动力参数对植被组合的响应规律、水流阻力变化规律和阻力构成。[结果]不同植被组合对坡面水深、平均流速、流型和阻力系数均有显著影响(p单一植被>裸坡。植被覆盖下的坡面阻力系数明显增加,约为裸坡的1.25~25.45倍,阻水缓流能力表现为单一灌木组>灌草交错组>单一草被组>裸坡。坡面阻力受植被组合方式和茎秆影响(p<0.05),单一植被覆盖坡面阻力主要由颗粒阻力和植被阻力构成;灌草交错覆盖坡面阻力不是各阻力简单线性叠加的结果,坡面上各粗糙元间互相干扰会产生附加阻力,且附加阻力随坡度增加出现削弱水流阻力现象,但相同坡度条件下随流量增大呈增强水流阻力趋势。[结论]单一灌木组的阻水缓流效果最好,灌草交错组的效果相似。

关键词：坡面流植被组合阻力系数阻力构成

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基于SMOTE和Inception-CNN的种植和组培金线莲鉴别

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光谱学与光谱分析 2024年第1期44卷 158-163页

作者：蓝艳王武许文柴琴琴李玉榕张勋福州大学电气工程与自动化学院福建福州350108 福建中医药大学药学院福建福州350122

金线莲是一种珍贵中药材,其治疗、保健作用十分显著。金线莲培育方式主要有种植、组培等,不同培育方式的金线莲,在性状上仅表现出细微差异,但药用、市场价值差异显著,培育方式鉴别能有效保证药用疗效、维护良好市场秩序,然而由于不同品... 详细信息

金线莲是一种珍贵中药材,其治疗、保健作用十分显著。金线莲培育方式主要有种植、组培等,不同培育方式的金线莲,在性状上仅表现出细微差异,但药用、市场价值差异显著,培育方式鉴别能有效保证药用疗效、维护良好市场秩序,然而由于不同品系、产地、培育时间等复合差异的影响,增加了培育方式鉴别难度与复杂度。提出一种基于改进1D-Inception-CNN模型的金线莲培育方式鉴别方法。采用近红外光谱仪采集种植、组培金线莲的光谱,首先使用合成少数类过采样技术(SMOTE)进行过采样以解决种植品、组培品样本比例不平衡问题,其次构建基于改进Inception结构的一维卷积神经网络对来自不同品系、产地、培育时间的金线莲进行种植品、组培品鉴别,最后采用贝叶斯优化方法对构建的卷积神经网络模型超参数进行优化;最终五折交叉验证平均鉴别准确率、精确率、召回率、综合评价指标高达97.95%、 96.16%、 100%、 98.02%。研究表明,实验提出的鉴别模型为快速鉴别金线莲种植品、组培品提供一种有效方法。

关键词：金线莲少数类过采样技术 Inception模块一维卷积神经网络贝叶斯优化

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