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Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy 2022年第1期7卷 64-94页

作者： Huan Cao Lixia Duan yan Zhang Jun Cao kun Zhang Department of Nuclear Medicine West China Hospitaland National Engineering Research Center for BiomaterialsSichuan University610064 ChengduP.R.China Department of Medical Ultrasound and Central Laboratory Shanghai Tenth People's HospitalTongji University School of MedicineNo.301 Yan-chang-zhong Road200072 ShanghaiPeople's Republic of China School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties(e.g.,stiffness,pore size,viscoelasticity,microarchitecture,degradability,liga nd prese ntation,stimulus-resp on sive properties,etc.)and in flue nee cell signaling cascades and *** the past few decades,a plethora of pioneering studies have been implemented to explore the cell-hydrogel matrix interactions and figure out the underlying mechanisms,paving the way to the lab-to-clinic translation of hydrogel-based *** this review,we first introduced the physicochemical properties of hydrogels and their fabrication approaches ***,the comprehensive description and deep discussion were elucidated,wherein the influences of different hydrogels properties on cell behaviors and cellular signaling eve nts were *** behaviors or events in eluded integrin clustering,focal adhesion(FA)complex accumulation and activation,cytoskeleton rearrangement,protein cyto-nuelei shuttling and activation(e.g.,Yes-associated protein(YAP),catenin,etc.),cellular compartment reorganization,gene expression,and further cell biology modulation(e.g.,spreading,migration,proliferation,lineage commitment,etc.).Based on them,current in vitro and in vivo hydrogel applications that mainly covered diseases models,various cell delivery protocols for tissue regeneration and disease therapy,smart drug carrier,bioimaging,biosensor,and conductive wearable/implantable biodevices,*** further summarized and *** significantly,the dinical translation potential and trials of hydrogels were presented,accompanied with which the remaining challenges and future perspectives in this field were ***,the comprehe nsive and deep in sights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate

关键词： hydrogel summarized rational

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Relationship between the real contact behavior and tribological characteristics of cotton fabric

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Friction 2021年第5期9卷 1050-1060页

作者： Rongxin CHEN Jiaxin YE Wei ZHANG Jiang WEI yan ZHANG kun LIU Institute of Tribology Hefei University of TechnologyHefei 230009China School of Mechanical&Automotive Engineering Fujian University of TechnologyFuzhou 350118China

The tribological characteristics of cotton fibers play an important role in engineering and materials science,and real contact behavior is a significant aspect in the friction behavior of cotton *** this study,the tribological characteristics of cotton fibers and their relationship with the real contact behavior are investigated through reciprocating linear tribotesting and real contact *** show that the friction coefficient decreases with a general increase in load or velocity,and the load and velocity exhibit a co‐influence on the friction *** dynamic change in the real contact area is recorded clearly during the experiments and corresponds to the fluctuations observed in the friction ***,the friction coefficient is positively correlated with the real contact area based on a quantitative analysis of the evolution of friction behavior and the real contact area at different loads and *** correlation is evident at low velocities and medium load.

关键词： cotton fabric real contact behavior tribological characteristics loading condition velocity condition

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Purification and studies on characteristics of cholinesterases from Daphnia magna

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第4期14卷 325-335页

作者： yan-xia yanG Li-zhi NIU shao-nan LI Institute of Pesticide and Environmental Toxicology College of Agriculture and BiotechnologyZhejiang University

Due to their significant value in both economy and ecology,Daphnia had long been employed to investigate in vivo response of cholinesterase(ChE) in anticholinesterase exposures,whereas the type constitution and property of the enzyme remained unclear.A type of ChE was purified from Daphnia magna using a three-step procedure,i.e.,Triton X-100 extraction,ammonium sulfate precipitation,and diethylaminoethyl(DEAE)-Sepharose Fast-Flow *** to sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE),molecular mass of the purified ChE was estimated to be 84 *** on substrate studies,the purified enzyme preferred butyrylthiocholine iodide(BTCh) [with maximum velocity(Vmax)/Michaelis constant(Km)=8.428 L/(min·mg protein)] to acetylthiocholine iodide(ATCh) [with V max /Km =5.346 L/(min·mg protein)] as its *** of the purified enzyme was suppressed by high concentrations of either ATCh or *** studies showed that the purified enzyme was more sensitive towards inhibition by tetraisopropylpyrophosphoramide(iso-OMPA) than by 1,5-bis(4-allyldimethylammoniumphenyl) pentan-3-one dibromide(BW284C51).Result of the study suggested that the purified ChE was more like a type of pseudocholinesterase,and it also suggested that Daphnia magna contained multiple types of ChE in their bodies.

关键词： Crustacea Pseudocholinesterase Cholinesterase Substrate preference Selective inhibitors

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Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

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Chinese Journal of Cancer 2017年第3期36卷 121-130页

作者： Hong-yan Xie Zhi-Min shao Da-Qiang Li Shanghai Cancer Center and Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Cancer Institute Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Key Laboratory of Breast Cancer in Shanghai Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Breast Surgery Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China

Distant metastasis to specific target organs is responsible for over 90%of breast cancer?related deaths,but the underlying molecular mechanism is *** evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ?specific metastasis of this lethal ***,we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis;we also discuss potential therapeutic intervention strategies aimed at targeting compo?nents of the tumor microenvironment.

关键词： Breast cancer Invasion and metastasis Tumor microenvironment

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Mu-Opioid Receptors Expressed in Glutamatergic Neurons are Essential for Morphine Withdrawal

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Neuroscience Bulletin 2020年第10期36卷 1095-1106页

作者： Xin-yan Zhang Qing Li Ye Dong Wei yan kun Song Yong-Qin Lin yan-Gang Sun Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China

Although opioids still remain the most powerful pain-killers,the chronic use of opioid analgesics is largely limited by their numerous side-effects,including opioid ***,the mechanism underlying this dependence is largely *** this study,we used the withdrawal symptoms precipitated by naloxone to characterize opioid dependence in *** determined the functional role of mu-opioid receptors(MORs)expressed in different subpopulations of neurons in the development of morphine *** found that conditional deletion of MORs from glutamatergic neurons expressing vesicular glutamate transporter 2(Vglut2^+)largely eliminated the naloxone-precipitated withdrawal *** contrast,conditional deletion of MORs expressed in GABAergic neurons had a limited effect on morphine ***,mice with MORs deleted from Vglut2^+glutamatergic neurons also showed no morphine-induced locomotor ***,morphine withdrawal and morphine-induced hyperactivity were not significantly affected by conditional knockout of MORs from dorsal spinal *** together,our data indicate that the development of morphine withdrawal is largely mediated by MORs expressed in Vglut2^+glutamatergic neurons.

关键词： Morphine Mu-opioid receptor Naloxoneprecipitated withdrawal Dorsal spinal cord Locomotor hyperactivity

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Novel Quasi Solid-State Succinonitrile-based Electrolyte with Low-flammability for Lithium-ion Battery

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Chinese Journal of Polymer Science 2023年第11期41卷 1695-1705,I0005页

作者： yan-kun Xie Lu-kun Feng Dong-Dong Li Yin Tang Cai-Zhen Zhu Ming-Liang Wang Jian Xu Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

Quasi solid-state succinonitrile(SN)-based polymer electrolytes have emerged for lithium-metal batteries due to their excellent ionconductivity at room temperature,wide electrochemical stability window(ESW,usually>5 V).However,the practical application of these solid SN-based polymer electrolytes is hampered by the flammability and the inherent instability of SN to Li-metal *** this work,solid SN-based polymer electrolytes were prepared with succinonitrile,ethoxylated trimethylolpropane triacrylate(ETPTA),triethyl phosphate(TEP)and fluoroethylene carbonate for Li-metal battery via in situ polymerization *** SN-based polymer electrolytes with 5 wt%triethyl phosphate and FEC showed good nonflammability,superior ion-conductivity as high as 1.01×10^(-3)S/cm,and wide ESW of 5.41 *** SN-based polymer electrolyte also exhibited excellent interfacial compatibility to lithium metal *** it also delivered a high specific capacity of 156m Ah/g at 0.2 C at ambient temperature,and presented stable cycling at 1.0 C with a specific capacity retention of 98.4%after 1000 *** work provides an alternative and simple strategy to realize the practical application of the solid-state SN-based polymer electrolyte.

关键词： Solid polymer electrolyte Succinonitrile Solid-state battery In situ polymerization Low-flammability

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Six million Q factor micro fused silica shell resonator with teeth-like tines released by femtosecond laser-assisted chemical etching

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Science China(Technological Sciences) 2024年第6期67卷 1923-1932页

作者： ZHAO Tao SHI yan LU kun XI Xiang WU XueZhong XIAO DingBang College of Intelligence Science and Engineering National University of Defense TechnologyChangsha410073China

The quality factor(Q factor)is a crucial performance parameter for *** this paper,a novel release method for highquality micro fused silica shell resonators with teeth-like tines with good surface morphology is *** method is based on femtosecond laser-assisted chemical ***,the optimal energy range of femtosecond laser modification is obtained through mechanism ***,the optimal parameters for a straight line and arc pattern are determined by optimizing the average output power,processing speed,and processing *** results demonstrate why edge breakage in rounded corners is easy under different ***,according to these conclusions,the processing is performed on a micro fused silica shell resonator with a Q factor exceeding 6 *** addition,subsurface damage is rare throughout the fabrication process,and the surface roughness of the released cross section reaches the nanometer *** improved Q factor helps suppress mechanical thermal noise and reduce zero bias and zero bias drift,constituting the primary method for enhancing the performance of the resonant gyroscope.

关键词： micro hemispherical resonator fused silica laser-assisted chemical etching quality factor

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Role of capillary adhesion in the friction peak during the tacky transition

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Friction 2022年第8期10卷 1208-1216页

作者： Tianyan GAO Jiaxin YE Kaisen ZHANG Xiaojun LIU yan ZHANG kun LIU Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China

The friction peak that occurs in tire–road sliding when the contact changes from wet to dry was previously attributed to capillary cohesion,van der Waals attraction,and surface roughness,but the detailed mechanisms have yet to be *** this study,friction and static contact experiments were conducted using a custom-built in situ optical microtribometer,which allowed us to investigate the evolution of the friction,normal load,and contact area between a polydimethylsiloxane(PDMS)film and a silicon nitride ball during water *** friction coefficient increased by 100%,and the normal force dropped by 30%relative to those in the dry condition during the wet-to-dry *** static contact experiments,the probe indentation depth increased,and the normal load decreased by~60%as the water *** the friction and static contact results,we propose that the large friction peak that appeared in this study can be attributed to the combined effects of increased adhesive capillary force and increased plowing during the wet-to-dry transition.

关键词： friction peak capillary adhesion tacky condition polydimethylsiloxane(PDMS)film silicon nitride

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Overexpression of Sweet Pepper Glycerol-3-Phosphate Acyltransferase Gene Enhanced Thermotolerance of Photosynthetic Apparatus in Transgenic Tobacco

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Journal of Integrative Plant Biology 2008年第5期50卷 613-621页

作者： kun yan Na Chen yan-yan Qu Xin-Chun Dong Qing-Wei Meng Shi-Jie Zhao College of Life Sciences State Key Laboratory of Crop Biology Shandong Agricultural University Tai'an 271018 China

In order to investigate the relationship between the lipid composition in thylakoid membrane and thermostability of photosynthetic apparatus, tobacco transformed with sweet pepper sense glycerol-3-phosphate acyltransferase （GPAT） gene were used to analyze the lipid composition in thylakoid membrane, the net photosynthetic rate and chlorophyll fluorescence parameters under high temperature stress. The results showed that the saturated extent of monogalactosyldiacylglycerol （MGDG）, sulfoquinovosyldiacylglycerol, digalactosyldiacylglycerol and phosphatidylglycerol in thylakoid membrane of transgenic tobacco T1 lines increased generally. Particularly, the saturated extent in MGDG increased obviously by 16.2% and 12.6% in T1-2 and T1-1, respectively. With stress temperature elevating, the maximum efficiency of photosystem Ⅱ （PSⅡ） photochemistry （Fv/Fm）, actual photochemical efficiency of PSll in the light （ФPSⅡ） and net photosynthetic rate （Pn） of the two lines and wild type tobacco plants decreased gradually, but those parameters decreased much less in transgenic plants. Even though the recovery process appeared differently in the donor and acceptor side of PSⅡ in transgenic tobacco compared with wild-type plants, the entire capability of PSⅡ recovered faster in transgenic tobacco, which was shown in the parameters of PI, Fv/Fm and ФPSⅡ, as a result, the recovery of Pn was accelerated. Conclusively, we proposed that the increase in saturated extent of thylakoid membrane lipids in transgenic plants enhanced the stability of photosynthetic apparatus under high temperature stress.

关键词： glycerol-3-phosphate transferase lipids in thylakoid membrane photosynthesis thermotolerance tobacco.

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Theoretical Studies on the Abstraction Reaction of Atomic O(^3p) with Si2H6

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Chinese Chemical Letters 2002年第7期13卷 662-665页

作者： Qing Zhu ZHANG Chun Sheng WANG shao kun WANG Yue Shu GU School of Chemistry and chemical engineering Shandong UniversityJinan 250100

ion reaction of O (3P) with Si2H6 has been studied theoretically. Two transition states of 3A and 3A symmetries have been located for this abstraction reaction. Geometries have been optimized at the UMP2 level with 6-311G+(d) basis set. G3MP2 has been used for the final single-point energy calculation. The rate constants have been calculated over a wide temperature range of 200~3000 K using canonical variational transition-state theory (CVT) with small curvature tunneling effect (SCT). The calculated CVT/SCT rate constants match well with the experimental value.

关键词： O (3P) disilane ab initio calculation variational transition state rate constants.

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