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Participation of the inositol 1,4,5-trisphosphategated calcium channel in the zona pellucida- and progesterone-induced acrosome reaction and calcium influx in human spermatozoa

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Asian Journal of Andrology 2020年第2期22卷 192-199页

作者： Ying-Ya Li yan-Ping Jia Li-yan Duan kun-Ming Li Center of Reproductive Medicine Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China

The acrosome reaction is a prerequisite for fertilization,and its signaling pathway has been investigated for *** of the type of inducers present,the acrosome reaction is ultimately mediated by the elevation of cytosolic *** 1,4,5-trisphosphate-gated calcium channels are important components of the acrosome reaction signaling pathway and have been confirmed by several *** this study,we used a novel permeabilization tool BioPORTER?and first demonstrated its effectiveness in *** inositol 1,4,5-trisphosphate type-1 receptor antibody was introduced into spermatozoa by BioPORTER?and significantly reduced the calcium influx and acrosome reaction induced by progesterone,solubilized zona pellucida,and the calcium ionophore *** finding indicates that the inositol 1,4,5-trisphosphate type-1 receptor antibody is a valid inositol 1,4,5-trisphosphate receptor inhibitor and provides evidence of inositol 1,4,5-trisphosphate-gated calcium channel involvement in the acrosome reaction in human ***,we demonstrated that the transfer of 1,4,5-trisphosphate into spermatozoa induced acrosome reactions,which provides more reliable evidence for this *** addition,by treating the spermatozoa with inositol 1,4,5-trisphosphate/BioPORTER?in the presence or absence of calcium in the culture medium,we showed that the opening of inositol 1,4,5-trisphosphate-gated calcium channels led to extracellular calcium *** particular extracellular calcium influx may be the major process of the final step of the acrosome reaction signaling pathway.

关键词： acrosome reaction human spermatozoa inositol 1,4,5-trisphosphate zona pellucida progesterone

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A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research International 2024年第1期31卷 74-91页

作者： yan yan Guang-hao Shang Li-ping Zhang shao-ying Li Han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

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Applications of urinary proteomics in biomarker discovery

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Science China(Life Sciences) 2011年第5期54卷 409-417页

作者： shao Chen WANG yan GAO YouHe National Key Laboratory of Medical Molecular Biology Department of Physiology and Pathophysiology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic Medicine Peking Union Medical College Beijing 100005 China

Urine is an important source of biomarkers. This article reviews current advances, major challenges, and future prospects in the field of urinary proteorrfics. Because the practical clinical problem is to distinguish diseases with similar symptoms, merely comparing samples from patients of a particular disease to those of healthy individuals is inadequate for finding biomarkers with sufficient diagnostic power. In addition, the variation of expression levels of urinary proteins among healthy individuals and individuals under different physiological conditions adds to the difficulty in identifying biomarkers. We propose that es- tablishing the natural variation in urinary protein expression among a healthy population can serve as a reference to help iden- tify protein abundance changes that are caused by disease, not by individual variations or physiological changes. We also dis- cuss that comparing protein expression levels between urine and plasma may reveal the physiological function of the kidney and that may facilitate biomarker discovery. Finally, we propose that establishing a data-sharing platform for data collection and integrating results from all urinary biomarker studies will help promote the development of urinary proteomics.

关键词： urine proteomics biomarker

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Impacts of Urbanization on the Precipitation Characteristics in Guangdong Province, China

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Advances in Atmospheric Sciences 2020年第7期37卷 696-706页

作者： Meng yan Johnny C.LCHAN kun ZHAO School of Atmospheric Sciences Nanjing UniversityNanjing 210023China School of Energy and Environment City University of Hong KongHong KongChina State Key Laboratory of Severe Weather and Joint Center for Atmospheric Radar Research CMA/NJUBeijing 100081China

With the development of urbanization,whether precipitation characteristics in Guangdong Province,China,from 1981 to 2015 have changed are investigated using rain gauge data from 76 *** characteristics include annual precipitation,rainfall frequency,intense rainfall(defined as hourly precipitation≥20 mm),light precipitation(defined as hourly precipitation≤2.5 mm),and extreme rainfall(defined as hourly rainfall exceeding the 99.9 th percentile of the hourly rainfall distribution).During these 35 years,the annual precipitation shows an increasing trend in the urban *** rainfall frequency and light precipitation have a decreasing trend,intense rainfall frequency shows an increasing *** heavy and extreme rainfall frequency both exhibit an increasing trend in the Pearl River Delta region,where urbanization is the most *** trends in both the warm seasons(May-October)and during the pre-flood season(April-June)appear to be more *** the contrary,the annual precipitation amount in rural areas has a decreasing *** the heavy and extreme precipitation also show an increasing trend,it is not as strong and significant as that in the urban *** periods in which a tropical cyclone makes landfall along the South China Coast,the rainfall in urban areas has been consistently more than that in surrounding *** precipitation in the urban areas and to their west is higher after 1995,when the urbanization *** results suggest that urbanization has a significant impact on the precipitation characteristics of Guangdong Province.

关键词： rainfall flood extreme

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Association of glutathione S-transferase T1 and M1 gene polymorphisms with ischemic stroke risk in the Chinese Han population

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Neural Regeneration Research 2012年第18期7卷 1420-1427页

作者： Rui Wang yan Wang Junhong Wang kun yang Department of Neurology Affiliated Hospital of Qingdao University Medical College Qingdao 266003 Shandong Province China Central Laboratory Affiliated Hospital of Qingdao University Medical College Qingdao 266003 Shandong Province China

Atherosclerosis plays an important role in ischemic stroke, and oxidative stress participates in the entire process of atherosclerosis. Glutathione S-transferase （GST） acting with other antioxidant enzymes can eliminate reactive oxygen species and protect cells against oxidative damage. To assess the association of glutathione S-transferase （GSTT1 and GSTM1） gene polymorphisms with ischemic stroke in the Chinese Han population, the present study selected 315 patients with ischemic stroke and 210 healthy controls for comparison. GSTT1 and GSTM1 genotypes were determined using polymerase chain reactions, electrophoresis and imaging analysis. No obvious evidence of GSTTI-nulI, GSTMI-null and GSTTI/GSTMI-double null genotype distribution differences was found between case and control groups or between genders. Subgroup analysis showed that the risk of stroke was increased when hypertension was accompanied by GSTTl-null （odds ratio （OR） = 2.996, P 〈 0.001） and GSTMl-null （OR = 3.680, P 〈 0.001 ） genotypes; diabetes mellitus was accompanied by GSTTI-null （OR = 1.860, P = 0.031） and GSTMI-null （OR = 2.444, P = 0.002） genotypes, and smokers showed a GSTTl-null genotype （OR = 2.276, P = 0.003）. GSTT1- and GSTMl-null genotypes may interact synergistically with hypertension, diabetes mellitus and smoking to increase the incidence risk of ischemic stroke.

关键词： glutathione S-transferase GSTT1 GSTM1 gene polymorphism ischemic stroke risk factors stroke neural regeneration

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The Backup 2-Median Problem on Block Graphs

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Acta Mathematicae Applicatae Sinica 2014年第2期30卷 309-320页

作者： Yu-kun CHENG Li-ying KANG Hong yan Zhejiang University of Finance and Economics Department of Mathematics Shanghai University Department of Logistics and Maritime Studies The Hong Kong Polytechnic University

The backup 2-median problem is a location problem to locate two facilities at vertices with the minimum expected cost where each facility may fail with a given probability. Once a facility fails, the other one takes full responsibility for the services. Here we assume that the facilities do not fail simultaneously. In this paper, we consider the backup 2-median problem on block graphs where any two edges in one block have the same length and the lengths of edges on different blocks may be different. By constructing a tree-shaped skeleton of a block graph, we devise an O（n log n q- m）-time algorithm to solve this problem where n and m are the number of vertices and edges, respectively, in the given block graph.

关键词： location theory backup median block graph

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Changing Spring Phenology Dates in the Three-Rivers Headwater Region of the Tibetan Plateau during 1960–2013

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Advances in Atmospheric Sciences 2018年第1期35卷 116-126页

作者： Shuang YU Jiangjiang XIA Zhongwei yan kun yanG Key Laboratory.of Regional Climate-Environment for East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100107China University of Chinese Academy of Sciences Beijing 100049China

The variation of the vegetation growing season in the Three-Rivers Headwater Region of the Tibetan Plateau has recently become a controversial topic. One issue is that the estimated local trend in the start of the vegetation growing season(SOS)based on remote sensing data is easily affected by outliers because this data series is short. In this study, we determine that the spring minimum temperature is the most influential factor for SOS. The significant negative linear relationship between the two variables in the region is evaluated using Moderate Resolution Imaging Spectroradiometer–Normalized Difference Vegetation Index data for 2000–13. We then reconstruct the SOS time series based on the temperature data for 1960–*** regional mean SOS shows an advancing trend of 1.42 d(10 yr)during 1960–2013, with the SOS occurring on the 160th and 151st days in 1960 and 2013, respectively. The advancing trend enhances to 6.04 d(10 yr)during the past 14 years. The spatiotemporal variations of the reconstructed SOS data are similar to those deduced from remote sensing data during the past 14 years. The latter exhibit an even larger regional mean trend of SOS [7.98 d(10 yr)] during 2000–13. The Arctic Oscillation is found to have significantly influenced the changing SOS, especially for the eastern part of the region,during 2000–13.

关键词： start of growing season normalized difference vegetation index spring minimum temperature Three-Rivers Headwater Region Arctic Oscillation

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Assessment of the Performance of WEPP in Purple Soil Area with Simulated Rainfall Experiments

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Journal of Mountain Science 2012年第4期9卷 570-579页

作者： FU Bin WANG Yukuan XU Pei yan kun Key Laboratory of Mountain Hazards and Earth Surface Process ChineseAcademy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China

The water erosion prediction project （WEPP） model is a popular water erosion prediction tool developed on the basis of the physical processes of water erosion. Although WEPP has been widely used around the world, its application in China is still insufficient. In this study, the performance of WEPP used to estimate the runoff and soil loss on purple soil （Calcaric Regosols in FAO taxonomy） sloping cropland was assessed with the data from runoff plots under simulated rainfall conditions. Based on measured soil properties, runoff and erosion parameters, namely effective hydraulic conductivity, inter-rill erodibility, rill erodibility, and critical shear stress were determined to be 2.68 mm h-1, 5.54 x l0^6 kg s-1 m-4, 0.027 s m-1 and 3-5 Pa, respectively, by using the recommended equations in the WEPP user manual. The simulated results were not good due to the low Nash efficiency of 0.41 for runoff and negative Nash efficiency for soil loss. After the four parameters were calibrated, WEPP performed better for soil loss prediction with a Nash efficiency of 0.76. The different results indicated that the equations recommended by WEPP to calculate parameters such as erodiblity and critical shear stress are not suitable for the purple soil areas, Sichuan Province, China. Although the predicted results can be accepted by optimizing the runoff and erosion parameters, more research related to the determination of erodibility and critical sheer stress must be conducted to improve the application of WEPP in the purple soil areas.

关键词： WEPP Soil erosion Simulated rainfall Purple soil Erodibility

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Hopf bifurcation of a delayed predator-prey model with Allee effect and anti-predator behavior

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International Journal of Biomathematics 2023年第7期16卷 111-139页

作者： Xinyue Xu yan Meng yangyang shao School of Mathematics and Physics University of Science and Technology Beijing Beijing 100083P.R.China

This paper proposes a diffusive predator-prey model with Allee effect,time delay and anti-predator ***,the existence and stability of all equilibria are analyzed and the conditions for the appearance of the Hopf bifurcation are *** the normal form and center manifold theory,the formulas which can determine the direction,period and stability of Hopf bifurcation are *** simulations show that the Allee effect can determine the survival abundance of the prey and predator populations,and anti-predator behavior can greatly improve the stability of the coexisting equilibrium.

关键词： Predator-prey Hopf bifurcation delay and diffusion Allee effect numerical simulation

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Child with Wiskott–Aldrich syndrome underwent atypical immune reconstruction after umbilical cord blood transplantation: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3622-3631页

作者： Bo-Han Li shao-yan Hu Department of Hematology and Oncology Children’s Hospital of Soochow University

BACKGROUND Timely reconstitution of a donor-derived immune system is important for recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation(HSCT).We describe a case of Wiskott–Aldrich syndrome(WAS)treated by umbilical cord blood transplantation(UCBT)with atypical immune *** SUMMARY A 1-year-old Chinese male infant was diagnosed with *** gene sequencing identified the mutation c.777+1G>A(IVS8).On August 8,2017,he was admitted to our hospital for *** selected an unrelated Human leukocyte antigen 6/10-matched donor for *** HSCT,the immune reconstitution process was atypical,the lymphocytes reached 0.5×109/L on day 23,and the neutrophils reached 0.5×109/L on day *** patient’s recovery throughout the year was *** An increase in lymphocytes(especially T cells)earlier than granulocytes may be a marker of a good prognosis in UCBT.

关键词： Umbilical cord blood transplantation Wiskott-Aldrich syndrome Immune reconstruction Case report

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