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The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia

Neural Regeneration Research 2015年第9期10卷 1441-1449页

作者： Ya-yun yan Xiao-ming Wang yan Jiang Han Chen Jin-ting He Jing Mang yan-kun shao Zhong-xin Xu Department of Neurology China-Japan Union Hospital Jilin University

The Rho/Rho-kinase signaling pathway plays an important role in cerebral ischemia/reperfusion injury. However, very few studies have examined in detail the changes in the Rho/Rho-kinase signaling pathway in chronic cerebral ischemia. In this study, rat models of chronic cerebral ischemia were established by permanent bilateral common carotid artery occlusion and intra- gastrically administered 9 mg/kg fasudil, a powerful ROCK inhibitor, for 9 weeks. Morris water maze results showed that cognitive impairment progressively worsened as the cerebral ischemia proceeded. Immunohistochemistry, semi-quantitative RT-PCR and western blot analysis showed that the expression levels of Rho-kinase, its substrate myosin-binding subunit, and its relat- ed protein alpha smooth muscle actin, significantly increased after chronic cerebral ischemia. TUNEL staining showed that chronic cerebral ischemia could lead to an increase in neuronal apoptosis, as well as the expression level of caspase-3 in the frontal cortex of rats subjected to chronic cerebral ischemia. Fasudil treatment alleviated the cognitive impairment in rats with chronic cerebral ischemia, and decreased the expression level of Rho-kinase, myosin-binding subunit and alpha smooth muscle actin. Furthermore, fasudil could regulate cerebral injury by reducing cell apoptosis and decreasing caspase-3 expression in the frontal cortex. These findings demonstrate that fasudil can protect against cognitive impairment induced by chronic cerebral ischemia via the Rho/Rho-kinase signaling pathway and anti-apoptosis mechanism.

关键词： nerve regeneration chronic cerebral ischemia fasudil Rho-kinase alpha smooth muscleactin myosin-binding subunit cognitive impairment caspase-3 apoptosis neural regeneration

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Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death

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Neural Regeneration Research 2017年第5期12卷 779-786页

作者： Long-xing Xue Hong-yu Liu yang Cui Yue Dong Jiao-qi Wang Qiu-ye Ji Jin-ting He Min Yao Ying-ying Wang yan-kun shao Jing Mang Zhong-xin Xu Department of Neurology China-Japan Union Hospital lilin University Changchun Jilin province China Research Center China-Japan Union Hospital Jilin University Changchun Jilin Province China

Activin A, a member of the transforming growth factor-beta superfamily, plays a neuroprotective role in multiple neurological diseases. Endoplasmic reticulum（ER） stress-mediated apoptotic and autophagic cell death is implicated in a wide range of diseases, including cerebral ischemia and neurodegenerative diseases. Thapsigargin was used to induce PC12 cell death, and Activin A was used for intervention. Our results showed that Activin A significantly inhibited morphological changes in thapsigargin-induced apoptotic cells, and the expression of apoptosis-associated proteins [cleaved-caspase-12, C/EBP homologous protein（CHOP） and cleaved-caspase-3] and biomarkers of autophagy（Beclin-1 and light chain 3）, and downregulated the expression of thapsigargin-induced ER stress-associated proteins [inositol requiring enzyme-1（IRE1）, tumor necrosis factor receptor-associated factor 2（TRAF2）, apoptosis signal-regulating kinase 1（ASK1）, c-Jun N-terminal kinase（JNK） and p38]. The inhibition of thapsigargin-induced cell death was concentration-dependent. These findings suggest that administration of Activin A protects PC12 cells against ER stress-mediated apoptotic and autophagic cell death by inhibiting the activation of the IRE1-TRAF2-ASK1-JNK/p38 cascade.

关键词： nerve regeneration Activin A endoplasmic reticulum stress apoptosis autophagy c-Jun N-terminal kinase p38 neural regeneration

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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基于误差融合的自导鱼雷发现概率解析方法研究

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指挥控制与仿真 2022年第2期44卷 49-53页

作者：张祥甫闫少坤海装驻连云港地区军代室江苏连云港222061 江苏自动化研究所江苏连云港222061

为解决自导鱼雷发现概率实时计算的难题,建立了基于误差融合的自导鱼雷发现概率解析方法模型。以某型鱼雷为例,结合蒙特卡洛法,对比验证此自导鱼雷发现概率解析方法的正确性和可行性。除此之外,分析了鱼雷速度、敌弦角和雷目距离等边界... 详细信息

为解决自导鱼雷发现概率实时计算的难题,建立了基于误差融合的自导鱼雷发现概率解析方法模型。以某型鱼雷为例,结合蒙特卡洛法,对比验证此自导鱼雷发现概率解析方法的正确性和可行性。除此之外,分析了鱼雷速度、敌弦角和雷目距离等边界条件对鱼雷发现概率的影响。仿真结果表明:其他条件相同时,鱼雷速度越大,雷目距离越小,鱼雷发现概率越高;声自导鱼雷发现概率随敌弦角变大而先减小后缓慢增大,尾流自导鱼雷发现概率随敌弦角变大而先增大后缓慢降低。

关键词：自导鱼雷发现概率解析法误差融合

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工业工程的技术与方法在纺织企业的应用

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纺织科技进展 2017年第7期 5-8,29页

作者：吴雪冰温艳邵坤青岛大学商学院山东青岛266071

以纺织行业某龙头企业清花、粗纱、细纱、络筒等工序为研究对象,运用工业工程的联合作业分析、流程程序分析、MOD法等方法进行改善。降低了工人劳动量,缩短了工人劳动时间,提高了工作效率,使员工操作更加科学化,生产更加合理。运用的工... 详细信息

以纺织行业某龙头企业清花、粗纱、细纱、络筒等工序为研究对象,运用工业工程的联合作业分析、流程程序分析、MOD法等方法进行改善。降低了工人劳动量,缩短了工人劳动时间,提高了工作效率,使员工操作更加科学化,生产更加合理。运用的工业工程改善方法对其他纺织企业也有借鉴意义。

关键词：工业工程纺织工序优化

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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng yan kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan yang Xinxin yan shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Enhanced separation of Pd(Ⅱ)and Pt(Ⅳ)from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole

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Rare Metals 2020年第12期39卷 1473-1482页

作者： shao-Ping Feng kun Huang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Chemistry College of ScienceHonghe UniversityMengzi 661199China

Separation of palladium(Pd)and platinum(Pt)by solvent extraction is difficult because of their extremely similar physicochemical *** of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent *** this study,a new extractant,2-((2-methoxyethyl)thio)-1 H-benzimidazole(MOBI),which contains N,S,and O atoms,was synthesized and used to separate Pd(Ⅱ)and Pt(Ⅳ)from a hydrochloric acid aqueous *** experimental results revealed that Pd(Ⅱ)and Pt(Ⅳ)were effectively separated under the optimal conditions:MOB I concentration of 0.005 mol·L^(-1),HCl concentration of0.2 mol·L^(-1),organic/aqueous(O/A)phase ratio of 1.0,and contact time of 15 *** separation coefficient between Pd(Ⅱ)and Pt(Ⅳ)was 1246.40,which indicates that MOBI has a higher selectivity for Pd(Ⅱ)than Pt(Ⅳ).In addition,the mechanism of coordination between Pd(Ⅱ)and MOBI was demonstrated through the slope method,Fourier transform infrared spectroscopy(FTIR),hydrogen-1 nuclear magnetic resonance spectroscopy(^(1)H NMR),and carbon-13 nuclear magnetic resonance spectroscopy(^(13)C NMR).The results revealed that MOBI could coordinate with Pd(Ⅱ)via the N atom in the benzimidazole ring of MOBI molecules to form[Pd(MOBI)_(2)Cl_(2)](O).

关键词： 2-((2-methoxyethyl)thio)-1H-benzimidazole Palladium Platinum Extraction Separation

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使用光谱分析实现弯管中两相流含气率的预测

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光谱学与光谱分析 2025年第1期45卷 231-238页

作者：车少敏马世一刘雪婧殷雄周延熊兵李锟李飞西安交通大学能源与动力工程学院陕西西安710049 中国航发四川燃气涡轮研究院四川成都610500 西安石油大学电子工程学院陕西西安710065

空气被夹带进入发动机润滑油系统形成油气两相流后,会严重影响润滑系统的正常运行。因此实现发动机润滑油系统中油气两相流含气率的准确和快速测量具有十分重要的意义。基于光谱匹配方法,对发动机润滑油系统在弯管处的油气两相流含气率... 详细信息

空气被夹带进入发动机润滑油系统形成油气两相流后,会严重影响润滑系统的正常运行。因此实现发动机润滑油系统中油气两相流含气率的准确和快速测量具有十分重要的意义。基于光谱匹配方法,对发动机润滑油系统在弯管处的油气两相流含气率进行了测量研究。首先使用近红外、可见光和紫外光谱仪获取油气两相流在2个流速、5个温度工况下0.10%~1.00%含气率范围(间隔0.06%)的吸光度数据并进行分析,确认油气两相流在三个波段下均有吸收,且吸收强度与含气率有关;其次提出将数据预处理结合光谱相似性测度方法并应用于弯管含气率光谱分析中,显著降低了基于原始光谱的含气率预测的最大相对误差。在近红外波段通过使用数据增强方法如中心化(center)和标准化(autoscaling)并结合光谱角余弦方法,得出新润滑油的含气率最大相对误差相对于原始光谱得到的数值从48%降低到36%。利用该方法分别在三个波段进行含气率预测,试验工况包括2个流速、5个温度,分析了两相流的温度和流速对含气率预测的影响。温度30.0℃,流速5.1 m·min^(-1)下,含气率信息在紫外波段(193.5~413.8 nm)与光谱向量的方向或形状差异的联系更为紧密,含气率预测的最大相对误差仅为6%。在近红外和可见光波段,流速或温度一定时,最大相对误差随着温度或流速的增加均有减小趋势。紫外波段下温度对含气率预测效果没有特定的影响规律,随着两相流的流速增加,含气率预测的最大相对误差有增大趋势。结果表明对于透光性较好的新润滑油,使用紫外光谱仪进行含气率数据的采集,含气率的预测选用标准化预处理结合光谱角余弦方法,得到的含气率预测最大相对误差最小。

关键词：气液两相流含气率光谱分析光谱匹配

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美丽园区建设的路径研究

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生态经济 2025年第1期41卷 44-51页

作者：陈吕军严坤田金平清华大学环境学院北京100084 清华大学生态文明研究中心北京100084 清华大学碳中和研究院北京100084

建设美丽中国是全面建设社会主义现代化国家、实现中华民族永续发展的重要举措。中国工业园区历经四十多年发展历程,已经成为建设实体经济、引领区域发展的先行者,目前已聚集全国80%的工业企业,推动工业园区建设成为人与自然和谐共生的... 详细信息

建设美丽中国是全面建设社会主义现代化国家、实现中华民族永续发展的重要举措。中国工业园区历经四十多年发展历程,已经成为建设实体经济、引领区域发展的先行者,目前已聚集全国80%的工业企业,推动工业园区建设成为人与自然和谐共生的美丽园区,对我国生态文明建设意义重大。论文回顾了中国工业园区的发展历程,面向新发展阶段存在的新挑战和新机遇,提出了工业园区在新时代需承担的高质量发展使命任务。在此基础上,本文针对园区社会、经济、自然三个子系统,从六个方面解析并详细阐述了中国工业园区打造美丽园区、支撑美丽中国建设的关键内涵。进一步地,根据国家对美丽中国建设提出的目标和计划,结合我国生态工业园区发展过程中形成的实践经验,从八个维度提出工业园区推进美丽中国建设的关键行动,支撑工业园区生态文明建设和美丽中国行动。

关键词：美丽中国工业园区美丽园区绿色发展生态文明

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Radar emitter multi-label recognition based on residual network

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Defence Technology（防务技术） 2022年第3期18卷 410-417页

作者： Yu Hong-hai yan Xiao-peng Liu shao-kun Li Ping Hao Xin-hong Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing100081China Beijing Institute of Telemetry Technology Beijing100081China

In low signal-to-noise ratio(SNR)environments,the traditional radar emitter recognition(RER)method struggles to recognize multiple radar emitter signals in *** paper proposes a multi-label classification and recognition method for multiple radar-emitter modulation types based on a residual *** method can quickly perform parallel classification and recognition of multi-modulation radar time-domain aliasing signals under low ***,we perform time-frequency analysis on the received signal to extract the normalized time-frequency image through the short-time Fourier transform(STFT).The time-frequency distribution image is then denoised using a deep normalized convolutional neural network(DNCNN).Secondly,the multi-label classification and recognition model for multi-modulation radar emitter time-domain aliasing signals is established,and learning the characteristics of radar signal time-frequency distribution image dataset to achieve the purpose of training ***,time-frequency image is recognized and classified through the model,thus completing the automatic classification and recognition of the time-domain aliasing *** results show that the proposed method can classify and recognize radar emitter signals of different modulation types in parallel under low SNRs.

关键词： Radar emitter recognition Image processing Parallel Residual network Multi-label

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