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Chinese Chemical Letters 2016年第4期27卷 518-522页

作者： yan-kai lia Jun-Ji Zhang Zi-Jun Bian You-Xin Fu Fei Liu Chen-Hui Wang Xiang Ma Jun Hu Hong-Lai Liu Key Laboratory for Advanced Materials and Department of Chemistry East China University of Science and Technology Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology Xi’an Thermal Power Research Institute Co. Ltd. (Suzhou Branch)

Infinite coordination polymers are recognized as excellent platform for *** motifs,which are one of the most attractive functional moieties,were incorporated into an infinite coordination polymer,to deliver a‘‘smart’’porous material that can response to external *** obtained dithienylethene-based infinite coordination polymers（named Cu-DTEDBA）share the advantages of both infinite coordination polymers（porosity and stability）and dithienylethene motifs（photochromism）.The physical and chemical properties of Cu-DTEDBA were characterized by FTIR,TEM,SEM,XRD,TGA,UV–vis,EDX and ***,the combination of dithienylethene and infinite coordination polymers gives rise to a synergistic effect,which induces functional behaviors of ammonia sensor *** open and closed forms of Cu-DTEDBA exhibit distinct colorimetric change upon exposure to gaseous ammonia,which is not observed in dithienylethene free molecules.

关键词： Dithienylethene Photochromism Infinite coordination polymers Synergistic effect Gaseous ammonia probe

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

踝关节骨折术后踝穴冠状位角度波动与关节功能恢复的关系

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中国组织工程研究 2025年第9期29卷 1820-1826页

作者：刘琰王铠吴敏泰州市中医院骨科江苏省泰州市225300

背景:踝关节骨折术后的踝穴形态指标会出现相应变化,而其中踝穴冠状位角度变化与踝关节的功能恢复之间存在一定的关联,既往研究大多探讨患者术后踝穴高度恢复,故研究踝关节骨折术后踝穴冠状位角度的波动与关节功能恢复的相关性具有一定... 详细信息

背景:踝关节骨折术后的踝穴形态指标会出现相应变化,而其中踝穴冠状位角度变化与踝关节的功能恢复之间存在一定的关联,既往研究大多探讨患者术后踝穴高度恢复,故研究踝关节骨折术后踝穴冠状位角度的波动与关节功能恢复的相关性具有一定参考意义。目的:探讨踝关节骨折术后踝穴冠状位角度变化对关节功能恢复的影响。方法:纳入进行手术治疗的86例踝关节骨折患者为研究对象,根据末次随访美国骨科足踝外科协会踝-后足评分结果分为优良组(n=45)和可差组(n=41),比较两组患者的一般资料。根据踝关节的踝穴位及侧位X射线片对比术后患者患侧和健侧的踝穴形态指标:包括踝穴宽度和深度、冠状位角度及矢状位角度,以及上述指标患侧和健侧之间的差值,并进一步进行组内比较分析。构建联合模型,利用Cox回归分析评估冠状位角度波动与关节功能恢复情况的关系。利用最小绝对收缩选择算子回归法和多因素Logistic回归分析影响患者关节功能恢复的危险因素。按踝穴冠状位角度从低到高等分为5分位数组(Q1-Q5),比较5组患者的临床资料特征,并采用多因素Logistic回归分析踝穴冠状位角度变化与关节功能恢复不良风险的相关性,建立限制性立方样条Logistic回归模型分析其剂量-反应关系。建立回归方程y=1-1/(1+e^(-z))预测模型并进行验证。结果与结论:①患者患侧的踝穴宽度和深度、冠状位角度及矢状位角度均显著大于健侧(P均<0.05);且与优良组患者相比,可差组患者踝穴宽度差值、深度差值、冠状位角度差值及矢状位角度差值均更大(P<0.05);②联合模型显示无论冠状位角度是否在正常范围内,冠状位角度每纵向增加1˚,关节功能恢复不良的风险增加3%;③最小绝对收缩选择算子回归和多因素Logistics回归分析显示,调整潜在混杂因素后发现年龄过大、早期功能锻炼缺乏、无跟骨牵引、内固定物未取出、术后并发症、踝冠状位角度增大均为影响患者关节功能恢复的独立危险因素(P<0.05);④术后3个月内的冠状位角度与关节功能恢复效果不良风险存在独立相关性(OR=1.57,95%CI:1.38-1.76,P=0.002),且术后各时间段冠状位角度从低到高5分位数组趋势性检验差异有统计学意义(P趋势<0.001);⑤限制性立方样条模型分析显示,男性或女性的踝穴冠状位角度变化与关节功能恢复效果不良风险均不存在非线性关系;经Bootstrap自抽样,预测模型区分度、准确度较好;⑥提示踝关节骨折术后踝穴冠状位角度减小对关节功能恢复起到明显的促进作用,因此在踝关节骨折术后重点检测踝穴冠状位角度有助于了解患者关节功能恢复情况。

关键词：踝关节骨折踝穴冠状位角度关节功能 Logistic回归分析

Composition Operators with Universal Translates on S^(2)(D)

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Acta Mathematica Sinica,English Series 2023年第12期39卷 2452-2464页

作者： kai kai HAN yan yan TANG School of Mathematics and Statistics Hebei University of Economics and BusinessShijiazhuang 050061P.R.China School of Mathematics and Statistics He'nan UniversityKaifeng 475004P.R.China

It is known that the Invariant Subspace Problem for Hilbert spaces is equivalent to the statement that all minimal non-trivial invariant subspaces for a universal operator are one *** this paper,we characterize all linear fractional composition operators and their adjoints that have universal translates on the space S^(2)(D).Moreover,we characterize all adjoints of linear fractional composition operators that have universal translates on the Hardy space H^(2)(D).In addition,we consider the minimal invariant subspaces of the composition operator Cφa on S^(2)(D),where φa(z)=az+1-a,a ∈(O,1).Finally,some relationships between complex symmetry and universality for bounded linear operators and commuting pairs of operators on a complex separable,infinite dimensional Hilbert space are explored.

关键词： Universal operator composition operator invariant subspace complex symmetry

Fuzzy Clustering with the Structural α-Entropy

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Chinese Journal of Electronics 2018年第6期27卷 1118-1125页

作者： LI kai GAO yan School of Cyber Security and Computer Hebei University

We study fuzzy clustering with the structural α-entropy and present a unified framework for fuzzy clustering with fuzzy entropy, which can be regarded fuzzy clustering with fuzzy entropy as its special case. Then,aiming at weighting exponent m equal to the structuralα-entropy index α in the presented unified framework, we obtain the fuzzy membership degrees and cluster centers using Lagrange method. Further, we propose the Structural α-entropy based fuzzy c-means(SEFCM) ***, to solve clustering of the complicated data, we also present the Structural α-entropy based kernel fuzzy c-means(SEKFCM) algorithm. In experiment, some University of California Irvine(UCI) data sets and synthetic data sets are used to test the performance of the presented algorithms and the role of the structural α-entropy. The experimental results show that the presented algorithms obtain better clustering result.

关键词： Structural α-entropy Unified framework Kernel function Fuzzy clustering Structural α-entropy based fuzzy c-means(SEFCM) algorithm Structural α-entropy based kernel fuzzy c-means(SEKFCM) algorithm

Leakage Is Prohibited:Memory Protection Extensions Protected Address Space Randomization

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Tsinghua Science and Technology 2019年第5期24卷 546-556页

作者： Fei yan kai Wang the Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education School of Cyber Science and Engineering Wuhan University

Code reuse attacks pose a severe threat to modern applications. These attacks reuse existing code segments of vulnerable applications as attack payloads and hijack the control flow of a victim application. With high code entropy and a relatively low performance overhead, Address Space Layout Randomization(ASLR) has become the most widely explored defense against code reuse attacks. However, a single memory disclosure vulnerability is able to compromise this defense. In this paper, we present Memory Protection Extensions(MPX)-assisted Address Space Layout Randomization(M-ASLR), a novel code-space randomization scheme. M-ASLR uses several characteristics of Intel MPX to restrict code pointers in memory. We have developed a fully functioning prototype of M-ALSR, and our evaluation results show that M-ASLR:(1) offers no interference with normal operation;(2) protects against buffer overflow attacks, code reuse attacks, and other sophisticated modern attacks;and(3) adds a very low performance overhead(3.3%) to C/C++ applications.

关键词： Address Space Layout Randomization (ASLR) Intel Memory Protection Extensions (MPX) code reuse attack

MoS_(2) on topological insulator Bi_(2)Te_(3) thin films:Activation of the basal plane for hydrogen reduction

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Journal of Energy Chemistry 2021年第11期30卷 516-522,I0012页

作者： Guowei lia Jue Huang Qun yang Liguo Zhang Qingge Mu yan Sun Stuart Parkin kai Chang Claudia Felser Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Max Planck Institute for Microstructure Physics 06120 HalleGermany Beijing Academy of Quantum Information Sciences 100193 BeijingChina

2H-MoS_(2) is a well-studied and promising non-noble metal electrocatalyst for heterogeneous reactions,such as the hydrogen evolution reaction(HER).The performance is largely limited by the chemically inert basal plane,which is unfavorable for surface adsorption and ***,we report a facile method to boost the HER activities of 2H-MoS_(2) by coupling with epitaxial Bi2Te3 topological insulator *** as-obtained MoS_(2)/Bi2Te3/SrTiO3 catalyst exhibits prominent HER catalytic activities compared to that of pure MoS_(2) structures,with a 189 mV decrease in the overpotential required to reach a current density of 10 mA cm^(−2) and a low Tafel slope of 58 mV dec−*** investigations suggest that the enhanced catalytic activity originates from the charge redistribution at the interface between the Bi2Te3topological insulator films and the MoS_(2) *** delocalized sp-derived topological surface states could denote electrons to the MoS_(2) layer and activate the basal plane for hydrogen *** study demonstrates the potential of manipulating topological surface states to design high-performance electrocatalysts.

关键词： MoS_(2) Topological insulator Hydrogen evolution Surface states Electron transfer

COASTAL AND PORT ENGINEERING IN CHINA

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China Ocean Engineering 1989年第1期4卷 1-38页

作者： yan, kai Hohai Univ China

In this paper, a brief account of the characteristic features of the coast of China is given, followed by the present status and future prospects of coastal and port engineering in China, experiences gained and problems encountered. China has attached much importance to the rehabilitation and modernization of war damaged existing ports and the construction of new ports, as well as the maintenance and strengthening of coast protection works.

关键词： Coastal Zones Ports and Harbors Rivers Estuaries

改进YOLOv8的无人机航拍图像目标检测算法

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计算机工程与应用 2025年第01期61卷 121-130页

作者：梁燕何孝武邵凯陈俊宏重庆邮电大学通信与信息工程学院信号与信息处理重庆市重点实验室

针对无人机航拍图像存在多个小目标聚集、目标尺度变化大的问题，提出一种改进YOLOv8的目标检测算法TS-YOLO(tiny and scale-YOLO)。在主干部分去除冗余的特征提取层，设计了一种高效特征提取模块（efficient feature extraction module... 详细信息

针对无人机航拍图像存在多个小目标聚集、目标尺度变化大的问题，提出一种改进YOLOv8的目标检测算法TS-YOLO(tiny and scale-YOLO)。在主干部分去除冗余的特征提取层，设计了一种高效特征提取模块（efficient feature extraction module,EFEM），避免小目标特征消失在冗余信息中。在颈部设计了一种双重跨尺度加权特征融合方法（dual cross-scale weighted feature-fusion,DCWF），融合多尺度信息的同时抑制噪声干扰，提升特征表达能力。通过构建一种参数共享检测头（parameter-shared detection header,PSDH），使回归和分类任务实现参数共享，保证检测精度的同时有效降低了模型的参数量。所提模型在VisDrone-2019数据集上的精度（P）和召回率（R）分别达到54.0%、42.5%；相比于原始YOLOv8s模型，mAP50提高了5.0个百分点，达到44.5%，且参数量减少了55.8%，仅有4.94×106；在DOTAv1.0遥感数据集上，mAP50达到71.9%，仍具有较好的泛化能力。

关键词：目标检测无人机航拍图像 YOLOv8 小目标特征融合

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Preparation,physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesicles

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World Journal of Gastroenterology 2010年第8期16卷 1008-1013页

作者： lia, Lin Zheng, Jian-Jun Jiang, Shu-Man Huang, kai-Hong Guangzhou Med Coll Guangzhou Municipal Peoples Hosp 1 Dept Gastroenterol Guangzhou 510180 Guangdong Peoples R China Zhongshan Univ Dept Gastroenterol Affiliated Hosp 2 Guangzhou 510000 Guangdong Peoples R China

AIM:To investigate the preparation,physicochemical characterization and cytotoxicity in vitro of Gemcitabine-loaded poly(ethylene glycol)-block-poly(D,L-lactide) (PEG-PDLLA) nanovesicles. METHODS:The nanovesicle carriers were prepared from the amphiphilic block copolymer of PEG-PDLLA by a double emulsion technique,and gemcitabine was used as the model drug. The morphology of the nanovesicles was determined by scanning and transmission electron microscopy,and the drug content,drug entrapment and drug-release curve in vitro were detected by UV-Vis-NIR spectrophotometry. Cytotoxicity in the human pancreatic cancer cell line SW1990 was tested by 3-(4,5-dimethyl) ethiazole (MTT) ***:The gemcitabine-loaded nanovesicles were hollow nanospheres with a mean size of 200.6 nm,drugloading of 4.14% and drug embedding ratio of 20.54%. The nanovesicles showed excellent controlled release that was characterized by a fast initial release during the first 72 h,followed by a slower and continuous release. The MTT assay demonstrated that gemcitabine-loaded nanovesicles exhibited dose-dependent and time-delayed cytotoxicity in the human pancreatic cancer cell line ***:Gemcitabine-loaded PEG-PDLLA nanovesicles prepared by a double emulsion technique exhibited good performance for controlled drug release,and had similar cytotoxic activity to free gem-citabine.

关键词： Copolymer Cytotoxicity Gemcitabine Nanovesicles