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电针对MPTP诱导的PD模型小鼠mGLuR5的影响

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时珍国医国药 2024年第8期35卷 2035-2039页

作者：荣臻李亚楠汪瑶张小蕾胡梦妮马骏湖北中医药大学湖北武汉430000

目的观察电针“风府”“太冲”穴对帕金森病(PD)小鼠代谢性谷氨酸5(mGluR5)及其通路的影响,探讨电针治疗PD的可能机制。方法 C57BL/6小鼠随机分为正常组(Ctrl)、模型组(MPTP)、抑制剂组(CHPG)、抑制剂加电针组(CHPG+EA),电针组(EA组),... 详细信息

目的观察电针“风府”“太冲”穴对帕金森病(PD)小鼠代谢性谷氨酸5(mGluR5)及其通路的影响,探讨电针治疗PD的可能机制。方法 C57BL/6小鼠随机分为正常组(Ctrl)、模型组(MPTP)、抑制剂组(CHPG)、抑制剂加电针组(CHPG+EA),电针组(EA组),每组10只。用MPTP连续腹腔注射7天复制PD模型。电针“风府”“太冲”穴,30 min/次,1次/d,连续治疗12天。观察各组小鼠行为学变化;免疫组化法检测mGluR5表达;Western blot法检测黑质中mGluR5、p-ERK、p-CREB、BDNF蛋白表达,PCR法检测mGluR5、ERK、CREB、BDNF mRNA表达水平。结果与Ctrl组相比,MPTP组、CHPG组、CHPG+EA组小鼠出现行为学改变(P<0.01),而EA组小鼠行为学有所改善(P<0.01)。MPTP组、CHPG组、CHPG+EA组小鼠黑质mGluR5阳性表达上升(P<0.01),EA组小鼠黑质mGluR5阳性表达下降(P<0.01)。MPTP组、CHPG组、CHPG+EA组mGluR5的mRNA相对表达量及蛋白表达上升(P<0.01),EA组mGluR5的mRNA相对表达量及蛋白表达下调(P<0.01)。MPTP组、CHPG组、CHPG+EA组ERK1/2、CREB和BDNF的mRNA相对表达量及蛋白表达下调(P<0.01),EA组ERK1/2、CREB和BDNF的mRNA相对表达量及蛋白表达上调(P<0.01)。结论电针“风府”“太冲”穴可以改善PD小鼠的运动功能障碍,同时抑制中脑黑质mGluR5通路的激活。

关键词：帕金森病电针突触可塑性 mGluR5

基于定量CT的肺血栓体积评估中高危急性肺栓塞的诊断价值

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西安交通大学学报（医学版） 2024年第1期45卷 126-132页

作者：姚彦娥李岩松王雄慧黄晓旗任涛冯筠郭佑民沈聪延安大学附属医院影像科陕西延安716000 西安国际医学中心医院核医学科陕西西安710000 西北大学计算机学院陕西西安710127 西安交通大学第一附属医院影像科陕西西安710061

目的探讨基于计算机辅助定量的肺血栓体积(pulmonary embolism volume,PEV)在识别中高危急性肺栓塞(acute pulmonary embolism,APE)中的诊断价值。方法回顾性收集2017年1月至2020年12月延安大学附属医院可疑APE并经计算机断层肺动脉成像... 详细信息

目的探讨基于计算机辅助定量的肺血栓体积(pulmonary embolism volume,PEV)在识别中高危急性肺栓塞(acute pulmonary embolism,APE)中的诊断价值。方法回顾性收集2017年1月至2020年12月延安大学附属医院可疑APE并经计算机断层肺动脉成像(CTPA)确诊的患者共143例,按2018中国《肺血栓栓塞症诊治与预防指南》分为低危组(n=88)和中高危组(n=55),收集患者的基本人口学资料、临床表现及血清中的N末端-B型钠尿肽前体(NT-proBNP)、D-二聚体水平。根据CTPA图像人工评价肺血栓栓塞程度,得到肺动脉阻塞指数(pulmonary artery obstruction index,PAOI)。采用“数字肺”肺血栓检测工具分割血栓,计算PEV。比较低危组与中高危组之间临床指标、实验室指标及PAOI、PEV的差异,采用受试者工作特征(ROC)曲线分析PAOI、PEV在识别中高危APE中的诊断价值,采用Logistic回归分析筛选中高危APE的独立危险因素,并建立不同的模型。结果中高危APE组较低危组年龄大、舒张压低(P<0.05),D-二聚体和NT-proBNP水平高(P<0.05),血小板计数、动脉血氧分压和动脉血二氧化碳分压低(P<0.05),PAOI和PEV高(P<0.001)。ROC曲线分析显示,PEV、PAOI识别中高危APE的曲线下面积分别为0.809(95%CI:0.734~0.884)、0.753(95%CI:0.667~0.839)。Logistic回归分析显示,PEV、NT-proBNP是中高危APE的独立危险因素(P<0.05)。结论PEV、NT-proBNP是预测中高危APE的独立危险因素。

关键词：急性肺栓塞危险分层肺血栓体积计算机辅助定量

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Effectiveness of Zhenqi Buxue Oral Liquid Combined with Progesterone for Treatment of Oligomenorrhea and Hypomenorrhea with Qi-Blood and Kidney(Shen)Essence Deficiency:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2023年第11期29卷 963-970页

作者： GAN Jing-wen LV De-xin FU Jin SHI Liang-yan YUAN Chun-yan ZENG Xiao-qin LI jun SUN Ai-jun National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College Address:Peking Union Medical College Hospital(East)Beijing(100730)China Department of Obstetrics and Gynecology Liuzhou Maternal and Child Health Care HospitalLiuzhouGuangxi Zhuang Autonomous Region(545001)China Department of Obstetrics and Gynecology Sichuan University West China Second University HospitalChendu(610066)China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Hubei ProvinceWuhan(430070)China Department of Obstetrics and Gynecology Southeast University Zhongda HospitalNanjing(210009)China Department of Obstetrics and Gynecology Guangzhou Women and Children's Medical CenterGuangzhou(510623)China Department of Obstetrics and Gynecology the First Hospital of Hebei Medical UniversityShijiazhuang(050000)China

Objective:To evaluate the effectiveness and safety of Zhenqi Buxue Oral Liquid(ZQ),progesterone capsules,and their combination in treating oligomenorrhea and hypomenorrhea with qi-blood and Kidney(Shen)essence ***:This was a prospective,randomized,multi-center controlled trial between june 2022 to December ***-six oligomenorrhea and hypomenorrhea patients with qi-blood and Shen essence deficiency were randomly assigned to receive ZQ(ZQ group,29 cases),progesterone capsules(PG group,32 cases),or the combined Chinese and Western medicine(COM group,31 cases)at a ratio of 1:1:*** in the ZQ or PG group took daily 10 m L twice a day of ZQ or 200 mg once a day of progesterone capsules for 10 consecutive days on day 15 of the menstrual cycle respectively,and patients in the COM group received the same ZQ combined with progesterone *** treatment course lasted for 3 months and follow-up was performed at 1 and 3 months after the end of *** endpoint was the menstrual Traditional Chinese Medicine Syndrome Scale(TCMSS)*** endpoints included pictorial blood loss assessment chart(PBAC)scores,clinical efficacy rate,36-item Short Form Health Survey(SF-36)scores,sex hormones and thickness of *** events(AEs)were ***:TCMSS scores after 1-and 3-month treatment in all groups were significantly lower than those at baseline(P<0.05).Only TCMSS scores after 3-month treatment in the ZQ and COM groups continuously decreased compared with those after 1-month treatment in the same group(P<0.01).TCMSS scores after 3-month treatment in the ZQ and COM groups were significantly lower than those in the PG group(P<0.05,P<0.01).Compared with baseline,PBAC scores in the ZQ and COM groups after 3 months of treatment were also significantly higher(both P<0.01).The total effective rates of TCM syndrome of 3-month treatment were significantly improved in all groups compared with that after 1 month of treatment(P<0.

关键词： Kidney Blood treatment

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离散小波去噪后冬小麦叶片含水量高光谱估算

光谱学与光谱分析 2024年第9期44卷 2559-2567页

作者：王延仓朱玉晨齐焱鑫张志通曹会琼王金杲顾晓鹤唐瑞尹何跃君李笑芳罗巍北华航天工业学院遥感信息工程学院河北廊坊065000 廊坊师范学院河北廊坊065000 中国地质科学院水文地质环境地质研究所河北石家庄050061 北京农林科学院信息技术研究中心北京100097 航天遥感信息应用技术国家地方联合工程研究中心河北廊坊065000 河北省航天遥感信息处理与应用协同创新中心河北廊坊065000

光谱噪声去除是遥感区域应用的必要过程,噪声去除效果能直接影响区域地表信息的监测精度。为分析离散小波算法对光谱数据的分解机理,探寻基于离散小波算法光谱噪声信息去除与光谱处理方法,以冬小麦冠层光谱与叶片含水量为数据源,先利用... 详细信息

光谱噪声去除是遥感区域应用的必要过程,噪声去除效果能直接影响区域地表信息的监测精度。为分析离散小波算法对光谱数据的分解机理,探寻基于离散小波算法光谱噪声信息去除与光谱处理方法,以冬小麦冠层光谱与叶片含水量为数据源,先利用离散小波算法对光谱数据进行去噪处理,采用的小波基为Meyer;然后以Meyer、Sym2、Coif2为小波基对去噪后的光谱数据进行信息分离,并结合相关性分析算法、偏最小二乘算法构建冬小麦叶片含水量估测模型,研究结论如下:(1)在离散小波算法下,合并的光谱曲线随合并尺度数的不断增加,原光谱曲线局部的大、中、小特征依次凸显;随H10—H1分解尺度的依次加入,分解信息对合并曲线的修正幅度也逐步减弱,其中,将H3—H1依次合并后,合并的光谱曲线几乎无变动。(2)提出的去噪方法可在一定程度上改变了部分光谱对冬小麦叶片含水量的敏感性及敏感波段的分布:其中在1~3尺度内,降低了光谱对冬小麦叶片含水量的敏感性,改变了敏感波段的波段位置的分布情况。在4~10尺度内,能明显提升光谱对冬小麦叶片含水量的敏感性(Coif2);提出的去噪方法可提升局部波段对冬小麦叶片含水量的敏感性(Sym2)。(3)提出的去噪方法能明显提升光谱对模型的稳定性,能提升Sym2、Coif2小波基内最优模型的精度与稳定性,其中验证精度提高了8.6%(Sym2)、34.1%(Coif2),表明该研究提出的去噪处理是有效的。

关键词：冬小麦叶片含水量离散小波噪声信息高光谱

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氧化石墨烯对活性污泥脱氮性能影响的机制

中国环境科学 2024年第7期44卷 3759-3766页

作者：殷牧辰李军吴耀东李东岳高鹏边雪莹裴艳雪梁东博北京工业大学城市建设学部城市污水深度处理与资源化利用技术国家工程实验室北京100124 北京市勘察设计研究院有限公司北京100038 中国城市建设研究院有限公司北京100120

本研究建立了3个不同浓度GO(0.1和10mg/L)的序批式反应器(SBR)以明晰氧化石墨烯(GO)恶化活性污泥(AS)脱氮性能的内在机理.结果表明.1mg/L GO对AS性能无明显抑制作用.10mg/L GO使AS总氮(TN)去除效率降低17.63%.并且.GO暴露使AS中氧化应... 详细信息

本研究建立了3个不同浓度GO(0.1和10mg/L)的序批式反应器(SBR)以明晰氧化石墨烯(GO)恶化活性污泥(AS)脱氮性能的内在机理.结果表明.1mg/L GO对AS性能无明显抑制作用.10mg/L GO使AS总氮(TN)去除效率降低17.63%.并且.GO暴露使AS中氧化应激水平分别提升198.51%和307.13%.而微生物通过分泌更多的胞外聚合物(EPS)以应对GO胁迫.16S rRNA gene测序结果表明.GO显著影响了具有脱氮功能的菌属丰度.常见的负责硝化过程的菌属(Nitrosomonas和Nitrospira)和反硝化过程的菌属(Candidatus_Accumulibacter、和Thauera等)丰度随着GO浓度升高而降低.功能基因预测显示.GO降低了和脱氮有关的基因丰度.与NH_(4)+-N氧化的相关的基因(***)和NO_(2)--N还原的相关的基因(***)丰度均随着GO的累积而显著下降.本研究从功能基因的角度深入解析了GO恶化AS脱氮性能的内在机理.

关键词：氧化石墨烯脱氮性能胞外聚合物微生物群落结构功能基因

Effect of organic amendment amount on soil nematode community structure and metabolic footprints in soybean phase of a soybean-maize rotation on Mollisols

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Pedosphere 2020年第4期30卷 544-554页

作者： Fengjuan PAN Xiaozeng HAN Na LI jun yan yanli XU National Observation Station of Hailun Agro-ecology System Key Laboratory of Mollisols AgroecologyNortheast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081(China)

It has been well documented that organic amendment affects soil nematode community ***,little is known about the effect of organic amendment amount on soil *** assess the effect of the amount of organic amendments on soil nematode community structure and metabolic activity,the community composition,abundance,and metabolic footprints of soil nematodes were determined in a long-term field experiment with various amounts of organic amendment in Northeast *** treatments included an unfertilized control(CK),chemical fertilizer without manure amendment(OM0),manure applied at 7.5 Mg ha^-1 plus chemical fertilizer(OM1),and manure applied at 22.5 Mg ha^-1 plus chemical fertilizer(OM2).A total of 46 nematode genera were *** with the largest amount of organic amendment had the smallest number of plant parasite genera(5),but a largest number of dominant genera(7).Soil nematodes,bacterivores,and fungivores were the most abundant in OM2,followed by OM1,and the lowest in OM0 and *** amendment increased the enrichment index(EI),and the large amount of organic amendment increased the metabolic footprints of bacterivore(Baf)and fungivore(Fuf)and enrichment footprint(Ef).The relationships between Baf(or Fuf)and the increases in soil organic carbon(?SOC)and total nitrogen(?TN)were stronger than those of bacterivore(or fungivore)abundance with?SOC and?TN,except for the relationship between bacterivore abundance and ?*** EI and Ef were positively correlated with ?SOC and ?*** findings suggest that the amount of organic amendment affects soil nematode activity and function at entry levels in soil food web,and that metabolic footprints of soil nematodes may be better indicators than their abundances in assessing their relationships with soil nutrients.

关键词： community composition ecosystem function enrichment footprint enrichment index metabolic activity soil food web trophic group

水葫芦生物炭联合高碘酸盐高效去除水中磺胺嘧啶

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中国环境科学 2024年第7期44卷 3767-3779页

作者：张悦袁玉龙晏彩霞姜一晗苏美淇丁明军王鹏聂明华江西师范大学地理与环境学院鄱阳湖湿地与流域研究教育部重点实验室流域生态智能监测与综合治理江西省重点实验室江西南昌330022

以入侵植物水葫芦为原料,制备了水葫芦生物炭(EBC),发现EBC能够高效活化高碘酸盐(PI),促进磺胺嘧啶(SD)的降解,且效能优于喜旱莲子草BC和加拿大一枝黄花BC.相较于其他热解温度,500℃条件下制备的EBC(EBC500)可更好地活化PI,在较低剂量的... 详细信息

以入侵植物水葫芦为原料,制备了水葫芦生物炭(EBC),发现EBC能够高效活化高碘酸盐(PI),促进磺胺嘧啶(SD)的降解,且效能优于喜旱莲子草BC和加拿大一枝黄花BC.相较于其他热解温度,500℃条件下制备的EBC(EBC500)可更好地活化PI,在较低剂量的PI(0.15mmol/L)条件下,20min内可将SD完全去除.随着EBC500和PI投加量的提升,SD的去除速率不断提高.猝灭实验和电子顺磁共振分析表明,碘自由基(⋅IO_(3),⋅IO_(4))、超氧自由基(O_(2)^(•−))、单线态氧(1 O_(2))是EBC500/PI体系降解SD的主要活性物种.同时,在EBC500和PI投加量分别为0.15g/L和0.15mmol/L的条件下,SD能够在较宽泛的初始pH值范围内(5~9)被完全去除.Cl^(−)、SO_(4)^(2−)和NO_(3)^(−)对SD的降解没有显著影响,但HCO_(3)^(−)和腐殖酸会抑制SD的去除.EBC500/PI体系可较好地应用于实际水体中SD的去除,对于其他典型磺胺类抗生素的降解也有良好的应用潜能,且EBC500具有良好的重复使用性.此外,根据6种中间产物,提出了SD的降解途径.通过生态毒性分析和植物种子萌发实验证明,EBC500/PI体系可显著降低SD溶液的生物毒性,说明该体系具有广阔的应用前景.

关键词：高级氧化技术高碘酸盐生物炭磺胺嘧啶降解

Shock Tube Measurement of Ethylene Ignition Delay Time and Molecular Collision Theory Analysis

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Chinese Journal of Chemical Physics 2016年第6期29卷 761-766,I0002页

作者： Xiao-he Xiong yan-jun Ding Shuo Shi Zhi-min Peng StateKeyLabofPowerSystems DepartmentofThermalEngineeringTsinghuaUniversityBeij'inE100084China

In this study, 75% and 96% argon diluent conditions were selected to determine the ig- nition delay time of stoichiometric mixture of C2Ha/O2/Ar within a range of pressures （1.3-：3.0 arm） and temperatures （1092-1743 K）. Results showed a logarithmic linear rela- tionship of the ignition delay time with the reciprocal of temperatures. Under both two diluent conditions, ignition delay time decreased with increased temperature. By multiple linear regression analysis, the ignition delay correlation was deduced. According to this correlation, the calculated ignition delay time in 96% diluent was found to be nearly five times that in 75% diluent. To explain this discrepancy, the hard-sphere collision theory was adopted, and the collision numbers of ethylene to oxygen were calculated. The total collision numbers of ethylene to oxygen were 5.99×10^30 s^-1cm^-3 in 75% diluent and 1.53×10^29 s^-1cm^-3 in 96% diluent （about 40 times that in 75% diluent）. According to the discrepancy between ignition delay time and collision numbers, viz. 5 times corresponds to 40 times, the steric factor can

关键词： Shock tube Ethylene Ignition delay Molecule collision

Effect of Water Absorption on the Mechanical Property and Failure Mechanism of Hollow Glass Microspheres Composite Epoxy Resin Solid Buoyancy materials

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China Ocean Engineering 2023年第5期37卷 876-884页

作者： DING Yue ZHAI Gang-jun ma Zhe WEI Zi-hao LI Xin State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116024China

To study the water absorption of hollow glass microspheres(HGMs)composite epoxy resin solid buoyancy materials in the marine environment and its effect on the mechanical properties,the water absorption was measured by immersing the material in distilled water for 36 days at ambient temperature and fitted to Fick’s second *** strength of materials before and after water absorption were tested by uniaxial experiments,and the effects of the filling ratio and water absorption on the mechanical properties of the materials were analyzed and ***,the failure modes and mechanism of the hollow glass microspheres composite material were explicated from the microscopic level by scanning electron microscope(SEM).This research will help solve the problems of solid buoyancy materials in ocean engineering applications.

关键词： solid buoyancy material water absorption mechanical property failure mechanism scanning electron microscope