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Selective targeted adsorption and inactivation of antibiotic-resistant bacteria by Cr-loaded mixed metal oxides

Frontiers of Environmental Science & Engineering 2022年第6期16卷 1-12页

作者： yanlin Li Bo Wang Lei Zhu Yixing Yuan Lujun Chen jun ma State Key Laboratory of Urban Water Resources and Environment(SKLUWRE) Harbin Institute of TechnologyHarbin 150090China Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology School of Environmental Science and Safety EngineeringTianjin University of TechnologyTianjin 300384China Jiangsu Yihuan Group Co. Ltd.Yixing 214206China School of Environment Tsinghua UniversityBeijing 100084China

Herein we provide a novel high-efficiency nanocomposite for bacterial capture based on mixed metal oxides(MMOs)with deleterious chromium *** both the layer structure of layered double hydroxides(LDHs)and the magnetic properties of Fe,MMOs enrich the location of ionic forms on the surface,providing a good carrier for adsorption of the heavy metal Cr(VI).The capacity for adsorption of Cr(VI)by MMOs can be as high as 98.80 mg/*** prepared Cr(VI)-MMOs achieved extremely expeditious location of gram-negative antibiotic-resistant ***-1 by identifying lipid ***-MMOs with a Cr loading of 19.70 mg/g had the best bactericidal effect,and the concentration of ***-1 was decreased from~10^(8) to~10^(3) CFU/mL after 30 min of *** binding of nitrogen and phosphorus hydrophilic groups to chromate generated realistic models for density functional theory(DFT)*** specific selectivity of MMOs toward bacterial cells was improved by taking Cr(VI)as a transferable medium,thereby enhancing the antibacterial activity of *** the combined action of chemical and physical reactions,Cr(VI)-MMOs achieved high capacity for inactivation of ***,the metallic elements ratio in Cr-MMOs remained stable in their initial valence states after *** guaranteed high removal efficiency for both heavy metals and bacteria,allowing recycling of the adsorbent in practical applications.

关键词： Heavy metal adsorption magnetic hydrotalcite ARBs removal Cr(VI)-MMOs combined antibacterial activity

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3D Printed Multi-material Medical Phantoms for Needle-tissue Interaction Modelling of Heterogeneous Structures

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Journal of Bionic Engineering 2021年第2期18卷 346-360页

作者： jun Yin manqi Li Guangli Dai Hongzhao Zhou Liang ma Yixiong Zheng The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China Department of Medical Engineering Ningbo First HospitalNingbo 315010China Department of Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

The fabrication of multi-material medical phantoms with both patient-specificity and realistic mechanical properties is of great importance for the development of surgical planning and medical *** this work,a 3D multi-material printing system for medical phantom manufacturing was *** and elastomeric materials are firstly combined in such application for an accurate tactile *** phantom is designed with multiple layers,where silicone ink,Thermoplastic Polyurethane(TPU),and Acrylonitrile Butadiene Styrene(ABS)were chosen as printing materials for skin,soft tissue,and bone,***,the printed phantoms were utilized for the investigation of needle-phantom interaction by needle insertion *** mechanical needle-phantom interaction was characterized by skin-soft tissue interfacial puncture force,puncture depth,and number of insertion force *** experiments demonstrated that the manufacturing conditions,*** silicone grease ratio,interfacial thickness and the infill rate,played effective roles in regulating mechanical needle-phantom ***,the influences of material properties,including interfacial thickness and ultimate stress,on needle-phantom interaction were studied by finite element ***,a patient-specific forearm phantom was printed,where the anatomical features were acquired from Computed Tomography(CT)*** study provided a potential manufacturing method for multi-material medical phantoms with tunable mechanical properties and offered guidelines for better phantom design.

关键词： 3D printing biomimetic multi-material medical phantom needle-phantom interaction Finite Element Analysis(FEA)

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Survey on applications of algebraic state space theory of logical systems to finite state machines

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Science China(Information Sciences) 2023年第1期66卷 5-24页

作者： Yongyi yan Daizhan CHENG jun-E FENG Haitao LI Jumei YUE College of Information Engineering Henan University of Science and Technology Institute of Systems Science Chinese Academy of Sciences School of mathematics Shandong University School of mathematics and Statistics Shandong Normal University College of Agricultural Equipment Engineering Henan University of Science and Technology

Algebraic state space theory(ASST) of logical systems, developed based on the semi-tensor product(STP) which is a new matrix analysis tool built in recent ten years, provides an algebraic analysis approach for many fields of science, such as logical dynamical systems, finite-valued systems, discrete event dynamic systems, and networked game systems. This study focuses on comprehensively surveying the applications of the ASST method to the field of finite state machines(FSMs). Some necessary preliminaries on the method are first reviewed. Then the applications of the method in the FSM field are reviewed, including deterministic FSMs, nondeterministic FSMs, probabilistic FSMs, networked FSMs, and controlled and combined FSMs. In addition, other applications related to both STP and FSMs are surveyed, such as the application of FSM to Boolean control networks and the application of graph theory to FSMs. Finally, some potential research directions with respect to the ASST method in the FSM field are predicted.

关键词： Boolean control network Boolean network finite state machine learning system semi-tensor product (STP) ASST

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Association between mitochondrial DNA haplotype compatibility and increased efficiency of bovine intersubspecies cloning

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Journal of Genetics and Genomics 2011年第1期38卷 21-28页

作者： Hao yan Zhonghai yan Qingwen ma Fei Jiao Shuzhen Huang Fanyi Zeng Yitao Zeng Shanghai Institute of Medical Genetics Shanghai Jiao Tong University 24/1400 West Beijing Road Shanghai 200040 China The Key Lab of Embryo Molecular Biology Ministry of Health China and Shanghai Lab of Embryo and Reproduction Engineering 24/1400 West Beijing Road Shanghai 200040 China Institute of Medical Science Shanghai Jiao Tong University School of Medicine 280 South Chongqing Road Shanghai 200025 China

Reconstructed embryos derived from intersubspecies somatic cell nuclear transfer （SCNT） have poorer developmental potential than those from intrasubspecies SCNT. Based on our previous study that Holstein dairy bovine （HD） mitochondrial DNA （mtDNA） haplotype compatibility between donor karyoplast and recipient cytoplast is crucial for SCNT embryo development, we performed intersubspecies SCNT using HD as donor karyoplast and Luxi yellow heifer （LY） as recipient cytoplast according to mtDNA haplotypes determined by polymerase chain reaction- restriction fragment length polymorphism （PCR-RFLP） analysis. The results demonstrated that intersubspecies mtDNA homotype SCNT embryos had higher pre- and post-implantation developmental competence than intrasubspecies mtDNA heterotype embryos as well as improved blastocyst reprogramming status, including normal H3K9 dimethylation pattern and promoter hypomethylation of pluripotent genes such as Oct4 and Sox2, suggesting that intersubspecies SCNT using LY oocytes maintains HD cloning efficiency and may reprogram HD nuclei to develop into a normal cloned animal ultimately. Our results indicated that karyoplast-cytoplast interactions and mtDNA haplotype compatibility may affect bovine intersubspecies SCNT efficiency. This study on bovine intersubspecies SCNT is valuable for understanding the mechanisms of mtDNA haplotype compatibility between karyoplast and cytoplast impacting the bovine SCNT efficiency, and provides an alternative and economic resource for HD cloning.

关键词： Somatic cell nuclear transfer (SCNT) Mitochondria mtDNA haplotype Epigenetic modification Bovine Intersubspecis Intrasubspecis Developmental competence

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基于主量元素地球化学的岩屑层位源解析

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煤炭学报 2024年第2期49卷 929-940页

作者：桂和荣李俊陈永青余浩王浩叶爽陈大星梁展胡洋郭艳许继影国家煤矿水害防治工程技术研究中心(宿州学院) 安徽宿州234000 安徽省矿井勘探工程技术研究中心安徽宿州234000 中国科学技术大学地球与空间学院安徽合肥230000 安徽恒源煤电股份有限公司安徽宿州234000

近年来,岩屑录井在“华北型”煤田底板灰岩层注浆加固工程中发挥了重要作用。然而,现有的岩屑录井仅停留在颜色、颗粒大小及形貌特征等物理指标的识别上,难以精准判层,钻孔设计“顺层率”难以保障,制约着底板灰岩水害区域治理效果。基... 详细信息

近年来,岩屑录井在“华北型”煤田底板灰岩层注浆加固工程中发挥了重要作用。然而,现有的岩屑录井仅停留在颜色、颗粒大小及形貌特征等物理指标的识别上,难以精准判层,钻孔设计“顺层率”难以保障,制约着底板灰岩水害区域治理效果。基于石炭纪太原组薄层灰岩及其碎屑岩夹层的元素地球化学差异特点,选取淮北煤田桃园煤矿为研究区,对太原组上段薄层灰岩L_(1)灰~L_(4)灰地层(注浆治理目的层为L_(3)灰)垂直钻孔岩心进行取样,利用X射线荧光光谱仪(XRF)定量测定了薄层灰岩及其夹层的主量元素背景值,通过聚类分析、因子分析等数理统计手段建立薄层灰岩主量元素地球化学识别模式;同时对地面定向钻水平分支孔岩屑同样开展主量元素测试,并基于已建立的地球化学识别模式进行岩屑层位源解析以及识别模式验证。结果显示:高CaO丰度、烧失量(LOI)可以作为注浆加固改造目的层L_(3)灰的特征指标,MgO(0.5%±)、MnO(0.03%±)、P_(2)O_(5)(0.08%±)丰度可作为注浆目的层上覆标志层J3的识别指标;聚类分析识别模式可有效区分太原组一灰~三灰(L_(1)灰~L_(3)灰);以元素因子得分建立的识别模式可以将太原组碎屑岩夹层与薄层灰岩进行有效区分;以岩样地球化学背景值运行判别模型得到的Fisher判别方程对注浆目的层L_(3)灰岩屑来源解析的准确率为100%。基于上述认识,论证了以确保设计“顺层率”为目标的水平分支孔岩屑地球化学源解析方法应用之可行性,进而提出了一种地面定向钻“顺层率”控制技术方案。本研究基于元素地球化学理论,对地面定向钻岩屑携带的特征地球化学信息进行了目的层层位辨识,在现场快速定量测试技术手段的支持下,可为解决华北型煤田底板灰岩水害区域注浆改造顺层难题提供了新的思路。

关键词：主量元素丰度地球化学识别模式顺层率太原组薄层灰岩底板灰岩水害区域治理

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Effects of Fe content on the microstructure and properties of CuN i10FeM n1 alloy tubes fabricated by HCCM horizontal continuous casting

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International Journal of Minerals,Metallurgy and materials 2016年第4期23卷 449-457页

作者： yan-bin Jiang jun Xu Xin-hua Liu Jian-xin Xie Key Laboratory for Advanced materials Processing of the Ministry of Education University of Science and Technology Beijing Beijing Laboratory of Metallic materials and Processing for Modern Transportation University of Science and Technology Beijing

Heating-cooling combined mold（HCCM） horizontal continuous casting technology developed by our research group was used to produce high axial columnar-grained CuN i10 FeM n1 alloy tubes with different Fe contents. The effects of Fe content（1.08wt%–2.01wt%） on the microstructure, segregation, and flushing corrosion resistance in simulated flowing seawater as well as the mechanical properties of the alloy tubes were investigated. The results show that when the Fe content is increased from 1.08wt% to 2.01wt%, the segregation degree of Ni and Fe elements increases, and the segregation coefficient of Ni and Fe elements falls from 0.92 to 0.70 and from 0.92 to 0.63, respectively. With increasing Fe content, the corrosion rate of the alloy decreases initially and then increases. When the Fe content is 1.83wt%, the corrosion rate approaches the minimum and dense, less-defect corrosion films, which contain rich Ni and Fe elements, form on the surface of the alloy; these films effectively protect the α-matrix and reduce the corrosion rate. When the Fe content is increased from 1.08wt% to 2.01wt%, the tensile strength of the alloy tube increases from 204 MPa to 236 MPa, while the elongation to failure changes slightly about 46%, indicating the excellent workability of the CuNi10FeMn1 alloy tubes.

关键词： copper nickel alloys iron content casting segregation mechanical properties corrosion resistance

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Memristive neuron model with an adapting synapse and its hardware experiments

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Science China(Technological Sciences) 2021年第5期64卷 1107-1117页

作者： BAO BoCheng ZHU YongXin ma jun BAO Han WU HuaGan CHEN Mo School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China Department of Physics Lanzhou University of TechnologyLanzhou 730050China

Electromagnetic induction effect caused by neuron potential can be mimicked using *** paper considers a fluxcontrolled memristor to imitate the electromagnetic induction effect of adapting feedback synapse and presents a memristive neuron model with the adapting *** memristive neuron model is three-dimensional and *** has the time-varying equilibria with multiple stabilities,which results in the global coexistence of multiple firing *** numerical plots are executed to uncover diverse coexisting firing patterns in the memristive neuron ***,a nonlinear fitting scheme is raised and a fitting activation function circuit is employed to implement the memristive mono-neuron *** coexisting firing patterns are observed from the hardware experiment circuit and the measured results verify the numerical simulations well.

关键词： memristor neuron model coexisting firing patterns nonlinear fitting scheme hardware experiment

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Diffusion of Acetic Acid Across Oil/Water Interface in Emulsification-Internal Gelation Process for Preparation of Alginate Gel Beads

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Chemical Research in Chinese Universities 2007年第5期23卷 579-584页

作者： LIU Xiu-dong YU Wei-ting LIN jun-zhang ma Xiao-jun YUAN Quan Laboratory of Biomedical material Engineering Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 P. R. China College of Environment and Chemical Engineering Dalian University Dalian 116622 P. R. China

Alginate has been widely used in cell microencapsulation and drug delivery systems in the form of gel beads or *** an alternative novel emulsification-internal gelation technology has been established and both the properties and the potential applications of the beads in drug delivery systems have been studied,the mechanism has not been well understood compared with the traditional droplet method（external gelation technology）.On the basis of our previous knowledge that the novel technology is composed of complicatedly consecutive processes with multistep diffusion and reaction,and the diffusion of acetic acid across oil/water interface being the prerequisite that determines the occurrence and rate for the reactions and the structures and properties of final produced gel beads,a special emphasis was placed on the diffusion *** the aid of diffusion modeling and simple experimental design,the diffusion rate constant and diffusion coefficient of acetic acid across oil/water interface were determined to be in the orders of magnitude of 10-6 and 10-16,*** knowledge will be of particular importance in understanding and interpreting the formation,structure of the gel beads and the relationship between the structure and properties and guiding the preparation and quality control of the gel beads.

关键词： Emulsification-internal gelation technology Alginate Gel bead Diffusion rate constant Diffusion coefficient

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金砖五国药物国际贸易政策及对中国的启示

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中国卫生政策研究 2024年第4期17卷 65-71页

作者：刘佐坤马望尧顾亦梧张雨阳马继炎庞明樊孙一诺黄旸木北京大学公共卫生学院北京100191 北京大学医学人文学院北京100191 中国疾病预防控制中心北京102206 北京大学全球健康发展研究院北京100191

本文采用政策文本分析法,基于金砖五国相关政策文本,旨在比较分析其药物国际贸易政策目标、发展及成效。金砖五国药物国际贸易政策的主要目标为保障药物供应的持续性、营造良好的国际贸易环境以及扩大本国药物出口。围绕上述目标,巴西... 详细信息

本文采用政策文本分析法,基于金砖五国相关政策文本,旨在比较分析其药物国际贸易政策目标、发展及成效。金砖五国药物国际贸易政策的主要目标为保障药物供应的持续性、营造良好的国际贸易环境以及扩大本国药物出口。围绕上述目标,巴西、俄罗斯与南非均通过大量进口药物保障药物供应,同时采取了专利强制许可、推动外企本土化等手段减少进口依赖;印度通过抵制进口保护本土产业以保障药物供应,同时推动医药产品出口;中国则不断优化审批与监管程序,以营造良好贸易环境并扩大出口。中国应在确保国内药物研发与供应性自主性的同时,进一步完善药物国际贸易政策,更好地在金砖国家形成合力,推动全球公共医药产品的可及性。

关键词：金砖国家药物政策国际贸易全球卫生

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Static softening behaviors of 7055 alloy during the interval time of multi-pass hot compression

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Rare Metals 2013年第3期32卷 241-246页

作者： Liang-Ming yan Jian Shen jun-Peng Li Bai-Ping mao School of materials Science and Engineering Innermongolia University of Technology Department of Processing Business General Research Institute for Nonferrous Metals Science and Technology Department Aluminum Corporation of China Limited

Multipass plain strain compression test of 7055 alloy was carried out on Gleeble 1500D thermomechanical simulator to study the effect of interval time on static softening behavior between two passes. Microstructural features of the alloy deformed with delay times varying from 0 to 180 s after achieving a reduction of ,-~52 % in the 13 stages was investigated through TEM and EBSD observations. The 14th pass of peak stresses after different delay times were gained. The peak stress decreases with the interstage delay time increasing, but the decreasing trend is gradually slower. Static recovery, metadynamic recrystallization, and/or static recrystallization can be found in the alloy during two passes. The recovery and recrystallization degree increases with longer interstage delay time. The static recovery is the main softening mechanism. Subgrain coalescence and subgrain growth together with particle-stimulated nucleation are the main nucleation mechanisms for static recrystallization.

关键词： 7055 aluminum alloy Hot compression Microstructure Interval time

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