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丹参川芎嗪注射液联合阿替普酶静脉溶栓对急性脑梗死患者血液流变学及神经功能的影响

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蛇志 2019年第1期31卷 111-112,115页

作者：闫卫静河南省鹤壁市人民医院脑卒中中心二病区河南鹤壁458030

目的探讨阿替普酶联合丹参川芎嗪注射液静脉溶栓治疗急性脑梗死的效果及对患者神经功能及血液流变学的影响。方法将97例急性脑梗死患者按抽签法分为两组,单药组48例给予阿替普酶静脉溶栓和常规治疗,联合组49例在对照组的基础上加用丹参... 详细信息

目的探讨阿替普酶联合丹参川芎嗪注射液静脉溶栓治疗急性脑梗死的效果及对患者神经功能及血液流变学的影响。方法将97例急性脑梗死患者按抽签法分为两组,单药组48例给予阿替普酶静脉溶栓和常规治疗,联合组49例在对照组的基础上加用丹参川芎嗪注射液治疗,治疗2周后,比较两组患者的临床疗效及血液流变学情况。结果治疗2周末,联合组患者的纤维蛋白原、全血高切黏度、全血低切黏度、血细胞比容血小板聚集率及乏力气短、半身不遂、脉细弱、口眼斜等症状评分均低于单药组。治疗总有效率高于单药组,组间比较差异均有统计学意义(均P<0.05)。结论阿替普酶联合丹参川芎嗪注射液治疗急性脑梗死能明显改善患者神经功能及血流动力学指标。

关键词：丹参川芎嗪注射液急性脑梗死阿替普酶血液流变学神经功能

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不同产地加工炮制方法对栀子质量的影响

中国中药杂志 2018年第16期43卷 3285-3290页

作者：梁献葵王艳慧雷敬卫谢彩侠唐维维杜婷婷河南中医药大学

通过测定栀子中指标性成分的含量，考察不同产地加工方法对栀子药材质量的影响，确定栀子产地加工炮制最佳煮制时间。测定不同产地加工炮制品存放前、存放半年后、存放一年后栀子中栀子苷、西红花苷 I、总环烯醚萜苷的含量。在存放过程... 详细信息

通过测定栀子中指标性成分的含量，考察不同产地加工方法对栀子药材质量的影响，确定栀子产地加工炮制最佳煮制时间。测定不同产地加工炮制品存放前、存放半年后、存放一年后栀子中栀子苷、西红花苷 I、总环烯醚萜苷的含量。在存放过程中：直接烘干栀子中栀子苷、西红花苷 I、总环烯醚萜苷的含量变化范围依次为1．68％，0．45％，6．45％；不同蒸制时间栀子中栀子苷、西红花苷 I、总环烯醚萜昔的含量变化范围依次为1．34％～0．5％，0．28％～0．06％，6．09％～1．59％；不同水煮（加明矾）时间栀子中栀子苷、西红花苷 I、总环烯醚萜苷的含量变化范围依次为1．42％～0．41％，0．35％～0．07％，6．40％～1．65％。栀子采摘后直接烘干不能达到杀酶保苷的作用，栀子产地加工炮制蒸制的时间13min、水煮（加明矾）8min后，指标性成分降解的酶类基本被破坏，达到杀酶保苷的作用。

关键词：栀子产地加工含量测定杀酶保苷

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou wei yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： Ultraviolet photoelectron spectroscopy

养正消积胶囊对晚期结肠癌化疗减毒作用及生活质量的影响

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中国现代医学杂志 2015年第28期25卷 98-101页

作者：魏艳静卞红磊河北医科大学实验诊断教研室河北石家庄050017 河北医科大学第三医院肛肠科河北石家庄050051

目的探讨养正消积胶囊对晚期结肠癌化疗减毒作用及生活质量的影响。方法将2012年4月-2014年5月在该院接受治疗的90例晚期结肠癌患者纳入研究对象,采用数字表法随机分为接受养正消积胶囊联合FOLFOX化疗的观察组和接受FOLFOX化疗的对照组... 详细信息

目的探讨养正消积胶囊对晚期结肠癌化疗减毒作用及生活质量的影响。方法将2012年4月-2014年5月在该院接受治疗的90例晚期结肠癌患者纳入研究对象,采用数字表法随机分为接受养正消积胶囊联合FOLFOX化疗的观察组和接受FOLFOX化疗的对照组。比较两组患者的营养状况、免疫功能以及生活质量。结果治疗后4周时,观察组血红蛋白及清蛋白含量分别为(118.31±13.43)和(43.21±5.75)g/L,上臂肱三头肌皮褶厚度、上臂围及上臂肌围分别为(1.29±0.21)、(26.95±3.84)及(23.55±3.02)cm,CD4+含量(38.34±5.91),Ig G、Ig A及Ig M分别为(15.58±2.25)、(2.99±0.36)及(1.63±0.20)g/L,水平均明显高于对照组,CD8+含量(20.95±3.51),明显低于对照组;物质生活维度、躯体健康维度、心理健康维度及社会功能维度评分分别为(55.15±6.62)、(62.88±7.91)、(65.95±8.13)及(62.52±6.87),均明显高于对照组患者。结论养正消积胶囊有助于改善机体的营养状况和免疫功能,提高整体生存质量,是晚期结肠癌化疗时理想的减毒治疗方法。

关键词：结肠癌养正消积胶囊毒副作用生活质量免疫功能

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma jing wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang wei Ming Longfu Chen Tianliang Song Moxi Yele Hao Zhang Long yang Gegen Sarula Benliang Liang Luting yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

Deliberate design of MOF-based pre-catalyst rationalizing the structural reconstruction toward efficient oxygen evolution reaction

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Science China Chemistry 2025年

作者： Yunhui Chen Meng Tian Zhongqi Zhang Guangzhao Wang yan Guo jing Wu Dawei Qi Zhenhua yan Xiangyu Liu Xi Liu State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia University Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information Engineering Yangtze Normal University Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) State Key Laboratory of Advanced Chemical Power Sources College of Chemistry Nankai University School of Chemistry and Chemical Engineering In-situ Center for Physical Sciences Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University

Metal-organic frameworks （MOFs）,that have emerged as promising electrocatalysts in oxygen evolution reaction （OER）,usually undergo structural reconstruction to form metal hydroxides as active ***,it remains a great challenge to design and synthesize ideal MOF-based pre-catalysts for properly cognizing and utilizing the reconstruction process toward efficient OER ***,the well-defined MOF-808 is post-modified by 2-hydroxyphosphonoacetic acid （HPAA） to form a micro-adsorber that enables to capture of metal ions ***3+and Ni2+ions are synergistically anchored into the microadsorber,developing a Fe/Ni-containing pre-catalyst that can be dynamically electrooxidized to be an active and stable dual-site electrocatalyst denoted by R-MOF-HPAA@FeNi with abundant metal *** a result,R-MOF-HPAA@FeNi exhibits an excellent OER performance with a low overpotential of 272 mV and Tafel slope of 35.9 m V dec-1,as well as long-term stability over 300 h at 10 m A *** and theoretical calculations suggest the resulting catalyst mainly follows a lattice oxygen mechanism （LOM） of dual-metal-site mechanism （DMSM）.Owing to the chelating role of HPAA,the post-synthesized MOF-HPAA behaves as a trap to uniformly and firmly adhere Fe3+and Ni2+ions,leading to a functionalized MOF-based pre-catalyst which can be structurally evolved into atomic level-distributed OER electrocatalysts.

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变速恒频双馈风电机控制与全功率试验分析

仪器仪表用户 2009年第3期16卷 63-65页

作者：井延伟田沛华北电力大学自动化系保定071003

近年来,风力发电机组容量不断增大,提高运行效率、最大程度地利用风能已经成为风电技术研究的重要内容。可实现最大风能追踪的变速恒频双馈风电技术成为目前工程研究的热点。全功率试验是指在地面上建立针对双馈式风电机组进行各种型式... 详细信息

近年来,风力发电机组容量不断增大,提高运行效率、最大程度地利用风能已经成为风电技术研究的重要内容。可实现最大风能追踪的变速恒频双馈风电技术成为目前工程研究的热点。全功率试验是指在地面上建立针对双馈式风电机组进行各种型式试验的功率试验平台,该试验平台要求能够达到风电机组的额定功率输出。在该试验台上可以对风电机组的发电机、变流器、控制系统等部件进行全面的检测和试验分析。

关键词：风力发电变速恒频双馈式风电机全功率试验

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基于虚拟样机技术的车辆平顺性研究

计算机仿真 2012年第5期29卷 333-337页

作者：丁金刚黄志刚严凌闫伟静北京工商大学材料与机械工程学院北京100048 北京理工大学机械与车辆学院北京100081

研究某轿车动力学模型优化,多体动力学理论,采用虚拟样机技术,对车辆行驶的平顺性,建立包含前后悬架、转向系统、车轮、制动系统、车身等在内的整车多体动力学虚拟样机模型,依据国家标准,在ADAMS/Car Ride中成功地对轿车进行脉冲输入和... 详细信息

研究某轿车动力学模型优化,多体动力学理论,采用虚拟样机技术,对车辆行驶的平顺性,建立包含前后悬架、转向系统、车轮、制动系统、车身等在内的整车多体动力学虚拟样机模型,依据国家标准,在ADAMS/Car Ride中成功地对轿车进行脉冲输入和随机路面输入的平顺性仿真,得到的数据输入到MATLAB编制的平顺性评价程序中。对比结果表明,车平顺性较好。在此基础上,并将整车模型简化为二自由度1/4车辆模型,在Matlab/Simulink上建立振动模型,分析了悬架刚度、阻尼比、轮胎刚度对车辆平顺性的影响,得出车身加速度随悬架刚度、阻尼比及轮胎动载荷变化的规律。

关键词：车辆平顺性脉冲输入随机路面