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Phosphorylation of SiRAV1 at Ser31 regulates the SiCAT expression to enhance salt tolerance in Setaria italica

Journal of Integrative Agriculture 2023年第12期22卷 3638-3651页

作者： LI Qiao-lu LI Zhi-yong WANG Meng-meng yan jing-wei FANG Lin Guangdong Provincial Key Laboratory of Applied Botany/South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650P.R.China Institute of Millet Crops Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050000P.R.China Nanjing Institute of Environmental Science Ministry of Ecology and EnvironmentNanjing 210042P.R.China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300P.R.China

Salinity severely affects plant growth and ***,it is crucial to identify the genes functioning in salt stress response and unravel the mechanism by which plants against salt *** study used the phosphoproteomic assay and found that 123 of the 4000 quantitative analyzed phosphopeptides were induced by salt *** functional annotation of the non-redundant protein database(NR)showed 23 differentially expressed transcription factors,including a phosphopeptide covering the Serine 31 in the RAV(related to ABI3/VP1)transcription factor(named SiRAV1).SiRAV1 was located in the *** and physiological analysis showed that overexpressing SiRAV1 in foxtail millet enhanced salt tolerance and alleviated the salt-induced increases of H_(2)O_(2) accumulation,malondialdehyde(MDA)content,and percent of electrolyte *** analysis showed that SiRAV1 positively regulated SiCAT expression to modulate the catalase(CAT)activity by directly binding to the SiCAT promoter in vivo and in ***,we found that phosphorylation of SiRAV1 at the Ser31 site positively regulated salt tolerance in foxtail millet via enhancing its binding ability to SiCAT promoter but did not affect its subcellular ***,our results define a mechanism for SiRAV1 function in salt response where salt-triggered phosphorylation of SiRAV1 at Ser31 enhances its binding ability to SiCAT promoter,and the increased SiCAT expression contributes to salt tolerance in foxtail millet.

关键词： foxtail millet salt stress phosphoproteomic SiRAV1 SiCAT

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Long term clinical outcomes in patients with moderate renal insufficiency undergoing stent based percutaneous coronary intervention

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Chinese Medical Journal 2006年第14期119卷 1176-1181页

作者： ZHANG Rui-yan NI jing-wei ZHANG Jian-sheng HU Jian yanG Zhen-kun ZHANG Qi LUE An-kang SHEN wei-feng Department of Cardiology Shanghai Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025

Background Patients with end-stage renal disease have a high mortality from coronary artery disease, but the impact of moderate renal insufficiency on clinical outcomes after percutaneous coronary intervention （PCI） and the effect of drug-eluting stent implantation in these patients remain unclear. This study determined the long-term effect of moderate renal insufficiency on death and major adverse cardiac events （MACE） after stent based PCI and examined whether drug-eluting stent implantation could favourably influence clinical outcome. Methods Major adverse cardiac events and causes of mortality were determined for 1012 patients undergoing percutaneous intervention from January 1, 2002 to December 31, 2004 at Shanghai Ruijin Hospital. Based on estimated creatinine clearance levels, long term outcomes were compared between patients with estimated creatinine clearance 〈60 ml/min （renal insufficiency group; n=410） and those with estimated creatinine clearance ≥60 ml/min （control group; n=602）. Subgroup analysis was also made for patients with renal insufficiency between drug eluting stent （n=264） and bare metal stent implantation （n=146） during PCI. Results During follow-up （average 17 months） after successful PCI, all causes of death （7.1% vs 2.3%, P〈0.01） and cardiac death （3.4% vs 1.0%, all P〈0.01） were significantly higher in renal insufficiency group than in control group. For patients with moderate renal insufficiency, drug-eluting stent implantation reduced significantly all causes of death （5.3% vs 10.9%, P〈0.05） and occurrence of major cardiac adverse events （15.1% vs 24.6%, P〈0.05） compared with bare metal stents. Conclusions Moderate renal insufficiency is an important clinical factor influencing the mortality after PCI in patients with coronary artery disease and the use of drug-eluting stents should be the preferred therapy for the improvement of long-term outcomes in such patients.

关键词： long term outcome percutaneous coronary intervention renal insufficiency drug eluting stent

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Cloud Services Optimization Problem on Energy Utility Resource Allocation

Cloud Services Optimization Problem on Energy Utility Resour...

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第26届中国控制与决策会议

作者： Ming-hai Jiao Ping yan Chen Li Qiang Wang yan-jing wei Computing Center Northeastern University College of Information Science and Engineering Northeastern University School of Economics and Management Shenyang Aerospace University

In this paper, the cloud services optimization problem considering energy consumption cost is discussed. The queue model is presented for customer request service on data center. Since the server energy utility is based on the CPU core frequency, the novel trade-off optimization model between services revenue and energy loss cost is proposed in the paper, including allocating the dynamic CPU frequency of server. The HPSO algorithm is proposed for solving the mixed integer programming model. Then novel particle encoding substituting discrete variables and continuous variables efficiently improves solution quality. Finally, the dynamic penalty function method is discussed to convert the constraint optimization problem to non-constraint optimization problem.

关键词： Cloud Services Resource Allocation Energy Utility Particle Swarm Optimization

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电动汽车一体化驱动系统三相3H桥逆变器的故障相短接容错控制策略

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电机与控制学报 2016年第11期20卷 107-116页

作者：孙鹤旭张厚升井延伟河北工业大学控制科学与工程学院天津300130 山东理工大学电气与电子工程学院淄博255049

具有车载型充电器的电动汽车拥有相互独立的电机驱动系统与电池充电装置,针对两套装置并不同时工作,成本高、重量大、占据空间资源较大等问题,提出了一种电动汽车驱动与充电一体化的新型拓扑结构,在牵引模式下该一体化拓扑的主要驱动模... 详细信息

具有车载型充电器的电动汽车拥有相互独立的电机驱动系统与电池充电装置,针对两套装置并不同时工作,成本高、重量大、占据空间资源较大等问题,提出了一种电动汽车驱动与充电一体化的新型拓扑结构,在牵引模式下该一体化拓扑的主要驱动模块等效于一个三相3H桥逆变器。研究该逆变器的电压空间矢量与消除共模电压的控制策略,分析开绕组PMSM在不同坐标系下的数学模型,给出逆变器发生桥臂开关管开路或者短路故障时将故障相短接的重构拓扑与容错控制策略,在转速、电流双闭环控制的基础上,设计"重复控制+PI"的电流内环控制方案,提出一种两相SVPWM控制策略,分析三相2H桥逆变器电压矢量状态切换过程,提出一种改进的七段式两相SVPWM控制策略。仿真和实验结果表明,如果三相3H桥逆变器发生短路故障,一体化系统通过逆变器的拓扑重构,能够实现PMSM系统的良好运行性能。

关键词：电动汽车三相3H桥逆变器三相2H桥 PMSM SVPWM 短路故障

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酸枣仁黄酮部位不同配伍的解郁安神作用及谱-效相关性分析

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中草药 2018年第5期49卷 1123-1131页

作者：宋伟唐生安曹冰雁符敬伟乔卫天津医科大学药学院天津市临床药物关键技术重点实验室天津300070

目的建立酸枣仁黄酮部位不同配伍的HPLC指纹图谱,研究其与解郁安神功效的谱效关系。方法采用Spearman分析、灰色关联度分析、多元回归分析方法将HPLC指纹图谱中各组分特征峰的峰面积与小鼠行为学指标数据相关联。结果酸枣仁黄酮部位HPL... 详细信息

目的建立酸枣仁黄酮部位不同配伍的HPLC指纹图谱,研究其与解郁安神功效的谱效关系。方法采用Spearman分析、灰色关联度分析、多元回归分析方法将HPLC指纹图谱中各组分特征峰的峰面积与小鼠行为学指标数据相关联。结果酸枣仁黄酮部位HPLC指纹图谱中与药效有较强相关性的成分有5个,分别为维采宁-Ⅱ、牡荆素葡萄糖苷、斯皮诺素、6′″-阿魏酰斯皮诺素、6′″-对羟基苯甲酰斯皮诺素。结论通过谱-效相关性分析,推测出酸枣仁黄酮部位发挥抗抑郁、镇静催眠作用的有效成分,为酸枣仁有效成分筛选及质量控制方法的建立提供了依据。

关键词：酸枣仁黄酮谱效关系维采宁-Ⅱ 牡荆素葡萄糖苷斯皮诺素 6′″-阿魏酰斯皮诺素 6′″-对羟基苯甲酰斯皮诺素

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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专利制度焦点变迁及其演进协同管理研究

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经济体制改革 2017年第2期 107-113页

作者：魏延辉魏静张慧颖山东工商学院工商管理学院天津大学管理与经济学部天津大学教育学院

本文分析了主要发达国家和发展中国家专利制度发展概况,总结了各国专利制度从特色到融合的动态演进过程特点,提出目前专利制度协同管理主线,包括:专利申请数量与专利申请质量协同;专利制度国家特色与国际标准的协同;专利制度与产业政策... 详细信息

本文分析了主要发达国家和发展中国家专利制度发展概况,总结了各国专利制度从特色到融合的动态演进过程特点,提出目前专利制度协同管理主线,包括:专利申请数量与专利申请质量协同;专利制度国家特色与国际标准的协同;专利制度与产业政策及区域政策的协同;专利存量的利用与专利增量的开发协同等。从差异中走向融合,在融合中保持差异,可以大略概括为世界专利制度的改革走向,这为中国专利制度协同发展提供了参考。

关键词：专利制度动态演进融合协同管理

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen wei Yufei Mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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基于谱相减改进算法的语音增强研究

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铁道学报 2004年第1期26卷 64-67页

作者：徐岩杨静王维汉兰州交通大学信息与电气工程学院甘肃兰州730070

根据传统的谱相减增强型算法 ,提出了抑制噪声的谱减改进算法 ,暨根据带噪语音帧频谱功率与噪声帧频谱功率比值 ,动态调整α、β谱减系数 ,使之谱减效果在较大提高信噪比的同时 ,又能将残留的音乐噪声和语音失真保持在人耳听觉的容忍范... 详细信息

根据传统的谱相减增强型算法 ,提出了抑制噪声的谱减改进算法 ,暨根据带噪语音帧频谱功率与噪声帧频谱功率比值 ,动态调整α、β谱减系数 ,使之谱减效果在较大提高信噪比的同时 ,又能将残留的音乐噪声和语音失真保持在人耳听觉的容忍范围之内 ,保证原始语音信号质量达到一定的可懂度和清晰度。借助MATLAB语言进行试验仿真 ,仿真结果与原算法相比较。

关键词：语音增强谱相减算法噪声抑制

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电源滤波器抑制阻尼振荡波的试验研究

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电力自动化设备 2006年第4期26卷 47-49,97页

作者：由建刘洋井延伟谷雪松华北电力大学电气工程学院河北保定071003 华北电力大学自动化系河北保定071003

针对变电站一次回路开关操作产生的暂态干扰,分析电源滤波器的插入损耗和特征阻抗,进行电源滤波器抑制阻尼振荡波抗扰度试验,研究了电源滤波器在抑制开关操作引起的电磁干扰方面的作用,为在变电站电磁环境内选用电源滤波器提供了参考。

关键词：开关操作阻尼振荡波电源滤波嚣

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