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Toripalimab combined with targeted therapy and chemotherapy achieves pathologic complete response in gastric carcinoma:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6184-6191页

作者： Rui Liu Xia Wang Zhi Ji Ting Deng Hong-Li Li yan-hui zhang Yu-Chong yang Shao-Hua Ge Le zhang Ming Bai Tao Ning Yi Ba National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300000China

BACKGROUND Neoadjuvant or perioperative chemotherapy combined with surgery can reduce postoperative recurrence and improve the long-term survival rate of patients with locally advanced resectable gastric *** combined with chemotherapy has been recommended by the National Comprehensive Cancer Network guidelines as a first-line therapy for advanced gastric carcinoma/adenocarcinoma of the gastroesophageal junction and serves as the basis for immunotherapy combined with chemotherapy to become a neoadjuvant ***,we report a case in which pathologic complete response was achieved by neoadjuvant administration of toripalimab,Herceptin,and docetaxel,oxaliplatin,calcium folinate,and fluorouracil(FLOT)chemotherapy followed by surgery for human epidermal growth factor receptor 2(HER2)-and programmed deathligand 1(PD-L1)-positive locally advanced gastric *** hope that this case will shed some light on neoadjuvant therapy for gastric *** SUMMARY The patient was diagnosed with locally advanced adenocarcinoma of the *** of the baseline tissues suggested that the tissues were HER2-(fluorescent in situ hybridization)and PD-L1-positive(combined positive score=1).The patient underwent surgery following a four-cycle neoadjuvant therapy comprising Herceptin,toripalimab,and FLOT *** postoperative pathological findings showed mild atypical hyperplasia of the local glands with chronic mucosal inflammation(proximal stomach),no clear residual tumor(tumor regression grade 0),no regional lymph node metastasis,and negative upper and lower cut *** levels of tumor markers were reduced to normal levels after *** good postoperative recovery,the four-cycle preoperative chemotherapy was continued at the same dosage as that previously *** the treatment,the patient was monitored every 3 mo with a follow-up of 12 mo(4 times).As of February 27,2022,he was in a good condition without dise

关键词： Toripalimab Targeted therapy Chemotherapy Perioperative management Gastric carcinoma Case report

Left-invariant metrics on a class of solvable Lie Groups

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Acta Mathematica Sinica,English Series 2024年

作者： Zhi Qi CHEN Ke yan hui zhang School of Mathematics and Statistics Guangdong University of Technology College of Science National University of Defense Technology School of Mathematics Southeast University

Left-invariant Riemannian metrics on Lie groups G_(RHn-1)×R and GRH2×Rn-2（n ≥ 3） have been classified by Hiroshi, Takahara and Tamaru. It is easily seen that G_(RHn-1)×R and GRH2×Rn-2（n ≥ 3） have the same automorphism group, which is denoted by L_n. In this paper, we first classify n-dimensional simply connected Lie groups with automorphism group L_n, then we classify the leftinvariant Riemannian metrics on such Lie groups. As an application, we get the m-quasi Einstein metrics.

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Potential Anti-cancer Activity of Furanodiene

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Chinese Journal of Cancer Research 2009年第2期21卷 154-158页

作者： Zhen-zhen Ba yan-ping Zheng hui zhang Xiu-yan Sun Dong-hai Lin School of Pharmaceutical Science Yantai University Yantai 264005 China

Objective： To study the isolated from the essential oil VIVO anti-tumor activities of furanodiene of the rhizome of Curcuma wenyujin （C15H200）, a primary sesquiterpene compound YH Chen et C. Ling（Wen Ezhu）, in vitro and in Methods： In vitro MTT assay was used to further study the effects of time and dosage on anti-proliferation of furanodiene against the sensitive Hela, Hep-2, HL-60, U251 cells, based on the cytotoxic effects of furanodiene on 12 human malignant tumor cell lines with the essential oil of Wen Ezhn as control., and the half-inhibitory concentration （IC50） was observed. In vivo uterine cervix （U14） tumor cell was selected and the conventional assay method of anti-tumor activity was employed. Furanodiene liposome was administered intraperitoneally, and tumor-inhibitory rate, thymus and spleen indexes were observed. Results： The inhibitive effects on cell proliferation were shown in all of the twelve cell lines and the cytotoxic effects of furanodiene against Hela, Hep-2, HL-60, U251 cells were observed after 12 h of administration, the effect could last for at least 48 h in a dose dependent manner, and the IC50 values were 0.6, 1.7, 1.8, 7.0μg/ml, respectively. Furanodiene was also found to show inhibitive effects on the proliferation of uterine cervix （U14） tumor induced in mice. The tumor inhibition rates were 36.09% （40 mg/kg）, 41.55% （60 mg/kg）, 58.29% （80 mg/kg）, respectively. Conclusion： Furanodiene is one of primary anti-cancer active components in the essential oil of Wen Ezhu, and also a very effective agent against uterine cervix cancer, and has protection effect on the immune function.

关键词： Essential oil of Wen Ezhu Furanodiene Anti-cancer Uterine cervix cancer

The Sasa-Satsuma equation with high-order discrete spectra in space-time solitonic regions:soliton resolution via the mixed■-Riemann-Hilbert problem

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Communications in Theoretical Physics 2024年第6期76卷 13-25页

作者： Minghe zhang Zhenya yan KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

In this paper,we investigate the Cauchy problem of the Sasa-Satsuma(SS)equation with initial data belonging to the Schwartz *** SS equation is one of the integrable higher-order extensions of the nonlinear Schrödinger equation and admits a 3×3 Lax *** the aid of the■nonlinear steepest descent method of the mixed■-Riemann-Hilbert problem,we give the soliton resolution and long-time asymptotics for the Cauchy problem of the SS equation with the existence of second-order discrete spectra in the space-time solitonic regions.

关键词： Sasa-Satsuma equation inverse scattering ■-Riemann-Hilbert problem ■steepest descent method soliton resolution

USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

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当代医学科学（英文） 2024年第4期44卷 707-717页

作者： Xiao-hui yan Yin-na ZHU yan-ting ZHU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of Nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China Nephrology and Hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective:Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of high glucose(HG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods:HK-2 cells were exposed to a combination of HG and ***19 mRNA expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2'-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** USP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and ***:In HG+FFA-challenged HK-2 cells,USP19 was highly ***19 knockdown attenuated HG+FFA-triggered growth inhibition and apoptosis promotion in HK-2 ***,USP19 knockdown alleviated HG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROS)generation in HK-2 ***,USP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the USP19 knockdown-mediated phenotypic changes and PINKl/Parkin pathway activation in HG+FFA-challenged HK-2 ***:The findings revealed that USP19 plays a crucial role in promoting HK-2 cell dysfunction induced by combined stimulation with HG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： HK-2 cells USP19 deubiquitination dysfunction free fatty acid high glucose

Enhanced degradation of florfenicol by microscale SiC/Fe:Dechlorination via hydrogenolysis

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Chinese Chemical Letters 2024年第7期35卷 218-221页

作者： Yun-Fei zhang Chun-hui zhang Jian-hui Xu Lei Li Dan Li Jin-Hong Fan Jiale Gao Xin Quan Qi Wu Yue Zou yan-Ling Liu Dongguan University of Technology School of Environment and Civil EngineeringDongguan 523830China State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Herein,the degradation of florfenicol(FLO)over zero-valent iron(ZVI)enhanced by SiC was systematically *** was found that 5 g/L of ZVI/SiC(1:3)at pH 3.0 could completely degrade 20 mg/L of FLO within 1 h,with a Kobsvalue of 0.0873 min^(-1),12.5 times greater than that of pure ZVI(0.0069 min^(-1)).Vibrating sample magnetometer(VSM)characterizations revealed that the use of SiC supporter reduces the magnetic intensity of ZVI,which mitigates iron particle agglomeration,increases Brunauer-Emmett-Teller(BET)surface area,and enhances FLO degradation ***,ZVI/SiC exhibits a much lower hydrogen evolution potential(HEP)and significantly higher corrosion currents compared to pure *** was proposed to undergo degradation via reductive dechlorination,involving a hydrogenolysis mechanism that entails the cleavage of theσ*** study provides new insights into the reduction hydrogenation mechanism of ZVI.

关键词： Zero-valent iron Silicon carbide Reductive dechlorination Hydrogenolysis Florfenicol

Dual-curvilinear beam enabled tunable manipulation of high-and low-refractive-index particles

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Photonics Research 2024年第7期12卷 1427-1436页

作者： ZHENG YUAN CHENCHEN zhang YUAN GAO WENXIANG yan XIAN LONG ZHI-CHENG REN XI-LIN WANG JIANPING DING hui-TIAN WANG National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Collaborative Innovation Center of Solid-State Lighting and Energy-Saving Electronics Nanjing 210093China

We present an innovative approach for the simultaneous agile manipulation of high-refractive-index(HRI) and low-refractive-index(LRI) particles. Our method involves introducing a dual-curvilinear optical vortex beam(DC-OVB) generated by superimposing a pair of curved beams: HRI and LRI particles are controlled by the bright curve and the dark channel between the two curves, respectively. The proposed DC-OVB provides customizable motion paths and velocities for both LRI and HRI particles. Each curve of the DC-OVB can support a distinct orbital flow density(OFD), enabling the application of torques to HRI and LRI particles, guiding them to orbit along specified trajectories and prompting them to execute various curvilinear motions simultaneously,including curvilinear movement, revolution, and rotation.

关键词： tunable refractive beam

Dynamics of a Reaction-diffusion-ODE System in a Heterogeneous Media

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 275-301页

作者： Cong-hui zhang Hai-feng zhang Mei-rong zhang School of Science Beijing University of Civil Engineering and ArchitectureBeijing 102616China Institute of Applied System Analysis Jiangsu UniversityZhenjiang 212013China Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China

The existence and stability of stationary solutions for a reaction-diffusion-ODE system are investigated in this *** first show that there exist both continuous and discontinuous stationary *** a good understanding of the stability of discontinuous stationary solutions is gained under an appropriate *** addition,we demonstrate the influences of the diffusion coefficient on stationary *** results we obtained are based on the super-/sub-solution method and the generalized mountain pass ***,some numerical simulations are given to illustrate the theoretical results.

关键词： reaction-diffusion-ODE system discontinuous stationary solutions stability asymptotic behavior monotone solutions

Effect of dissolved-oxygen on the flotation behavior of pyrite at high altitude area

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2148-2158页

作者： yan Miao Guangke Ye Guofan zhang School of Minerals Processing and Bio-engineering Central South UniversityChangsha 410083China

With the continuous development of mineral resources to high altitude areas,the study of sulfide ore flotation in unconventional systems has been *** is a consensus that moderate oxidation of sulfide ore is beneficial to flotation,but the specific suitable dissolved oxygen value is inconclusive,and there are few studies on sulfide ore flotation under low dissolved oxygen environment at high *** this paper,we designed and assembled an atmosphere simulation flotation equipment to simulate the flotation of pyrite at high altitude by controlling the partial pressure of N_(2)/O_(2) and dissolved oxygen under atmospheric conditions.X-ray photoelectron spec-troscopy(XPS),atomic force microscope(AFM),Fourier transform infrared spectrometer(FT-IR),UV-vis spectrophotometer,zeta po-tential,and contact angle measurements were used to reveal the effects of surface oxidation and agent adsorption on pyrite at high altitude(4600 m dissolved oxygen(DO)=4.0 mg/L).The results of pure mineral flotation indicated that the high altitude and low dissolved oxy-gen environment is favorable for pyrite *** angle measurements and XPS analysis showed that the high altitude atmosphere nslows down the oxidation of pyrite surface,facilitates S_(n)^(2-)/S^(0) production and enhances surface *** calcula-tions and zeta potential analysis showed that the influence of atmosphere on the form of pyrite adsorption is small,and the different atmo-spheric conditions are consistent with dixanthogen electrochemical adsorption,with lower Zeta potential under high altitude atmosphere and significant potential shift after sodium isobutyl xanthate(SIBX)*** results of FT-IR,UV-vis,and AFM analysis showed that SIBX adsorbed more on the surface of pyrite under high altitude atmosphere and adsorbed on the surface in a mesh structure com-posed of column/*** results of the experimental study revealed the reasons for the easy flotation of sul

关键词： high altitude dissolved-oxygen pyrite flotation oxidation