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MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer

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Chinese Journal of Cancer 2011年第1期30卷 54-61页

作者： Jian-Ping Cheng Ying yan Xiang-Yi Wang yuan-Li Lu yan-hua yuan Jun Jia Jun Ren Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology Department of Medical Oncology Beijing Cancer Hospital & Institute Beijing 100142 P. R. China.

Chemotherapy plays an important role in the treatment of metastatic breast cancer. It is important to monitor chemotherapeutic efficacy, to find a simple and efficient tool to guide treatment, and to predict the efficacy of treatment in a timely and accurate manner. This study aimed to detect mucin-1 (MUC1) - positive circulating tumor cells and MUC1 protein in the peripheral blood of patients with metastatic breast cancer and to investigate their relationship to chemotherapeutic efficacy. MUC1 mRNA was detected in the peripheral blood of 34 patients with newly diagnosed metastatic breast cancer by reverse transcription- polymerase chain reaction. The positive rates of MUC1 mRNA were 88.2% before chemotherapy and 70.6% after chemotherapy, without a significant difference (P = 0.564); MUC1 mRNA expression before chemotherapy had no correlation with treatment effectiveness (P = 0.281). The response rate of MUC1 mRNA -negative patients after first-cycle chemotherapy was significantly higher (P = 0.009) and the progression-free survival (PFS) was clearly longer than those of MUC1 mRNA-positive patients (P = 0.095). MUC1 protein in peripheral blood plasma was detected by an ELISA competitive inhibition assay. The patients with decreased MUC1 protein after chemotherapy had a significantly longer PFS than those with elevated MUC1 protein (P = 0.044). These results indicate that the outcomes of MUC1 mRNA - negative patients after chemotherapy are better than those of MUC1 mRNA-positive patients. In addition, patients with decreased expression of MUC1 protein have a better PFS.

关键词： MUC1 治疗效果肿瘤细胞阳性率乳腺癌转移性粘蛋白化疗

Current status of Mycoplasma pneumoniae infection in China

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World Journal of Pediatrics 2024年第1期20卷 1-4页

作者： Chao yan Guan-hua Xue Han-Qing Zhao yan-Ling Feng Jing-hua Cui Jing yuan Department of Bacteriology Capital Institute of PediatricsNo.2Yabao RoadBeijing 100020People's Republicof China

Mycoplasma pneumoniae(***)is one of the most important pathogens for community-acquired pneumonia worldwide,especially in children and adolescents[1,2].*** is easily transmitted through droplets or direct contact in densely populated,enclosed,or poorly ventilated *** incubation period is 1-3 weeks,and it is contagious from the incubation period to a few weeks after clinical symptom *** infection can occur in any season,and there are differences in the epidemic seasons among regions in China[3].The most suitable culture temperature for *** is between 35℃C and 37 C,and therefore,hot weather may make it survive longer in the environment and spread *** is more common in autumn and winter in northern China,while it is more prevalent in summer and autumn in southern China.

关键词： winter weather autumn

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

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Chinese Journal of Cancer Research 2012年第4期24卷 323-331页

作者： Li Che yan-hua yuan Jun Jia Jun Ren Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Medical OncologyPeking University Cancer Hospital & Institute

Objective： The activation of hedgehog （HH） pathway is implicated in the development of human malignancies including hepatocellular carcinoma （HCC）. However, the clinical impact of HH activation in HCC patients is still unclear. This study was conducted to confirm whether the expression of HH pathway components was associated with HCC progression and clinical outcome. Methods： This study was a sample-expanded and prolonged follow up of one of our previous studies. It included 46 HCC patients who underwent surgical treatment from 2002 to 2005. The expression of sonic HH （SHIq）, patched-1 （PTCHI）, smoothened （SMOH） and glioma-associated oncogene-1 （GLI1） genes in tumor and adjacent normal tissues extracted from the patients were examined by reverse transcription- polymerase chain reaction （RT-PCR） to explore the relationship between these genes and the clinical prognosis of HCC. Results： The expression levels ofSHH, PTCH1, SMOH and GLI1 in HCC tissues were 60.87%, 50.00%, 32.61% and 54.35%, respectively. The expression levels of SHH-related molecules were relatively intense in cancer tissue, but insignificantly correlated with any clinicopathological factors of tumor. Transcriptional factor GLI1 was the only molecule associated with poor prognosis among the HCC patients. The expression of GLI1 gene in tumor tissues was significantly related with disease-free survival （DFS）（P=0.042） and overall survival （OS）（P=0.030）. The simultaneous expression of GLI1 in tumor and adjacent normal liver tissues correlated with DFS （P〈0.029） and OS （P〈0.025）. Conclusions： HH signaling activation is an important event in the development of human HCC. The expression of GLI1 in SHH pathway is possibly involved in HCC progression, which may be a useful prognostic indicator of HCC.

关键词： Hepatocellular carcinoma hedgehog GLII sonic hedgehog patched smoothened prognosis

Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： hua-Shan Lai Hao Chen Chu-Hao Xia Si-yuan Yu Cheng He yan-Feng Chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

Correlation between pre-anesthesia anxiety and emergence agitation in non-small cell lung cancer surgery patients

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World Journal of Psychiatry 2024年第6期14卷 930-937页

作者： Fen yan Li-hua yuan Xiao He Kai-Feng Yu Department of Anesthesiology Wuhan Pulmonary HospitalWuhan Institute for Tuberculosis ControlWuhan 430000Hubei ProvinceChina

BACKGROUND Preoperative anxiety is a common emotional problem during the perioperative period and may adversely affect postoperative *** agitation(EA)is a common complication of general anesthesia that may increase patient discomfort and hospital stay and may be associated with the development of postoperative ***-anesthetic anxiety may be associated with the development of EA,but studies in this area are *** To determine the relationship between pre-anesthetic anxiety and EA after radical surgery in patients with non-small cell lung cancer(NSCLC).METHODS Eighty patients with NSCLC undergoing surgical treatment between June 2020 and June 2023 were conveniently *** used the Hospital Anxiety and Depression Scale’s(HADS)anxiety subscale(HADS-A)to determine patients’anxiety at four time points(T1-T4):Patients’preoperative visit,waiting period in the surgical waiting room,after entering the operating room,and before anesthesia induction,*** Riker Sedation-Agitation Scale(RSAS)examined EA after *** plots of HADS-A and RSAS scores assessed the correlation between patients’pre-anesthesia anxiety status and *** performed a partial correlation analysis of HADS-A scores with RSAS *** NSCLC patients’HADS-A scores gradually increased at the four time points:7.33±2.03 at T1,7.99±2.22 at T2,8.05±2.81 at T3,and 8.36±4.17 at *** patients’postoperative RSAS score was 4.49±1.18,and 27 patients scored≥5,indicating that 33.75%patients had ***-A scores at T3 and T4 were significantly higher in patients with EA(9.67±3.02 vs 7.23±2.31,12.56±4.10 vs 6.23±2.05,P<0.001).Scatter plots showed the highest correlation between HADS-A and RSAS scores at T3 and *** correlation analysis showed a strong positive correlation between HADS-A and RSAS scores at T3 and T4(r=0.296,0.314,P<0.01).CONCLUSION Agitation during anesthesia recovery in patients undergoing radical resection for NSCLC correlated with anxie

关键词： Non-small cell lung cancer Operative treatment Anesthesiology department Pre-anesthetic anxiety Emergence agitation Correlation study

Electrochemically recycling degraded superalloy and valorizing CO_(2)in the aff ordable borate-modified molten electrolyte

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Tungsten 2024年第2期6卷 382-393页

作者： Xiang Chen yuan Sun Long Wang Xin Qu yan Zhao Hong-Wei Xie Di-hua Wang hua-Yi Yin Key Laboratory for Ecological Metallurgy of Multimetallic Mineral of Ministry of Education School of MetallurgyNortheastern UniversityShenyang 110819China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China School of Resource and Environmental Science Wuhan UniversityWuhan 430072China

Integrating electrochemical reduction of CO_(2)and electrochemical oxidation to recycle degraded superalloys is a promising solution to ease resource scarcity and safeguard environmental ***,we propose an electrochemical technique for the conversion of bulk superalloy scraps and CO_(2)into oxide powder at the anode and solid carbon at the cathode,*** particular,a borax-modifi ed CaCl_(2)-based molten salt electrolyte is used for enhancing the electrochemical oxidation of superalloy *** a temperature of 700℃and a voltage of 2.8 V,90.55 wt.%of alloy scraps were oxidized in a molten CaCl_(2)–NaCl–CaCO_(3)–Na_(2)B_(4)O_(7)with an acid–base ratio(K_(a/b))of *** synergy of Cl−and B_(4)O_(7)2−of electrolyte prevents the passivation of the alloy anode and enables continuous ***,the Ni and Co in the anode products are recovered by sulfation roasting with recovery efficiencies of 85.58%and 95.27%for Ni and Co,***,modulating the alkalinity of the electrolyte for enhancing oxidation/pulverization of alloy scrap anode provides new insight into electrochemically recovering superalloy scraps.

关键词： Superalloy scraps Recycling Molten salt Alkalinity Electrochemical oxidation Cobalt

Identification of survival-associated biomarkers based on three datasets by bioinformatics analysis in gastric cancer

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World Journal of Clinical Cases 2023年第20期11卷 4763-4787页

作者： Long-Kuan Yin hua-yan yuan Jian-Jun Liu Xiu-Lian Xu Wei Wang Xiang-Yu Bai Pan Wang Department of Gastrointestinal Surgery Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Sichuan Key Laboratory of Medical Imaging North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors with poor prognosis in terms of advanced ***,the survival-associated biomarkers for GC remains *** To investigate the potential biomarkers of the prognosis of patients with GC,so as to provide new methods and strategies for the treatment of *** RNA sequencing data from The Cancer Genome Atlas(TCGA)database of STAD tumors,and microarray data from Gene Expression Omnibus(GEO)database(GSE19826,GSE79973 and GSE29998)were *** differentially expressed genes(DEGs)between GC patients and health people were picked out using R software(x644.1.3).The intersections were underwent between the above obtained co-expression of differential genes(co-DEGs)and the DEGs of GC from Gene Expression Profiling Interactive Analysis database,and Gene Ontology(GO)analysis,Kyoto Encyclopedia of Gene and Genome(KEGG)pathway analysis,Gene Set Enrichment Analysis(GSEA),Protein-protein Interaction(PPI)analysis and Kaplan-Meier Plotter survival analysis were performed on these *** Immunohistochemistry(IHC)database of Human Protein Atlas(HPA),we verified the candidate Hub *** With DEGs analysis,there were 334 co-DEGs,including 133 up-regulated genes and 201 down-regulated *** enrichment analysis showed that the co-DEGs were involved in biological process,cell composition and molecular function *** enrichment analysis suggested the co-DEGs pathways were mainly enriched in ECM-receptor interaction,protein digestion and absorption pathways,*** pathway analysis showed that co-DEGs mainly concentrated in cell cycle progression,mitotic cell cycle and cell cycle pathways,*** analysis showed 84 nodes and 654 edges for the *** survival analysis illustrated 11 Hub genes with notable significance for prognosis of patients were ***,using IHC database of HPA,we confirmed the above candidate Hub genes,and 10 Hub genes that associated with prognos

关键词： Gastric cancer Survival-associated biomarkers Bioinformatics analysis Hub genes

Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes:A meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2159-2167页

作者： yuan-hua Song Wen-Ling Li Zhen yang yan Gao Zhi-Ping Feng Department of Oncology Kunming Children's HospitalKunming 650103Yunnan ProvinceChina Department of Nuclear Medicine The Third Affiliated Hospital of Kunming Medical University(Yunnan Cancer Hospital)Kunming 650118Yunnan ProvinceChina

BACKGROUND The research findings suggest that the prognosis of children with Wilms tumor(WT)is affected by various *** scholars have indicated that loss of heterozygosity(LOH)on chromosome 16q is associated with a poor prognosis in patients with *** To further elucidate this relationship,we conducted a *** This meta-analysis was registered in INPLASY(INPLASY2023100060).We systematically searched databases including Embase,PubMed,Web of Science,Cochrane,and Google Scholar up to May 31,2020,for randomized trials reporting any intrapartum fetal surveillance *** meta-analysis was performed within a frequentist framework,and the quality and network inconsistency of trials were *** ratios and 95%CIs were calculated to report the relationship between event-free survival and 16q LOH in patients with *** Eleven cohort studies were included in this meta-analysis to estimate the relationship between event-free survival and 16q LOH in patients with WT(I^(2)=25%,P<0.001).As expected,16q LOH can serve as an effective predictor of eventfree survival in patients with WT(risk ratio=1.95,95%CI:1.52–2.49,P<0.001).CONCLUSION In pediatric patients with WT,there exists a partial correlation between 16q LOH and an unfavorable treatment *** detection of 16q chromosome LOH warrants increased attention to the patient’s prognosis.

关键词： Loss of heterozygosity Wilms tumor Survival time Chromosomes 16q

UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN yuan-yuan WANG Ya-hui TAN Jin-hua SU Lian-lin yan Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine