检索结果-南通市图书馆

Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

当代医学科学（英文） 2024年第4期44卷 809-819页

作者： Chen-guang YAO Zi-jia ZHAO Ting TAN Jiang-ning yan Zhong-wei CHEN Jun-tao XIONG Han-luo LI yan-hong wei Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education & Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National"111"Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan 430068China Centerfor Evaluation of Hubei Medical Products Administration Wuhan 430068China

Objective:Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying ***:Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related ***:MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 ***:Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer mitochondria mitophagy polyoxometalate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2021年广西稻瘟病菌致病性分化及其无毒基因分析

引用

西南农业学报 2024年第6期37卷 1281-1287页

作者：颜群岑贞陆农倩李焜华张月雄韦丽丽晏卫红韦善富广西农业科学院植物保护研究所/农业农村部华南果蔬绿色防控重点实验室/广西作物病虫害生物学重点实验室南宁530007 广西农业科学院水稻研究所/广西水稻遗传育种重点实验室南宁530007

【目的】探究广西稻瘟病菌的致病力、优势种群和优势生理小种,分析其无毒基因,了解其生理小种及无毒基因组成与分布情况,为水稻抗性育种和品种推广提供参考。【方法】使用7个我国统一鉴别品种和26份已知抗病基因的近等基因系,采用室内... 详细信息

【目的】探究广西稻瘟病菌的致病力、优势种群和优势生理小种,分析其无毒基因,了解其生理小种及无毒基因组成与分布情况,为水稻抗性育种和品种推广提供参考。【方法】使用7个我国统一鉴别品种和26份已知抗病基因的近等基因系,采用室内苗期人工喷雾接种方法对2021年从广西南部(桂南)、中部(桂中)、北部(桂北)和高寒山区4个不同生态稻作区分离得到的128株稻瘟病单孢菌株进行致病性测定。【结果】60.16%供试稻瘟病菌菌株表现出强致病力,128株稻瘟病菌株被划分为7个种群26个生理小种,ZB群为优势种群,出现频率为69.53%,优势生理小种为ZB_(13)和ZB_9,出现频率分别为25.00%、14.84%。供试菌株对26个抗病基因的毒力频率为28.12%~100.00%,其中,供试病菌对Pik、Pikm、Pi1、Pi9基因的毒力频率较低,分别为28.12%、28.91%、35.94%、37.50%。供试的广西稻瘟病菌含有与测试抗病基因相对应的无毒基因,其中15个无毒基因在桂南、桂中、桂北和高寒山区4个不同稻作区均有分布,无毒基因Avr-Pia(1)、Avr-Pia(2)、Avr-Pii、Avr-Pik^(s)、Avr-Pib、Avr-Pit、Avr-Pish(2)、Avr-Pi3(t)、Avr-Pi5(t)、Avr-Pi12(t)、Avr-Pi19(t)出现频率均低于20.00%。携带有5、6、7、8、10个无毒基因组合的菌株较多,其在供试菌株中占比分别为19.53%、11.72%、11.72%、15.63%、10.16%。【结论】2021年广西稻瘟病菌致病力强,优势种群为ZB群,优势生理小种为ZB_(13)和ZB_9,无毒基因Avr-Pia(1)、Avr-Pia(2)、Avr-Pii、Avr-Pik^(s)、Avr-Pib、Avr-Pit、Avr-Pish(2)、Avr-Pi3(t)、Avr-Pi5(t)、Avr-Pi12(t)和Avr-Pi19(t)出现频率较低,在水稻抗病育种与品种布局中,与之对应的抗病基因应慎用。

关键词：稻瘟病菌致病性无毒基因出现频率广西

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Mn含量对Mg-1Al合金微观组织和变形机制的影响

引用

材料热处理学报 2024年第1期45卷 70-77页

作者：彭怡张丹颜宏伟彭鹏龙帅张诚杨青山戴庆伟重庆科技学院冶金与材料工程学院重庆401331

采用拉伸实验、扫描电镜、电子背散射衍射技术和粘塑性自洽(VPSC)模拟计算等方法分析了不同Mn含量对挤压Mg-1Al-xMn(x=1、2和3,mass%)合金微观组织和塑性变形机制的影响。结果表明:随着Mn含量从1 mass%增加至3 mass%,Mg-1Al挤压合金的... 详细信息

采用拉伸实验、扫描电镜、电子背散射衍射技术和粘塑性自洽(VPSC)模拟计算等方法分析了不同Mn含量对挤压Mg-1Al-xMn(x=1、2和3,mass%)合金微观组织和塑性变形机制的影响。结果表明:随着Mn含量从1 mass%增加至3 mass%,Mg-1Al挤压合金的强度和塑性得到同步提升,其中Mg-3Mn-1Al合金的力学性能表现良好,拉伸屈服强度、极限拉伸强度和断裂伸长率分别为302 MPa、325 MPa和21%。随着Mn含量的增加,Mg-1Al挤压合金中的第二相数量显著增加,且沿着挤压方向呈带状分布,Mg-3Mn-1Al合金的晶粒最细小,出现明显的混晶组织,平均晶粒尺寸为1.31μm。VPSC模拟结果表明,在Mg-1Al合金中加入Mn元素可以有效抑制基面滑移的启动,有利于促进锥面滑移系的激活,非基面滑移的启动能够有效协调应变,进而提升合金的塑性变形能力,最终实现强度和塑性的同步提升。

关键词：镁合金晶粒组织变形机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development and application of software packages in welding engineering

引用

Frontiers of Materials Science 2011年第2期5卷 160-167页

作者： yan-hong wei Xiao-hong ZHAN Zhi-Bo DONG School of Material Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China State Key Laboratory of Advanced Welding Technology Production Harbin Institute of Technology Harbin 150001 China

The weldabiUty of some material is analyzed with simple calculating program in this paper, and weldability testing data are shared through database system. The welding procedures are designed with help of expert systems, and the knowledge is shared among welding engineers. Not only the preparing progress of the welding documents is completed with database systems but also the complex decision on the necessity of the qualification test according to the present procedure qualification records （PQRs） and manufacture codes is made. Moreover, the artificial neural network （ANN） technique is proven to be one of the effective ways to predict mechanical properties of welded joints when there are enough tested data to train the models. Finally, the achievements in modeling microstructure of welded joints are introduced, especially in solid transformation and grain growth in both heat-affected zone （HAZ） and welded molten pool.

关键词： welding software package, finiteelementmethod (FEM), welding procedurequalification, mechanical properties of welded joints expert system, database system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in papillary thyroid carcinoma

引用

World Journal of Clinical Cases 2019年第1期7卷 49-57页

作者： wei Jiang hong-yan wei Hai-yan Zhang Qiu-Luan Zhuo Department of Ultrasound Shenzhen Nanshan District People’s Hospital

BACKGROUND Cervical lymph node metastasis in papillary thyroid carcinoma(PTC) affects the treatment and prognosis of patients. Ultrasound is a common imaging method for detecting cervical lymph nodes in PTC patients; however, it is not accurate in determining lymph node *** To evaluate the value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in *** A total of 94 patients with PTC were recruited. According to pathological results,lymph nodes were divided into two groups: metastatic group(n = 50) and reactive group(n = 63). The routine ultrasound findings, contrast-enhanced ultrasound and elastography data were recorded and compared. Logistic regression was used to generate predictive probability distributions for the diagnosis of lymph node metastasis with different indicators. Receiver operating characteristic curve analysis was used to test the efficacy of contrast-enhanced ultrasound combined with elastography based on routine ultrasound in evaluating PTC cervical lymph node *** The ratio of long diameter/short diameter(L/S) ≤ 2, irregular marginal morphology, missing lymphatic portal, peripheral or mixed blood flow distribution, peak intensity(PI), non-uniform contrast distribution and elasticity score in the metastatic group were significantly higher than those in the reactive group(P < 0.05). L/S ratio, missing lymphatic portal, PI and elasticity score had a significant influence on the occurrence of PTC cervical lymph node metastasis(P< 0.05). Furthermore, the area under the curve(AUC) for lymph node metastasis diagnosed using the combination of PI ratio, elasticity score, missing lymphatic portal and LS was 0.936, which was significantly higher than the AUC for PI ratio alone. The difference was statistically significant(P < 0.05). The fitting equation for the combined diagnosis was logit(P) =-12.341 + 1.482 × L/S ratio + 3.529 ×missing lymphatic portal + 0.392 × PI + 3

关键词： Contrast-enhanced ultrasound Elastography Papillary thyroid cancer Cervical lymph node metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two New Copper Complexes by H_4AQTC(Anthraquinone-1,4,5,8-tetracarboxylic Acid):Syntheses,Structures and Properties

引用

Chinese Journal of Structural Chemistry 2021年第3期40卷 349-356,273页

作者： yan wei-hong ZENG Xian-Cai School of Biology and Chemical Engineering Nanyang Institute of TechnologyHenan Key Laboratory of Industrial Microbial Resources and Fermentation TechnologyNanyang 473004China

Two new complexes[Cu(AQTC)_(0.5)(H_(2)O)_(3)]·3H_(2)O}_(n) (1,H_(4)AQTC=anthraquinone-1,4,5,8-tetracarboxylic acid) and Cu[(Py)_(2)C(OH)_(2)]_(2)(H_(2)AQTC)·2H_(2)O (2,(Py)_(2)CO=di-2-pyridyl ketone) have been prepared and characterized by elemental analyses and IR spectroscopy.X-ray crystallographic studies show that complex 1crystallizes in monoclinic space group C2/m and complex 2 in monoclinic space group P2_1/*** 1 features a1D chain structure by carboxyl oxygen *** 2 displays a mononuclear structure and anions and cations are ***'s interesting is that the ligand of H_(4)AQTC with eight carboxyl oxygen atoms and two quinone oxygen atoms does not directly coordinate with metals,and only exist as a counter-anion in complex ***-dimensional structures of two complexes are formed by intermolecular *** thermogravimetric analyses of two complexes are *** luminescent properties of complex 1 are investigated as well.

关键词： anthraquinone-1 4 5 8-tetracarboxylic acid di-2-pyridyl ketone syntheses crystal structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrochemical behavior of different shelled microcapsule composite copper coatings

引用

International Journal of Minerals,Metallurgy and Materials 2011年第3期18卷 377-384页

作者： Xiu-qing Xu yan-hong Guo wei-ping Li Li-qun Zhu School of Materials Science and Engineering Beihang University Beijing 100191 China

Copper/liquid microcapsule composite coatings with polyvinyl alcohol （PVA）, gelatin or methyl cellulose （MC） as shell materials were prepared by electrodeposition. The influence of shell materials on the corrosion resistance of the composite coatings in 0.1 M H2SO4 was investigated by means of electrochemical techniques, scanning electron microscopy （SEM）, and energy dispersion spectrometry （EDS）. The results show that the participation of microcapsules can enhance the corrosion resistance of the composite coatings compared with the traditional copper layer. Based on the analysis of electrochemical test results, the release ways of microcapsules were deduced. Gelatin and MC as the shell materials of microcapsules are easy to release quickly in the composite coating. On the contrary, the releasing speed of PVA microcapsules is relatively slow due to their characteristics.

关键词： composite coatings shell materials copper microcapsules electrochemical properties corrosion resistance electrodeposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental study on the bank erosion and interaction with near-bank bed evolution due to fluvial hydraulic force

引用

International Journal of Sediment Research 2015年第1期30卷 81-89页

作者： Ming-hui YU hong-yan wei Song-bai WU State Key Laboratory of Water Resources and Hydropower Engineering Sciences Wuhan University

Bank erosion is a typical process of lateral channel migration,which is accompanied by vertical bed *** a main sediment source,the failed bank soil may directly cause the increase of sediment concentration and considerable channel evolution in a short *** paper presents an experimental study on non-cohesive and cohesive homogenous bank failure processes,influence of the failed bank soil on bank re-collapse,as well as the interaction between bank failure and near-bank bed evolution due to fluvial hydraulic force.A series of experiments were carried out in a 180° bend rectangular *** results reveal the iteration cycle between bank erosion and bed deformation:undercutting of the riverbank,slip failure of the submerged zone of the bank,as well as cantilever failure of the overhang,failed bank soil staying at bank toe temporarily or hydraulic transportation,exchange between the failed bank soil and bed material,bed material load being re-transported either as bed load or as suspended load,and bed *** as bank failure,the mixing of failed bank soil and bed material is more severe near the curved flow ***,non-cohesive bank failure tends to occur near the water surface while cohesive bank failure near the bank *** non-cohesive dense(sandy) soil,the bank erosion amount and residual amount of failed bank soil on the bed increase with the near-bank velocity or bed *** for cohesive soil,only bank erosion amount follows the above *** results are expected to provide theoretical basis for river management and flood prevention.

关键词： Bank erosion Near-bank bed evolution Hydraulic transport Interaction Flume experiment

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Clinical characteristics and risk factors of Talaromyces marneffei infection in human immunodeficiency virus-negative patients: A retrospective observational study

引用

World Journal of Emergency Medicine 2021年第4期12卷 281-286页

作者： hong-yan wei Wen-jie Liang Bin Li Ling-yu wei An-qi Jiang wei-dong Chen Peng-hao Guo Jia Xu Department of Emergency Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Pulmonary and Critical Care Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Clinical Trial Unit the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

BACKGROUND: To investigate the clinical characteristics and risk factors of human immunodeficiency virus(HIV)-negative patients with Talaromyces marneffei(T. marneffei) ***: We retrospectively collected the clinical information of HIV-negative patients with T. marneffei infection from January 1, 2010 to June 30, 2019, and analyzed the related risk factors of poor ***: Twenty-five cases aging 22 to 79 years were included. Manifestations of T. marneffei infection included fever, cough, dyspnea, chest pain or distress, lymphadenopathy, ear, nose, and throat(ENT) and/or skin lesions, bone or joint pain, edema and pain in the lower extremities, digestive symptoms, icterus, malaise, and hoarseness. Two cases had no comorbidity, while 23 cases suff ered from autoimmune disease, pulmonary disease, cancer, and other chronic diseases. Sixteen cases had a medication history of glucocorticoids, chemotherapy or immunosuppressors. Pulmonary lesions included interstitial infiltration, nodules, atelectasis, cavitary lesions, pleural effusion or hydropneumothorax, bronchiectasis, pulmonary fibrosis, pulmonary edema, and consolidation. The incidence of osteolytic lesions was 20%. Eight patients received antifungal monotherapy, and 11 patients received combined antifungal agents. Fifteen patients survived and ten patients were dead. The Cox regression analysis showed that reduced eosinophil counts, higher levels of blood urea nitrogen(BUN), alanine aminotransferase(ALT), aspartate aminotransferase(AST), lactic dehydrogenase(LDH), myoglobin(Mb), procalcitonin(PCT), and galactomannan were related to poor prognosis(hazard ratio [HR]>1, P<0.05).CONCLUSIONS: Bone destruction is common in HIV-negative patients with T. marneffei infection. Defective cell-mediated immunity, active infection, multiple system, and organ damage can be the risk factors of poor prognosis.

关键词： Talaromyces marneffei Human immunodeficiency virus Bone destruction Risk factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new anthraquinone glycoside from seeds of Cassia obtusifolia

引用

Chinese Chemical Letters 2008年第9期19卷 1083-1085页

作者： Li Ying Tang Zhu Ju Wang Mei hong Fu yan He hong wei Wu Lu Qi Huang Institute of Traditional Chinese Materia Medica Chinese Academy of Medical Sciences Beijing 100700 China

A new anthraquinone glycoside 1, along with a known anthraquinone glycoside aurantio-obmsin-6-O-β-D-glucopyranoside 2, were isolated from the seeds of Cassia obtusifolia. On the basis of spectral and chemical evidences, the structure of 1 was established as 1-demethylaurantio-obtusin-2-O-β-D-glucopyranoside. Moreover, the 13C NMR of 2 was assigned totally and correctly for the first time based on the two-dimensional NMR.

关键词： ~assia obtusifolia Anthraquinone glycoside 1-Demethylaurantio-obtusin-2-O-β-D-glucopyranoside

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：